Drug resistance is a major obstacle in modern medicine, impacting millions of patients and costing billions of dollars annually. Resistance occurs when through rapid evolution a drug target maintains function while no longer being inhibited by the drug. Modern drug design strategies leave opportunity for drug resistance by ignoring function.
Disrupting the drug target’s activity is necessary but not sufficient for developing a robust drug that avoids resistance.
We combine a variety of experimental and computational techniques to understand the molecular basis of drug resistance and pay attention to the ways that the natural substrate specificity is maintained by the resistant viral variants. Our new paradigm of drug design minimizes chances of resistance.