- PMM Home
- Bioinformatics Core
Our Next Noon Seminar
Terence Flotte, Executive Deputy Chancellor, Provost and Dean
Talk Title: Clinical Gene Therapy for Alpha-1 Antitrypsin Deficiency
Victor R. Ambros, PhD, professor of molecular medicine, has been awarded a $3 million 2015 Breakthrough Prize in Life Sciences for his co-discovery of a new world of genetic regulation by microRNAs. (Article)
Raffi’s national and international impact in the field of infectious diseases and parasitic disease is enormous and we are pleased that his laboratory will be continuing their work at UMASS MED. A native of Worcester, MA, he earned his bachelor’s degree in physics at the Massachusetts Institute of Technology, and his PhD degree in biology from California Institute of Technology. Dr. Aroian is coming to UMMS from the University of California San Diego, where he was Professor, Section of Cell and Developmental Biology. After serving as a postdoctoral scholar with Bruce Alberts at UCSF, Dr Aroian began his career in biomedical research focused on the characterization of embryonic polarity genes in C. elegans. Raffi’s studies rapidly led to interest in the basic biology of infectious diseases using as models the free-living nematode, Caenorhabditis elegans, and the mouse parasitic nematode, Heligmosomoides polygyrus bakeri. A major focus of his research examines pore-forming toxins (PFTs), which are the most common toxin made by pathogenic bacteria. The laboratory studies a molecular genetic model of PFT pathogenesis, namely the interaction of C. elegans with the PFTs made by Bacillus thuringiensis (Bt). Raffi’s laboratory has discovered the intracellular pathways that enable C. elegans cells to counteract intoxication by PFTs, how these pathways are interconnected, and their protective functions during PFT attack. The laboratory is also exploring new therapies for soil-transmitted helminths (STH), including hookworm, whipworm, and Ascaris, which are the most common infections in humans, affecting in excess of 2 billion people worlwide. The Aroian laboratory has found that Crystal (Cry) proteins made by Bt are effective anthelmintics, and can cure two different worm infections in two different rodent models. Raffi is currently using the mouse parasite H. polygyrus to study basic and applied research questions of how to optimize Cry protein anthelmintic therapies and how to bring Cry proteins into human clinical trials.
UMass Medical School scientists Job Dekker, PhD, and John L. Sullivan, MD, have been named Fellows of the American Association for the Advancement of Science (AAAS). Election as a Fellow is an honor bestowed upon AAAS members by their peers. (Full Article)
The Indiana University School of Medicine Steven C. Beering Award honors an internationally recognized individual for outstanding research contributions to the advancement of biomedical or clinical science. The Beering Award was established in 1983, honoring the important contributions Dr. Beering made to the Indiana University School of Medicine as its dean from 1974 to 1983. Dr. Beering was the youngest Dean appointed to the School of Medicine. He left the School to become the president of Purdue University, serving until his retirement on August 14th, 2000. The creation of the award was announced on June 24th, 1983 and the award is presented annually and consists of a medal and a prize of $25,000. Five of the past Beering Award recipients have become Nobel laureates, either before or after receipt of this award.
2013 Awardee: Roger J. Davis, PhD
The 2013 Steven C. Beering Award was presented to Roger J. Davis, PhD, Professor of Molecular Medicine and Biochemistry & Molecular Biology at University of Massachusetts Medical School on October 30, 2013.
To view the recorded Beering lectures, please visit here
The 18th Keio Medical Science Prize has been awarded to Victor R. Ambros, PhD, the Silverman Chair in Natural Science and professor of molecular medicine; and Shigekazu Nagata, PhD, professor of medical chemistry in the Graduate School of Medicine at Kyoto University.
Keio University annually awards the Keio Medical Science Prize “to recognize researchers who have made an outstanding contribution to the field of medicine or life sciences.”
It is the only prize of its kind awarded by a Japanese university, and six previous winners have gone on to win the Nobel Prize.
