Publications - Biochemistry & Molecular Biotechnology (BMB) Department

Author(s): Fengyun Sun,Kathleen Desevin,Yu Fu,Shanmathi Parameswaran,Jemma Mayall,Vera Rinaldi,Nils Krietenstein,Artur Manukyan,Qiangzong Yin,Carolina Galan,Chih-Hsiang Yang,Anastasia V Shindyapina,Vadim N Glady...

Source: bioRxiv : the preprint server for biology

Muscle-Specific Pyruvate Kinase Isoforms, Pkm1 and Pkm2, Regulate Mammalian SWI/SNF Proteins and Histone 3 Phosphorylation During Myoblast Differentiation

Monday, April 22, 2024

Author(s): Monserrat Olea-Flores,Tapan Sharma,Odette Verdejo-Torres,Imaru DiBartolomeo,Paul R Thompson,Teresita Padilla-Benavides,Anthony N Imbalzano

Source: bioRxiv : the preprint server for biology

Leveraging shape screening and molecular dynamics simulations to optimize PARP1-Specific chemo/radio-potentiators for antitumor drug design

Saturday, April 20, 2024

Author(s): Hifza Khizer,Arooma Maryam,Adnan Ansari,Muhammad Sajjad Ahmad,Rana Rehan Khalid

Source: Archives of biochemistry and biophysics

X-ray-activated polymerization expanding the frontiers of deep-tissue hydrogel formation

Monday, April 15, 2024

Author(s): Hailei Zhang,Boyan Tang,Bo Zhang,Kai Huang,Shanshan Li,Yuangong Zhang,Haisong Zhang,Libin Bai,Yonggang Wu,Yongqiang Cheng,Yanmin Yang,Gang Han

Source: Nature communications

Nuclear bodies: a gene expression collection for our time

Sunday, April 14, 2024

Author(s): Thoru Pederson

Source: Nucleus (Austin, Tex.)

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo

Saturday, April 13, 2024

Author(s): Samantha L Sarli,Hassan H Fakih,Karen Kelly,Gitali Devi,Julia M Rembetsy-Brown,Holly R McEachern,Chantal M Ferguson,Dimas Echeverria,Jonathan Lee,Jacquelyn Sousa,Hanadi F Sleiman,Anastasia Khvorova,Jo...

Source: Nucleic acids research

Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents

Wednesday, April 10, 2024

Author(s): Nishant M Karadkhelkar,Pranav Gupta,Leonard Barasa,Rameswari Chilamakuri,Christopher K Hlordzi,Nikita Acharekar,Saurabh Agarwal,Zhe-Sheng Chen,Sabesan Yoganathan

Source: ChemMedChem

Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

Thursday, April 04, 2024

Author(s): Alok K Mishra,Tianyi Ye,Shahid Banday,Ritesh P Thakare,Chinh Tran-To Su,Ngoc N H Pham,Amjad Ali,Ankur Kulshreshtha,Shreya Roy Chowdhury,Tessa M Simone,Kai Hu,Lihua Julie Zhu,Birgit Eisenhaber,Sara K D...

Source: Cell reports

GnRH Induces Citrullination of the Cytoskeleton in Murine Gonadotrope Cells

Thursday, March 28, 2024

Author(s): Elizabeth B Quigley,Stanley B DeVore,Shaihla A Khan,Zachary M Geisterfer,Heather M Rothfuss,Ari O Sequoia,Paul R Thompson,Jesse C Gatlin,Brian D Cherrington,Amy M Navratil

Source: International journal of molecular sciences

Triplet-triplet annihilation photon upconversion-mediated photochemical reactions

Friday, March 22, 2024

Author(s): Ling Huang,Gang Han

Source: Nature reviews. Chemistry

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Thursday, March 21, 2024

Author(s): Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J K...

