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Tang W, Seth M, Tu S, Shen EZ, Li Q, Shirayama M, Weng Z, Mello CC. (2018) A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans.

Seth M, Shirayama M, Tang W, Shen EZ, Tu S, Lee HC, Weng Z, Mello CC. (2018) The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans.

Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC. (2018) Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline.


Gammon DB, Ishidate T, Li L, Gu W, Silverman N, Mello CC. (2017) The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans.

Carmell MA, Dokshin GA, Skaletsky H, Hu YC, van Wolfswinkel JC, Igarashi KJ, Bellott DW, Nefedov M, Reddien PW, Enders GC, Uversky VN, Mello CC, Page DC. (2016) A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes.


Wen Tang, Shikui Tu, Heng-Chi Lee, Zhiping Weng, Craig C. Mello (2016) The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans.

Upasna Sharma, Colin C. Conine, Jeremy M. Shea, Ana Boskovic, Alan G. Derr, Xin Y. Bing, Clemence Belleanne, Alper Kucukural, Ryan W. Serra, Fengyun Sun, Lina Song, Benjamin R. Carone, Emiliano P. Ricci, Xin Z. Li, Lucas Fanquier, Melissa J. Moore, Robert Sullivan, Craig C. Mello, Manuel Garber, Oliver J. Rando (2016) Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals


Weifeng Gu, Glen R. Gallagher, Weiwei Dai, Ping Liu, Ruidong Li, Melanie I. Trombly, Don B. Gammon, Craig C. Mello, Jennifer P. Wang, and Robert W. Finberg (2015) Influenza A virus preferentially snatches noncoding RNA caps

Ahmed Elewa, Masaki Shirayama, Ebru Kaymak, Paul F. Harrison, David R. Powell, Zho Du, Christopher D. Chute, Hannah Woolf, Dongni Yi, Takao Ishidate, Jagan Srinivasan, Zhirong Bao, Traude H. Beilharz, Sean P. Ryder, Craig C. Mello (2015) POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA

Don B. Gammon, Craig C. Mello (2015) RNA interference-mediated antiviral defense in insects

Sarah J. Hainer, Weifeng Gu, Benjamin R. Carone, Benjamin D. Landry, Oliver J. Rando, Craig C. Mello, Thomas G. Fazzio (2015) Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF

Hsin-Yue Tsai, Chun-Chieh G. Chen, Darryl Conte Jr., James J. Moresco, Daniel A. Chaves, Shohei Mitani, John R. Yates III, Ming-Daw Tsai, Craig C. Mello (2015) A Ribonuclease Coordinates siRNA Amplification and mRNA Cleavage during RNAi

Darryl Conte Jr., Lesley T. MacNeil, Albertha J.M. Walhout, Craig C. Mello (2015) RNA Interference in Caenorhabditis elegans


Don B Gammon, Sophie Duraffour, Daniel K Rozelle, Heidi Hehnly, Rita Sharma, Michael E Sparks, Cara C West, Ying Chen, James J Moresco, Graciela Andrei, John H Connor, Darryl Conte Jr., Dawn E Gundersen Rindal, William L Marshall, John R Yates, Neal Silverman, Craig C Mello (2014) A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

Takao Ishidate, Ahmed Elewa, Soyoung Kim, Craig C Mello, and Masaki Shirayama (2014) Divide and differentiate CDK/Cyclins and the art of development

Heesun Kim, Takao Ishidate, Krishna S. Ghanta, Meetu Seth, Darryl Conte Jr., Masaki Shirayama, and Craig C. Mello (2014) A Co-CRISPR Strategy for EfficientGenome Editing in C. elegans

Masaki Shirayama, William Stanney III, Weifeng Gu, Meetu Seth, and Craig C. Mello (2014) The Vasa Homolog RDE-12 Engages Target mRNA and Multiple Argonaute Proteins to Promote RNAi in C. elegans


