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Plastic Surgery Research Laboratory



Lab Staff - Plastic Surgery Research LabActive areas of investigation include:

General Plastic Surgery
 Applications of fat grafting, mitigation of surgical drain complications, pressure sore prevention 

Craniofacial
Updated population based cephalic index norms, neonatal mandibular distraction  

Wound
Radiation and thermal injury effects on skin and their mitigation, external volume expansion devices, ventral hernia closure

Global Health
Quality and safety outcomes on international plastic surgery volunteer trips, best practices around global health education

All faculty and residents are actively involved in plastic surgery research and are frequent presenters at regional, national and international forums, including the journal Plastic and Reconstructive Surgery, New England Society of Plastic and Reconstructive Surgery, the Annual Meeting of the American Society of Plastic Surgery, the American Association of Plastic Surgeons, American Society of Reconstructive Microsurgery, The International Hernia Society and the International Society of Craniofacial Surgery.



Joyce McIntyre, MD 
– Joyce McIntyre, MD is a board certified plastic surgeon specializing in craniofacial and pediatric plastic surgery and is Assistant Professor of Surgery, Pediatrics and Neurosurgery.  She is Associate Program Director of the UMass Plastic Surgery Residency program and staff surgeon for both the UMass Craniofacial Team and the cleft team at Shriners Hospital for Children Springfield, MA .

Areas of special interest to Dr. McIntyre include complex craniofacial and skull disorders, quality and outcome measures in international plastic surgery, cleft lip and palate, functional problems with the jaw and airway, neonatal mandibular distraction, orthognathic surgery, vascular malformations and general pediatric plastic surgery.  She also staffs a regional plastic surgery clinic on Cape Cod where the Division of Plastic Surgery has been a leader in using telehealth technologies to increase patients’ access to reconstructive surgery. 

Dr. McIntyre graduated from Harvard College, UMass Medical School, UMass Plastic Surgery Integrated Plastic Surgery residency and the Craniofacial Fellowship at Rady Children’s Hospital San Diego and the University of California San Diego.

Janice F. Lalikos, MD – Dr. Lalikos graduated from Johns Hopkins University School of Medicine with an M.D. and a Master’s in Medical Illustration. She did a full general surgery residency training at Vanderbilt University Hospital and was boarded by the American Board of Surgery and is a Fellow of the American College of Surgeons. Her plastic surgery residency was completed at UMass Memorial Medical Center, and a craniofacial fellowship at the University of Pittsburgh - Presbyterian Medical Center. She is boarded by the American Board of Plastic Surgery and is an ABPS Board Examiner. Dr. Lalikos’ clinical interests include pediatric plastic surgery, wound care, and tissue engineering. Her curriculum vitae acknowledge 50+ peer reviewed publications, 12 grants and 1 patent. Dr. Lalikos is Professor, Residency Program Director and Section Chief, Pediatric Plastic Surgery at the UMass Medical School. 

Heather M. Strom Tessier, MA – Mrs. Tessier is the Division’s Research Lab Manager and main Research Associate. She graduated Magna Cum Laude from Mount Holyoke College with a Bachelor’s Degree in Biological Sciences in 2000. She received her Master’s Degree in Environmental Science and Policy from Clark University in 2011.  Her major duties include: coordinating all aspects of the lab/research projects, regulatory compliance, grant writing, budgeting and financial management, obtaining informed consent from research subjects, maintaining research records, retrieving, cataloging and processing samples, data analysis, and manuscript and IRB/IACUC protocol preparation.

The University of Massachusetts Medical School Office of Clinical Research

The Office of Clinical Research is the contracting entity for industry-sponsored clinical research at the University of Massachusetts Worcester and UMass Memorial Medical Center. For further information, please visit our website at www.umassmed.edu/ocr.

Under the supervision of the Office of Research (OOR) is the Clinical Trials Unit (CTU). The CTU is a newly renovated, 2,600-square-foot ambulatory site within UMass. The specialized clinical trials unit is a comfortable and accessible area for study participants. The area includes a waiting area, a conference room for study initiation, monitor visits and education meetings, four staff offices, three workstations for visiting staff, four exam rooms, an infusion room with two recliners, and a private infusion room for those subjects requiring special privileges.

The OOR also provides services such as: 

  • Promoting clinical investigator interests through industry liaisons
  • Assistance with feasibility review of new studies
  • Careful review and assessment of clinical study budgets
  • Thorough and timely review of Clinical Trial Agreements
  • Educational and training opportunities for clinical research staff
  • Investigational pharmacy support and consultation
  • Quality Improvement Initiative

For additional information on Clinical Study/Trial Agreements, please contact Sheila B. Noone, Ph.D. Director, Office of Clinical Research at University of Massachusetts Medical School at (508)856-5015 or e-mail at sheila.noone@umassmed.edu

Investigational Pharmacy Services

The Investigational Pharmacy Service plays a key role in facilitating subject safety for clinical trials being conducted at UMMS and UMMMC. Housed in the clinical system's ambulatory pharmacy, the service is staffed with 2 two full-time investigational pharmacists and a pharmacy technician.