Source: Nature communications

Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication

Friday, March 15, 2024

Author(s): Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch

Source: The Journal of biological chemistry

Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance

Tuesday, March 12, 2024

Author(s): Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon

Source: ACS infectious diseases

Enhancing Osteosacoma Killing and CT Imaging Using Ultra High Drug Loading and NIR-Responsive Bismuth Sulfide @Mesoporous Silica Nanoparticles

Saturday, March 09, 2024

Author(s): Yao Lu,Lihua Li,Zefeng Lin,Mei Li,Xiaoming Hu,Yu Zhang,Mingying Peng,Hong Xia,Gang Han

Source: Advanced healthcare materials

Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability

Friday, February 23, 2024

Author(s): Patrick J Kearney,Yuanxi Zhang,Marianna Liang,Yanglan Tan,Elizabeth Kahuno,Tucker L Conklin,Rita R Fagan,Rebecca G Pavchinskiy,Scott A Shaffer,Zhenyu Yue,Haley E Melikian

Source: NPJ Parkinson's disease

Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope

Saturday, February 17, 2024

Author(s): Nathan Bamidele,Han Zhang,Xiaolong Dong,Haoyang Cheng,Nicholas Gaston,Hailey Feinzig,Hanbing Cao,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Erik J Sontheimer

Source: Nature communications

Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536

Thursday, February 08, 2024

Author(s): Tae-Yoon Kim,Arkaprava Roychaudhury,Hyun-Taek Kim,Tae-Ik Choi,Seung Tae Baek,Summer B Thyme,Cheol-Hee Kim

Source: Translational psychiatry

Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation

Tuesday, January 23, 2024

Author(s): Julia M Flynn,Margot E Joyce,Daniel N A Bolon

Source: bioRxiv : the preprint server for biology

PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS

Monday, January 22, 2024

Author(s): Issa O Yusuf,Sepideh Parsi,Lyle W Ostrow,Robert H Brown,Paul R Thompson,Zuoshang Xu

Source: Neurobiology of disease

Gender equity: toward redefining values

Tuesday, January 16, 2024

Author(s): Chrystal A Starbird,Zara Y Weinberg,Mary Munson

Source: Nature cell biology

Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad

Wednesday, January 03, 2024

Author(s): Hyunju Cho,Yumeng Liu,SangYoon Chung,Sowmya Chandrasekar,Shimon Weiss,Shu-Ou Shan

Source: Nature communications

Revisiting chromatin packaging in mouse sperm

Thursday, December 21, 2023

Author(s): Qiangzong Yin,Chih-Hsiang Yang,Olga S Strelkova,Jingyi Wu,Yu Sun,Sneha Gopalan,Liyan Yang,Job Dekker,Thomas G Fazzio,Xin Zhiguo Li,Johan Gibcus,Oliver J Rando

Source: Genome research

RNA-mediated symmetry breaking enables singular olfactory receptor choice

Wednesday, December 20, 2023

Author(s): Ariel D Pourmorady,Elizaveta V Bashkirova,Andrea M Chiariello,Houda Belagzhal,Albana Kodra,Rachel Duffié,Jerome Kahiapo,Kevin Monahan,Joan Pulupa,Ira Schieren,Alexa Osterhoudt,Job Dekker,Mario Nicodem...

Source: Nature

A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors

Monday, December 18, 2023

Author(s): Zexiang Chen,Suet-Yan Kwan,Aamir Mir,Max Hazeltine,Minwook Shin,Shun-Qing Liang,Io Long Chan,Karen Kelly,Krishna S Ghanta,Nicholas Gaston,Yueying Cao,Jun Xie,Guangping Gao,Wen Xue,Erik J Sontheimer,Jo...

Source: The CRISPR journal

Food, nutrition, and fertility: from soil to fork

Friday, December 15, 2023

Author(s): Melissa Maitin-Shepard,Erika F Werner,Larry A Feig,Jorge E Chavarro,Sunni L Mumford,Blair Wylie,Oliver J Rando,Audrey J Gaskins,Denny Sakkas,Manish Arora,Rashmi Kudesia,Marla E Lujan,Joseph Braun,Dari...

Source: The American journal of clinical nutrition

Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA

Thursday, December 14, 2023

Author(s): Benjamin Geary,Bo Sun,Ronak R Tilvawala,Leonard Barasa,Konstantin Tsoyi,Ivan O Rosas,Paul R Thompson,I-Cheng Ho

Source: Frontiers in immunology

Differences in clamp loader mechanism between bacteria and eukaryotes

Monday, December 11, 2023

Author(s): Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch

Source: bioRxiv : the preprint server for biology

Nano-optogenetic CAR-T Cell Immunotherapy

Saturday, December 09, 2023

Author(s): Nhung Thi Nguyen,Siyao Liu,Gang Han,Yubin Zhou,Kai Huang

Source: Methods in molecular biology (Clifton, N.J.)