Colin C. Conine, James J. Moresco, Weifeng Gu, Masaki Shirayama, Darryl Conte, Jr., John R. Yates III, and Craig C. Mello (2013) Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

Takao Ishidate, Soyoung Kim, Craig Mello, and Masaki Shirayama (2013) Inductive asymmetric cell division The WRM leads the way

Soyoung Kima, Takao Ishidatea, Rita Sharma, Martha C. Sotoc, Darryl Conte, Jr., Craig C. Mello, and Masaki Shirayama (2013) Wnt and CDK-1 regulate cortical release of WRM-1/ β-catenin to control cell division orientation in early Caenorhabditis elegans embryos

Meetu Seth, Masaki Shirayama, Weifeng Gu, Takao Ishidate, Darryl Conte, Jr., and Craig C. Mello (2013) The C. elegans CSR-1 Argonaute Pathway Counteracts Epigenetic Silencing to Promote Germline Gene Expression


Andrea D’Ambrogio, Weifeng Gu, Tsuyoshi Udagawa, Craig C. Mello, and Joel D. Richter, (2012) Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation

Weifeng Gu, Heng-Chi Lee, Daniel Chaves, Elaine M. Youngman, Gregory J. Pazour, Darryl Conte, Jr., and Craig C. Mello (2012) CapSeq and CIP-TAP Identify Pol II Start Sites and Reveal Capped Small RNAs as C. elegans piRNA Precursors

Heng-Chi Lee, Weifeng Gu, Masaki Shirayama, Elaine Youngman, Darryl Conte, Jr., and Craig C. Mello (2012) C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts

Liande Li, Weifeng Gu, Chunyang Liang, Qinghua Liu, Craig C Mello & Yi Liu (2012) The translin–TRAX complex (C3PO) is a ribonuclease in tRNA processing

Masaki Shirayama, Meetu Seth, Heng-Chi Lee, Weifeng Gu, Takao Ishidate, Darryl Conte, Jr., and Craig C. Mello (2012) piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

Caroline Thivierge, Neetha Makil, Mathieu Flamand, Jessica J Vasale, Craig C Mello, James Wohlschlegel, Darryl Conte Jr & Thomas F Duchaine (2012) Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi


Jun Xie, Qing Xie, Hongwei Zhang, Stefan L Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C Mello, Zhiping Weng, Terence R Flotte, Phillip D Zamore and Guangping Gao (2011) MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression


Colin C. Conine, Pedro J. Batista, Weifeng Gu, Julie M. Claycomba, Daniel A. Chaves, Masaki Shirayama, and Craig C. Mello (2010) Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans

Darryl Conte Jr. and Craig C. Mello (2010) Primal RNAs: The End of the Beginning?

Heng-Chi Lee, Liande Li, Weifeng Gu, Zhihong Xue, Susan K. Crosthwaite, Alexander Pertsemlidis, Zachary A. Lewis, Michael Freitag, Eric U. Selker, Craig C. Mello, and Yi Liu (2010) Diverse Pathways Generate MicroRNA-like RNAs and Dicer-Independent Small Interfering RNAs in Fungi

Ji Liu, Lisa L. Maduzia, Masaki Shirayama, Craig C. Mello (2010) NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division

Jessica J. Vasale, Weifeng Gu, Caroline Thivierge, Pedro J Batista, Julie M. Claycomb, Elaine M. Youngman, Thomas F. Duchaine, Craig C. Mello, and Darryl Conte Jr. (2010) Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway


Julie M. Claycomb, Pedro J. Batista, Ka Ming Pang, Weifeng Gu, Jessica J. Vasale, Josien C. van Wolfswinkel, Daniel A. Chaves, Masaki Shirayama, Shohei Mitani, Rene´ F. Ketting, Darryl Conte, Jr., and Craig C. Mello. (2009) The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