The investigational pharmacy has a critical role in safe clinical trial conduct as it directs receipt, dispensing and storage of investigational drugs. It also has a distinct role as investigator consultant, regulatory expert and compliance professional as it relates to study drugs and their use.

For additional information, please contact: IDS@umassmemorial.org

For additional information on wound research, please contact Dr. Raymond M. Dunn at Raymond.Dunn@umassmemorial.org.


Most Recent Publications:

Lujan-Hernandez, J. Chin, MS. Editor’s Invited Paper: “Discussion of “Creating a Favorable Micro-Environment for Fat Grafting in a Novel Model of Radiation Induced Mammary Fat Pad Fibrosis”. Plastic and Reconstructive Surgery Journal, In Press.

Lujan-Hernandez J, Chin MS, Perry DJ, Chappell A, Lancerotto L, Yu N, Slamin R, Bannon E, Fitzgerald TJ, Lalikos JF.  “Improving Fat Grafting Outcomes after Radiation Therapy with External Volume Expansion Preconditioning: Effects on the graft”. Plastic and Reconstructive Surgery Journal. In Press, January 2020.

Harvey, Joshua; Sen, Devdip; Baez, Angel; Hickle, Kelli; Tessier, Heather; Slamin, Robert; Dunn, Raymond; McNeill, John; Mendelson, Yitzhak. "Correlation of bioimpedance changes after compressive loading of murine tissues in vivo." Physiological Measurement. In press, October 2019.

Lujan-Hernandez J. “The PRS Resident Network: An Online Network for Plastic Surgery Residents and Medical Students to Improve Education and Residency Application Process” Special supplement from the ACAPS Winter Retreat Abstracts 2018, Plastic and Reconstructive Surgery – Global Open. 7(5S):1, May 2019.

Lujan-Hernandez J, Ibrahim, MM, Taub PJ. International Medical Graduates and the Integrated Plastic Surgery Match. Annals of Plastic Surgery, February 2019.

Hickle K, Slamin R, Baez A, Tessier H, et al. Wireless Pressure Ulcer Sensor: Validation in an Animal Model. Annals of Plastic Surgery. 2019; 82(4S):S215-S221.

Rojas-Rodriguez R, Lujan-Hernandez J, Min SY, DeSouza T, Teebagy P, Desai A, Tessier H, Slamin R, Siegel-Reamer L, Berg C, Baez A, Lalikos J, Corvera S. Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells. Tissue Eng Part A. 2018 Oct 11. doi: 10.1089/ten.TEA.2018.0067.

Sen D, McNeill J, Mendelson Y, Dunn R, Hickle K. A New Vision for Preventing Pressure Ulcers: Wearable Wireless Devices Could Help Solve a Common-and Serious-Problem. IEEE Pulse. 2018; 9(6):28-31.

  1. Figy and J. McIntyre, “Burns” chapter in Irwin & Rippe’s Intensive Care Medicine, eighth ed., 2017.

McIntyre, Joyce K. M.D.; Schoenbrunner, Anna R. M.A.S.; Kelley, Kristen D. M.A.S.; Gosman, Amanda A. M.D., “Predictors, Quality Markers, and Economics of Volunteering Internationally: Results from a Comprehensive Survey of American Society of Plastic Surgeons Members.” Plastic and Reconstructive Surgery: September 2017 - Volume 140 - Issue 3 - p 617-626. doi: 10.1097/PRS.0000000000003594

Chin MS, Lujan-Hernandez J, Babchenko OO, Perry DJ, Chappell A, Bannon E, Lo YC, Fitzgerald TJ, Lalikos JF  “Reply: External Volume Expansion in Irradiated Tissue: Effects on the Recipient Site. Plastic and Reconstructive Surgery Journal. Jan 2017

Ascherman, Jeffrey A.; Zeidler, Kamakshi; Morrison, Kerry A.; Appel, James Z.; Berkowitz, R. L.; Castle, John; Colwell, Amy; Chun, Yoon; Johnson, Debra; Mohebali, Khashayar Less. “Carbon Dioxide–Based versus Saline Tissue Expansion for Breast Reconstruction: Results of the XPAND Prospective, Randomized Clinical Trial.” Plastic & Reconstructive Surgery. 138(6):1161-1170, December 2016.

Chin MS, Babchenko O, Lujan-Hernandez J, Nobel L, Ignotz R, Lalikos JF. Hyperspectral Imaging for Burn Depth Assessment in an Animal Model. Plastic and Reconstructive Surgery Global Open. December 2016

Lujan-Hernandez J, Lancerotto L, Nabzdyk C, Hassan Kazi Z, Giatsidis, G,  Khouri Jr RK, Chin MS, Bassetto F, Lalikos JF, Orgill DP. “Reply: Induction of Adipogenesis by External Volume Expansion”. Plastic and Reconstructive Surg J. October 2016.

