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UMass Medical School - Marian Walhout featured in Cell Marian Walhout featured in Cell ‘More is different’ in systems biology, says Dr. Walhout Jim Fessenden UMass Medical School Communications   A leader in the field of systems biology, Marian Albertha J. Walhout, PhD, associate professor of molecular medicine, was featured this month in a special issue of Cellexploring the future of this increasingly important field.  Systems biology focuses on how relatively simple cellular and molecular

Marian Walhout receives $4.1 million outstanding investigator award from NIH Marian Walhout receives $4.1 million outstanding investigator award from NIH Grant will further study of metabolism and gene expression and how they interact Megan Bard UMass Medical School Communications UMass Medical School researcher Marian Walhout received a $4.1 million Maximizing Investigators’ Research Award to continue study of metabolism and gene expression. Marian Walhout, PhD, has received a 5-year, $4.1

edition of Nature Methods describe innovative techniques for identifying the complex interactions among genes, proteins and transcription factors that comprise gene regulatory networks in worms, plants, humans and flies. Marian Walhout, systems biology, enhanced yeast Marian Walhout, PhD  A major challenge in the field of systems biology involves understanding the complex and interconnected ways that gene regulatory networks drive development, physiology and pathology. A series of papers in the latest

produce significant changes in gene expression that could negatively impact physiology and health. gene expression and physiology, Marian Walhout   Boston Globe covers UMMS diet research A.J. Marian Walhout’s new research on how diet influences gene expression and physiology is featured in Boston Globe reporter Carolyn Johnson’s “Science in Mind” blog. Dr. Walhout tells the Globe that the work, outlined in two papers published in Cell, shows that even the smallest portions of food affect an individual

Systems Megan Bard UMass Medical School Communications Marian Walhout, PhD, and Lutfu Safak Yilmaz, PhD, present the first genome-scale reconstruction of the C. elegans metabolic network. Marian Walhout, PhD, and Lutfu Safak Yilmaz, PhD, present the first genome-scale reconstruction of the C. elegans metabolic network and show that scientists can use mathematical simulation to convert bacterial diet into C. elegans biomass.     Marian Walhout, PhD, and Lutfu Safak Yilmaz, PhD Scientists at UMass Medical

and efficiently describe genomic variations underlying complex, multi-gene diseases. Scientists in the lab of Marian Walhout, PhD, have applied a powerful tool in a new way to characterize genetic variants associated with human disease that will allow researchers to more easily and efficiently describe genomic variations underlying complex, multi-gene diseases.     Marian Walhout, PhD, professor of molecular medicine and co-director of the Program in Systems Biology Scientists at UMass Medical School

Program in Systems Biology, Albert Sherman Center, Job Dekker, Marian Walhout, 5th discipline of biology The recently formed Program in Systems Biology is now at home in the new, state-of-the art Albert Sherman Center, where it exemplifies the interdisciplinary approach to answering deep, complex questions about science for which the Sherman Center was designed. “Teamwork is incredibly important in systems biology,” said Marian Walhout, PhD, co-director of systems biology and professor of molecular medicine

model system that allows researchers to examine how a single nutrient or vitamin changes gene expression and physiology in the model organism C. elegans, in a study appearing in the journal Cell. Vitamin B12, Gene expression, A.J. Marian Walhout A.J. Marian Walhout, PhD Everyday our cells take in nutrients from food and convert them into the building blocks that make life possible. However, it has been challenging to pinpoint exactly how a single nutrient or vitamin changes gene expression and physiology

April 20, 2017. A study by Marian Walhout, PhD, and colleagues, shows that C. elegans, fed a diet of E.coli bacteria, are 100 times more sensitive to the chemotherapy drug floxuridine, commonly used to treat colon cancer, than worms fed different bacteria. These findings suggest that the bacteria residing in your digestive tract may play an important role in your ability to respond to chemotherapy. Results of the study were published in Cell.      Marian Walhout, PhD, and Aurian Garcia Gonzalez The

UMass Medical School - Worcester: New program focuses on biological process at a system level New program focuses on biological process at a system level Dekker and Walhout to lead Program in Systems Biology Mark Shelton UMass Medical School Communications A new interdisciplinary research program, the Program in Systems Biology, has been established at UMass Medical School, Terence R. Flotte, MD, the Celia and Isaac Haidak Professor of Medicine, executive deputy chancellor, provost and dean