Campus Alert: Find the latest UMMS campus news and resources at umassmed.edu/coronavirus

Search Close Search
Search Close Search
Page Menu

Current Lab Members

Paul Thompson

Paul Thompson, PhD

Principal Investigator
Professor and Director of Chemical Biology 

LRB 825
Tel: 508-856-8492

Dr. Paul Thompson received his BSc and PhD degrees from McMaster University in Canada before moving to the US to take a postdoctoral position with Philip Cole at the Johns Hopkins School of Medicine.  Paul then moved to the University of South Carolina to begin his independent career before moving to the Department of Chemistry at The Scripps Research Institute, Scripps Florida, in May 2010.  Paul subsequently moved to UMASS Med in Aug 2014.  Paul has published more than 152 articles in major scientific journals including Nature, Cell, Nature Structural and Molecular Biology, and the Journal of the American Chemical Society.  Paul has also won a number of awards including a Canadian Institutes of Health Research Postdoctoral Fellowship and a Camille Dreyfus Teacher-Scholar Award.

Janneke Doedee

Janneke Doedee

Graduate Student

LRB 860C
 
Janneke’s research is focused on characterizing the molecular mechanisms of Tir1, the worm ortholog of SARM1. Like SARM1, Tir1 is a NAD glycohydrolase that plays an important role in neuronal cell death. These studies will aid our efforts to develop inhibitors targeting the human enzyme and thereby provide therapies for a broad range of diseases including traumatic brain injury and peripheral neuropathies.

Heather Loring

Heather Loring

Graduate Student

LRB 860C
 
Heather’s research is focused on characterizing the enzymatic mechanism and structure of SARM1, a novel NAD glycohydrolase that plays an important role in neuronal cell death and peripheral neuropathy. The development of inhibitors targeting this enzyme will provide therapeutic benefit for a range of diseases.  In 2018 Heather was awarded a Ruth L. Kirschstein National Research Service Award for Individual Predoctoral Fellow (F31).  And her doctoral research is supposed by the National Institute of Neurological Disorders and Stroke at the NIH.

Santanu Mondal

Santanu Mondal, PhD

Postdoctoral Associate

LRB 860C
 
Santanu is currently working on the design, synthesis and biological evaluation of inhibitors targeting the PAD family of enzymes. His work also focuses on the development of isozyme-selective inhibitors and probes for the PADs.

Sangram Parelkar

Sangram Parelkar, PhD

Manager of Research Operations for Small Molecule Screening Facility 

LRB 860D
 
Using High Throughput and High Content based biochemical and cellular approaches, Sangram is working towards discovering novel small molecule therapeutic candidates for various biological processes.
More info about SMSF: http://www.umassmed.edu/smsf/

Archie Reyes

Archie Reyes, PhD

Postdoctoral Associate

LRB 860D
 
Archie is currently focused on developing probes to identify and characterize citrulline specific proteases. He is also discovering the factors that regulate the activity of the protein arginine deiminases. 

 

Ari Salinger

Ari Salinger, PhD

Postdoctoral Associate

LRB 860C
 
Ari is currently focused on using chemoproteomic methods to identify citrullinated proteins and disease associated biomarkers.  This work is being performed jointly with the Weerapana group at Boston College.
In 2018 Ari has been awarded a Ruth L. Kirschtein fellowship by the NIH and the award was given to Ari for his proposal to develop enhanced methods for identifying the sites of citrullnation in proteins.

Sudeshna Sen

Sudeshna Sen, PhD

Postdoctoral Associate

LRB 860C
 
Sudeshna’s current research is focused on characterizing the catalytic mechanism and developing activity based probes forNNMT, a nicotinamide methyltransferase whose activity is aberrantly upregulated in cancer and other diseases. Inhibitors targeting NNMT represent promising anti-cancer therapeutics.

Ronak Tilvawala

Ronak Tilvawala, PhD

Postdoctoral Associate

LRB 860C
 
Ronak is currently focused on identifying citrullinated biomarkers associated with Rheumatoid Arthritis and breast cancer.  In addition, Ronak is studying the functional impact of these citrullination events on protein function, enzymatic activity and the generation of antibodies targeting citrullinated proteins.