Keio Medical Science Prize Laureates will receive a certificate of merit, a medal and a monetary award at a ceremony and lecture in Tokyo on Nov. 27. - (Full article)
TIME’s annual list of the 100 most influential people in the world - link to article
FIFTEEN SEARLE SCHOLARS NAMED FOR 2013
April 3, 2013: Chicago, Illinois - Fifteen researchers in the chemical and biological sciences have been named as the 2013 Searle Scholars. Each will be awarded $300,000 to support his or her work during the next three years. (Full Article)
A team of researchers from UMMS, Johns Hopkins and the University of Mississippi have reported the first case of a so-called “functional cure” in an HIV-infected infant, which may help pave the way for eliminating HIV infection in children. (Full Article)
UMMS research answers why substances that give some foods their bitter flavor also act to reverse the contraction of airway cells. (Full Article)
January, 9 2013
Roger Davis and Craig Mello were recently named as 2012 Charter Fellows of the National Academy of Inventors (NAI). The NAI recognized 101 top scientists, innovators, and leaders from the academic world for their exceptional achievements "in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society."
The newly elected class of Fellows is made up of inventors and innovators from 56 prestigious research universities and non-profit research institutes across the U.S. and around the world. All are named inventors on patents issued by the United States Patent and Trademark Office (USPTO). Collectively, they hold an impressive number of U.S. patents—over 3,200. Dr Robert Brown and Dr John Ware from UMMS were also named as Charter Fellows.
Included among the Fellows are eight Nobel Laureates, 14 presidents of research universities and non-profit research institutes, 53 members of the National Academies (National Academy of Sciences, National Academy of Engineering, Institute of Medicine), 11 inductees of the National Inventors Hall of Fame, two Fellows of the Royal Society, five recipients of the National Medal of Technology and Innovation, four recipients of the National Medal of Science, and 31 AAAS Fellows, among other major awards and distinctions.
In October, the American Association for the Advancement of Science Council elected Roger Davis, PhD, Howard Hughes Medical Institute Investigator, H. Arthur Smith Chair in Cancer Research and professor of molecular medicine and biochemistry & molecular pharmacology to the section on biological sciences. Fellows are nominated and selected by their peers for their meritorious efforts to advance science and its applications. The 701 fellows elected in 2012 will be recognized at the AAAS annual meeting in Boston in February.
Recent Molecular Medicine Publications
Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ.
Dev Cell. 2014 Nov 10;31(3):279-90. doi: 10.1016/j.devcel.2014.09.011. Epub 2014 Oct 30.
PMID: 25446516 (Paper)
Ivshina M, Alexandrov IM, Vertii A, Doxsey S, Richter JD.
Mol Cell Biol. 2014 Dec 1. pii: MCB.00800-14. PMID: 25452303 (Paper)
Manning BJ, Peterson CL.
Proc Natl Acad Sci U S A. 2014 Dec 1. pii: 201420096. PMID: 25453095 (Paper)
Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT. Dev Cell. 2014 Nov 10;31(3):291-304. doi: 10.1016/j.devcel.2014.09.012. Epub 2014 Nov 10. (Paper)
Bornstein C, Winter D, Barnett-Itzhaki Z, David E, Kadri S, Garber M, Amit I.
Mol Cell. 2014 Nov 20. pii: S1097-2765(14)00798-9. doi: 10.1016/j.molcel.2014.10.014. (Paper)
Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S.
J Biol Chem. 2014 Jun 27;289(26):18327-38. doi: 10.1074/jbc.M113.545798. Epub 2014 Apr 28.
PMID: 24778188 (Paper)
Nelson C, Ambros V, Baehrecke EH.
Mol Cell. 2014 Oct 8. pii: S1097-2765(14)00718-7. doi: 10.1016/j.molcel.2014.09.011. [Epub ahead of print]
PMID: 25306920 (Paper)
Xue L, Pulikkan JA, Valk PJ, Castilla LH.
Blood. 2014 Jul 17;124(3):426-36. doi: 10.1182/blood-2013-12-541730. Epub 2014 Jun 3.
PMID: 24894773 (Paper)
Amcheslavsky A, Song W, Li Q, Nie Y, Bragatto I, Ferrandon D, Perrimon N, Ip YT.
Cell Rep. 2014 Sep 24. pii: S2211-1247(14)00728-1. doi: 10.1016/j.celrep.2014.08.052. (Paper)
Chun-Ting Chen, Heidi Hehnly, Qing Yu, Debby Farkas, Guoqiang Zheng, Sambra D. Redick, Hui-Fang Hung, Rajeev Samtani, Agata Jurczyk, Schahram Akbarian, Carol Wise, Andrew Jackson, Michael Bober, Yin Guo, Cecilia Lo, and Stephen Doxsey (Paper)
Smith CL, Matheson TD, Sun X, Trombly DJ, Campeau E, Han X, Yates JR 3rd, and Kaufman PD (Paper)
Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP.
