Representative publications (updated November 2012)

For updated publications, please see our Profiles page.

Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis. PLoS Pathog. 2013 Jul; 9(7):e1003419.  View in: PubMed

Rittershaus ES, Baek SH, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe. 2013 Jun 12; 13(6):643-51. View in: PubMed

O'Sullivan BP, Sassetti CM. Infection control in cystic fibrosis: share and share alike. Lancet. 2013 May 4; 381(9877):1517-9. View in: PubMed

Padilla-Benavides T, Long JE, Raimunda D, Sassetti CM, Argüello JM. A Novel P1B-type Mn2+-transporting ATPase Is Required for Secreted Protein Metallation in Mycobacteria. J Biol Chem. 2013 Apr 19; 288(16):11334-47. View in: PubMed

Dejesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics. 2013 Mar 15; 29(6):695-703. View in: PubMed

Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1ß. Nat Immunol. 2013 Jan; 14(1):52-60. View in: PubMed

Cyclic-AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Li, H.J., Fortune, S.F., Sassetti, C.M. Alber, T. Nat. Struc. Mol. Biol. 19: 811–818 (2012).

Zhang, Y.J., Ioerger, T.R., Huttenhower, C., Long, J.E., Sassetti, C.M., Sacchettini, J.C. and Rubin, E.J. Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis. Plos Pathog. PLoS Pathog 8(9): e1002946. doi:10.1371/journal.ppat.1002946.
Role in metal homeostasis of CtpD, a Co(2+) transporting P(1B4) -ATPase of Mycobacterium smegmatis. Raimunda D, Long JE, Sassetti CM, Argüello JM. Mol Microbiol. 84(6):1139-49 (2012)

Griffin, J.E.,, Pandey, A.K., GilmoreS.A., MizrahiV., Mckinney, J.D., Bertozzi, C.B., and Sassetti, C.M. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. In Press. Chemistry and Biology (2012).

Gee, C.L., Papavinasasundaram, K.G., Blair, S..R., Baer, C., Falick, A.M., King, D.S., Griffin. J., Venghatakrishnan, H., Christopher M. Sassetti* and Tom Alber*. A pseudokinase complex controls cell wall synthesis in mycobacteria. *Corresponding authors. In Press. Science Signalling. (2012).

Griffin, J.E., Gawronski, J.D., DeJesus, M.A., Ioerger, T. R., Akerley, B. A., Sassetti, C.M. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathogens. 7(9): e1002251 (2011)

Baek, S., Li, A.H., Sassetti, C.M. Metabolic regulation mycobacterial growth and antibiotic sensitivity. PLoS Biol 9(5): e1001065. doi:10.1371/journal.pbio.1001065 (2011).

Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. Mar 31;6(3):e18367. (2011)

Wei, J.R., Krishnamoorthy, V., Murphy, K.C., Kim, J., Schnappinger, D., Alber, D.A., Sassetti, C.M., Rhee, K.Y. and Rubin, E.J. Antibiotic targets vary in their sensitivity to inhibition by depletion. PNAS 108 (10) 4176-4181. (2011)

Fong SS, Rearden P, Kanchagar C, Sassetti C, Trevejo J, Brereton RG. Automated Peak Detection and Matching Algorithm for Gas Chromatography-Differential Mobility Spectrometry. Anal Chem. (2011)

Ioerger, T. R., Feng, Y., Ganesula, K., Chen, X., Dobos, K. M., Fortune, S., Jacobs, W. R., Jr., Mizrahi, V., Parish, T., Rubin, E., Sassetti, C.M., Sacchettini, J. C. Variation Among Genome Sequences of H37Rv Strains of M. tuberculosis from Multiple Laboratories. J. Bacteriology. (2010)

Chang, J.C., Miner, M.D., Pandey, A.K., Gill, W.P., Harik, N.S., Sassetti, C.M., and Sherman, D.R. igr Genes and M. tuberculosisCholesterol Metabolism. J. Bacteriology. 191:5232-5239. (2009)

Coulombe, F., Divangahi, M., Veyrier, F., de Léséleuc, L., Gleason, J.L., Yang, Y., Kelliher, M.A., Pandey, A.K., Sassetti, C.M., Reed, M., Behr, M.A.. Increased NOD2-Mediated Recognition of N-Glycolyl Muramyl Dipeptide. J. Exp. Med206:1709-1716. (2009)

Murry, J. M., Pandey, A.K., Sassetti, C.M., Rubin, E. J. Phthiocerol dimycocerosate transport is required for resisting IFN gamma-independent immunity. Journal of Infectious Diseases200:774-782 (2009)

Pandey, A., Yang, Y., JiangZ., Fortune, S., CoulombeF., BehrM.A., FitzgeraldK.A., Sassetti, C.M.*, Kelliher, M.A*. NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis. PLoS Pathogens. 5(7): e1000500. doi:10.1371/journal.ppat.1000500 (2009). *corresponding authors.

Pandey, A. K, Raman, S, Proff, R, Joshi, S, Kang, C., Rubin, E., Husson, R., and Sassetti, C.M. Nitrile-inducible gene expression in mycobacteria. Tuberculosis 89:12-16 (2009).

Pandey, A.K. and Sassetti, C.M. Mycobacterial persistence requires the utilization of host cholesterol. Proc. Nat. Acad. Sci. 105 (11):4376-4380. (2008)

Yang, Y., Yin, C., Pandey, A.K., Abbott,D., Sassetti, C.M., Kelliher, M.A. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J. Biol. Chem. 282:36223-9. (2007)

Joshi, S. M., Pandey, A.K., Capite, N., Fortune, S.M., Rubin, E.J., and Sassetti, C.M. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc. Nat. Acad. Sci. 103:11760-11765. (2006)

Murry, J., Sassetti, C.M., Moreira, J., Lane, J., and Rubin, E.J.. A new site-specific integration system for mycobacteria. Tuberculosis. 85(5-6):317-23, (2005).

Fortune S.M, Jaeger A., Chase M.R, Sarracino, D.A, Sassetti C.M, Sherman D.R., Bloom B.R. and Rubin E.J. Mutually-dependent secretion of proteins required for mycobacterial virulence. Proc. Nat. Acad. Sci. 102:10676-81. (2005).

Rengarajan,J., Sassetti, C. M., NaroditskayaV., SloutskyA., BloomB.R. and Rubin, E. J.The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Molecular Microbiology 53:275-282 (2004)

Sassetti, C. M. and Rubin, E. J. Genetic requirements for mycobacterial survival during infection. Proc. Nat. Acad. Sci. 100:12989-12994 (2003)

Sassetti, C. M., Boyd, D. H. and Rubin, E. J. Genes required for mycobacterial growth defined by high density mutagenesis.Molecular Microbiology. 48: 77-84. (2003)

Sassetti, C. M., Boyd, D. H. and Rubin, E. J. Comprehensive identification of conditionally essential genes in mycobacteria.Proc. Nat. Acad. Sci. 98: 12712-12717. (2001)