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Kara Smith, MD, publication report from PubMed

Total: 20 results

  • Intellectual function and psychiatric comorbidities in patients with epilepsy with eyelid myoclonia

    Sunday, February 01, 2026
    Author(s): Hannah Padilla,Eva C Alden,Isha Snehal,Jeffrey W Britton,Lily C Wong-Kisiel,Elaine C Wirrell,Kelsey M Smith
    Source: Epilepsy & behavior : E&B
    CONCLUSIONS: EEM is associated with a wide range of cognitive abilities, with half of our patients having a below average IQ. Psychiatric comorbidities were common. Identifying cognitive impairment and psychiatric comorbidities is crucial to implement appropriate management strategies.

  • Tegmental kappa-opioid receptor neurons modulate opioid withdrawal via the periaqueductal gray

    Saturday, January 24, 2026
    Author(s): Ruby A Holland,Kelly M Smith,Isabel B Bleimeister,Jeffrey J Okoro,Samantha A Sherman,Ava V Zoltanski,Michael C Chiang,BaDoi N Phan,Bryan M Hooks,Andreas R Pfenning,Eileen K Nguyen,Sarah E Ross
    Source: Brain : a journal of neurology
    Opioid withdrawal is a common and distressing manifestation of opioid dependence which, if left untreated, frequently results in relapse, accidental overdose, and suicide. While much is known about the role of mesolimbic and mesocortical dopaminergic neurons in mu opioid receptor-mediated reward, much less is understood about the impact of chronic opioid use on parallel aversive pathways mediated by the kappa opioid receptor and its endogenous ligand dynorphin. In the present study, we...

  • Correction to: Stochastic Models of Zoonotic Avian Influenza with Multiple Hosts, Environmental Transmission, and Migration in the Natural Reservoir

    Friday, January 23, 2026
    Author(s): Rowan L Hassman,Iona M H McCabe,Kaia M Smith,Linda J S Allen
    Source: Bulletin of mathematical biology
    No abstract

  • Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

    Wednesday, January 21, 2026
    Author(s): Ashley Rider,Henry J Grantham,Graham R Smith,David S Watson,John Casement,Simon J Cockell,Jack Gisby,Amy C Foulkes,Rafael Henkin,Wasim A Iqbal,Tom Ewen,Shoba Amarnath,Sandra Ng,Paolo Zuliani,Nick Dand,Deborah Stocken,Christopher Traini,Elizabeth Thomas,Shanker Kalyana-Sundaram,Deepak K Rajpal,Kathleen M Smith,Jonathan N Barker,Christopher E M Griffiths,Paola Di Meglio,Catherine H Smith,Richard B Warren,Michael R Barnes,Nick J Reynolds,PSORT consortium
    Source: Communications medicine
    CONCLUSIONS: These findings delineate gene-environmental and genetic effects on the psoriasis transcriptome linked to disease severity.

  • Speech Acoustic Markers Can Detect Mild Cognitive Impairment in Parkinson's Disease

    Monday, January 19, 2026
    Author(s): Kara M Smith,James R Williamson,Thomas F Quatieri
    Source: IEEE journal of selected topics in signal processing
    CONCLUSION: PD-MCI has a distinct speech acoustic signature that may be harnessed to develop better tools to detect and monitor this complication.

  • Translational characterization of a house dust mite-induced murine model of dermatitis

    Saturday, January 10, 2026
    Author(s): Zhi Su,Samrawit Aforki,Zachary K Goldsmith,Sheila Cummings,Kathleen M Smith,Xin Chen,Stacy H Ryu,Anastasia E Marinopoulos,Joseph B Wetter,Samuel Karsen,Nancy Crosbie,Laura Wasserman,Elizabeth Asque,Gricelda Simler,Stephanie E Paulsboe,Samantha Ciura,Danyal Butt,Heath A McDonald,Ramkrishna Sadhukhan,Viktor Todorović,Victoria E Scott,Jacqueline Loud
    Source: Scientific reports
    House dust mites (HDM), common allergens that can induce atopic dermatitis (AD), are widely employed to generate mouse models of AD. In the current study, we compared the AD-like phenotypes between two mouse strains, NC/Nga, and BALB/c, in response to HDM, and performed cellular, molecular, and pharmacological characterization of HDM-induced dermatitis in NC/Nga mice. In-life endpoints included skin clinical scores, ear thickness, transepidermal water loss (TEWL), and scratching bouts. Terminal...