A neuronal coping mechanism linking stress-induced anxiety to motivation for reward

Wednesday, December 06, 2023

Author(s): Paul M Klenowski,Rubing Zhao-Shea,Timothy G Freels,Susanna Molas,Max Zinter,Peter M'Angale,Cong Xiao,Leonora Martinez-Núñez,Travis Thomson,Andrew R Tapper

Source: Science advances

Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors

Wednesday, December 06, 2023

Author(s): Selina Pasquero,Francesca Gugliesi,Matteo Biolatti,Valentina Dell'Oste,Camilla Albano,Greta Bajetto,Gloria Griffante,Linda Trifirò,Bianca Brugo,Stefano Raviola,Davide Lacarbonara,Qiao Yang,Sen Sudeshn...

Source: PLoS pathogens

Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

Wednesday, December 06, 2023

Author(s): Aastha Jain,Ramesh Govindan,Alex R Berkman,Jeremy Luban,Marco A Díaz-Salinas,Natasha D Durham,James B Munro

Source: PLoS pathogens

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo

Thursday, November 30, 2023

Author(s): Han Zhang,Karen Kelly,Jonathan Lee,Dimas Echeverria,David Cooper,Rebecca Panwala,Nadia Amrani,Zexiang Chen,Nicholas Gaston,Atish Wagh,Gregory A Newby,Jun Xie,David R Liu,Guangping Gao,Scot A Wolfe,Ana...

Source: Nucleic acids research

IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus

Tuesday, November 28, 2023

Author(s): Mehmet Hakan Guney,Karthika Nagalekshmi,Sean Matthew McCauley,Claudia Carbone,Ozkan Aydemir,Jeremy Luban

Source: bioRxiv : the preprint server for biology

Tributaries of the 2023 Nobel Prize in Physiology or Medicine, and lessons learned

Tuesday, November 21, 2023

Author(s): Thoru Pederson

Source: RNA (New York, N.Y.)

A nematode model to evaluate microdeletion phenotype expression

Monday, November 13, 2023

Author(s): Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder

Source: G3 (Bethesda, Md.)

Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains

Friday, October 27, 2023

Author(s): Shixia Wang,Kun-Wei Chan,Danlan Wei,Xiuwen Ma,Shuying Liu,Guangnan Hu,Saeyoung Park,Ruimin Pan,Ying Gu,Alexandra F Nazzari,Adam S Olia,Kai Xu,Bob C Lin,Mark K Louder,Nicole A Doria-Rose,David Montefio...

Source: Research square

Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus

Monday, October 16, 2023

Author(s): Adrian Padron,Prem Prakash,Jui Pandhare,Jeremy Luban,Chris Aiken,Muthukumar Balasubramaniam,Chandravanu Dash

Source: Journal of virology

New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility

Friday, October 06, 2023

Author(s): Yasuhiro Fujiwara,Kouhei Saito,Fengyun Sun,Sabrina Petri,Erina Inoue,John Schimenti,Yuki Okada,Mary Ann Handel

Source: Reproduction (Cambridge, England)

Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells

Sunday, October 01, 2023

Author(s): Teng Xue,Shujia Fei,Jian Gu,Nan Li,Pengxue Zhang,Xiaoqiu Liu,Paul R Thompson,Xuesen Zhang

Source: Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Protein citrullination: inhibition, identification and insertion

Sunday, October 01, 2023

Author(s): Leonard Barasa,Paul R Thompson

Source: Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Beyond genome-wide association studies: Investigating the role of noncoding regulatory elements in primary sclerosing cholangitis

Wednesday, September 27, 2023

Author(s): Henry E Pratt,Tong Wu,Shaimae Elhajjajy,Jeffrey Zhou,Kate Fitzgerald,Tom Fazzio,Zhiping Weng,Daniel S Pratt

Source: Hepatology communications

Developmental priming of cancer susceptibility

Monday, September 25, 2023

Author(s): Ilaria Panzeri,Luca Fagnocchi,Stefanos Apostle,Megan Tompkins,Emily Wolfrum,Zachary Madaj,Galen Hostetter,Yanqing Liu,Kristen Schaefer,Yang Chih-Hsiang,Alexis Bergsma,Anne Drougard,Erez Dror,PERMUTE,D...

