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Total: displaying 10 out of 35 results

NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2

Saturday, January 08, 2022

Author(s): Heidi Erlandsen,Anne M Jecrois,Jeffry C Nichols,James L Cole,William E Royer

Source: FEBS letters
NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)

Monday, February 01, 2021

Author(s): Jeffry C Nichols,Celia A Schiffer,William E Royer

Source: The Journal of biological chemistry
Cryo-EM structure of CtBP2 confirms tetrameric architecture

Wednesday, December 02, 2020

Author(s): Anne M Jecrois,M Michael Dcona,Xiaoyan Deng,Dipankar Bandyopadhyay,Steven R Grossman,Celia A Schiffer,William E Royer

Source: Structure (London, England : 1993)
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures

Friday, March 06, 2020

Author(s): Gordon J Lockbaum,Florian Leidner,William E Royer,Nese Kurt Yilmaz,Celia A Schiffer

Source: Acta crystallographica. Section D, Structural biology
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

Wednesday, May 01, 2019

Author(s): M Michael Dcona,Priyadarshan K Damle,Francisco Zarate-Perez,Benjamin L Morris,Zaid Nawaz,Michael J Dennis,Xiaoyan Deng,Sudha Korwar,Sahib J Singh,Keith C Ellis,William E Royer,Dipankar Bandyopadhyay,C...

Source: Molecular pharmacology
Assembly of human C-terminal binding protein (CtBP) into tetramers

Saturday, April 28, 2018

Author(s): Andrew G Bellesis,Anne M Jecrois,Janelle A Hayes,Celia A Schiffer,William E Royer

Source: The Journal of biological chemistry
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Saturday, April 29, 2017

Author(s): Takahide Kouno,Tania V Silvas,Brendan J Hilbert,Shivender M D Shandilya,Markus F Bohn,Brian A Kelch,William E Royer,Mohan Somasundaran,Nese Kurt Yilmaz,Hiroshi Matsuo,Celia A Schiffer

Source: Nature communications
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP)

Monday, May 09, 2016

Author(s): Sudha Korwar,Benjamin L Morris,Hardik I Parikh,Robert A Coover,Tyler W Doughty,Ian M Love,Brendan J Hilbert,William E Royer,Glen E Kellogg,Steven R Grossman,Keith C Ellis

Source: Bioorganic & medicinal chemistry
Structure-guided design of a high affinity inhibitor to human CtBP

Saturday, January 31, 2015

Author(s): Brendan J Hilbert,Benjamin L Morris,Keith C Ellis,Janet L Paulsen,Celia A Schiffer,Steven R Grossman,William E Royer

Source: ACS chemical biology
Insight into the allosteric mechanism of Scapharca dimeric hemoglobin

Friday, October 31, 2014

Author(s): Jennifer M Laine,Miguel Amat,Brittany R Morgan,William E Royer,Francesca Massi

Source: Biochemistry
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

Tuesday, March 25, 2014

Author(s): Brendan J Hilbert,Steven R Grossman,Celia A Schiffer,William E Royer

Source: FEBS letters
Resolution of structural heterogeneity in dynamic crystallography

Thursday, May 23, 2013

Author(s): Zhong Ren,Peter W Y Chan,Keith Moffat,Emil F Pai,William E Royer,Vukica Šrajer,Xiaojing Yang

Source: Acta crystallographica. Section D, Biological crystallography
Tertiary and quaternary allostery in tetrameric hemoglobin from Scapharca inaequivalvis

Wednesday, March 06, 2013

Author(s): Luca Ronda,Stefano Bettati,Eric R Henry,Tara Kashav,Jeffrey M Sanders,William E Royer,Andrea Mozzarelli

Source: Biochemistry
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures

Friday, December 16, 2011

Author(s): Zhong Ren,Vukica Srajer,James E Knapp,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Friday, November 19, 2010

Author(s): Keith P Romano,Akbar Ali,William E Royer,Celia A Schiffer

Source: Proceedings of the National Academy of Sciences of the United States of America
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces

Tuesday, February 16, 2010

Author(s): Shivender M D Shandilya,Madhavi N L Nalam,Ellen A Nalivaika,Phillip J Gross,Johnathan C Valesano,Keisuke Shindo,Ming Li,Mary Munson,William E Royer,Elena Harjes,Takahide Kono,Hiroshi Matsuo,Reuben S H...

