Molecular Medicine Special Seminar

Thursday, February 11, 2016 at 4:00PM

Michael Pacold, M.D., Ph.D.
Whitehead Institute for
iomedical Research

Talk Title: Targeting Dehydrogenases in Cancer Metabolism




Chair's Message

In House Seminars

Molecular Medicine History

2005 - 2008 - 2012 - 2015

Michael Green Election to the National Academy of Sciences 2014

Nobel Prize Reception

Davis Royal Society Reception

Ambros Lasker Reception

Ambros Silverman Lecture



Joel Richter named to newly endowed chair - (Article)

Michael Green elected to National Academy of Medicine - (Article)

UMMS scientists identify genes that shut down HIV-1; research published in Nature - (Article)

Discoveries in Luban, Gottlinger labs point to new strategies for disabling viruses - (Article)

Zhao Zhang receives the 2015 Larry Sandler Memorial Award - (Article)

Jeremy Luban and Manuel Garber receive $6.1 Million over 3 years to
establish one of five Genomics of Gene Regulation Programs - (article) 

Victor Ambros awarded 2015 $3M Breakthrough Prize for co-discovery of microRNAs - (Article)

Joel Richter receives $9.3 million over 5 years to establish one of three national Centers for Collaborative Research in Fragile X - (NIH Article)

Victor Ambros named co-recipient of 2014 Gruber Genetics Prize - (Article)

Heinrich Gottlinger, M.D. recipient of 2014 Avant-Garde Award - (Article)

Michael Green elected to National Academy of Sciences - (Article)

Jeremy Luban elected fellow of the American Academy of Microbiology - (Article)

Victor Ambros named recipient of Israel's 2014 Wolf Prize. - (Article)

Thomas Fazzio named one of the nations top scientists - (Article)

Foreign Policy names Luzuriaga a ‘Leading Global Thinker of 2013’ for HIV research - (Article)

Dekker, Sullivan named fellows of prestigious scientific society
American Association for the Advancement of Science fellows announced - (Article)

Roger Davis wins 2013 Steven C. Beering Award - (Article)

Victor Ambros wins Keio Medical Science Prize - (Article)

Katherine Luzuriaga named one of TIME magazine’s TIME 100 - (Article)

Eduardo Torres Named 2013 Searle Scholar - (Article)

Researchers describe first 'functional HIV cure' in an infant (Article)

Bitter taste receptors in airway cells could help treat asthma attacks - (Article)

Roger Davis elected a Fellow of AAAS - (Article)


Recent Molecular Medicine Publications


Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.

Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S.   Nat Med. 2016 Jan 25. doi: 10.1038/nm.4031. [Epub ahead of print]. PMID:  26808348.  (Paper)

Highly selective in vivo labeling of subcutaneous white adipocyte precursors with Prx1-Cre.

Sanchez-Gurmaches J, Hsiao WY, Guertin DA.   Stem Cell Reports. 2015 Apr 14;4(4):541-50. doi: 10.1016/j.stemcr.2015.02.008. Epub 2015 Mar 19.  PMID: 25801508.  (Paper)

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.

Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. 
Nat Commun. 2015; 6: 8995.  Published online 2015 Dec 21. doi:  10.1038/ncomms9995. 
PMCID: PMC4703891 (Paper)

Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis.

Rege M, Subramanian V, Zhu C, Hsieh TS, Weiner A, Friedman N, Clauder-Münster S, Steinmetz LM, Rando OJ, Boyer LA, Peterson CL.   Cell Rep. 2015 Nov 11. pii: S2211-1247(15)01200-0. doi: 10.1016/j.celrep.2015.10.030. [Epub ahead of print]  PMID: 26586442 [PubMed - as supplied by publisher]  (Paper)

A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. 

Greenough TC, Straubhaar JR, Kamga L, Weiss ER, Brody RM, McManus MM, Lambrecht LK, Somasundaran M, Luzuriaga KF.   J Immunol. 2015 Nov 1;195(9):4185-97. doi: 10.4049/jimmunol.1401513. Epub 2015 Sep 28.  PMID: 26416268.  PMCID:PMC4610856(Paper)


Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed.

Sanchez-Gurmaches J, Guertin DA.  Nat Commun. 2014 Jun 19;5:4099. doi: 10.1038/ncomms5099.  PMID: 24942009 [PubMed - indexed for MEDLINE] (Paper)

PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1.

Kahn RA, Lambright DG.  Structure.  2015 Nov 3;23(11):1971-3. doi: 10.1016/j.str.2015.10.002 PMID: 26536378 [PubMed - in process]. (Paper)

TRIM5 retroviral restriction activity correlates with the ability to induce innate immune signaling.

Lascano J, Uchil P, Mothes W, Luban J.   J Virol. 2015 Oct 14. pii: JVI.02496-15. [Epub ahead of print]  PMID: 26468522.  (Paper)

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.

Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M. Nature. 2015 Sep 30. doi: 10.1038/nature15399. [Epub ahead of print]. PMID: 26416734.  (Paper)

Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus.

Rojas-Rodriguez R, Lifshitz LM, Bellve KD, Min SY, Pires J, Leung K, Boeras C, Sert A, Draper JT, Corvera S, Moore Simas TA. Diabetologia. 2015 Sep;58(9):2106-14. doi: 10.1007/s00125-015-3662-0. Epub 2015 Jun 13. PMID: 2606736.  (Paper)

Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal.

Zinovyeva AY, Veksler-Lublinsky I, Vashisht AA, Wohlschlegel JA, Ambros VR.  Proc Natl Acad Sci U S A. 2015 Sep 8. pii: 201506576. [Epub ahead of print]. PMID:26351692.  PMCID: PMC4586838  [Available on 2016-03-22] (Paper)

s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways.

Ding W, Smulan LJ, Hou NS, Taubert S, Watts JL, Walker AK.  Cell Metab. 2015 Aug 26. pii: S1550-4131(15)00342-3. doi: 10.1016/j.cmet.2015.07.013. [Epub ahead of print].  PMID:  26321661. (Paper)

Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans.

Burke SL, Hammell M, Ambros V.   Genetics. 2015 Aug;200(4):1201-18. doi: 10.1534/genetics.115.179184. Epub 2015 Jun 15. PMID:26078280 [PubMed - in process].  (Paper)

Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration

Pizzato  M,  McCauley SM,  Neagu MR,  Pertel T, Firrito C, Ziglio S, Dauphin A, Zufferey M, Berthoux L, Luban J.      PLoS Pathog.  2015 Jul 16;11(7):e1005050.  doi 10.1371/journal.ppat.1005050.  eCollection 2015.  PMID: 26181333.  PMCID:  PMC4504712.  (Paper)

POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. 

Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC.  Dev Cell. 2015 Jun 17. pii: S1534-5807(15)00360-3. doi: 10.1016/j.devcel.2015.05.024.  [Epub ahead of print]  PMID: 26096734 [PubMed - as supplied by publisher].   (Paper)

Infection of ectocervical tissue and universal targeting of T-cells medicated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.

Peters PJ, Gonazlez-Perez MP, Musich T, Moore Simas TA, Lin R, Morse AN, Shattock RJ, Derdeyn CA, Clapham PR.   Retrovirology.  2015 Jun 9;12(1):48.  PMID: 26055104.  PMCID: PMC4459458.  (Paper)

Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells.

Lyengar S, Kasheta M, Ceol CJ.  Developmental Cell 33, 1-13, June 22, 2015 (Paper)

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW.  Nature. 2015 May 28;521(7553):520-4. doi: 10.1038/nature14269. Epub 2015 Mar 25. PMID: 25807483(Paper)

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.

Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. Development. 2015 May 28. pii: dev.115261. [Epub ahead of print]  PMID: 26023097 (Paper)

Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C.

Watanabe S, Tan D, Lakshminarasimhan M, Washburn MP, Erica Hong EJ, Walz T, Peterson CL.  Nat Commun. 2015 May 12;6:7108.doi: 10.1038.   PMID: 25964121. PMCID: PMC4431590 (Paper)

Biodistribution and function of extracellular miRNA-155 in mice.

Bala S, Csak T, Momen-Heravi F, Lippai D, Kodys K, Catalano D, Satishchandran A, Ambros V, Szabo G. Sci Rep. 2015 May 29;5:10721. doi: 10.1038/srep10721. PMID:26024046. PMCID:PMC4448655.  (Paper)

Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress.

Ren Z, Ambros VR.   Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2366-75. doi: 10.1073/pnas.1422858112. Epub 2015 Apr 20. PMID: 25897023. PMCID: PMC4426397 (Paper)

JNK-interacting protein 1 mediates Alzheimer's-like pathological features in AICD-transgenic mice.

Margevicius DR, Bastian C, Fan Q, Davis RJ, Pimplikar SW. Neurobiol Aging. 2015 Apr 30. pii: S0197-4580(15)00235-3. doi: 10.1016/j.neurobiolaging.2015.04.013. [Epub ahead of print]
PMID: 26022769 (Paper)

The lipid droplet protein Hypoxia-inducible gene 2 promotes hepatic triglyceride deposition by inhibiting lipolysis. 

DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP.  J Biol Chem. 2015 Apr 28. pii: jbc.M115.650184. [Epub ahead of print].  PMID: 25922078.  (Paper)

Inducible deletion of protein kinase Map4k4 in obese mice improves insulin sensitivity in liver and adipose tissues. 

