For the latest COVID-19 campus news and resources, visit umassmed.edu/coronavirus.

Buscar Close Search
Buscar Close Search
Page Menu

Structural and Mechanistic Studies of Macromolecular Machines

The Lab

 Lab_picture.001.jpg

Uncovering the Principles of Molecular Machinery at the Atomic Level

We use a combination of biochemistry, biophysics and structural methods to elucidate how these vitally important protein complexes are integrated into cellular pathways.

Meet the Lab

Research Focus

 top_view_multiple_hydrolyses1_test2-3.gif

Structure and Mechanism of Large Macromolecular Complexes

The Kelch lab is interested in determining how macromolecular machines work, with special emphasis on machines involved in DNA replication and repair.  Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics and antibiotics.

Read More

Publications

 PubmedPubs.jpg
Total: 1 results
  • CaMKII binds both substrates and activators at the active site

    miércoles, julio 13, 2022
    Author(s): Can Özden,Roman Sloutsky,Tomohiro Mitsugi,Nicholas Santos,Emily Agnello,Christl Gaubitz,Joshua Foster,Emily Lapinskas,Edward A Esposito,Takeo Saneyoshi,Brian A Kelch,Scott C Garman,Yasunori Hayashi,Margaret M Stratton
    Source: Cell reports
All Publications

 

Follow our research, stay in touch – join the lab! 


Contact Us

Office:
Lazare Research Building 923
Campus Map (pdf)

Phone:
508-856-8322 (office)
508-856-6868 (Lab)

Email:
Brian.Kelch@umassmed.edu

Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Brian Kelch/BMB Department
364 Plantation St LRB923
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

Read more here

Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.