  • Drug-resistant glutamic acid decarboxylase 65-associated epilepsy: Pre-surgical evaluation and comparison to temporal lobe epilepsy of other etiology

    Wednesday, December 31, 2025
    Author(s): Anna N Thomsen,Gloria Ortiz-Guerrero,Divyanshu Dubey,Jeffrey W Britton,Kelsey M Smith
    Source: Epilepsia
    High-titer glutamic acid decarboxylase 65 (GAD65) antibodies (20 nmol/L) are linked to chronic focal epilepsy, usually of temporal regional onset. Identification of these antibodies has treatment and prognostic implications. We compared patients with drug-resistant epilepsy and high-titer GAD65 antibodies to an age- and sex-matched control group with drug-resistant GAD65 antibody-negative temporal lobe epilepsy. From 1432 patients presented at a single-center surgical epilepsy conference...

  • Imaging in Movement Disorders: A Clinician's Perspective on Novel Applications

    Friday, December 26, 2025
    Author(s): Kara M Smith,Manojkumar Saranathan
    Source: Seminars in neurology
    The utility of neuroimaging in the diagnosis and management of movement disorders has been steadily increasing as both imaging and image analysis technologies have advanced in the last decade. Neuroimaging is also playing a critical role in the search for novel therapies to prevent, slow down, and treat various movement disorders. This article reviews both standard and innovative imaging tools available for both clinicians and researchers. We focus predominantly on the clinician's perspective,...

  • Scoping review of patient and family engagement interventions in diagnosis: a paradox of too much, yet so little

    Tuesday, December 23, 2025
    Author(s): Mary A Hill,Helen Haskell,Katie N Dainty,Kerry Kuluski,Christine Shea,Layla Heimlich,Sharifa Kazi,Mark Sochaniwskyj,Alessia Priore,Taylor Leslie Marie Mason,Tess Coppinger,Simran Isani,Nicole Scala,Sara Shearkhani,Sadaf Kazi,Traber D Giardina,Kristen E Miller,Kelly M Smith,Patient-Partnered Diagnostic Center of Excellence
    Source: BMJ quality & safety
    CONCLUSION: PFE interventions exist across the diagnostic process, but few target referrals and physical examinations. The evidence remains weak, and current interventions cannot be considered effective. Future research should prioritise equity, patient involvement and rigorous evaluation.

  • Nicotine delivery from and user reactions to nicotine pouches compared to cigarettes

    Friday, December 12, 2025
    Author(s): Dunja Przulj,Katie Myers Smith,Hayden McRobbie,Francesca Pesola,Irina Ananina,Daniella Ladmore,Peter Hajek
    Source: Psychopharmacology
    CONCLUSIONS: The initial appeal of pouches to smokers is likely to be more limited than the appeal of products that resemble smoking more closely, and ZYN pouches with 9 mg of nicotine may be too strong for light smokers. However, in terms of nicotine delivery and effects on urges to smoke, pouches have good potential to provide effective replacement for smoking.

  • CT catches these too: Characterizing pediatric cervical spine injuries managed with rigid collars

    Thursday, December 11, 2025
    Author(s): Christopher E Clinker,Jack H Scaife,Mitchell S Kirkham,Anastasia M Kahan,Karch M Smith,Stephanie E Iantorno,Rajiv R Iyer,Robert A Swendiman,Katie W Russell
    Source: Injury
    CONCLUSION: A substantial proportion of pediatric CSI patients are managed nonoperatively with rigid collars due to persistent symptoms. CT identified all patients needing further evaluation, and MRI clarified soft tissue injuries in symptomatic cases. Spine surgeon review confirmed these injuries were not unstable and did not require surgery. These findings highlight CT as an effective screening tool, the value of MRI in select cases, and the importance of clinical judgment and...