Chappell AG, Lalikos JF. An Old Idea Revisited: Reflections on the Role of Aesthetic Surgery in Behavioral and Social Change. Plastic and Reconstructive Surgery Journal. September 2016

Chin MS, Lujan-Hernandez J, Babchenko OO, Perry DJ, Chappell A, Bannon E, Lo YC, Fitzgerald TJ, Lalikos JF.  “External Volume Expansion in Irradiated Tissue: Effects on the Recipient Site. Plastic and Reconstructive Surgery Journal. May 2016

McIntyre J, Schoenbrunner A, Kelley KD, Gosman A, Quality Markers in Residents' International Surgical Experiences and Impact on Future Volunteering: Results from a Comprehensive Survey of American Society of Plastic Surgery (ASPS) Members, PRS Global Open, April 2016.

McIntyre J, Schoenbrunner A, Sethi H, Proudfoot J, Jones M, Gosman A, “Number of Surgical Procedures for Patients with Cleft Lip and Palate From Birth to 21 Years Old at a Single Children's Hospital”,  Annals of Plastic Surgery, 76 (3):S205-208, April 2016. PMID:27070669

Lujan-Hernandez J, Lancerotto L, Nabzdyk C, Hassan Kazi Z, Giatsidis, G, Khouri Jr RK, Chin MS, Bassetto F, Lalikos JF, Orgill DP. “Induction of Adipogenesis by External Volume Expansion”. Plastic and Reconstructive Surgery J. January 2016.

Chin MS, Freniere BB, Lancerotto L , Lujan-Hernandez JR, Saleeby J, Lo YC, Orgill DP, Lalikos JF, Fitzgerald TJ. "Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage". In Press. Frontiers in Radiation Research. October 2015

Lujan-Hernandez J, Perez Martinez M , Lalikos JF. “Breast Reconstruction: Closing the Loop After Breast Cancer”. Opinion Paper. Archives of Plastic Surgery. July 2015.

Perry D, Albert M, Akyurek M. Use of smartphone cameras for simplified and cost-effective video recording of microvascular techniques. Plastic and Reconstructive Surgery J. May 2015.

Chappell A, Lujan-Hernandez J, Perry DJ, Corvera S, Lalikos JF.  “Alternatively Activated M2 Macrophages Improve Autologous Fat Graft Survival in a Mouse Model through Induction of Angiogenesis”. Letter to the Editor. Plastic and Reconst Surg J. July 2015.

Lancerotto L; Chin MS; Freniere, B; Lujan-Hernandez JR ; Li, Q ; ,Valderrama Vasquez, A; Bassetto F; Del Vecchio DA; Lalikos J; Orgill, DP . "Reply to: "Does External Skin Expansion Really Create New Tissue,". Plastic and Reconstructive Surgery J.  March 2014.

 Lancerotto, Luca, Michael S. Chin, Brian Freniere, Jorge R. Lujan-Hernandez, Qiong Li, Alessandro Valderrama Vasquez, Franco Bassetto, Daniel A. Del Vecchio, Janice Lalikos, and Dennis P. Orgill. "Mechanisms of action of External Volume Expansion devices." Plastic and reconstructive surgery (2013).

Chin, Michael S., Brian B. Freniere, Caitlin F. Bonney, Luca Lancerotto, Jonathan H. Saleeby, Yuan-Chyuan Lo, Dennis P. Orgill, Thomas J. Fitzgerald, and Janice F. Lalikos. "Skin Perfusion and Oxygenation Changes in Radiation Fibrosis." Plastic and reconstructive surgery 131, no. 4 (2013): 707-716.

Chin, Michael S., Brian B. Freniere, Sami Fakhouri, John E. Harris, Janice F. Lalikos, and Alfred J. Crosby. "Cavitation Rheology as a Potential Method for In Vivo Assessment of Skin Biomechanics." Plastic and reconstructive surgery 131, no. 2 (2013): 303e-305e.

Lee, David T., Nelson L. Jenkins, Alexandra J. Anastasopulos, A. George Volpe, Bernard T. Lee, and Janice F. Lalikos. "Transdermal Scopolamine and Perioperative Anisocoria in Craniofacial Surgery: A Report of 3 Patients." Journal of Craniofacial Surgery 24, no. 2 (2013): 470-472.

Chin, Michael S., Brian B. Freniere, Yuan-Chyuan Lo, Jonathan H. Saleeby, Stephen P. Baker, Heather M. Strom, Ronald A. Ignotz, Janice F. Lalikos, and Thomas J. Fitzgerald. "Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin." Journal of biomedical optics 17, no. 2 (2012): 0260101-0260105.

Broderick, G., J. McIntyre, M. Noury, H. M. Strom, C. Psoinos, A. Christakas, K. Billiar et al. "Dermal collagen matrices for ventral hernia repair: comparative analysis in a rat model." Hernia 16, no. 3 (2012): 333-343.

O'Brien, Julie Anne, Genevieve B. Broderick, Zachary M. Hurwitz, Richard Montilla, John Castle, Raymond M. Dunn, Mustafa Akyurek, and Janice F. Lalikos. "Fleur-de-lis panniculectomy after bariatric surgery: our experience." Annals of Plastic Surgery 68, no. 1 (2012): 74-78.

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