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Maternal mRNA regulation
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Recent Publications
Total:
displaying 10 out of
61
results
The pos-1 3' untranslated region governs germline specification and proliferation to ensure reproductive robustness
Wednesday, December 17, 2025
Author(s):
Haik V Varderesian,Juliet N Utaegbulam,Hannah E Brown,Beverly Ramirez,Melina Velcani,Sean P Ryder
Source:
bioRxiv : the preprint server for biology
During fertilization, haploid gametes combine to form a zygote. The male (sperm) and female (oocyte) gametes contribute a similar amount of DNA, but the oocyte contributes nearly all the cytoplasm. Oo...
A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability
Wednesday, August 27, 2025
Author(s):
Asli Ertekin,Sharon T Noronha,Christable Darko,Francesca Massi,Sean P Ryder
Source:
RNA (New York, N.Y.)
Sexually reproducing organisms make haploid gametes-oocytes and spermatocytes-that combine during fertilization to make an embryo. While both gametes contain similar DNA content, oocytes contain the b...
The mex-3 3' untranslated region is essential for reproduction during temperature stress
Monday, August 11, 2025
Author(s):
Hannah E Brown,Haik V Varderesian,Oscar Lam,Sara A Keane,Sean P Ryder
Source:
Development (Cambridge, England)
Organisms must sense temperature and modify their physiology to survive environmental stress. Elevated temperature reduces fertility in most sexually reproducing organisms. Maternally supplied mRNAs a...
A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability
Wednesday, June 04, 2025
Author(s):
Asli Ertekin,Sharon T Noronha,Christable Darko,Francesca Massi,Sean P Ryder
Source:
bioRxiv : the preprint server for biology
Sexually reproducing organisms make haploid gametes-oocytes and spermatocytes-that combine during fertilization to make an embryo. While both gametes contain similar DNA content, oocytes contain the b...
Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity
Wednesday, September 25, 2024
Author(s):
Asli Ertekin,Brittany R Morgan,Sean P Ryder,Francesca Massi
Source:
Biochemistry
CCCH-type tandem zinc finger (TZF) motifs are found in many RNA-binding proteins involved in regulating mRNA stability, translation, and splicing. In Caenorhabditis elegans, several RNA-binding protei...
The mex -3 3' untranslated region is essential for reproduction during temperature stress
Monday, May 27, 2024
Author(s):
Hannah E Brown,Haik V Varderesian,Sara A Keane,Sean P Ryder
Source:
bioRxiv : the preprint server for biology
Organisms must sense temperature and modify their physiology to survive environmental stress. Elevated temperature reduces fertility in most sexually reproducing organisms. Maternally supplied mRNAs a...
A nematode model to evaluate microdeletion phenotype expression
Monday, November 13, 2023
Author(s):
Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder
Source:
G3 (Bethesda, Md.)
Microdeletion syndromes are genetic diseases caused by multilocus chromosomal deletions too small to be detected by karyotyping. They are typified by complex pleiotropic developmental phenotypes that ...
The role of RNA-binding proteins in orchestrating germline development in Caenorhabditis elegans
Monday, January 23, 2023
Author(s):
Mennatallah M Y Albarqi,Sean P Ryder
Source:
Frontiers in cell and developmental biology
RNA passed from parents to progeny controls several aspects of early development. The germline of the free-living nematode Caenorhabditis elegans contains many families of evolutionarily conserved RNA...
The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans
Monday, August 23, 2021
Author(s):
Mennatallah M Y Albarqi,Sean P Ryder
Source:
PLoS genetics
RNA regulation is essential to successful reproduction. Messenger RNAs delivered from parent to progeny govern early embryonic development. RNA-binding proteins (RBPs) are the key effectors of this pr...
Analysis of Emerging Variants in Structured Regions of the SARS-CoV-2 Genome
Friday, May 21, 2021
Author(s):
Sean P Ryder,Brittany R Morgan,Peren Coskun,Katianna Antkowiak,Francesca Massi
Source:
Evolutionary bioinformatics online
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has motivated a widespread effort to understand its epidemiology and pathogenic mechanisms. Modern high-throughput sequencing ...
Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome
Thursday, June 25, 2020
Author(s):
Sean P Ryder,Brittany R Morgan,Francesca Massi
Source:
bioRxiv : the preprint server for biology
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has motivated a widespread effort to understand its epidemiology and pathogenic mechanisms. Modern high-throughput sequencing ...
A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5
Thursday, April 16, 2020
Author(s):
Davide Tavella,Asli Ertekin,Hila Schaal,Sean P Ryder,Francesca Massi
Source:
Biophysical journal
CCCH-type tandem zinc finger (TZF) domains are found in many RNA-binding proteins (RBPs) that regulate the essential processes of post-transcriptional gene expression and splicing through direct prote...