Weifeng Gu, Masaki Shirayama, Darryl Conte, Jr., Jessica Vasale, Pedro J. Batista, Julie M. Claycomb, James J. Moresco, Elaine M. Youngman, Jennifer Keys, Matthew J. Stoltz, Chun-Chieh G. Chen, Daniel A. Chaves, Shenghua Duan, Kristin D. Kasschau, Noah Fahlgren, John R. Yates III, Shohei Mitani, James C. Carrington, and Craig C. Mello (2009) Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline

Josien C. van Wolfswinkel, Julie M. Claycomb, Pedro J. Batista, Craig C. Mello, Eugene Berezikov, and Rene´ F. Ketting (2009) CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs


Pedro J. Batista, J. Graham Ruby, Julie M. Claycomb, Rosaria Chiang, Noah Fahlgren, Kristin D. Kasschau, Daniel A. Chaves, Weifeng Gu, Jessica J. Vasale, Shenghua Duan, Darryl Conte, Jr., Shujun Luo, Gary P. Schroth, James C. Carrington, David P. Bartel, and Craig C. Mello (2008) PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans


Thomas F. Duchaine, James A. Wohlschlegel, Scott Kennedy, Yanxia Bei, Darryl Conte Jr., KaMing Pang, Daniel R. Brownell, Sandra Harding, Shohei Mitani, Gary Ruvkun, John R. Yates III, and Craig C. Mello (2006) Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways

Craig C. Mello (2006) Return to the RNAi World: Rethinking Gene Expression and Evolution (Nobel Lecture)

Masaki Shirayama, Martha C. Soto, Takao Ishidate, Soyoung Kim, Kuniaki Nakamura, Yanxia Bei, Sander van den Heuvel, and Craig C. Mello (2006) The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans

Erbay Yigit, Pedro J. Batista, Yanxia Bei, Ka Ming Pang, Chun-Chieh G. Chen, Niraj H. Tolia, Leemor Joshua-Tor, Shohei Mitani, Martin J. Simard and Craig C. Mello (2006) Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi


Chun-Chieh G. Chen, Martin J. Simard, Hiroaki Tabara, Daniel R. Brownell, Jennifer A. McCollough, and Craig C. Mello (2005) A Member of the Polymerase Nucleotidyltransferase Superfamily Is Required for RNA Interference in C. elegans

Kuniaki Nakamura, Soyoung Kim, Takao Ishidate, et al. (2005) Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos

Bastiaan B. J. Tops, Hiroaki Tabara, Titia Sijen, Femke Simmer, Craig C. Mello, Ronald H. A. Plasterk and Rene´ F. Ketting (2005) RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans

Duo Wang, Scott Kennedy, Darryl Conte Jr, John K. Kim, Harrison W. Gabel, Ravi S. Kamath, Craig C. Mello & Gary Ruvkun (2005) Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants


Anastasia P. Grigorenko, Yuri K. Moliaka, Martha C. Soto, Craig C. Mello, and Evgeny I. Rogaev (2004) The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

Gyorgy Hutvagner, Martin J. Simard, Craig C. Mello, Phillip D. Zamore (2004) Sequence-Specific Inhibition of Small RNA Function

Craig C Mello & Michael P Czech (2004) Micromanaging insulin secretion

Craig C. Mello & Darryl Conte Jr (2004) Revealing the world of RNA interference

Ka Ming Pang, Takao Ishidate, Kuniaki Nakamura, Masaki Shirayama, Chris Trzepacz, Charlotte M. Schubert, James R. Priess, and Craig C. Mello (2004) The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos


Tae Ho Shin and Craig C Mello (2003) Chromatin regulation during C. elegans germline development

Lisa Timmons, Hiroaki Tabara, Craig C. Mello, and Andrew Z. Fire (2003) Inducible Systemic RNA Silencing in Caenorhabditis elegans

Kavitha Venkatesan, Heather R. McManus, Craig C. Mello, Temple F. Smith and Ulla Hansen (2003) Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead


Yanxia Bei, Jennifer Hogan, Laura A. Berkowitz, Martha Soto, Christian E. Rocheleau, Ka Ming Pang, John Collins, and Craig C. Mello.(2002) SRC-1 and Wnt Signaling Act Together to Specify Endoderm and to Control Cleavage Orientation in Early C. elegans Embryos

Martha C. Soto, Hiroshi Qadota, Katsuhisa Kasuya, et al. (2002) The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans

Hiroaki Tabara, Erbay Yigit, Haruhiko Siomi, and Craig C. Mello (2002) The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

Yingdee Unhavaithaya, Tae Ho Shin, Nicholas Miliaras, Jungsoon Lee, Tomoko Oyama, and Craig C. Mello (2002) MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans


Alla Grishok, Amy E. Pasquinelli, Darryl Conte, Na Li, Susan Parrish, Ilho Ha, David L. Baillie, Andrew Fire, Gary Ruvkun, and Craig C. Mello (2001) Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing


Alla Grishok et al. Science 287, 2494 (2000) Genetic Requirements for Inheritance of RNAi in C. elegans


Christian E. Rocheleau, Jun Yasuda, Tae Ho Shin, Rueyling Lin, Hitoshi Sawa, Hideyuki Okano, James R. Priess, Roger J. Davis, and Craig C. Mello (1999) WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans

Tae Ho Shin, Jun Yasuda, Christian E. Rocheleau, Rueyling Lin, Martha Soto, Yanxia Bei, Roger J. Davis, and Craig C. Mello (1999) MOM-4, a MAP Kinase Kinase Kinase–Related rotein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans

Hiroaki Tabara, Russell J. Hill, Craig C. Mello, James R. Priess, and Yuji Kohara (1999) pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans

Hiroaki Tabara, Madathia Sarkissian, William G. Kelly, Jamie Fleenor, Alla Grishok, Lisa Timmons, Andrew Fire, and Craig C. Mello (1999) The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans


Letters to Nature (1998)


Christian E. Rocheleau, William D. Downs, Rueyling Lin, Claudia Wittmann, Yanxia Bei, Yoon-Hee Cha, Mussa Ali, James R. Priess and Craig C. Mello (1997) Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos


Bruce W. Draper, Craig C. Mello, Bruce Bowerman, Jeff Hardin, and James R. Priess (1996) MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos

Katherine M. Mickey, Craig C. Mello, Mary K. Montgomery, Andrew Fire and James R. Priess (1996) An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell

Jennifer L. Watts, Bijan Etemad-Moghadam, Su Guo, Lynn Boyd, Bruce W. Draper, Craig C. Mello, James R. Priess and Kenneth J. Kemphues (1996) par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3


Diane J. Levitan, Lynn Boyd, Craig C. Mello, Kenneth J. Kemphues, and Dan T. Stinchcomb (1994) par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs

Craig C. Mello, Bruce W. Draper, and James R. Priess (1994) The Maternal Genes apx-1 and glp-1 and Establishment of Dorsal-Ventral Polarity in the Early C. elegans Embryo


Bruce Bowerman, Bruce W. Draper, Craig C. Mello, and James R. Priess (1993) The Maternal Gene skn.1 Encodes a Protein That Is Distributed Unequally in Early C, elegans Embryos

Marion H. Sibley, Jeffrey J. Johnson, Craig C. Meno, and James M. Kramer (1993) Genetic Identification, Sequence, and Alternative Splicing of the Caenorhabditis elegans c 2(IV) Collagen Gene


Craig C. Mello, Bruce W. Draper, Michael Krause, Harold Weintraub, and James Ft. Priess (1992) The pie-1 and mex-I Genes and Maternal Control of Blastomere Identity in Early C. elegans Embryos


Craig C. Mello, James M. Kramer, Dan Stinchcomb and Victor Ambros (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences