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Publications

Bioluminescence imaging in mice with synthetic luciferin analogues.
Ji X, Adams ST Jr, Miller SC.
Methods Enzymol. 2020;640:165-183. doi: 10.1016/bs.mie.2020.04.033. Epub 2020 May 31.

Enzymatic promiscuity and the evolution of bioluminescence.
Adams ST Jr, Miller SC.
FEBS J. 2019 Dec 11. doi: 10.1111/febs.15176. [Epub ahead of print] Review.

Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes.
Sharma DK, Adams ST Jr, Liebmann KL, Choi A, Miller SC.
Org Lett. 2019 Mar 15;21(6):1641-1644. doi: 10.1021/acs.orglett.9b00173. Epub 2019 Mar 5.

Computational investigation into the fluorescence of luciferin analogues.
Vreven T, Miller SC.
J Comput Chem. 2019 Jan 15;40(2):527-531. doi: 10.1002/jcc.25745.

Silicon Substitution in Oxazine Dyes Yields Near-Infrared Azasiline Fluorophores That Absorb and Emit beyond 700 nm.
Choi A, Miller SC.
Org Lett. 2018 Jul 17. doi: 10.1021/acs.orglett.8b01786. [Epub ahead of print]

Lessons Learned from Luminous Luciferins and Latent Luciferases.
Miller SC, Mofford DM, Adams ST Jr.
ACS Chem Biol. 2018 Jul 20;13(7):1734-1740.

Luciferase Activity of Insect Fatty Acyl-CoA Synthetases with Synthetic Luciferins.
Mofford DM, Liebmann KL, Sankaran GS, Reddy GSKK, Reddy GR, Miller SC.
ACS Chem Biol. 2017 Dec 15;12(12):2946-2951.

Rapid Access to a Broad Range of 6'-Substituted Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors.
Sharma DK, Adams ST Jr, Liebmann KL, Miller SC.
Org Lett. 2017 Nov 3;19(21):5836-5839.

Palladium-Mediated Synthesis of a Near-Infrared Fluorescent K+ Sensor.
Bandara HMD, Hua Z, Zhang M, Pauff SM, Miller SC, Davie EAC, Kobertz WR.
J Org Chem. 2017 Aug 4;82(15):8199-8205.

Reductively-labile sulfonate ester protecting groups that are rapidly cleaved by physiological glutathione.
Choi A, Miller SC.
Org Biomol Chem. 2017 Feb 7;15(6):1346-1349.

Firefly Luciferase Mutants Allow Substrate-Selective Bioluminescence Imaging in the Mouse Brain.
Adams ST Jr, Mofford DM, Reddy GS, Miller SC.
Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4943-6.

Luciferins behave like drugs.
Mofford DM, Miller SC.
ACS Chem Neurosci. 2015 Aug 19;6(8):1273-5.

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity.
Mofford DM, Adams ST Jr, Reddy GS, Reddy GR, Miller SC.
J Am Chem Soc. 2015 Jul 15;137(27):8684-7.

Aminoluciferins extend firefly luciferase bioluminescence into the near-infrared and can be preferred substrates over D-luciferin.
Mofford DM, Reddy GR, Miller SC.
J Am Chem Soc. 2014 Sep 24;136(38):13277-82.

Beyond D-luciferin: expanding the scope of bioluminescence imaging in vivo.
Adams ST Jr, Miller SC.
Curr Opin Chem Biol. 2014 Aug;21:112-20.

Latent luciferase activity in the fruit fly revealed by a synthetic luciferin.
Mofford DM, Reddy GR, Miller SC.
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4443-8.

A synthetic luciferin improves bioluminescence imaging in live mice.
Evans MS, Chaurette JP, Adams ST Jr, Reddy GR, Paley MA, Aronin N, Prescher JA, Miller SC.
Nat Methods. 2014 Apr;11(4):393-5.

A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.
Godinat A, Park HM, Miller SC, Cheng K, Hanahan D, Sanman LE, Bogyo M, Yu A, Nikitin GF, Stahl A, Dubikovskaya EA.
ACS Chem Biol. 2013 May 17;8(5):987-99.

A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore.
Pauff SM, Miller SC.
J Org Chem. 2013 Jan 18;78(2):711-6.

Identification of mutant firefly luciferases that efficiently utilize aminoluciferins.
Harwood KR, Mofford DM, Reddy GR, Miller SC.
Chem Biol. 2011 Dec 23;18(12):1649-57.

Synthesis of near-IR fluorescent oxazine dyes with esterase-labile sulfonate esters.
Pauff SM, Miller SC.
Org Lett. 2011 Dec 2;13(23):6196-9.

Design and application of esterase-labile sulfonate protecting groups.
Rusha L, Miller SC.
Chem Commun (Camb). 2011 Feb 21;47(7):2038-40.

Robust light emission from cyclic alkylaminoluciferin substrates for firefly luciferase.
Reddy GR, Thompson WC, Miller SC.
J Am Chem Soc. 2010 Oct 6;132(39):13586-7.

Profiling sulfonate ester stability: identification of complementary protecting groups for sulfonates.
Miller SC.
J Org Chem. 2010 Jul 2;75(13):4632-5.

Leveraging a small-molecule modification to enable the photoactivation of rho GTPases.
Harwood KR, Miller SC.
Chembiochem. 2009 Dec 14;10(18):2855-7.

Labeling tetracysteine-tagged proteins with a SplAsH of color: a modular approach to bis-arsenical fluorophores.
Bhunia AK, Miller SC.
Chembiochem. 2007 Sep 24;8(14):1642-5.

Synthesis and phenotypic screening of a Guanine-mimetic library.
Miller SC, Mitchison TJ.
Chembiochem. 2004 Jul 5;5(7):1010-2. 

oNBS-SPPS: A New Method for Solid-Phase Peptide Synthesis.
Miller, S.C.; Scanlan, T.S.
J. Am. Chem. Soc. 120, 2690-2691 (1998).

Site-Selective N-Methylation of Peptides on Solid Support.
Miller, S.C.; Scanlan, T.S. 
J. Am. Chem. Soc. 119, 2301-2302 (1997).

Coupling between trans/cis proline isomerization and protein stability in staphylococcal nuclease.
Truckses, D.M.; Somoza, J.R.; Prehoda, K.E.; Miller, S.C.; Markley, J.L. 
Protein Science 5, 1907-1916 (1996).