Source: bioRxiv : the preprint server for biology

A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels

Sunday, September 24, 2023

Author(s): Janneke Doedée Icso,Paul Ryan Thompson

Source: The Journal of biological chemistry

Implications of a multiscale structure of the yeast nuclear pore complex

Friday, September 22, 2023

Author(s): Christopher W Akey,Ignacia Echeverria,Christna Ouch,Ilona Nudelman,Yi Shi,Junjie Wang,Brian T Chait,Andrej Sali,Javier Fernandez-Martinez,Michael P Rout

Source: Molecular cell

ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids

Friday, September 15, 2023

Author(s): Yang You,Zhengrong Zhang,Nadia Sultana,Maria Ericsson,Yuka A Martens,Min Sun,Takahisa Kanekiyo,Seiko Ikezu,Scott A Shaffer,Tsuneya Ikezu

Source: Science advances

Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates

Thursday, September 14, 2023

Author(s): Bin Liu,Xiaolong Dong,Chunwei Zheng,David Keener,Zexiang Chen,Haoyang Cheng,Jonathan K Watts,Wen Xue,Erik J Sontheimer

Source: Nature biotechnology

Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

Thursday, September 14, 2023

Author(s): David Gentien,Elnaz Saberi-Ansari,Nicolas Servant,Ariane Jolly,Pierre de la Grange,Fariba Némati,Géraldine Liot,Simon Saule,Aurélie Teissandier,Deborah Bourc'his,Elodie Girard,Jennifer Wong,Julien Mas...

Source: Cell reports

pomBseen: An automated pipeline for analysis of fission yeast images

Tuesday, September 12, 2023

Author(s): Makoto Ohira,Nicholas Rhind

Source: PloS one

Development of LB244, an Irreversible STING Antagonist

Monday, September 11, 2023

Author(s): Leonard Barasa,Sauradip Chaudhuri,Jeffrey Y Zhou,Zhaozhao Jiang,Shruti Choudhary,Robert Madison Green,Elenore Wiggin,Michael Cameron,Fiachra Humphries,Katherine A Fitzgerald,Paul R Thompson

Source: Journal of the American Chemical Society

Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection

Friday, September 01, 2023

Author(s): Amrita Arpita Padhy,David Mavor,Subhashree Sahoo,Daniel N A Bolon,Parul Mishra

Source: Cell reports

The enduring quest for effective and accessible women's sexual and reproductive healthcare

Tuesday, August 29, 2023

Author(s): Thoru Pederson

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Nucleolar structure connects with global nuclear organization

Wednesday, August 23, 2023

Author(s): Chen Wang,Hanhui Ma,Susan J Baserga,Thoru Pederson,Sui Huang

Source: Molecular biology of the cell

An Intermittent Cytochemist

Wednesday, August 23, 2023

Author(s): Thoru Pederson

Source: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Targeting STING oligomerization with small-molecule inhibitors

Monday, August 07, 2023

Author(s): Fiachra Humphries,Liraz Shmuel-Galia,Zhaozhao Jiang,Jeffrey Y Zhou,Leonard Barasa,Santanu Mondal,Ruth Wilson,Nadia Sultana,Scott A Shaffer,Sze-Ling Ng,G Scott Pesiridis,Paul R Thompson,Katherine A Fit...

Source: Proceedings of the National Academy of Sciences of the United States of America

Identification of selective inhibitors for phosphodiesterase 5A using e-pharmacophore modelling and large-scale virtual screening-based structure guided drug discovery approaches

Monday, August 07, 2023

Author(s): Arooma Maryam,Abdul Rauf Siddiqi,Sundeep Chaitanya Vedithi,Abdulilah Ece,Rana Rehan Khalid

Source: Journal of biomolecular structure & dynamics

Modulating On-Demand Release of Vancomycin from Implant Coatings via Chemical Modification of a Micrococcal Nuclease-Sensitive Oligonucleotide Linker

Monday, July 31, 2023

Author(s): Jordan D Skelly,Feiyang Chen,Shing-Yun Chang,Rewati R Ujjwal,Ananta Ghimire,David C Ayers,Jie Song

