BROADENTM Study for Major Depressive Disorder Recruitment is currently closed
Participate in clinical research evaluating brain stimulation for MDD
• Have you been diagnosed with major depressive disorder?
• Are you between 21 and 70 years of age?
• Did you experience your first depressive episode before age 45?
• Have you tried at least four treatments in your current episode with unsatisfactory results?
Medications such as Zoloft®, Prozac®, Lexapro®, Wellbutrin®, Paxil®, Effexor®, Cymbalta®, and combinations of these or other medications
Psychotherapy, cognitive behavioral therapy (CBT), or other talk therapies
Vagus nerve stimulation (VNS) or transcranial magnetic stimulation (TMS or rTMS)
Electroconvulsive therapy (ECT)
If you answered yes and are open to considering a surgical option for your depression, you may qualify to participate in a clinical research study evaluating deep brain stimulation to treat severe major depressive disorder (MDD).
The study is investigating whether or not using a deep brain stimulation (DBS) system* to stimulate a structure in the brain known as Brodmann Area 25 is safe and effective for treating depression that is refractory to currently available therapies.
If you would like more information, please call Chelsea 508-334-2812.
See the recent Wall Street Journal article for more stories on the deep brain stimulation.
*Caution: Investigational device. Limited by United States law to investigational use.
Docket # H-13482
National Institute of Mental Health (NIMH)
Sustaining Remission of Psychotic Depression Study
Patients that are currently suffering from depression with irrational worries are invited to participate in a research study to determine how long people need to stay on an antipsychotic medication after they recover from their symptoms. Study participation will last up to 20 weeks and patients will receive a combination of an antipsychotic medication and an antidepressant medication. Patients must be:
- 21 to 85 years of age
- experiencing symptoms of depression with irrational worries
- not be pregnant
Patients will receive study medication and study-related care at no cost. Qualifying patients will be eligible to participate in 9-month follow-up study. Compensation provided.
Contact Chelsea Kosma @ 508-334-2812.
Docket # H-14207
Hormones in Pregnancy and Brain Imaging in Postpartum Depression Research Study
Women can be at increased risk of having depression in late pregnancy or after giving birth. The goal of this research is to see if women at increased risk for developing postpartum depression have changes in certain hormone levels during pregnancy which differ from the hormone levels of women who do not become depressed and remain healthy during this time.
This NIH-funded study will monitor for symptoms of depression and anxiety during late pregnancy (2 visits) and after giving birth (3 visits). We also monitor blood hormone levels (each visit) and in the postpartum, participants will have one brain MRI scan done. Total participation is about 4-7 hours.
Participants in this study:
· are 18-40 years old and pregnant
· are either: healthy without mood symptoms OR have some symptoms of depression or anxiety/stress
· plan to give birth at UMass Memorial Medical Center
· are not taking an antidepressant or steroid medication
Participants will receive financial compensation as well study-related evaluations at no cost. Participants who complete the MRI brain scan will also receive a picture of their brain MRI scan.
To learn more, please contact the study doctor, Kristina M. Deligiannidis, M.D. @ 508.334.2828 or study coordinator Nina Jaitly @ 508-334-7880.
Docket # H-00001214
Brain Imaging and hormone levels in Postpartum Depression Research Study
Women can be at increased risk of having depression after giving birth. The goal of this research is to see if women who develop postpartum depression have changes in certain hormone levels in the postpartum period which differ from the hormone levels of women who do not become depressed and compare these levels to brain activity.
The one study visit involves assessment of symptoms of depression and anxiety, taking one blood and urine sample and a having a brain MRI (magnetic resonance imaging) after giving birth.
Participants in this study:
· are 18-40 years old
· developed postpartum depression within 12 weeks of delivering their child
· are not currently taking an antidepressant medication or steroid medication
Participants will receive financial compensation as well as study-related evaluations at no cost.
Contact the research coordinator Nina Jaitly @ 508-334-7880 or by email @ Nina.Jaitly@umassmed.edu or
Principal Investigator Kristina M. Deligiannidis, M.D. @ 508.334.2828 or by email @ Kristina.Deligiannidis@umassmemorial.org
Docket # H-14373
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