Asthma - Extended version
Objectives:
- Develop an understanding of the pathogenesis and diagnosis of asthma
- Develop a differential diagnosis for wheeze and cough in early childhood. Understand the relationship between early childhood wheezing, chronic cough and asthma
- Understand the National Asthma Education and Prevention Program (NAEPP) and Global Initiative for Asthma (GINA) guidelines and review recent updates in clinical management
- Understand treatment options including anti-inflammatory “controller” medications and rescue medications, including methods of medication delivery and treatment side effects
- Recognize common asthma triggers and learn how to manage environmental factors
- Review management of asthma exacerbations and the rationale for institutional protocols
- Recognize different asthma phenotypes in childhood
- Know how to evaluate sports performance and the management of exercise-induced bronchoconstriction
- Understand how biologic therapies are included in the pathway of treatment
- Review the current understanding of how COVID-19 infection affects asthma
- Recognize the determinants of health in patients with asthma
Articles:
- GINA 2024 Guidelines - GINA = Global Strategy for Asthma Management and Prevention! The new guideline incorporates new scientific information about asthma based on a review of recent scientific literature by an international panel of experts on the GINA Science Committee. This comprehensive and practical resource about one of the most common chronic lung diseases worldwide contains extensive citations from the scientific literature and forms the basis for other GINA documents and programs.
- Excellent Lancet paper from 2018 with a great summary of asthma pathophysiology. The paper includes a very useful diagnostic table showing features, symptoms and signs that will help differentiate between different respiratory disease processes. The manuscript has detailed rationale for each step of asthma control. It also includes a summary of the clinical trial data for the new biologic therapies. The paper concludes with a practical way to evaluate a patient having a suspected asthma exacerbation. Note: References the GINA guidelines [Objectives 1,2,3,4,6]
- Must-read 2019 article from Pediatrics in Review. It includes a great summary of differential diagnoses by age. It is a fantastic review all currently available asthma medications, and the paper also comments on the evidence supporting various treatments for asthma in the acute setting. [Objectives 1,4,6]
- This Pediatrics in Review article is most useful for diagnostic approach, asthma exacerbation management and patient education. Note: References the NAEPP guidelines [Objectives 1,6]
- Not all that wheezes is asthma! This paper is a great review on the differential diagnosis of childhood wheeze. [Objective 2]
- This is a great review paper of common asthma triggers and ways to mitigate them! The paper includes practical advice for patients and families to help avoid asthma exacerbations. [Objective 5]
- Delve deeper into the immune-modulated mechanisms of asthma in this Nature review article. [Objectives 1,5]
- This classic study published in the New England Journal of Medicine investigates the pathophysiology and outcomes of wheezing in the first six years of life. [Objective 2]
- This is a follow-up study to understand the outcomes of early wheezing into adolescence. [Objective 2]
- Chronic cough may represent a diagnosis of asthma, however it is important to consider other diagnoses. This classic 2008 paper published in Chest describes how to work up a patient with chronic cough. [Objective 2]
- Asthma is commonly managed with inhaled glucocorticoids, systemic glucocorticoids and long acting beta agonists (LABAs). The following classic studies have shaped current management guidelines. [Objectives 4,6]
- Many patients are worried about the lasting effects of glucocorticoids. These classic papers explore the effects of glucocorticoids on height and behavior. [Objective 4]
- Learn how microbial exposure might protect against asthma in this New England Journal of Medicine paper. [Objective 5]
- Concise review article summarizing the different phenotypes of asthma. [Objective 7]
- Paper highlighting the different asthma heterogeneity by age and the natural history of the disease. [Objective 7]
- Asthma in Children and Adults-What Are the Differences and What Can They Tell us About Asthma?
- Exercise-induced bronchoconstriction poses a challenge for many children with and without asthma. For a better understanding of the diagnosis, management and patient impact of this process, read this paper. [Objective 8]
- Biologic therapies are becoming increasingly important in the treatment of severe asthma. These review articles from 2018 and 2019 highlight the pathophysiology and efficacy of the currently available biologics. Role of Biologics in Asthma focuses on molecular targets of these agents and presents key efficacy data. A Review of Respiratory Biologic Agents in Severe Asthma is an excellent summary on the indications and efficacy of biologics based on clinical trials. The paper also includes the pharmacodynamics and pharmacokinetics of each agent. [Objective 9]
- The use of inhaled and systemic corticosteroids in patients with asthma during the COVID-19 pandemic has been questioned. These articles highlight current thoughts on the topic. [Objective 10]
- Asthma and medication adherence, like most diseases, is impacted by the determinants of health. It is important to recognize racial and ethnic disparities and how they have evolved over time. [Objective 11]
- Social Determinants of Health in Asthma Through the Life Course
- School-based asthma learning, featuring our own amazing pulmonologists
Additional Resources:
- Handy Asthma Care Guide developed by Dr. Dy and updated intermittently by our pulm team
- The GINA Pocket guide provides an in-depth view into the diagnosis and management of asthma. It is a very useful read to understand the rationale for treatment options, including a discussion on new asthma guidelines recommending ICS-formoterol as Step 1 therapy. The guide also includes a glossary of all medication classes, when to consider using each and the potential adverse effects. These guidelines differ somewhat from the NAEPP guidelines, mainly in terms of the use of ICS-LABAs for patients with mild disease. [Objectives 3,4]
- NAEPP asthma guidelines provide excellent tables on classifying asthma severity. Also included is a useful table with common outpatient medications and appropriate dosages by age. These guidelines differ somewhat from the GINA guidelines, mainly in terms of the use of ICS-LABAs for patients with mild disease. [Objectives 3,4]
- Clinical pathways improve outcomes for patients who need to be managed acutely for asthma exacerbations. A clinical pathway is a treatment protocol that aims to ensure that all patients receive standard, guidelines-based treatment, improve outcomes, and reduce costs. Here is an example of a Pediatric ED clinical pathway for an asthma exacerbation and an inpatient clinical pathway. [Objective 6]
- An asthma action plan provides patients with clear information about the use of their medicines, the actions they are to take at home for asthma attacks, and either the degree of symptoms and/or the actual peak flow measurements that they should use as a guide. Please be sure to make them in Epic for our patients![Objective 4]
- Videos demonstrating how to use asthma devices: [Objective 4]
- The American Thoracic Society has published guidelines on the management of persistent or recurrent wheezing in infants. The paper poses a series of questions representing common clinical scenarios with responses to each question. [Objective 2]
- Basic book chapter written by Dr. Miles Weinberger which is helpful for understanding the epidemiology and natural history of asthma in preschool children. The chapter also addresses other causes of wheezing and cough in early childhood and how to differentiate them from asthma. [Objectives 1,2]
- Pictorial of all inhalers from the Allergy & Asthma Network – Mother of Asthmatics from 2013 [Objective 4]
- Commentary on the pros and cons of breath-actuated inhalers [Objective 4]
- The IMPACT DC (Improving Pediatric Asthma Care in the District of Columbia) program has a number of family friendly educational videos. [Objective 4]
- Link to additional family education resources developed by Boston Children’s Hospital [Objective 4]