Source: ACS applied materials & interfaces

Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation

Saturday, July 29, 2023

Author(s): Teresita Padilla-Benavides,Monserrat Olea-Flores,Tapan Sharma,Sabriya A Syed,Hanna Witwicka,Miriam D Zuñiga-Eulogio,Kexin Zhang,Napoleon Navarro-Tito,Anthony N Imbalzano

Source: International journal of molecular sciences

Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2

Thursday, July 27, 2023

Author(s): Aniuska Becerra-Artiles,Padma P Nanaware,Khaja Muneeruddin,Grant C Weaver,Scott A Shaffer,J Mauricio Calvo-Calle,Lawrence J Stern

Source: PLoS pathogens

Regulation of the Wnt signaling pathway during myogenesis by the mammalian SWI/SNF ATPase BRG1

Monday, July 24, 2023

Author(s): Tapan Sharma,Monserrat Olea-Flores,Anthony N Imbalzano

Source: Frontiers in cell and developmental biology

Donald Brown: Pioneer of embryo development and advocate for early career funding

Wednesday, July 19, 2023

Author(s): Thoru Pederson

Source: Proceedings of the National Academy of Sciences of the United States of America

Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1

Monday, July 17, 2023

Author(s): Lindsay Moritz,Samantha B Schon,Mashiat Rabbani,Yi Sheng,Ritvija Agrawal,Juniper Glass-Klaiber,Caleb Sultan,Jeannie M Camarillo,Jourdan Clements,Michael R Baldwin,Adam G Diehl,Alan P Boyle,Patrick J O...

Source: Nature structural & molecular biology

RNA polymerase II dynamics shape enhancer-promoter interactions

Monday, July 10, 2023

Author(s): Gilad Barshad,James J Lewis,Alexandra G Chivu,Abderhman Abuhashem,Nils Krietenstein,Edward J Rice,Yitian Ma,Zhong Wang,Oliver J Rando,Anna-Katerina Hadjantonakis,Charles G Danko

Source: Nature genetics

FruitFire: a luciferase based on a fruit fly metabolic enzyme

Monday, July 10, 2023

Author(s): Spencer T Adams,Jacqueto Zephyr,Markus F Bohn,Celia A Schiffer,Stephen C Miller

Source: bioRxiv : the preprint server for biology

Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis

Monday, July 03, 2023

Author(s): Sabriya A Syed,Kristina Shqillo,Ankita Nand,Ye Zhan,Job Dekker,Anthony N Imbalzano

Source: bioRxiv : the preprint server for biology

Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease

Friday, June 30, 2023

Author(s): Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon

Source: ACS infectious diseases

Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis

Thursday, June 29, 2023

Author(s): Yetao Wang,Lawrence Lifshitz,Noah J Silverstein,Esther Mintzer,Kevin Luk,Pamela StLouis,Michael A Brehm,Scot A Wolfe,Steven G Deeks,Jeremy Luban

Source: The EMBO journal

Gut microbial fatty acid isomerization modulates intraepithelial T cells

Wednesday, June 28, 2023

Author(s): Xinyang Song,Haohao Zhang,Yanbo Zhang,Byoungsook Goh,Bin Bao,Suelen S Mello,Ximei Sun,Wen Zheng,Francesca S Gazzaniga,Meng Wu,Fangfang Qu,Qiangzong Yin,Michael S Gilmore,Sungwhan F Oh,Dennis L Kasper

Source: Nature

Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP

Monday, June 26, 2023

Author(s): Sneha Shah,Kevin J Sharp,Sithara Raju Ponny,Jonathan Lee,Jonathan K Watts,Elizabeth Berry-Kravis,Joel D Richter

Source: Proceedings of the National Academy of Sciences of the United States of America

Firefly luciferin methyl ester illuminates the activity of multiple serine hydrolases

Tuesday, June 20, 2023

Author(s): Innus Mohammad,Kate L Liebmann,Stephen C Miller

Source: Chemical communications (Cambridge, England)

