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New mTORC2 research published in Molecular Cell

Date Posted: Thursday, August 08, 2019


Su Myung Jung, PhD and former graduate student Chien-Min Hung (now a post doc at the Salk Institute) celebrate co-first authorship on a paper published in Molecular Cell.

They found that inhibiting mTORC2 in brown fat can protect against obesity and fatty liver disease.  They went on to show that the mechanism is at least in part through a non-canonical pathway involving the deacetylase SIRT6 and the transcription factor FoxO1. 

We would like to thank our collaborators Christian Metallo and Raul Mostoslavasky for critical help, and all members of our labs past and present who contributed to this research. 

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

Jung SM1, Hung CM1, Hildebrand SR1, Sanchez-Gurmaches J2, Martinez-Pastor B3, Gengatharan JM4, Wallace M4, Mukhopadhyay D1, Martinez Calejman C1, Luciano AK1, Hsiao WY1, Tang Y1, Li H1, Daniels DL5, Mostoslavsky R3, Metallo CM4, Guertin DA6.
 2019 Aug 22;75(4):807-822.e8. doi: 10.1016/j.molcel.2019.07.023.