Image 1 Image 2 Image 3 Image 4
Image 1 Image 2 Image 3 Image 4
Image 1 Image 2 Image 3 Image 4

NICHD Logo

Welcome to the Eunice Kennedy Shriver National Institute of Child Health and Human Development Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of Massachusetts Medical School.

The IDDRC Program at UMass Medical School provides core support and facilities for cohesive, interdisciplinary research and research training to advance efforts to understand, ameliorate, and prevent intellectual and developmental disabilities.

Core Services

Featured Investigator

Organizational chart of Intellectual & Developmental Disabilities Research Center

Administration, Communications, & Mentorship

statistical formulas on blackboard

Quantitative Methodologies

Psychologist with boy during assessment

Clinical and Translational
Research Support

Ginns EdwardA research team led by Dr. Edward Ginns, Co-Director of the Intellectual and Developmental Disabilities Research Center at the University of Massachusetts Medical School, has identified what is likely a key molecular pathway, called the sonic hedgehog signaling pathway, underlying bipolar disorder.  This breakthrough could lead to better drugs for treating bipolar affective disorder, as well as other related mood disorders.  The roles of sonic hedgehog (Shh) signaling in the brain have also attracted more interest due to increased recognition of Shh involvement in regulation of neuron production and neuronal electrophysiological activity.  Higher levels of Shh expression are found in Autism Spectrum Disorders (ASD).  Shh signaling appears to be an important mechanism in regenerative processes in the nervous system, and a target for novel treatment approaches for ASD, as well as for affective (mood) disorders.  The paper “Disruption of Sonic Hedgehog Signaling in Ellis-van Creveld Dwarfism Confers Protection Against Bipolar Affective Disorder” is published online in Nature Molecular Psychiatry (October 14, 2014).

Read more....

AUCD logo
The Intellectual & Developmental Disabilities Research Center (IDDRC) and the University Center of Excellence in Developmental Disabilities (UCEDD) at the University of Massachusetts Medical School are both members of the Association of University Centers on Disabilities (AUCD).