Two research scientists from UMass Chan Medical School — Kevin Donahue, MD and Marian Walhout, PhD — have been awarded funds for research on much-needed therapies for certain rare diseases...
Several years ago, we began investigating the mechanism by which genes are turned off on the X chromosome — a process termed X chromosome inactivation (XCI). In females, XCI is a naturally occurring phenomenon in which one of the X chromosomes is randomly turned off, or silenced, as a way to equalize the dosage of the X chromosome between females (who have two X chromosomes) and males (who have one).
