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Selected Recent Publications

A complete list of published work can be found in My Bibliography

In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate.

Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA.
Cell Rep. 2021 Jul 27;36(4):109459. doi: 10.1016/j.celrep.2021.109459. PubMed PMID: 34320357; PubMed Central PMCID: PMC8369932.

The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

Hsiao WY, Jung SM, Tang Y, Haley JA, Li R, Li H, Calejman CM, Sanchez-Gurmaches J, Hung CM, Luciano AK, DeMambro V, Wellen KE, Rosen CJ, Zhu LJ, Guertin DA.
Cell Rep. 2020 Oct 6;33(1):108223. doi: 10.1016/j.celrep.2020.108223. PubMed PMID: 33027655; PubMed Central PMCID: PMC7607535.

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villén J, Wellen KE, Guertin DA.
Nat Commun. 2020 Jan 29;11(1):575. doi: 10.1038/s41467-020-14430-w. PubMed PMID: 31996678; PubMed Central PMCID: PMC6989638.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA.
Mol Cell. 2019 Aug 22;75(4):807-822.e8. doi: 10.1016/j.molcel.2019.07.023. PubMed PMID: 31442424.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA.
Cell Metab. 2018 Jan 9;27(1):195-209.e6. doi: 10.1016/j.cmet.2017.10.008. Epub 2017 Nov 16. PubMed PMID: 29153407; PubMed Central PMCID: PMC5762420.