Developmental Neurobiology

The Lab

Genetic and epigenetic control of neural development

The mature CNS is very complex - containing many cell types making myriads of connections. To build such a complex structure seems daunting and yet the CNS forms efficiently during development of almost every vertebrate embryo. As developmental neurobiologists, we take advantage of early embryos to better understand CNS formation. We are particularly interested in understanding the genetic and epigenetic control of this process. To this end, we use biochemistry, cell biology, classical genetics and molecular genomics to study neural development in the zebrafish – a simple vertebrate with a CNS structure similar to that of humans.

Meet the Lab

Research Focus

Development of the vertebrate hindbrain

Our current research focuses on identifying the genes controlling formation of the hindbrain, which serves as a powerful model for CNS development in general. The hindbrain is an embryonic structure that gives rise to cerebellum and brainstem in the adult and defective hindbrain development can cause disorders such as autism. We are using ChIP-seq and RNA-seq to identify the gene regulatory network controlling hindbrain development. We then use CRISPR/Cas9 to mutate key genes in the network and assess their role in hindbrain development. Lastly, biochemical and cell biological methods are used to define the mechanism whereby these genes act in hindbrain development.

Read More

Publications

Kobertz PublicationsAn emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system.
Author(s): Zannino DA, Sagerström CG 
 
All Publications

 

Follow our research, stay in touch – join the lab! 


Contact Us

Office:
Lazare Research Building 815
Campus Map (pdf)

Phone:
508-856-8006 (office)

Email:
Charles.Sagerstrom@umassmed.edu

Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Charles Sagerstrom/BMP department
364 Plantation St LRB815
Worcester, MA 01605

Join Us

We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

Read more here

Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.