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Welcome to the Humphries Lab in the Division of Innate Immunity

Research focus: Metabolic Regulation of Innate Immunity

Regulation of inflammasomes and cell death
Metabolic regulators of Innate immunity
Metabolic regulation of viral pathogenesis
Therapeutic targeting of innate immune signaling pathways

Representative publications

Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 Sep 25;369(6511):1633-1637.
Humphries F, Shmuel-Galia L, Jiang Z, Wilson R, Landis P, Ng SL, Parsi KM, Maehr R, Cruz J, Morales-Ramos A, Ramanjulu JM, Bertin J, Pesiridis GS, Fitzgerald KA. A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection. Sci Immunol. 2021 May 18;6(59):eabi9002.
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 Jun 8;54(6):1137-1153.e8.

Join our Lab

The Humphries Lab is currently recruiting a post-doctoral fellow. If you are interested in joining our lab, please send a cover letter, CV, and contact information for three references to Dr. Fiachra Humphries.

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