PRMT5 links lipid metabolism to contractile function of skeletal muscles

Monday, June 19, 2023

Author(s): Kun Ho Kim,Zhihao Jia,Madigan Snyder,Jingjuan Chen,Jiamin Qiu,Stephanie N Oprescu,Xiyue Chen,Sabriya A Syed,Feng Yue,Bruno T Roseguini,Anthony N Imbalzano,Changdeng Hu,Shihuan Kuang

Source: EMBO reports

SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism

Monday, June 12, 2023

Author(s): Janneke D Icso,Leonard Barasa,Paul R Thompson

Source: Biochemistry

Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype

Friday, June 09, 2023

Author(s): Patrick J Kearney,Yuanxi Zhang,Yanglan Tan,Elizabeth Kahuno,Tucker L Conklin,Rita R Fagan,Rebecca G Pavchinskiy,Scott A Shafer,Zhenyu Yue,Haley E Melikian

Source: Research square

Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection

Monday, June 05, 2023

Author(s): Sun-Young Lim,Zhiru Guo,Ping Liu,Lindsay G A McKay,Nadia Storm,Anthony Griffiths,Ming Da Qu,Robert W Finberg,Mohan Somasundaran,Jennifer P Wang

Source: COVID

A high-performance metal halide perovskite-based laser-driven display

Wednesday, May 31, 2023

Author(s): Shaoan Zhang,Zhenzhang Li,Zaijin Fang,Bao Qiu,Janak L Pathak,Kaniyarakkal Sharafudeen,S Saravanakumar,Zhanjun Li,Gang Han,Yang Li

Source: Materials horizons

Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis

Monday, May 29, 2023

Author(s): Xuewu Sui,Kun Wang,Kangkang Song,Chen Xu,Jiunn Song,Chia-Wei Lee,Maofu Liao,Robert V Farese,Tobias C Walther

Source: Nature communications

HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues

Saturday, May 27, 2023

Author(s): Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali

Source: European journal of medicinal chemistry

In Vitro Reconstitution of Pseudouridylation Catalyzed by Human Box H/ACA Ribonucleoprotein Particles

Thursday, May 11, 2023

Author(s): Hironori Adachi,Jonathan L Chen,Qiangzong Yin,Pedro Morais,Yi-Tao Yu

Source: Methods in molecular biology (Clifton, N.J.)

Rit2 silencing in dopamine neurons drives a Parkinsonian phenotype

Wednesday, May 10, 2023

Author(s): Patrick J Kearney,Yuanxi Zhang,Yanglan Tan,Elizabeth Kahuno,Tucker L Conklin,Rita R Fagan,Rebecca G Pavchinskiy,Scott A Shafer,Zhenyu Yue,Haley E Melikian

Source: bioRxiv : the preprint server for biology

Current insights into the role of citrullination in thrombosis

Saturday, May 06, 2023

Author(s): R Madison Green,Paul R Thompson

Source: Current opinion in chemical biology

Structural insights into the mechanism of resistance to bicalutamide by the clinical mutations in androgen receptor in chemo-treatment resistant prostate cancer

Friday, May 05, 2023

Author(s): Abdul Majeed,Muhammad Tahir Ul Qamar,Arooma Maryam,Muhammad Usman Mirza,Laila Alhussain,Seham Obaid Al Otaibi,Ahmad Almatroudi,Khaled S Allemailem,Faris Alrumaihi,Abdulaziz A Aloliqi,Faez Falah Alsheh...

Source: Journal of biomolecular structure & dynamics

Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope

Wednesday, May 03, 2023

Author(s): Nathan Bamidele,Han Zhang,Xiaolong Dong,Nicholas Gaston,Haoyang Cheng,Karen Kelly,Jonathan K Watts,Jun Xie,Guangping Gao,Erik J Sontheimer

Source: bioRxiv : the preprint server for biology

Apoptotic cell death in disease-Current understanding of the NCCD 2023

Wednesday, April 26, 2023

Author(s): Ilio Vitale,Federico Pietrocola,Emma Guilbaud,Stuart A Aaronson,John M Abrams,Dieter Adam,Massimiliano Agostini,Patrizia Agostinis,Emad S Alnemri,Lucia Altucci,Ivano Amelio,David W Andrews,Rami I Aqei...

