RNA Therapeutics Institute Faculty

Neil Aronin, M.D.
Professor, Department of Medicine


Focus:
Pathogenesis of neurodegenerative diseases, especially Parkinson's disease and Huntington's disease.

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David Grunwald

David Grunwald, Ph.D.
Associate Professor


Focus:
The interface between microscopy development and (nuclear) cell biology, with a strong focus on the travels of mRNA and nucleocytoplasmic transport.

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Anastasia Khvorova

Anastasia Khvorova, Ph.D.
Professor


Focus:
Development of novel oligonucleotide-based therapeutics, drug development. Mechanism of small RNA trafficing, RNA medicinal chemistry and delivery.

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Andrei Korostelev, Ph.D.
Associate Professor

Focus:
Structure and function of ribosome.

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Craig Mello, Ph.D.
Investigator Howard Hughes Medical Institute,
Blais Chair of Molecular Medicine, Professor


Focus:
Investigation of the mechanism of RNA interference; investigation of how embryonic cells differentiate and communicate during development.

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Melissa J. Moore, Ph.D.
Eleanor Eustis Farrington Chair in Cancer Research, Professor


Focus:
Post-transcriptional gene regulation in eukaryotes via mechanisms involving RNA.

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Athma Pai

Athma A. Pai, Ph.D.
Assistant Professor


Focus:
Kinetics of RNA processing; genetic and genomic investigations of the dynamics of alternative mRNA splicing.

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Erik Sontheimer

Erik Sontheimer, Ph.D.
Professor


Focus:
Biology and mechanism of RNA-based gene regulation; CRISPR interference; RNA-directed genome editing and gene control.

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Jon Watts

Jonathan K. Watts, Ph.D.
Associate Professor


Focus:
Chemistry and chemical biology of oligonucleotides; Nucleic acid drug development.

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Wen Xue

Wen Xue, Ph.D.
Assistant Professor


Focus:
Mouse models of cancer. Use CRISPR genome editing to functionally dissect cancer mutations in liver and lung cancer.

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Phillip Zamore, Ph.D.
Investigator Howard Hughes Medical Institute, Gretchen Stone Cook Professor of Biomedical Sciences, Chair and Professor


Focus:
Dissecting the RNAi and miRNA pathways

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Departmental Faculty


 Darryl Conte, PH.D.

Darryl Conte, Ph.D.
Research Assistant Professor

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Angela Messmer-Blust, Ph.D.

Angela Messmer-Blust, Ph.D.
Senior Scientific Advisor,
Assistant  Professor

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RTI Affiliated Faculty


Raffi Aroian

Raffi V. Aroian, Ph.D.
Professor, Program in Molecular Medicine


Focus:
Intestinal parasitic nematodes, drug discovery, autoimmune diseases, host-pathogen interactions. Bacillus thuringiensis. Cellular responses to pore-forming toxins.

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Robert Brown, M.D.
Professor and Chair, Department of Neurology


Focus:
Neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.

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Vivian Budnik

Vivian Budnik, Ph.D.
Professor, Neurobiology


Focus:
Molecular Mechanisms of Synapse Assembly and Plasticity

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Michael P. Czech, Ph.D.
Professor and Chair, Program in Molecular Medicine


Focus:
RNAi-based therapeutic strategies for inflammatory and metabolic diseases.

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Terence Flotte, M.D.
Dean School of Medicine, Provost and Executive Deputy Chancellor, Professor, Pediatrics


Focus:
Recombinant adeno-associated virus (AAV) gene therapy vectors for, cystic fibrosis (CF), alpha-1-antitrypsin deficiency (AAT) and fatty oxidation disorders (FAO)

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Jane E. Freedman, M.D.
Director, Translational Research, UMass Memorial Heart & Vascular Center, Professor, Department of Medicine


Focus:
Immunity, inflamation and circulation transcripts in atherothrombotic disease in a basic and high-throughput laboratory.

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Fen-Biao Gao, Ph.D.
Professor, Neurology


Focus:
Understanding frontotemporal dementia and neuronal microRNAs.

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Guangping Gao, Ph.D.
Professor Department of Microbiology and Physiological Systems, Director Gene Therapy Center & Vector Core, Scientific Director UMMS-China Translational Research Initiatives


Focus:
Adeno-associated virus (AAV) vector mediated gene transfer for gene therapy & gene therapy of inherited neurodegenerative Canavan Disease.

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Manuel Garber

Manuel Garber, Ph.D.
Associate Professor Program in Molecular Medicine, Director of the UMMS Bioinformatics core


Focus:
Molecular evolution, mechanisms of transcriptional regulation of innate immune responses, functional characterization of the non-coding genome

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Michael Green, Ph.D., M.D.
Professor and Director, Program in Gene Function and Expression, Professor Program in Molecular Medicine


Focus:
Eukaryotic gene regulation and cancer molecular biology.

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Dale L. Greiner Ph.D.
Professor Program in Molecular Medicine


Focus:
To understand the etiology and pathogenesis of autoimmune type 1 diabetes mellitus (T1D).

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Gang Han, Ph.D.
Assistant Professor, Biochemistry and Molecular Pharmacology


Focus:
Synthetic nanomaterials for siRNA delivery and biomolecule imaging.

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David HarlanDavid M. Harlan M.D.
Professor,  Department of Medicine; Chief, Diabetes; Co-Director, Diabetes Center of Excellence


Focus:
Focus:  Tolerance mechanisms and organ/tissue transplantation.  Autoimmune illnesses, especially insulin dependent diabetes mellitus. Human beta cell biology. Improving diabetes care delivery systems.

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Allan Jacobson, Ph.D.
Professor and Chair, Department of Microbiology and Physiological Systems


Focus:
Cytoplasmic Aspects of the Post-transcriptional Regulation of Gene Expression.

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Arthur Krieg

Arthur M Krieg, M.D.
Professor, RNA Therapeutics Institute, Chief Executive Officer,  Checkmate Pharmaceuticals


Focus:
Oligonucleotide therapeutics in oncology, checkpoint inhibitors, CpG oligonucleotide therapy, combination therapy.

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Nathan Lawson, Ph.D.
Associate Professor, Program in Molecular Medicine


Focus:
Role of non-coding RNA's in vascular development and disease.

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Jeremy Luban, M.D.
David L. Freelander Memorial Professor in HIV/AIDS Research, Professor in Molecular Medicine


Focus:
HIV-1 replication, pathogenesis, and immunity.

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Rene Maehr

Rene Maehr, Ph.D.
Assistant Professor, Program in Molecular Medicine


Focus:
Pluripotent stem cell-based models of immune deficiencies and autoimmunity.

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Gary Ostroff, Ph.D.
Research Professor, Program in Molecular Medicine


Focus:
Nanomaterial science to develop delivery technology targeting chronic diseases.

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Joel Richter, Ph.D.
Professor, Program in Molecular Medicine


Focus:
Translational Control of Meiosos, Mitosos, and Neuronal Synaptic Platicity.

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Sean Ryder, Ph.D.
Associate Professor, Biochemistry and Molecular Pharmacology


Focus:
RNA-binding proteins in development and disease.

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William Theurkauf, Ph.D.
Professor, Program in Molecular Medicine


Focus:
Eukaryotic gene regulation and cancer molecular biology.

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Zuoshang Xu, M.D., Ph.D.
Professor, Biochemistry and Molecular Pharmacology


Focus:
Mechanism and Therapy of Neurodegenerative Diseases.

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