For the latest COVID-19 campus news and resources, visit

Search Close Search
Search Close Search
Page Menu

Selected Publications (out of 32 total)

  1. ND Peterson, JD Isco, JE Salisbury, T Rodriguez, PR Thompson, R Pukkila-Worley. Pathogen infeciton and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. eLife 2022; 11e74206. Cover.

  2. SM Anderson and Pukkila-Worley R. Immunometabolism in Caenorhabditis elegans. PLOS Pathogens 2020 16:e1008897

  3. KJ Foster, HK Cheesman, P Liu, ND Peterson, R Pukkila-Worley. Innate immunity in the C. elegans intestine is programmed by a neuronal regulator of AWC olfactory neuron development. Cell Reports. 2020;31:1007478

  4. J Nhan, CD Turner, SM Anderson, CA Yen, HM Dalton, HK Cheesman, DL Reuter, N Uma Naresh, CM Haynes, AA Soukas, R Pukkila-Worley,* SP Curran.* Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. PNAS USA. 2019;116:22322-22330. *co-corresponding authors

  5. SM Anderson, ND Peterson, HK Cheesman, JE Salisbury, AA Soukas, R Pukkila-Worley.The monounsaturated fatty acid oleate is required for innate immune activation in C. elegans. PLOS Pathogens. 2019;15:e1007893.

  6. ND Peterson,HK Cheesman, P Liu, SM Anderson, KJ Foster,R Chhaya, P Perrat, J Thekkiniath, Q Yang, CM Haynes, R Pukkila-Worley. The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegansPLOS Genetics. 2019;15:e1007935.

  7. P Deng, N Uma Naresh, Y Du, R Pukkila-Worley and CM Haynes. Pseudomonas aeruginosa virulence impairs the UPRmt by engaging a host negative feedback loop. Proceedings of the National Academy of Sciences U.S.A. 2019;116:22322-22330.

  8. ND Peterson and R Pukkila-Worley. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Current Opinion in Immunology. 2018;54:59-65.

  9. HK Cheesman, RL Feinbaum, J Thekkiniath, RH Dowen, AL Conery, R Pukkila-Worley. Aberrant activation of p38 MAP kinase-dependent innate immune responses is toxic to C. elegans. G3: Genes, Genomes, Genetics. 2016;6:541-549.

  10. R Pukkila-Worley. Surveillance immunity: An emerging paradigm of Innate Defense Activation in Caenorhabditis elegansPLOS Pathogens. 2016;12:e1005795.

  11. R Pukkila-Worley,* RL Feinbaum, DL McEwan, AL Conery, FM Ausubel. The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLOS Pathogens. 2014; 10:e1004143.*corresponding author

  12. R Pukkila-Worley, N Valentina and JA Branda. Case records of the Massachusetts General Hospital. Case-28-2014: A 39-year-old man with a rash, headache, fever, nausea and photophobia. New England Journal of Medicine. 2014;371:1051-1060.

  13. R Pukkila-Worley, R Feinbaum, NV Kirienko, J Larkins-Ford, AL Conery, FM Ausubel. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLOS Genetics. 2012;8:e1002733.

  14. R Pukkila-Worley and FM Ausubel. Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Current Opinion in Immunology. 2012;1:3-9.

  15. R Pukkila-Worley, FM Ausubel and E Mylonakis. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLOS Pathogens. 2011;7:e1002074. (pdf)

  16. R Pukkila-Worley, AY Peleg, E Tampakakis and E Mylonakis. Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model. Eukaryotic Cell. 2009;8:1750. (Cover)