Danai LV, Roth Flach RJ, Virbasius JV, Garcia Menendez L, Jung DY, Kim JH, Kim JK, Czech MP. Mol Cell Biol. 2015 Apr 27. pii: MCB.00150-15. [Epub ahead of print]. PMID: 25918248.  [PubMed - as supplied by publisher].  (Paper)

Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.

Del Campo CM, Mishra AK, Wang YH, Roy CR, Janmey PA, Lambright DG.  Structure. 2014 Mar 4;22(3):397-408. doi: 10.1016/j.str.2013.12.018. Epub 2014 Feb 13. PMID: 24530282.  PMCID:  PMC3974903 (Paper)

Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans.

Harandi OF, Ambros VR.  Proc Natl Acad Sci USA. 2015 Jan 20;112(3):E287-96. doi: 10.1073/pnas.1422852112.  Epub 2015 Jan 5.  PMID: 25561544.  (Paper)

Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme.

Manning BJ, Peterson CL.  Proc Natl Acad Sci USA. 2014 Dec 16;111(50):17827-33. doi: 10.1073/pnas.1420096111. Epub 2014 Dec 1. PMID: 25453095. (Paper)

Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. 

Hainer SJ, GU W, Carone BR, Landry BD, Rando OJ, Mello CC, Fazzio TG.  Genes Dev. 2015 Feb 15;29(4):362-78. doi: 10.1101/gad.253534.114  PMID: 25691467.  (Paper)

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI.  Cell. 2015 Feb 12;160(4):745-58. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5.  PMID: 25662011.  (Paper)

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

Kearns NA, Pham H, Tabak B, Genga RM, Silverstein NJ, Garber M, Maehr R.  Nat Methods. 2015 Mar 16. doi: 10.1038/nmeth.3325. [Epub ahead of print]  PMID: 25775043 (Paper)

Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.

May-Simera HL, Petralia RS, Montcouquiol M, Wang YX, Szarama KB, Liu Y, Lin W, Deans MR, Pazour GJ, Kelley MW. Development 2015 Feb Feb 1;142(3):555-66. doi: 10.1242/dev.113696.  PMID: 25605782 (Paper)

An efficient and sensitive method for preparing cDNA libraries from scarce biological samples.

Sterling CH, Veksler-Lublinsky I, Ambros V. Nucleic Acids Res. 2015 Jan;43(1):e1. doi: 10.1093/nar/gku637. Epub 2014 Jul 23.  PMID: 25056322 (Paper)

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.

Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH. 
Science. 2015 Feb 13;347(6223):779-84. doi: 10.1126/science.aaa0314.
PMID: 25678665 (Paper)

The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families.

Schwarz EM, Hu Y, Antoshechkin I,  Miller MM, Sternberg PW, Aroian RV.
Nat Gent. 2015 Mar 2. doi: 10.1038/ng.3237
PMID: 25730766  (Paper)

The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.

Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ. Cell Metab. 2014 Sep 2;20(3):512-25. doi: 10.1016/j.cmet.2014.06.010. Epub 2014 Jul 17.
PMID: 25043817 (Paper)

The Ino80 complex prevents invasion of euchromatin into silent chromatin.

Xue Y, Van C, Pradhan SK, Su T, Gehrke J, Kuryan BG, Kitada T, Vashisht A, Tran N, Wohlschlegel J, Peterson CL, Kurdistani SK, Carey MF.
Genes Dev. 2015 Feb 15;29(4):350-5. doi: 10.1101/gad.256255.114.
PMID: 25691465 (Paper)







Molecular Medicine Awards


Joel Richter named to newly endowed chair

Gregory Pazour

Gregory Pazour, PhD, receives Lillian Jean Kaplan International Prize

Victor Ambros, Ph.D.

Victor Ambros awarded 2015 Breakthrough Prize, Also, 2008 Lasker Prize,  Keio Medical Science Award and the Wolf Prize.

Craig Mello, Ph.D.

Craig Mello receives 2006 Nobel Prize 

Roger Davis, PhD.

Roger Davis elected to Royal Society of London and EMBO

Michael Green, M.D., Ph.D.

Michael Green elected to National Academy of Sciences and EMBO

Jenn Benanti

 Jennifer Benanti receives 2011 Smith Family Award Program for Excellence in Biomedical Research

Eduardo Torres Eduardo Tores receives 2012 Smith Family Award Program for Excellence in Biomedical Research
Dave Guertin, Ph.D.

David Guertin receives 2010 PEW award

Picture of Katherine Luzuriaga  Katherine Luzuriaga named one of Time's most influential people
Picture of Silvia Corvera Silvia Corvera receives Endowed Chair in Diabetes Research
Thomas Fazzio, Ph.D.

Thomas Fazzio receives 2011 PEW award and the Presidential Early Career Awards for Scientists and Engineers

Jeremy Luban, M.D. Jeremy Luban receives Avant-Garde award



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