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Characterize the toxicity of overexpressed exogenous ASPA in cells of the CNS and peripheral organs, with the group of Guangping Gao, Gene Therapy Center & Vector Core, Horae Gene Therapy Center, UMass Chan Medical School

This collaboration relates with mitochondrial dysfunction in Canavan disease.

Determine the causes of the disruption of endoplasmic reticulum homeostasis observed in early presymptomatic ALS with the group of Zuoshang Xu, Department of Biochemistry and Molecular Pharmacology, UMass Chan Medical School

This collaboration relates with the serious compromise of the endoplasmic reticulum membrane biogenesis observed in ALS-mouse models.

Characterize the mitochondrial energetic profiles of Autism Spectrum Disorders patients with the group of Andrew Zimmerman, MD., Departments of Neurology and Pediatrics, UMass Chan Medical School.

This collaboration relates with the evaluation of the cellular bioenergetics profiles of ASD patients and try to stablish a base line to check the effectiveness of therapies.