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Current Lab Members

Paul Thompson

Paul Thompson, PhD

Principal Investigator
Professor and Director of Chemical Biology 

LRB 825
Tel: 508-856-8492

Dr. Paul Thompson received his BSc and PhD degrees from McMaster University in Canada before moving to the US to take a postdoctoral position with Philip Cole at the Johns Hopkins School of Medicine.  Paul then moved to the University of South Carolina to begin his independent career before moving to the Department of Chemistry at The Scripps Research Institute, Scripps Florida, in May 2010.  Paul subsequently moved to UMASS Med in Aug 2014.  Paul has published more than 152 articles in major scientific journals including Nature, Cell, Nature Structural and Molecular Biology, and the Journal of the American Chemical Society.  Paul has also won a number of awards including a Canadian Institutes of Health Research Postdoctoral Fellowship and a Camille Dreyfus Teacher-Scholar Award.

Leonard Barasa

Leonard Barasa

Postdoctoral Associate

LRB 860C
 
Leonard is currently working on the design, synthesis and biological evaluation of reversible and irreversible inhibitors of the PAD family of enzymes. His work also focuses on the development of inhibitors targeting the Main protease of SARS-CoV2.

Janneke Doedee

Janneke Doedee

Graduate Student

LRB 860C
 
Janneke’s research is focused on characterizing the molecular mechanisms of Tir1, the worm ortholog of SARM1. Like SARM1, Tir1 is a NAD glycohydrolase that plays an important role in neuronal cell death. These studies will aid our efforts to develop inhibitors targeting the human enzyme and thereby provide therapies for a broad range of diseases including traumatic brain injury and peripheral neuropathies.

Santanu Mondal

Santanu Mondal, PhD

Postdoctoral Associate

LRB 860C
 
Santanu is currently working on the design, synthesis and biological evaluation of inhibitors targeting the PAD family of enzymes. His work also focuses on the development of isozyme-selective inhibitors and probes for the PADs.

Archie Reyes

Archie Reyes, PhD

Postdoctoral Associate

LRB 860D
 
Archie is currently focused on developing probes to identify and characterize citrulline specific proteases. He is also discovering the factors that regulate the activity of the protein arginine deiminases. 

 

Sudeshna Sen

Sudeshna Sen, PhD

Postdoctoral Associate

LRB 860C
 
Sudeshna’s current research is focused on characterizing the catalytic mechanism and developing activity based probes forNNMT, a nicotinamide methyltransferase whose activity is aberrantly upregulated in cancer and other diseases. Inhibitors targeting NNMT represent promising anti-cancer therapeutics.