Source: Cell death and differentiation

The exocyst complex in neurological disorders

Friday, April 21, 2023

Author(s): Dilara O Halim,Mary Munson,Fen-Biao Gao

Source: Human genetics

Enhancement of Light and X-ray Charging in Persistent Luminescence Nanoparticle Scintillators Zn2SiO4:Mn2+, Yb3+, Li

Thursday, April 20, 2023

Author(s): Xiaohui Jiang,Xiuping Gao,Lingyi Li,Ping Zhou,Shasha Wang,Tao Liu,Jinyuan Zhou,Haodong Zhang,Kai Huang,Yang Li,Min Wang,Zhiwen Jin,Erqing Xie,Weisheng Liu,Gang Han

Source: ACS applied materials & interfaces

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors

Friday, April 14, 2023

Author(s): Samuel R Hildebrand,Adam K Hedger,Ken Yamada,Jonathan K Watts,Anastasia Khvorova

Source: RNA (New York, N.Y.)

Double Click: Unexpected 1:2 Stoichiometry in a Norbornene-Tetrazine Reaction

Friday, April 14, 2023

Author(s): Gitali Devi,Adam K Hedger,Richard J Whitby,Jonathan K Watts

Source: The Journal of organic chemistry

A nascent interest amplified

Thursday, April 13, 2023

Author(s): Thoru Pederson

Source: Nature reviews. Molecular cell biology

Nucleolar structure connects with global nuclear organization

Monday, April 10, 2023

Author(s): Chen Wang,Hanhui Ma,Susan J Baserga,Thoru Pederson,Sui Huang

Source: bioRxiv : the preprint server for biology

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

Monday, April 10, 2023

Author(s): Leonid Yurkovetskiy,Shawn Egri,Chaitanya Kurhade,Marco A Diaz-Salinas,Javier A Jaimes,Thomas Nyalile,Xuping Xie,Manish C Choudhary,Ann Dauphin,Jonathan Z Li,James B Munro,Pei-Yong Shi,Kuang Shen,Jerem...

Source: bioRxiv : the preprint server for biology

Approaches to address bias in letters of recommendation

Thursday, March 30, 2023

Author(s): Vivian Y Chang,Mary Munson,Christina Marie Termini

Source: Trends in pharmacological sciences

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

Thursday, March 30, 2023

Author(s): Han Zhang,Karen Kelly,Jonathan Lee,Dimas Echeverria,David Cooper,Rebecca Panwala,Zexiang Chen,Nicholas Gaston,Gregory A Newby,Jun Xie,David R Liu,Guangping Gao,Scot A Wolfe,Anastasia Khvorova,Jonathan...

Source: bioRxiv : the preprint server for biology

Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses

Thursday, March 30, 2023

Author(s): Sarah N Zvornicanin,Ala M Shaqra,Qiuyu J Huang,Elizabeth Ornelas,Mallika Moghe,Mark Knapp,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Nese Kurt Yilmaz

Source: Viruses

Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse

Monday, March 27, 2023

Author(s): Vera Rinaldi,Kathleen Messemer,Kathleen Desevin,Fengyun Sun,Bethany C Berry,Shweta Kukreja,Andrew R Tapper,Amy J Wagers,Oliver J Rando

Source: eLife

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

Wednesday, March 15, 2023

Author(s): Ean Spielvogel,Sook-Kyung Lee,Shuntai Zhou,Gordon J Lockbaum,Mina Henes,Amy Sondgeroth,Klajdi Kosovrasti,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer,Ronald Swanstrom

Source: eLife

Enzyme Grafting with a Cofactor-Decorated Metal-Organic Capsule for Solar-to-Chemical Conversion

Tuesday, March 14, 2023

Author(s): Jianwei Wei,Liang Zhao,Yu Zhang,Gang Han,Cheng He,Chong Wang,Chunying Duan

Source: Journal of the American Chemical Society

Short-term molecular consequences of chromosome mis-segregation for genome stability

Saturday, March 11, 2023

Author(s): Lorenza Garribba,Giuseppina De Feudis,Valentino Martis,Martina Galli,Marie Dumont,Yonatan Eliezer,René Wardenaar,Marica Rosaria Ippolito,Divya Ramalingam Iyer,Andréa E Tijhuis,Diana C J Spierings,Mich...

Source: Nature communications

Department Research Highlights

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Celia Schiffer elected to the National Academy of Sciences

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