  • A Hodge-FAST Framework for High-Resolution Dynamic Functional Connectivity Analysis of Higher Order Interactions in EEG Signals

    Wednesday, December 03, 2025
    Author(s): Om Roy,Yashar Moshfeghi,Jason Smith,Agustin Ibanez,Mario A Parra,Keith M Smith
    Source: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    We introduce a novel framework that integrates Hodge decomposition with Filtered Average Short-Term (FAST) functional connectivity to analyze dynamic functional connectivity (DFC) in EEG signals. This method leverages graph-based topology and simplicial analysis to explore transient connectivity patterns at multiple scales, addressing noise, sparsity, and computational efficiency. The temporal EEG data are first sparsified by keeping only the most globally important connections, instantaneous...

  • Barriers to and facilitators for implementing a Care Partner program for adult patients with persistent critical illness

    Friday, November 28, 2025
    Author(s): Laura Istanboulian,Anthony J Gilding,Lorrie Hamilton,Kelly M Smith,Karen Soldatić
    Source: Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
    CONCLUSION: The identification of multilevel barriers and facilitators can aid in the design and implementation of interventions addressing structural barriers to family engagement in critical care settings.

  • Success of restoration strategies in preventing extirpation of 2 critically endangered coral species

    Saturday, November 22, 2025
    Author(s): Erinn M Muller,Mark C Ladd,Richard Karp,Phanor H Montoya-Maya,Ilsa B Kuffner,Andrew C Baker,Erich Bartels,Amanda Bourque,Abigail S Clark,Nikkie Cox,Martine D'Alessandro,Ben Daughtry,Beth Firchau,Leneita Fix,David Gilliam,Dalton Hesley,Cindy Lewis,Diego Lirman,Caitlin Lustic,Kevin Macauley,Jennifer Moore,Ken Nedimyer,Keri O'Neil,Kristene T Parsons,Kylie M Smith,Jason Spadaro,Bailey C Thomasson,Joseph D Unsworth,David Vaughan,Margaret W Miller
    Source: Conservation biology : the journal of the Society for Conservation Biology
    An unprecedented marine heatwave in 2023 caused widespread coral bleaching and mortality throughout the Caribbean. In the Florida Keys (USA), 2 foundation species, elkhorn coral (Acropora palmata) and staghorn coral (Acropora cervicornis), were severely affected. These species have been the primary focus of reef restoration in Florida for decades. Substantial losses of these species occurred in outplanted populations, in ocean-based nurseries, and among remnant wild colonies, leading to...

  • Preliminary Psychometric Review of Neurologists' Speech Ratings on the Unified Parkinson's Disease Rating Scale

    Tuesday, November 18, 2025
    Author(s): Kimberly L Dahl,Magdalen A Balz,Kara M Smith,Cara E Stepp
    Source: American journal of speech-language pathology
    CONCLUSIONS: A critical communication outcome-intelligibility during unscripted speech-is not captured by MDS-UPDRS Part III speech ratings, suggesting weak concurrent validity of this widely used metric of speech function. The reproducibility of MDS-UPDRS Part III speech ratings across providers is fair. These speech ratings may be insufficient to assess the speech function of people with PD and identify those in need of speech services.

  • The Formylation of N,N‑Dimethylcorroles

    Monday, October 20, 2025
    Author(s): Sara Nardis,Alessia Fata,Francesco Pizzoli,Greta Imbesi,Greta Petrella,Daniel O Cicero,Frank R Fronczek,Kevin M Smith,Roberto Paolesse
    Source: ACS omega
    The chemistry of N-alkylcorroles is almost unexplored, although it could represent a promising route for further tuning the properties of this porphyrinoid. Herein, we report our investigations on the β-formylation of N(21),N(22)-dimethyl-5,10,15-tritolylcorrole, showing how different regioisomers can be obtained by modifying the functionalization reaction sequence. β-Formyl-N(21),N(22)-dimethyl-5,10,15-tritolylcorrole shows unprecedented reactivity toward acetone in basic conditions, affording...

