Target- based drug design
Our Lab
Chemical Biology of Arginine Modifying Enzymes
Welcome to the Thompson Lab! The focus of our group is the design of novel anti-cancer and anti-rheumatoid arthritis chemotherapeutics. Currently we are focusing our efforts on the development of potent and selective inhibitors of enzymes whose activities are involved in modulating chromatin structure.
Meet the Lab
Research Focus
Chemical Biology of Arginine Modifying Enzymes
Our major focus is the target-based design of novel anti-cancer and anti-rheumatoid arthritis chemotherapeutics. Currently we are focusing our efforts on the development of potent and selective inhibitors of enzymes whose activities are involved in modulating chromatin structure. The modulation of chromatin structure can have drastic effects on the transcription of particular genes. Our lab uses kinetic and structural analyses to guide the design of small molecule inhibitors, which we then synthesize and evaluate as inhibitors of these enzymes. Protein Arginine Methyl-Transferases (PRMTs) catalyze the mono-, asymmetric di-, and symmetric di-methylation of Arginine residues in a number of proteins including the core histone proteins.
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Contact
Office:Lazare Research Building LRB825
Campus Map (pdf)
Phone:
508.856.0028 (Admin. Assistant)
508.856.8874 (lab)
Email:
Paul.Thompson@umassmed.edu
Mailing Address:
UMass Chan Medical School
Paul Thompson, Ph.D.
Department of Biochemistry and Molecular Biotechnology
364 Plantation Street, LRB825
Worcester, MA 01605-4321