The research in the Mandon laboratory is devoted to understanding the role of mitochondria in neurodegeneration and aging. Mitochondria are an early target during the onset of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) Alzheimer’s, Parkinson’s, and Huntington’s disease, and mitochondrial damage contributes significantly to disease progression. Mitochondrial damage and dysfunction are also heavily involved in the aging process. Research in the Mandon laboratory focuses on two fundamental areas. First, the determination of the early events that trigger mitochondrial damage and second, the elucidation of the mechanisms that underlie mitochondrial dysfunction in the pathogenesis of human neurodegenerative diseases and in the aging process.
Biochemistry & Molecular Pharmacology