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Bogdanov A Jr, Matuszewski  L, Bremer C, Petrovsky  A, Weissleder R. Oligomerization of paramagnetic substrates results in signal amplification and can be used or MR imaging of molecular targets. Mol Imaging 1: 16-23, (2002)

Chen JW, Pham W, Weissleder R, Bogdanov A Jr. Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis. Magn Reson Med  52: 1021-1028, (2004).

Querol M, Chen JW, Weissleder R, Bogdanov A Jr. DTPA-bis-amide based MR sensor agents for peroxidase imaging. Org Lett 17: 1719-1722, (2005).

Querol MS, Chen JW, Weissleder R, Bogdanov A Jr. Myeloperoxidase activity imaging using 67-Ga labeled substrate. Molecular Imaging Biol. 7: 403-410, (2005)

Querol M, Chen JW, Bogdanov A Jr. A paramagnetic contrast agent with myeloperoxidase-sensing properties. Org Biomol Chem 4: 1887-1895, (2006). 

Chen JW, Querol M, Bogdanov A Jr,  Weissleder R Imaging myeloperoxidase in mice using novel amplifiable paramagnetic substrates. Radiology 240: 473-481, (2006). 

Bogdanov A Jr, Kang HW, Querol M, Pretorius PH, Yudina A. Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo. Bioconjug Chem. 18: 1123-1130, (2007).

Querol M,  Bennett DG,  Sotak C,  Kang HW,  Bogdanov A Jr. A paramagnetic contrast agent for detecting tyrosinase activity.  ChemBioChem 8: 1637-1641, (2007).

Ronald JA, Chen JW, Chen Y,  Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers K, Querol M, Bogdanov A, Weissleder R, Rutt B. Enzyme-sensitive MR imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation 120: 592-599, (2009).

Shazeeb MS, Sotak CH, Deleo M 3rd, Bogdanov AA. Targeted signal amplifying enzymes enhance magnetic resonance imaging of EGRF expression in an orthotopic model of human glioma. Cancer Res. 71:  2230-2239, (2011).

Shazeeb M, Xie Y, Gupta S, Bogdanov A Jr. A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo. Mol Imaging 11: 1536-0121, (2012).

Shazeeb MS, Gupta S, Bogdanov AA Jr . MR signal amplification for imaging of the mutant     EGF receptor in orthotopic human glioma model. Mol Imaging Biol. 6: 675-84 (2013).

FormulaRoyal Society of Chemistry©


Chemical Biology Issue 6 

YangXie2                                 IMG0876 

Dr. Yang Xie                                                                                           Dr. Manuel Querol