  • Surgical and patient factors associated with baseplate failures after reverse shoulder arthroplasty: a study by the ASES Complications of RSA Multicenter Research Group

    Friday, October 10, 2025
    Author(s): ASES Complications of RSA Research Group,Adam Bowler,Evan A Glass,Jason Corban,Declan R Diestel,Miranda McDonald-Stahl,Calista S Stevens,Regan P Arnold,Himmat Sahi,Richard Puzzitiello,Daniel P Swanson,Michael A Moverman,Ryan Lohre,Kuhan A Mahendraraj,Kiet Le,Warren R Dunn,Dylan J Cannon,Hunter Carlson,Peter J Chabot,Charles Cogan,Matthew R Colatruglio,Lisa Gm Friedman,Jaina A Gaudette,John Green,Lauren Grobaty,Michael Gutman,Jason C Ho,Keegan Hones,Ermyas Kahsai,Jacquelyn Kakalecik,Mitchell Kirkham,Michael A Kloby,Elliot N Konrade,Margaret C Knack,Tyler LaMonica,Amy Loveland,Joshua I Mathew,Emma Merrill,Albert D Mousad,Luke Myhre,Andrew Nahr,Jacob Nyfeler,Doug E Parsell,Midhat Patel,Marissa Pazik,Teja S Polisetty,Padmavathi Ponnuru,John Scanaliato,Arden Shen,Karch M Smith,Katherine A Sprengel,Ocean Thakar,Lacie Turnbull,Alayna Vaughan,John C Wheelwright,Anastasia Whitson,Anna B Williams,Tyler Williams,Joseph Abboud,April Armstrong,Luke Austin,Tyler Brolin,Vahid Entezari,Grant E Garrigues,Brian Grawe,Lawrence V Gulotta,Rhett Hobgood,John G Horneff,Joseph Iannotti,Jason E Hsu,Michael Khazzam,Joseph J King,Jacob M Kirsch,Jonathan C Levy,Anand Murthi,Surena Namdari,Gregory P Nicholson,Randall J Otto,Eric T Ricchetti,Robert Z Tashjian,Thomas Throckmorton,Thomas Wright,Andrew Jawa
    Source: Journal of shoulder and elbow surgery
    CONCLUSION: Revision surgery, bone grafting (especially allografts), and increased lateral offset were significantly associated with higher odds of baseplate failure after rTSA. Central screw fixation appears protective. Most failures were atraumatic, underscoring the importance of achieving stable bone ingrowth. These findings may inform surgical planning and patient counseling regarding factors associated with increased failure risk.

  • Ladder-Type Cu(II) Coordination Polymer with π-π Stacking of Planar Blatter Radical Ligands: Structural and Magnetic Characterization

    Monday, October 06, 2025
    Author(s): Hemant K Singh,Kayla M Smith,Jeremy M Rawson,Bruno Camargo,Ethan S Pollett,Oleksandr Hietsoi,Andrienne C Friedli,Piotr Kaszyński
    Source: Crystal growth & design
    The synthesis of two C(2)-pyridyl derivatives of the planar Blatter radical was developed by using the tris-(trimethylsilyl)-silane (TTMSS)-assisted cyclization of appropriate iodoarenes. These monodentate paramagnetic ligands were characterized by spectroscopic (UV-vis and electron paramagnetic resonance (EPR)) and electrochemical methods and reacted with (pdc)-Cu-(H(2)O)(3). A complex containing the 3-pyridyl group was characterized structurally, revealing novel polymeric Cu-O-Cu-O ladders...

  • Reported contributors to communication vulnerability for adult patients in critical care

    Saturday, September 13, 2025
    Author(s): Laura Istanboulian,Amy Freeman-Sanderson,Anthony Gilding,Praisy Rampogu,Kelly M Smith,Karen Soldatić
    Source: Intensive & critical care nursing
    CONCLUSIONS: This study presents patient, family, and healthcare provider reported contributors to patient communication vulnerability in the intensive care unit beyond patient-factors. Identifying socio-relational, environmental and structural related factors contributing to communication vulnerability provides multiple opportunities to improve patient communication practices and safety for adults in the intensive care unit.

  • Erratum: Invasive Neurostimulation During Pregnancy for Treatment of Epilepsy and Tourette Syndrome: Maternal and Fetal Outcomes

    Monday, August 11, 2025
    Author(s): Anhmai Vu,Aisha Abdulrazaq,Brian N Lundstrom,Lauren M Jackson,Jeffrey W Britton,William O Tatum,Cornelia Drees,Elizabeth A Coon,Linda M Szymanski,Gregory A Worrell,Kelsey M Smith
    Source: Neurology. Clinical practice
    [This corrects the article DOI: 10.1212/CPJ.0000000000200498.].