PLoS One. 2014 Sep 12;9(9):e107265. doi: 10.1371/journal.pone.0107265. eCollection 2014.
PMID: 25216251 (Paper)
Ma L, Shan Y, Bai R, Xue L, Eide CA, Ou J, Zhu LJ, Hutchinson L, Cerny J, Khoury HJ, Sheng Z, Druker BJ, Li S, Green MR.
Sci Transl Med. 2014 Sep 3;6(252):252ra121. doi: 10.1126/scitranslmed.3009073.
PMID: 25186176 (Paper)
Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL.
Nat Commun. 2014 Aug 28;5:4751. doi: 10.1038/ncomms5751.
PMID: 25163529 (Paper)
Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT.
Development. 2014 Jul;141(13):2621-32. doi: 10.1242/dev.106237.
PMID: 24961799 (Paper)
Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE.
Cell. 2014 Jun 5;157 (Paper)
Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, Curry SC, Ambros VR.
Proc Natl Acad Sci U S A. 2014 Aug 4. pii: 201412608. [Epub ahead of print]
PMID: 25092309 (Paper)
McJunkin K, Ambros V.
G3 (Bethesda). 2014 Jul 21. pii: g3.114.011973. doi: 10.1534/g3.114.011973. [Epub ahead of print]
PMID: 25053708 (Paper)
Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ.
Cell Metab. 2014 Jul 15. (Paper)
Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA. (Paper)
Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JC, Conte D, Gundersen-Rindal DE, Marshall WL, Yates J, Silverman N, Mello CC. (Paper)
Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, Ip YT. (Paper)
Sanchez-Gurmaches J, Guertin DA.
Nat Commun. 2014 Jun 19;5:4099. doi: 10.1038/ncomms5099.
PMID: 24942009 (Paper)
Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M.
Cell Metab. 2014 Jan 7;19(1):162-71. doi: 10.1016/j.cmet.2013.11.017. Epub 2013 Dec 26.
Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ.
Cell Rep. 2013 Aug 29;4(4):681-8. doi: 10.1016/j.celrep.2013.07.019. Epub 2013 Aug 15.
PMID: 23954791 [PubMed]
Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R.
Development. 2014 Jan;141(1):219-23. doi: 10.1242/dev.103341.
PMID: 24346702 [PubMed - indexed for MEDLINE]
Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. [Epub ahead of print]
PMID: 24429365 (Paper)
Washietl S, Kellis M, Garber M.
Genome Res. 2014 Jan 15. [Epub ahead of print] PMID:24429298 (Paper)
Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ.
Cytoskeleton (Hoboken). 2014 Mar 12. doi: 10.1002/cm.21173. [Epub ahead of print] PMID: 24619649 [PubMed - as supplied by publisher]
Serra RW, Fang M, Park SM, Hutchinson L, Green MR.
Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313.
PMID: 24623306 [PubMed]
Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ.
PLoS Genet. 2014 Feb 20;10(2):e1004170. doi: 10.1371/journal.pgen.1004170. eCollection 2014 Feb. PMID: 24586199 (Paper)
Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. (Paper)
Watson E, Macneil LT, Ritter AD, Yilmaz LS, Rosebrock AP, Caudy AA, Walhout AJ.
Cell. 2014 Feb 13;156(4):759-70. doi: 10.1016/j.cell.2014.01.047. PMID: 24529378 (Paper)
Hehnly H, Doxsey S.
Dev Cell. 2014 Feb 18. pii: S1534-5807(14)00037-9. doi: 10.1016/j.devcel.2014.01.014. PMID: 24561039 (Paper)
Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.
PMID: 24360276 (Paper)
Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD.
Nat Med. 2013 Nov;19(11):1473-7. doi: 10.1038/nm.3353. Epub 2013 Oct 20.
PMID: 24141422 [PubMed - indexed for MEDLINE] (Paper)
Cheng W, Ip YT, Xu Z.
Gene. 2013 Dec 1;531(2):294-300. doi: 10.1016/j.gene.2013.08.080. Epub 2013 Sep 17.
PMID: 24055424 [PubMed - indexed for MEDLINE] (Paper)
Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ.
Genes Dev. 2013 Nov 1;27(21):2345-55. doi: 10.1101/gad.223800.113.