#CRISPRbabies: Notes on a Scandal
Tuesday, January 29, 2019
Author(s):
Sean P Ryder
Source:
The CRISPR journal
No abstract
Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex
Wednesday, January 02, 2019
Author(s):
Shuang Hu,Lauren E Skelly,Ebru Kaymak,Lindsay Freeberg,Te-Wen Lo,Scott Kuersten,Sean P Ryder,Eric S Haag
Source:
Developmental biology
Proper germ cell sex determination in Caenorhabditis nematodes requires a network of RNA-binding proteins (RBPs) and their target mRNAs. In some species, changes in this network enabled limited XX spe...
Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote
Tuesday, December 26, 2017
Author(s):
Bingjie Han,Katianna R Antkowiak,Xintao Fan,Mallory Rutigliano,Sean P Ryder,Erik E Griffin
Source:
Current biology : CB
Intracellular protein gradients underlie essential cellular and developmental processes, but the mechanisms by which they are established are incompletely understood. During the asymmetric division of...
Protein-mRNA interactome capture: cartography of the mRNP landscape
Saturday, November 04, 2017
Author(s):
Sean P Ryder
Source:
F1000Research
RNA-binding proteins play a variety of roles in cellular physiology. Some regulate mRNA processing, mRNA abundance, and translation efficiency. Some fight off invader RNA through small RNA-driven sile...
Horizontal Gel Electrophoresis for Enhanced Detection of Protein-RNA Complexes
Wednesday, August 09, 2017
Author(s):
Megan E Dowdle,Susanne Blaser Imboden,Sookhee Park,Sean P Ryder,Michael D Sheets
Source:
Journal of visualized experiments : JoVE
Native polyacrylamide gel electrophoresis is a fundamental tool of molecular biology that has been used extensively for the biochemical analysis of RNA-protein interactions. These interactions have be...
PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions
Friday, July 14, 2017
Author(s):
Alex M Tamburino,Ebru Kaymak,Shaleen Shrestha,Amy D Holdorf,Sean P Ryder,Albertha J M Walhout
Source:
Translation (Austin, Tex.)
Interactions between RNA binding proteins (RBPs) and mRNAs are critical to post-transcriptional gene regulation. Eukaryotic genomes encode thousands of mRNAs and hundreds of RBPs. However, in contrast...
Efficient generation of transgenic reporter strains and analysis of expression patterns in Caenorhabditis elegans using library MosSCI
Tuesday, June 14, 2016
Author(s):
Ebru Kaymak,Brian M Farley,Samantha A Hay,Chihua Li,Samantha Ho,Daniel J Hartman,Sean P Ryder
Source:
Developmental dynamics : an official publication of the American Association of Anatomists
CONCLUSIONS: The results provide a generalizable and efficient strategy to assess the functional relevance of protein-RNA interactions in vivo, and reveal new regulatory connections between key RNA-bi...
POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA
Tuesday, June 23, 2015
Author(s):
Ahmed Elewa,Masaki Shirayama,Ebru Kaymak,Paul F Harrison,David R Powell,Zhuo Du,Christopher D Chute,Hannah Woolf,Dongni Yi,Takao Ishidate,Jagan Srinivasan,Zhirong Bao,Traude H Beilharz,Sean P Ryder,Cr...
Source:
Developmental cell
The regulation of mRNA translation is of fundamental importance in biological mechanisms ranging from embryonic axis specification to the formation of long-term memory. POS-1 is one of several CCCH zi...
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization
Tuesday, April 28, 2015
Author(s):
Markus-Frederik Bohn,Shivender M D Shandilya,Tania V Silvas,Ellen A Nalivaika,Takahide Kouno,Brian A Kelch,Sean P Ryder,Nese Kurt-Yilmaz,Mohan Somasundaran,Celia A Schiffer
Source:
Structure (London, England : 1993)
Deaminase activity mediated by the human APOBEC3 family of proteins contributes to genomic instability and cancer. APOBEC3A is by far the most active in this family and can cause rapid cell death when...
Personal reflection (RNA journal 20th anniversary)
Wednesday, March 18, 2015
Author(s):
Sean P Ryder
Source:
RNA (New York, N.Y.)
No abstract
A conserved three-nucleotide core motif defines Musashi RNA binding specificity
Wednesday, November 05, 2014
Author(s):
N Ruth Zearfoss,Laura M Deveau,Carina C Clingman,Eric Schmidt,Emily S Johnson,Francesca Massi,Sean P Ryder
Source:
The Journal of biological chemistry
Musashi (MSI) family proteins control cell proliferation and differentiation in many biological systems. They are overexpressed in tumors of several origins, and their expression level correlates with...
Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite
Wednesday, June 18, 2014
Author(s):
Carina C Clingman,Laura M Deveau,Samantha A Hay,Ryan M Genga,Shivender M D Shandilya,Francesca Massi,Sean P Ryder
Source:
eLife
Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for the...
RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1
Tuesday, September 10, 2013
Author(s):
Ebru Kaymak,Sean P Ryder
Source:
The Journal of biological chemistry
Maternally supplied mRNAs encode proteins that pattern early embryos in many species. In the nematode Caenorhabditis elegans, a suite of RNA-binding proteins regulates expression of maternal mRNAs dur...
hnRNP A1 and secondary structure coordinate alternative splicing of Mag
Saturday, May 25, 2013
Author(s):
N Ruth Zearfoss,Emily S Johnson,Sean P Ryder
Source:
RNA (New York, N.Y.)
Myelin-associated glycoprotein (MAG) is a major component of myelin in the vertebrate central nervous system. MAG is present in the periaxonal region of the myelin structure, where it interacts with n...
Metabolite sensing in eukaryotic mRNA biology
Thursday, May 09, 2013
Author(s):
Carina C Clingman,Sean P Ryder
Source:
Wiley interdisciplinary reviews. RNA
All living creatures change their gene expression program in response to nutrient availability and metabolic demands. Nutrients and metabolites can directly control transcription and activate second-m...
A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels
Friday, February 08, 2013
Author(s):
Alex M Tamburino,Sean P Ryder,Albertha J M Walhout
Source:
G3 (Bethesda, Md.)
Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs...
End-labeling oligonucleotides with chemical tags after synthesis
Tuesday, October 16, 2012
Author(s):
N Ruth Zearfoss,Sean P Ryder
Source:
Methods in molecular biology (Clifton, N.J.)
Many experimental strategies for determining nucleic acid function require labeling the nucleic acid with radioisotopes or a chemical tag. Labels enable nucleic acid detection, yield information about...
POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster
Friday, October 05, 2012
Author(s):
Brian M Farley,Sean P Ryder
Source:
Molecular biology of the cell
RNA-binding proteins (RBPs) coordinate cell fate specification and differentiation in a variety of systems. RNA regulation is critical during oocyte development and early embryogenesis, in which RBPs ...
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing
Thursday, September 01, 2011
Author(s):
Jennifer A Broderick,William E Salomon,Sean P Ryder,Neil Aronin,Phillip D Zamore
Source:
RNA (New York, N.Y.)
Small RNAs loaded into Argonaute proteins direct silencing of complementary target mRNAs. It has been proposed that multiple, imperfectly complementary small interfering RNAs or microRNAs, when bound ...
FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans
Tuesday, August 09, 2011
Author(s):
Irene Kalchhauser,Brian M Farley,Sandra Pauli,Sean P Ryder,Rafal Ciosk
Source:
The EMBO journal
Although the decision between stem cell self-renewal and differentiation has been linked to cell-cycle modifications, our understanding of cell-cycle regulation in stem cells is very limited. Here, we...
Pumilio RNA recognition: the consequence of promiscuity
Tuesday, March 15, 2011
Author(s):
Sean P Ryder
Source:
Structure (London, England : 1993)
In this issue, Lu and Hall (2011) reveal the structural basis for degenerate RNA recognition by human Pumilio proteins. The structures suggest an appealing model where nucleotides that do not contribu...
Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells
Saturday, January 22, 2011
Author(s):
N Ruth Zearfoss,Carina C Clingman,Brian M Farley,Lisa M McCoig,Sean P Ryder
Source:
PLoS genetics
In mice, Quaking (Qk) is required for myelin formation; in humans, it has been associated with psychiatric disease. QK regulates the stability, subcellular localization, and alternative splicing of se...
Insights into the structural basis of RNA recognition by STAR domain proteins
Friday, December 31, 2010
Author(s):
Sean P Ryder,Francesca Massi
Source:
Advances in experimental medicine and biology
STAR proteins regulate diverse cellular processes and control numerous developmental events. They function at the post-transcriptional level by regulating the stability, sub-cellular distribution, alt...
A quantitative RNA code for mRNA target selection by the germline fate determinant GLD-1
Tuesday, December 21, 2010
Author(s):
Jane E Wright,Dimos Gaidatzis,Mathias Senften,Brian M Farley,Eric Westhof,Sean P Ryder,Rafal Ciosk
Source:
The EMBO journal
RNA-binding proteins (RBPs) are critical regulators of gene expression. To understand and predict the outcome of RBP-mediated regulation a comprehensive analysis of their interaction with RNA is neces...
Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes
Thursday, November 25, 2010
Author(s):
John M Pagano,Carina C Clingman,Sean P Ryder
Source:
RNA (New York, N.Y.)
Sequence-specific recognition of nucleic acids by proteins is required for nearly every aspect of gene expression. Quantitative binding experiments are a useful tool to measure the ability of a protei...
Hidden ribozymes in eukaryotic genome sequence
Saturday, October 16, 2010
Author(s):
Sean P Ryder
Source:
F1000 biology reports
The small self-cleaving ribozymes fold into complex tertiary structures to promote autocatalytic cleavage or ligation at a precise position within their sequence. Until recently, relatively few exampl...
An economic framework to prioritize confirmatory tests after a high-throughput screen
Wednesday, June 16, 2010
Author(s):
S Joshua Swamidass,Joshua A Bittker,Nicole E Bodycombe,Sean P Ryder,Paul A Clemons
Source:
Journal of biomolecular screening
How many hits from a high-throughput screen should be sent for confirmatory experiments? Analytical answers to this question are derived from statistics alone and aim to fix, for example, the false di...
Structure and function of nematode RNA-binding proteins
Tuesday, April 27, 2010
Author(s):
Ebru Kaymak,L M Wee,Sean P Ryder
Source:
Current opinion in structural biology
RNA-binding proteins are critical effectors of gene expression. They guide mRNA localization, translation, and stability, and potentially play a role in regulating mRNA synthesis. The structural basis...
RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3
Tuesday, November 17, 2009
Author(s):
John M Pagano,Brian M Farley,Kingsley I Essien,Sean P Ryder
Source:
Proceedings of the National Academy of Sciences of the United States of America
Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon postt...
The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p
Wednesday, August 12, 2009
Author(s):
Melonnie L M Furgason,Chris MacDonald,Scott G Shanks,Sean P Ryder,Nia J Bryant,Mary Munson
Source:
Proceedings of the National Academy of Sciences of the United States of America
The Sec1/Munc18 (SM) protein family regulates intracellular trafficking through interactions with individual SNARE proteins and assembled SNARE complexes. Revealing a common mechanism of this regulati...
Monitoring assembly of ribonucleoprotein complexes by isothermal titration calorimetry
Wednesday, November 05, 2008
Author(s):
Michael I Recht,Sean P Ryder,James R Williamson
Source:
Methods in molecular biology (Clifton, N.J.)
Isothermal titration calorimetry (ITC) is a useful technique to study RNA-protein interactions as it provides the only method by which the thermodynamic parameters of free energy, enthalpy, and entrop...
Quantitative analysis of protein-RNA interactions by gel mobility shift
Wednesday, November 05, 2008
Author(s):
Sean P Ryder,Michael I Recht,James R Williamson
Source:
Methods in molecular biology (Clifton, N.J.)
The gel mobility shift assay is routinely used to visualize protein-RNA interactions. Its power resides in the ability to resolve free from bound RNA with high resolution in a gel matrix. We review th...
RNA target specificity of the embryonic cell fate determinant POS-1
Tuesday, October 28, 2008
Author(s):
Brian M Farley,John M Pagano,Sean P Ryder
Source:
RNA (New York, N.Y.)
Specification of Caenorhabditis elegans body axes and cell fates occurs prior to the activation of zygotic transcription. Several CCCH-type tandem zinc finger (TZF) proteins coordinate local activatio...
Post-transcriptional regulation of myelin formation
Wednesday, July 02, 2008
Author(s):
N Ruth Zearfoss,Brian M Farley,Sean P Ryder
Source:
Biochimica et biophysica acta
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and protects neurons from degeneration. In the central nervous system, extensively polarized oligodend...
Regulation of maternal mRNAs in early development
Friday, March 28, 2008
Author(s):
Brian M Farley,Sean P Ryder
Source:
Critical reviews in biochemistry and molecular biology
Most sexually reproducing metazoans are anisogamous, meaning that the two gametes that combine during fertilization differ greatly in size. By convention, the larger gametes are considered female and ...
Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5
Thursday, February 01, 2007
Author(s):
John M Pagano,Brian M Farley,Lisa M McCoig,Sean P Ryder
Source:
The Journal of biological chemistry
Embryonic development requires maternal proteins and RNA. In Caenorhabditis elegans, a gradient of CCCH tandem zinc finger (TZF) proteins coordinates axis polarization and germline differentiation. Th...
