Current Lab Members



Craig Peterson

Academic Background

Craig Peterson received his BS from the University of Washington in 1983 and his PhD from the University of California, Los Angeles in 1988. He was a Helen Hay Whitney Foundation postdoctoral fellow from 1988-1991, in the Department of Biochemistry and Biophysics at the University of California, San Francisco. In 1992, he joined the University of Massachusetts Medical School as a faculty member in the Program in Molecular Medicine.
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Kimberly Crowley

Officially I am the lab manager, but unofficially I am the Lab Mother! I do my best to help everyone in the lab with duties that range from pouring plates, making media and placing orders to helping purify proteins and many other things. I am also in charge of, and run, our Beckman XLI Analytical Ultracentrifuge.

Current Students

Benjamin Manning Benjamin Manning
I am interested in the biochemical means by which ATP-dependent chromatin remodeling enzymes such as yeast SWI/SNF, use the energy of ATP hydrolysis to alter the structure and composition of chromatin. Specifically, I am using a combination of biochemistry and yeast genetics to characterize novel remodeling mechanisms that SWI/SNF complex activates when its target lies within heterochromatin.

Sarah Swygert Sarah Swygert
I am interested in the structure and dynamics of yeast heterochromatin. My work involves reconstitution of Sir3 and Sir2,3,4 proteins on recombinant nucleosomal arrays and their analysis by analytical ultracentrifugation and other biophysical methods.
Mayuri Rege Mayuri Rege
As a graduate student, I am exploring a new transcriptional role for SWI/SNF that involves functional antagonism of the yeast silencing protein, SIR3, within euchromatin. My work involves extensive genetic techniques and large-scale genomic studies.

Current Postdocs

Christopher Van 

Christopher Van, Ph.D.

I am studying the function of chromatin remodeling enzymes during replication initiation and stress. I am also investigating how chromatin remodelers dynamically regulate histone variant incorporation during cell cycle progression.


Nicholas Adkins

Nicholas Adkins, Ph.D.

I am a postdoctoral fellow investigating the regulation of chromatin structure and its influence on biological processes. I am currently examining the role of nucleosomes and ATP-dependent chromatin remodeling complexes during homologous recombination.

Raushan Singh

Raushan Singh, Ph.D.

I am interested in mechanistic study of chromatin remodeling mediated via the SWR-C remodeling enzyme. SWR-C is known to deposit H2A.Z to the promoter-proximal nucleosomes and thereby regulates the transcription in eukaryotes. My current research project is aimed at understanding how various histone marks influence the specificity/promiscuity of the SWR-C catalyzed histone exchange reaction.


Research Faculty


Shinya Watanabe, Ph.D. (Research Instructor)

My current research objective is to dissect the functional interactions between three primary chromatin regulators - histone modifications, histone variants and ATP-dependent chromatin remodeling enzymes. Especially, I am interested in how histone variant H2A.Z is regulated by the SWR1/INO80 family of chromatin remodeling enzymes and acetylation of histone H3 lysine 56.

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