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Review on Acetyl-CoA Metabolism in Cancer in Nature Reviews Cancer

Date Posted: Monday, January 09, 2023

David Guertin published a review on Acetyl-CoA Metabolism in Cancer in the prestigious journal Nature Reviews Cancer with close collaborator, Katy Wellen from the University of Pennsylvania. Acetyl-CoA is a product of cellular metabolism involved in important functions to provide energy for cells and yields building blocks to create lipids, cholesterol and other key cellular components. 

Drs. Wellen and Guertin at the 2023 Keystone Symposia in Colorado

Acetyl-CoA can also be used for a process called protein acetylation, which helps to regulate gene expression.  Dysregulation of acetyl-CoA processes can promote tumor growth but dysfunctional acetyl-CoA metabolism is also central to obesity and type 2 diabetes.  The work discussed in this review is broadly relevant to human diseases.  

Acetyl-CoA Metabolism in Cancer

David A Guertin 1, Kathryn E. Wellen
PMID: 36658431  DOI: 10.1038/s41568-022-00543-5