Oskar gains weight
Tuesday, May 23, 2006
Author(s):
Sean P Ryder
Source:
Nature structural & molecular biology
No abstract
Specificity of the STAR/GSG domain protein Qk1: implications for the regulation of myelination
Tuesday, July 27, 2004
Author(s):
Sean P Ryder,James R Williamson
Source:
RNA (New York, N.Y.)
Inadequate formation and maintenance of myelin is the basis for several neurodegenerative disorders, including leukodystrophy and multiple sclerosis. In mice, oligodendrocyte differentiation and subse...
RNA target specificity of the STAR/GSG domain post-transcriptional regulatory protein GLD-1
Wednesday, January 14, 2004
Author(s):
Sean P Ryder,Leah A Frater,Dana L Abramovitz,Elizabeth B Goodwin,James R Williamson
Source:
Nature structural & molecular biology
The post-transcriptional regulation of gene expression underlies several critical developmental phenomena. In metazoa, gene products that are expressed, silenced and packaged during oogenesis govern e...
Biochemical detection of adenosine and cytidine ionization within RNA by interference analysis
Saturday, September 27, 2003
Author(s):
Scott A Strobel,Fatima D Jones,Adegboyega K Oyelere,Sean P Ryder
Source:
Nucleic acids research. Supplement (2001)
Perturbation of active site functional group pKas is an important strategy employed by protein enzymes to achieve catalysis. There is increasing evidence to indicate that RNAs also utilize functional ...
Comparative analysis of hairpin ribozyme structures and interference data
Saturday, March 09, 2002
Author(s):
Sean P Ryder,Scott A Strobel
Source:
Nucleic acids research
Great strides in understanding the molecular underpinnings of RNA catalysis have been achieved with advances in RNA structure determination by NMR spectroscopy and X-ray crystallography. Despite these...
An efficient ligation reaction promoted by a Varkud Satellite ribozyme with extended 5'- and 3'-termini
Tuesday, January 29, 2002
Author(s):
F D Jones,S P Ryder,S A Strobel
Source:
Nucleic acids research
The Neurospora Varkud Satellite (VS) RNA is capable of promoting a reversible self-cleavage reaction important for its replication pathway. In vivo the VS RNA performs a cis-cleavage reaction to gener...
Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping
Tuesday, October 30, 2001
Author(s):
S P Ryder,A K Oyelere,J L Padilla,D Klostermeier,D P Millar,S A Strobel
Source:
RNA (New York, N.Y.)
Tertiary structure in globular RNA folds can create local environments that lead to pKa perturbation of specific nucleotide functional groups. To assess the prevalence of functionally relevant adenosi...
Biological catalysis. The hairpin's turn
Thursday, April 12, 2001
Author(s):
S A Strobel,S P Ryder
Source:
Nature
No abstract
Chemical probing of RNA by nucleotide analog interference mapping
Thursday, June 01, 2000
Author(s):
S P Ryder,L Ortoleva-Donnelly,A B Kosek,S A Strobel
Source:
Methods in enzymology
No abstract
Nucleotide analog interference mapping of the hairpin ribozyme: implications for secondary and tertiary structure formation
Tuesday, August 10, 1999
Author(s):
S P Ryder,S A Strobel
Source:
Journal of molecular biology
The hairpin ribozyme is a small, naturally occurring RNA capable of folding into a distinct three-dimensional structure and catalyzing a specific phosphodiester transfer reaction. We have adapted a hi...
Nucleotide analog interference mapping
Tuesday, April 20, 1999
Author(s):
S P Ryder,S A Strobel
Source:
Methods (San Diego, Calif.)
Single-atom substitution experiments provide atomic resolution biochemical information concerning RNA structure and function. Traditionally, these experiments are performed using chimeric RNAs generat...
A minor groove RNA triple helix within the catalytic core of a group I intron
Thursday, December 10, 1998
Author(s):
A A Szewczak,L Ortoleva-Donnelly,S P Ryder,E Moncoeur,S A Strobel
Source:
Nature structural biology
Close packing of several double helical and single stranded RNA elements is required for the Tetrahymena group I ribozyme to achieve catalysis. The chemical basis of these packing interactions is larg...
Complementary sets of noncanonical base pairs mediate RNA helix packing in the group I intron active site
Friday, January 23, 1998
Author(s):
S A Strobel,L Ortoleva-Donnelly,S P Ryder,J H Cate,E Moncoeur
Source:
Nature structural biology
Helix packing is critical for RNA tertiary structure formation, although the rules for helix-helix association within structured RNAs are largely unknown. Docking of the substrate helix into the activ...
Ryder Lab
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Protein-RNA Interactions
Temperature and Embryogenesis
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