Welcome to the UMMS Transgenic Animal Modeling Core

Mission Statement

The mission of the Transgenic Animal Modeling Core (TAMC) is to produce genetically modified mice, rats, and stem cells for the UMMS Scientific Community in a timely and cost-efficient manner. Over the past 15 years, the TAMC has engineered more than 500 different mouse or rat models, has generated dozens of genetically altered ES cell or induced pluripotent stem cell lines, and has cryopreserved re-derived more than 450 rodent lines for UMASS researchers and other members of the scientific community.  The TAMC is composed of two facilities: the Animal Modeling Facility and the Gene Targeting & Stem Cell Facility.

Funding

Funding for the TAMC is provided by UMMS and by individual Investigators' user fees. Acknowledgment in pertinent manuscripts of assistance provided by the UMMS Transgenic Animal Modeling Core is greatly appreciated and helps to ensure continual Core funding.

Institute Animal Care and Use Committee Approval

Investigators must have approval of the UMMS Institute Animal Care and Use Committee (IACUC) and Institute Biosafety Committee (IBC) before the Core can undertake generation of genetically altered mice or rats. Relevant IACUC and IBC docket numbers must be provided with the service agreement. UMMS Investigators using the TAMC to generate animals do not need to describe the requisite experimental procedures in their own protocols, as the Core’s IACUC docket (A-619) covers these procedures.  Please contact the UMMS IACUC and UMMS IBC to procure docket numbers, and the UMMS Department of Animal Medicine to arrange for necessary vivarium space and husbandry of animals generated by the TAMC.

Contact the Core

The Transgenic Animal Modeling Core is under the scientific direction of Dr. Stephen Jones. Questions regarding the Core may be directed to stephen.jones@umassmed.edu