Representative publications

For updated publications, please see our Profiles page.

 

Nambi, S., Long, J.E., Mishra, B.B., Baker, R., Murphy, K., Olive, A.J., Nguyen, H., Shaffer, S. A., and Sassetti, C.M.  The oxidative stress network of M. tuberculosis reveals a novel oxidoreductase complex critical for virulence.  Cell Host and Microbe.  Volume 17, Issue 6, p829–837. (2015) PMID: 26067605  Pubmed

Meniche, X., Otten, R., Siegrist, S.M., Baer, C.E., Murphy, K.C., Bertozzi, C.R., Sassetti, C.M.  Sub-polar addition of new cell wall is directed by DivIVA in Mycobacteria.  Proc. Nat. Acad. Sci. (2014).  PMID: 25049412  Pubmed

Rittershaus ES, Baek SH, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe. 2013 Jun 12; 13(6):643-51. View in: PubMed

Padilla-Benavides T, Long JE, Raimunda D, Sassetti CM, Argüello JM. A Novel P1B-type Mn2+-transporting ATPase Is Required for Secreted Protein Metallation in Mycobacteria. J Biol Chem. 2013 Apr 19; 288(16):11334-47. View in: PubMed

Dejesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics. 2013 Mar 15; 29(6):695-703. View in: PubMed

Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1ß. Nat Immunol. 2013 Jan; 14(1):52-60. View in: PubMed

Cyclic-AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Li, H.J., Fortune, S.F., Sassetti, C.M. Alber, T. Nat. Struc. Mol. Biol. 19: 811–818 (2012).

Zhang, Y.J., Ioerger, T.R., Huttenhower, C., Long, J.E., Sassetti, C.M., Sacchettini, J.C. and Rubin, E.J. Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis. Plos Pathog. PLoS Pathog 8(9): e1002946. doi:10.1371/journal.ppat.1002946.
 
Role in metal homeostasis of CtpD, a Co(2+) transporting P(1B4) -ATPase of Mycobacterium smegmatis. Raimunda D, Long JE, Sassetti CM, Argüello JM. Mol Microbiol. 84(6):1139-49 (2012)
 

Griffin, J.E.,, Pandey, A.K., GilmoreS.A., MizrahiV., Mckinney, J.D., Bertozzi, C.B., and Sassetti, C.M. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. In Press. Chemistry and Biology (2012).

Gee, C.L., Papavinasasundaram, K.G., Blair, S..R., Baer, C., Falick, A.M., King, D.S., Griffin. J., Venghatakrishnan, H., Christopher M. Sassetti* and Tom Alber*. A pseudokinase complex controls cell wall synthesis in mycobacteria. *Corresponding authors. In Press. Science Signalling. (2012).

Griffin, J.E., Gawronski, J.D., DeJesus, M.A., Ioerger, T. R., Akerley, B. A., Sassetti, C.M. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathogens. 7(9): e1002251 (2011)

Baek, S., Li, A.H., Sassetti, C.M. Metabolic regulation mycobacterial growth and antibiotic sensitivity. PLoS Biol 9(5): e1001065. doi:10.1371/journal.pbio.1001065 (2011).

Coulombe, F., Divangahi, M., Veyrier, F., de Léséleuc, L., Gleason, J.L., Yang, Y., Kelliher, M.A., Pandey, A.K., Sassetti, C.M., Reed, M., Behr, M.A.. Increased NOD2-Mediated Recognition of N-Glycolyl Muramyl Dipeptide. J. Exp. Med206:1709-1716. (2009)

Pandey, A., Yang, Y., JiangZ., Fortune, S., CoulombeF., BehrM.A., FitzgeraldK.A., Sassetti, C.M.*, Kelliher, M.A*. NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis. PLoS Pathogens. 5(7): e1000500. doi:10.1371/journal.ppat.1000500 (2009). *corresponding authors.

Pandey, A. K, Raman, S, Proff, R, Joshi, S, Kang, C., Rubin, E., Husson, R., and Sassetti, C.M. Nitrile-inducible gene expression in mycobacteria. Tuberculosis 89:12-16 (2009).

Pandey, A.K. and Sassetti, C.M. Mycobacterial persistence requires the utilization of host cholesterol. Proc. Nat. Acad. Sci. 105 (11):4376-4380. (2008)

Yang, Y., Yin, C., Pandey, A.K., Abbott,D., Sassetti, C.M., Kelliher, M.A. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J. Biol. Chem. 282:36223-9. (2007)

Joshi, S. M., Pandey, A.K., Capite, N., Fortune, S.M., Rubin, E.J., and Sassetti, C.M. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc. Nat. Acad. Sci. 103:11760-11765. (2006)

Rengarajan,J., Sassetti, C. M., NaroditskayaV., SloutskyA., BloomB.R. and Rubin, E. J.The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Molecular Microbiology 53:275-282 (2004)

Sassetti, C. M. and Rubin, E. J. Genetic requirements for mycobacterial survival during infection. Proc. Nat. Acad. Sci. 100:12989-12994 (2003)

Sassetti, C. M., Boyd, D. H. and Rubin, E. J. Genes required for mycobacterial growth defined by high density mutagenesis.Molecular Microbiology. 48: 77-84. (2003)

Sassetti, C. M., Boyd, D. H. and Rubin, E. J. Comprehensive identification of conditionally essential genes in mycobacteria.Proc. Nat. Acad. Sci. 98: 12712-12717. (2001)

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