Publications
A complete list of published work can be found in My Bibliography
Selected Type 1 Diabetes Publications
The antigen presentation landscape of cytokine-stressed human pancreatic islets
Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ. Cell Rep. 2025 Aug 26;44(8):115927. doi: 10.1016/j.celrep.2025.115927. Epub 2025 Jul 19. PubMed PMID: 40684438; PubMed Central PMCID: PMC12624573
Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats
Arowosegbe A, Guo Z, Vanderleeden E, Derr AG, Wang JP. J Autoimmun. 2025 Feb;151:103358. doi: 10.1016/j.jaut.2025.103358. Epub 2025 Jan 16. PubMed PMID: 39823736.
Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases
Sundstrom J, Vanderleeden E, Barton NJ, Redick SD, Dawes P, Murray LF, Olson MN, Tran K, Chigas SM, Orszulak AR, Church GM, Readhead B, Oh HS, Harlan DM, Knipe DM, Wang JP, Chan Y, Lim ET. Cells. 2024 Nov 29;13(23). doi: 10.3390/cells13231978. PubMed PMID: 39682726; PubMed Central PMCID: PMC11640215.
An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
Derr AG, Arowosegbe A, Satish B, Redick SD, Qaisar N, Guo Z, Vanderleeden E, Trombly MI, Baer CE, Harlan DM, Greiner DL, Garber M, Wang JP. Diabetes. 2023 Feb 1;72(2):261-274. doi: 10.2337/db22-0521. PubMed PMID: 36346618; PubMed Central PMCID: PMC9871196.
Selected Respiratory Viruses Publications
Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19
Learnard H, Core J, Corkrey H, Sciaudone A, Rade J, Kornfeld H, Wang JP, Freedman JE, Tanriverdi K, Koupenova M. PLoS Pathog. 2025 Aug;21(8):e1013413. doi: 10.1371/journal.ppat.1013413. eCollection 2025 Aug. PubMed PMID: 40825056; PubMed Central PMCID: PMC12373281.
The HDL-transporting scavenger receptor B1 promotes viral infection through endolysosomal acidification
McConnell J, Lim SY, Cicuto T, Liu P, Kyawe PP, Kandpal M, Bradley ES, Okuda K, Silverman N, Wang JP, McDougall WM. iScience. 2025 Jun 20;28(6):112501. doi: 10.1016/j.isci.2025.112501. eCollection 2025 Jun 20. PubMed PMID: 40475258; PubMed Central PMCID: PMC12138404.
CRISPR editing of candidate host factors that impact influenza A virus infection
Kyawe PP, Liu P, Jiang Z, Bradley ES, Cicuto T, Trombly MI, Silverman N, Fitzgerald KA, McDougall WM, Wang JP. Microbiol Spectr. 2025 Mar 4;13(3):e0262724. doi: 10.1128/spectrum.02627-24. Epub 2025 Jan 31. PubMed PMID: 39887213; PubMed Central PMCID: PMC11878000.
Dysregulated pulmonary inflammatory responses exacerbate the outcome of secondary aspergillosis following influenza
Lee CK, Oliveira LVN, Akalin A, Specht CA, Lourenco D, Gomez CL, Ramirez-Ortiz ZG, Wang JP, Levitz SM. mBio. 2023 Oct 31;14(5):e0163323. doi: 10.1128/mbio.01633-23. Epub 2023 Sep 8. PubMed PMID: 37681974; PubMed Central PMCID: PMC10653922.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2219523120. doi: 10.1073/pnas.2219523120. Epub 2023 Mar 9. PubMed PMID: 36893269; PubMed Central PMCID: PMC10089225.
Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection
Lim SY, Guo Z, Liu P, McKay LGA, Storm N, Griffiths A, Qu MD, Finberg RW, Somasundaran M, Wang JP. COVID. 2022 Nov;2(11):1551-1563. doi: 10.3390/covid2110111. Epub 2022 Oct 28. PubMed PMID: 37274537; PubMed Central PMCID: PMC10238102.
Selected Clinical Trials
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NCT No. |
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NCT04368728 |
Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals |
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NCT04427501 |
A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Participants With Mild to Moderate COVID-19 Illness |
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NCT04955626 |
To Evaluate the Safety, Tolerability, Efficacy and Immunogenicity of BNT162b2 Boosting Strategies Against COVID-19 in Participants ≥12 Years of Age. |
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NCT05035212 |
Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults. |
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NCT05477524 |
An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease Vaccine (VLA15) |
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NCT05540522 |
A Study to Evaluate a Modified RNA Vaccine Against Influenza in Adults 18 Years of Age or Older |
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NCT05567952 |
A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/Ritonavir |
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NCT05624450 |
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen |
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NCT05648110 |
Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study |
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NCT07013474 |
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised |
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NCT06868264 |
C-BEYOND: Efficacy and Safety of BEM/RZR vs. SOF/VEL in Subjects With Chronic HCV |
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NCT06404086 |
RECOVER-SLEEP: Platform Protocol |
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NCT04977024 |
SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer |
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NCT05822583 |
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial |
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NCT06679140 |
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease |
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NCT04860297 |
A Study to Evaluate Safety and Immunogenicity of mRNA-1273 Vaccine to Prevent COVID-19 in Adult Organ Transplant Recipients and in Healthy Adult Participants |
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NCT04405076 |
Dose-Confirmation Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1273 COVID-19 Vaccine in Adults Aged 18 Years and Older |
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NCT04280705 |
Adaptive COVID-19 Treatment Trial (ACTT) |
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NCT04600895 |
The Prevent Severe COVID-19 (PRESECO) Study |
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NCT01227967 |
Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications |
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NCT02342249 |
Study of Acute Uncomplicated Seasonal Influenza A in Adult Subjects |
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NCT02008344 |
Phase 3 Efficacy and Safety Study of Favipiravir for Treatment of Uncomplicated Influenza in Adults |
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