PMID: 24186979 [PubMed - indexed for MEDLINE] (Paper)
Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.
PMID: 24360276 [PubMed - in process]
Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. Dev Cell. 2013 Dec 18. pii: S1534-5807(13)00695-3. doi: 10.1016/j.devcel.2013.11.014. [Epub ahead of print] (Paper)
Fuxman Bass JI, Diallo A, Nelson J, Soto JM, Myers CL, Walhout AJ.
Nat Methods. 2013 Nov 26;10(12):1169-76. doi: 10.1038/nmeth.2728.
PMID: 24296474 Paper
Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.
Elife. 2013 Dec 4;2(0):e01557. doi: 10.7554/eLife.01557.
PMID: 24302573 Paper
Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman D, Luzuriaga K.
N Engl J Med. 2013 Oct 23.
Malaby AW, van den Berg B, Lambright DG.
Proc Natl Acad Sci U S A. 2013 Aug 12. [Epub ahead of print]
PMID: 23940353 [PubMed - as supplied by publisher] Paper
Fazly A, Jain C, Dehner AC, Issi L, Lilly EA, Ali A, Cao H, Fidel PL, P Rao R, Kaufman PD. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13594-9. Paper
Kearns NA, Genga RM, Ziller M, Kapinas K, Peters H, Brehm MA, Meissner A, Maehr R. Stem Cell Res. 2013 Jun 29;11(3):1003-1012. doi: 10.1016/j.scr.2013.06.007. [Epub ahead of print] Paper
Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP.
Proc Natl Acad Sci U S A. 2013 Apr 29. Paper
Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL.
Science. 2013 Apr 12;340(6129):195-9. Paper
Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D Jr, Mello CC.
Cell. 2012 Dec 21;151(7):1488-500. doi: 10.1016/j.cell.2012.11.023.
PMID: 23260138 [PubMed - indexed for MEDLINE]
O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR.
J Virol. 2013 Jan;87(1):187-98. doi: 10.1128/JVI.01834-12. Epub 2012 Oct 10.
PMID: 23055568 [PubMed - indexed for MEDLINE]
Santoni FA, Guerra J, Luban J. Retrovirology. 2012 Dec 20;9(1):111. [Epub ahead of print] Paper
Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR.
PLoS Genet. 2012 Dec; Epub 2012 Dec 20. Paper
Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP. J Biol Chem. 2012 Dec 12 Paper
D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD.
Cell Rep. 2012 Nov 28. doi:pii: S2211-1247. Paper
Wang M, Amano SU, Roth Flach RJ, Chawla A, Aouadi M, Czech MP.
Mol Cell Biol. 2012 Dec 3. [Epub ahead of print] Paper
Chen CT, Doxsey SJ.
Mol Biol Cell. 2012 Oct;23(19):3775. Paper
Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA.
Cell Metab. 2012 Sep 5;16(3):348-62. Paper
Wang SZ, Ou J, Zhu LJ, Green MR.
Proc Natl Acad Sci U S A. 2012 Oct 22. Paper
Nechama M, Lin CL, Richter JD. Paper
Mol Cell Biol. 2012 Oct 22.
Hübner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ.
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12046-51. Paper
Molecular Medicine Awards
Roger Davis elected to Royal Society of London and EMBO
|Eduardo Tores receives 2012 Smith Family Award Program for Excellence in Biomedical Research|
David Guertin receives 2010 PEW award
|Katherine Luzuriaga named one of Time's most influential people|
|Silvia Corvera receives Endowed Chair in Diabetes Research|
Thomas Fazzio receives 2011 PEW award and the Presidential Early Career Awards for Scientists and Engineers
|Jeremy Luban receives Avant-Garde award|
Drs. Amy Walker, Rene Maehr, Manuel Garber and Eduardo Torres.
Assistant Professor Michael Lee
Dr Juleen R. Zierath joins Molecular Medicine as Adjunct Professor
Juleen R. Zierath is presently Professor of Clinical Integrative Physiology and Head of the Section of Integrative Physiology at the Department of Molecular Medicine and Surgery and the Department of Physiology and Pharmacology at Karolinska Institutet, Stockholm Sweden, where she is Director of the The Strategic Research Programme in Diabetes. She is also Professor of Integrative Physiology at University of Copenhagen, where she is a Scientific Director at the Marie Krogh Center for Metabolic Research, Copenhagen Denmark.