Recent Publications
All Ryder Lab publications can be viewed on myNCBI
Mennatallah M Y Albarqi, Sean P Ryder.
The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans
PLoS Genet
. 2021 Aug 23;17(8):e1009775. doi: 10.1371/journal.pgen.1009775. eCollection 2021 Aug.
PMID: 34424904
Sean P Ryder, Brittany R Morgan, Peren Coskun, Katianna Antkowiak, Francesca Massi.
Analysis of Emerging Variants in Structured Regions of the SARS-CoV-2 Genome.
Evol Bioinform Online. 2021 May 5;17:11769343211014167. doi: 10.1177/11769343211014167.
PMID: 34017166
Tavella D, Ertekin A, Schaal H, Ryder SP, Massi F.
A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5.
Biophys J. 2020 Apr 21;118(8):2001-2014. doi: 10.1016/j.bpj.2020.02.032. Epub 2020 Mar 19.
PMID: 32294479
Hu S, Ryan LE, Kaymak E, Freeberg L, Lo TW, Kuersten S, Ryder SP, Haag ES.
Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.
Dev Biol. 2019 Feb 15;446(2):193-205. doi: 10.1016/j.ydbio.2018.11.024. Epub 2018 Dec 30.
PMID: 30599151
Ryder SP
#CRISPRbabies: Notes on a Scandal.
CRISPR J. 2018 Dec 1;1(6):355-357. doi: 10.1089/crispr.2018.29039.spr. Epub 2018 Dec 20. No abstract available.
PMID: 30687814 PMCID: PMC6345105
Han B, Antkowiak KA, Rutigliano M, Ryder SP, Griffn EE.
Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.
Current Biology. 2018; 28(1):60-69.
PMID: 29276126, PMCID: PMC5763555
Dowdle ME, Imboden SB, Park S, Ryder SP, Sheets MD.
Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes.
Journal of visualized experiments : JoVE. 2017; (125).
NIHMSID: NIHMS909022, PMID: 28784977, PMCID: PMC5613780
Tamburino AM, Kaymak E, Shrestha S, Holdorf AD, Ryder SP, Walhout AJM.
PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions.
Translation. 2017; 5(1):e1295130.
PMID: 28702278, PMCID: PMC5501385
Kaymak E, Farley BM, Hay SA, Li C, Ho S, Hartman DJ, Ryder SP.
Efficient
generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI.
Developmental dynamics. 2016; 245(9):925-36.
NIHMSID: NIHMS794597, PMID: 27294288, PMCID: PMC4981527
Ryder SP.
Protein-mRNA interactome capture: cartography of the mRNP landscape.
F1000Research. 2016; 5:2627.
PMID: 29098073, PMCID: PMC5642310
Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H,
Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC.
POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Developmental cell. 2015; 34(1):108-18.
NIHMSID: NIHMS705200, PMID: 26096734, PMCID: PMC4507413
Bohn MF, Shandilya SMD, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA.
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Structure. 2015; 23(5):903-911.
NIHMSID: NIHMS679858, PMID: 25914058, PMCID: PMC4874493
Ryder SP.
Personal reflection (RNA journal 20th anniversary).
RNA. 2015; 21(4):725-6.
PMID: 25780210, PMCID: PMC4371352
Zearfoss NR, Deveau LM, Clingman CC, Schmidt E, Johnson ES, Massi F, Ryder SP.
A conserved three-nucleotide core motif defines Musashi RNA binding specificity.
The Journal of biological chemistry. 2014; 289(51):35530-41.
PMID: 25368328, PMCID: PMC4271237
Clingman CC, Deveau LM, Hay SA, Genga RM, Shandilya SM, Massi F, Ryder SP.
Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite.
eLife. 2014; 3.
PMID: 24935936, PMCID: PMC4094780
Kaymak E, Ryder SP.
RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1.
The Journal of biological chemistry. 2013; 288(42):30463-72.
PMID: 24014033, PMCID: PMC3798510
Zearfoss NR, Johnson ES, Ryder SP.
hnRNP A1 and secondary structure coordinate alternative splicing of Mag.
RNA. 2013; 19(7):948-57.
PMID: 23704325, PMCID: PMC3683929
Clingman CC, Ryder SP.
Metabolite sensing in eukaryotic mRNA biology.
Wiley interdisciplinary reviews. RNA. 2013; 4(4):387-96.
NIHMSID: NIHMS816492, PMID: 23653333, PMCID: PMC5026232
Tamburino AM, Ryder SP, Walhout AJ.
A compendium of Caenorhabditis elegans RNA
binding proteins predicts extensive regulation at multiple levels.
G3 (Bethesda, Md.). 2013; 3(2):297-304.
PMID: 23390605, PMCID: PMC3564989
Farley BM, Ryder SP.
POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster.
Molecular biology of the cell. 2012; 23(23):4473-83.
PMID: 23034181, PMCID: PMC3510010
Zearfoss NR, Ryder SP.
End-labeling oligonucleotides with chemical tags after synthesis.
Methods in molecular biology (Clifton, N.J.). 2012; 941:181-93.
NIHMSID: NIHMS816497, PMID: 23065562, PMCID: PMC5026237
Contact:
Sean Ryder, Ph.D.
Professor
Biochemistry and Molecular Biotechnology
UMass Medical School
364 Plantation Street LRB-906
Worcester, MA, 01605
Office (LRB-906)
508-856-1372
Lab (LRB-970W,X)
508-856-3568
Email
Website
Join Us!
Post-docs are welcome to apply at anytime. Please send a cover letter and a CV directly to Sean. Undergraduate students interested in summer internships should send a cover letter and a resume to Sean before February 1st. Graduate students interested in rotating in the Ryder Lab should contact Sean directly IF you are already matriculated in the GSBS program at UMass Medical School. All others should apply here