Source: Structure (London, England : 1993)
Structural insights into interferon regulatory factor activation

Saturday, January 02, 2010

Author(s): Weijun Chen,William E Royer

Source: Cellular signalling
Protein conformational dynamics of homodimeric hemoglobin revealed by combined time-resolved spectroscopic probes

Friday, November 20, 2009

Author(s): Jungkweon Choi,Srinivasan Muniyappan,John T Wallis,William E Royer,Hyotcherl Ihee

Source: Chemphyschem : a European journal of chemical physics and physical chemistry
Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis

Tuesday, November 17, 2009

Author(s): James E Knapp,Reinhard Pahl,Jordi Cohen,Jeffry C Nichols,Klaus Schulten,Quentin H Gibson,Vukica Srajer,William E Royer

Source: Structure (London, England : 1993)
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Tuesday, October 07, 2008

Author(s): Weijun Chen,Suvana S Lam,Hema Srinath,Zhaozhao Jiang,John J Correia,Celia A Schiffer,Katherine A Fitzgerald,Kai Lin,William E Royer

Source: Nature structural & molecular biology
Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3

Tuesday, April 29, 2008

Author(s): Weijun Chen,Hema Srinath,Suvana S Lam,Celia A Schiffer,William E Royer,Kai Lin

Source: Journal of molecular biology
Time-resolved x-ray crystallography of heme proteins

Friday, April 25, 2008

Author(s): Vukica Srajer,William E Royer

Source: Methods in enzymology
Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis

Friday, November 16, 2007

Author(s): Karin Nienhaus,James E Knapp,Pasquale Palladino,William E Royer,G Ulrich Nienhaus

Source: Biochemistry
Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling

Wednesday, February 07, 2007

Author(s): Weijun Chen,Suvana S Lam,Hema Srinath,Celia A Schiffer,William E Royer,Kai Lin

Source: The Journal of biological chemistry
An optical signal correlated with the allosteric transition in Scapharca inaequivalvis HbI

Thursday, December 21, 2006

Author(s): Jeffry C Nichols,William E Royer,Quentin H Gibson

Source: Biochemistry
Low resolution crystal structure of Arenicola erythrocruorin: influence of coiled coils on the architecture of a megadalton respiratory protein

Tuesday, November 07, 2006

Author(s): William E Royer,Michael N Omartian,James E Knapp

Source: Journal of molecular biology
Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex

Tuesday, July 18, 2006

Author(s): William E Royer,Hitesh Sharma,Kristen Strand,James E Knapp,Balaji Bhyravbhatla

Source: Structure (London, England : 1993)
Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin

Thursday, May 11, 2006

Author(s): James E Knapp,Reinhard Pahl,Vukica Srajer,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin

Thursday, November 03, 2005

Author(s): James E Knapp,Michele A Bonham,Quentin H Gibson,Jeffry C Nichols,William E Royer

Source: Biochemistry
Allosteric hemoglobin assembly: diversity and similarity

Saturday, June 04, 2005

Author(s): William E Royer,Hao Zhu,Thomas A Gorr,Jason F Flores,James E Knapp

Source: The Journal of biological chemistry
Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin

Wednesday, February 16, 2005

Author(s): Jason F Flores,Charles R Fisher,Susan L Carney,Brian N Green,John K Freytag,Stephen W Schaeffer,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Crystal structure of the hemoglobin dodecamer from Lumbricus erythrocruorin: allosteric core of giant annelid respiratory complexes

Wednesday, October 27, 2004

Author(s): Kristen Strand,James E Knapp,Balaji Bhyravbhatla,William E Royer

Source: Journal of molecular biology
Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments

Wednesday, March 24, 2004

Author(s): James E Knapp,Vukica Srajer,Reinhard Pahl,William E Royer

Source: Micron (Oxford, England : 1993)
Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis

Wednesday, November 05, 2003

Author(s): Eric J Bennett,Jens Bjerregaard,James E Knapp,David A Chavous,Alan M Friedman,William E Royer,Clare M O'Connor

Source: Biochemistry
Ligand-linked structural transitions in crystals of a cooperative dimeric hemoglobin

Wednesday, April 23, 2003

Author(s): James E Knapp,William E Royer

Source: Biochemistry