ASSERT Study Inclusion/Exclusion Criteria

Inclusion Criteria:

1. Clinically Definite Multiple Sclerosis (CDMS) according to Poser (Ann. Neurol. 1983) or McDonald (Ann. Neurol. 2001).

2. Subjects eligible to GA treatment based on the investigator’s clinical assessment and according to the current indication.

3. Subjects must have a relapsing remitting disease course.

4. Subjects must have had at least 1 documented relapse within the last year prior to study entry.

5. Subjects may be male or female. Women of childbearing potential must practice an acceptable method of birth control.

Acceptable methods include oral contraceptive, contraceptive patch, long-acting injectable contraceptive, double-barrier method (condom or IUD with spermicide), or partner’s vasectomy.

6. Subjects must be between the ages of 18 and 55 years inclusive.

7. Subjects must be ambulatory, with a Kurtzke EDSS score between 0 and 5.0 inclusive.

8. Subjects must be willing and able to give written informed consent prior to entering the study.

 

Exclusion Criteria:

1. Long-term glatiramer acetate users who have been on therapy within 6 months of the baseline MRI. (6 month washout period)

 New glatiramer acetate users who have initiated therapy for more than 6 weeks prior to the baseline MRI.

2. Previous use of cladribine.

3. Previous use of mitoxantrone.

4. Use of digitalis at study entry.

5. Previous use of immunosuppressive agents (such as azathioprine, cyclophosphamide or mycophenolate mofetil) in the last 6 months prior to screening.

6. Use of experimental or investigational drugs, including I.V. immunoglobulin within 6 months prior to screening.

7. Use of interferon agents within 1 month prior to the baseline MRI.

8. Use of corticosteroids (IV, IM and/or PO) within the 30 days prior to the baseline MRI.

9. Chronic corticosteroid (IV, IM and/or PO) treatment (more than 30 consecutive days) in the 6 months prior to the screening visit.

10. Subjects with diabetes.

11. Previous total body irradiation or total lymphoid irradiation.

12. Pregnancy or breast feeding.

13. Significant medical or psychiatric condition that affects the subject’s ability to give informed consent, or to complete the study, or any condition which the investigator feels may interfere with participation in the study (e.g. alcohol or drug abuse).

14. Other diseases that can cause brain atrophy (ex. neurodegenerative disorder, cerebrovascular disease, history of alcohol abuse).

15. Bone density less than -2.5 SD (osteoporosis).

16. A known history of sensitivity to mannitol.

17. Contraindication to or known history of sensitivity or severe reaction to steroids.

18. A known history of sensitivity to gadolinium.

19. Inability to successfully undergo MRI scanning.

20. Previous use of Natalizumab.