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Twarting antibiotic resistance in Pseudmonas aeruginosa

Read Pukkila-Worley, MD talks about the research in his laboratory

Pukkila-Worley laboratory

The major goal of the Pukkila-Worley laboratory is to characterize mechanisms of immune homeostasis in intestinal epithelial cells. We aim to use these discoveries to identify innate immune pathways that can be exploited to develop new therapies, which can modulate host immune activity.

Our laboratory uses C. elegans as a discovery platform to define evolutionarily ancient mechanisms of pathogen sensing and immune activation. On the right, a photograph of a nematode that has been infected with the important human bacterial pathogen Pseudomonas aerginosa, is shown. Individual bacteria can be visualized within the markedly distended intestinal lumen of the animals. Also shown is the whole lab at the major international meeting in our field.

Pukkila-Worley lab photo

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Nick Peterson, MD, PhD Candidate and Read Pukkila-Worley talk about the scientific and training environment at UMass Chan Medical School.





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ATTENTION Ph.D. and M.D., Ph.D. rotation students!

We want you to rotate with us!


5 Ph.D. Graduates since 2020

(One will defend in 2024)

Average time to graduation in the Pukkila-Worley lab: 3 years, 9 months

UMass Chan Average: 5 years, 9 months 

(Above data do not include the first year of rotations)

Recent Exciting News

  • 11/2/23: Amanda accepted! Future MD,PhD! Our lab is 3 for 3!!
  • 10/31/23: PLOS Pathogens paper- Mo's thesis research!
  • 8/2/23: New paper!  Congrats Sammy!
  • 7/20/23: Mo defended his Ph.D. thesis!!
  • 7/15/23: Subhash got a job! Assistant Professor, Indian
            Institute of Technology (IIT) Dharwad
  • 6/21/23: Nice article about the lab
  • 5/1/23: Sammy wins a prestigious grad student award!
  • 3/7/23: Nice write-up about our paper in UMass Chan NEWS
  • 2/17/23: Nick and Sammy published a paper in Immunity!!

  • 7/14/22: Nick won a Poster Award at #MAPS2022 Meeting
  • 6/30/22: Nick defended his thesis!
  • 6/1/22: Read got tenure.
  • 3/10/22: R01 #1 renewal success. Score in the 2nd percentile!!
  • 1/31/22: Nick's paper featured on the cover of eLife!!

  • 8/18/21: Nick featured on UMass Chan News
  • 6/28/21: OMG!  A score in the 1st percentile on a R01 #2!! 
  • 6/3/21: Nick won the Dean's Award for Outstanding Research!
  • 5/12/21: Sarah sucessfully defended her thesis!
  • 5/6/21: Outstanding Medical Educator Award to Read
  • 4/16/21: More funding! The Riccio Fund for Neuroscience!
  • 3/4/21: Fundable score on an R21 at NIAID.  Wahoo!
  • 1/12/21: Awesome write-up about Nick and Sammy!

More news...

eLife Journal Cover

Immunity Journal Cover


Email Read to apply or with questions or to apply.

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