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The Transitions, Risks, and Action in Coronary Events – Center for Outcomes Research and Education (TRACE-CORE) is a Center for Cardiovascular Outcomes Research funded by the National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH). TRACE-CORE is an observational cohort study of 2,187 patients hospitalized for acute coronary syndrome between April 2011 and May 2013. Participants were followed for up to two years after discharge from the hospital. The goal of TRACE-CORE is to illuminate the transition between hospital and home following an ACS and to identify potentially modifiable factors that influence longer-term outcomes. TRACE-CORE is also helping to develop the research careers of four early stage investigators.

For more information including eligibility criteria for inclusion in the cohort, please read the TRACE-CORE design and rationale paper: 



Principal Investigator: Catarina Kiefe, PhD, MD

Transitions Project PI: Jeroan Allison, MD, MScEpi 

Action Scores Project PI: Robert Goldberg, PhD

Early Stage Investigators: Milena Anatchkova, PhDDavid McManus, MD, MSCI;Jane Saczynski, PhDMolly Waring, PhD 

Project Director: Rebecca Gigliello  Contact, 508-856-8871

Types of Data that are Available

TRACE-CORE collected extensive data about its participants in Massachusetts and Georgia through patient interviews, medical records, vital statistics records, and other sources. Data were collected at various time points over a 2-year period, including during the index hospitalization, 1-, 3-, 6- and 12-months after discharge from the hospital, and vital status information up to December 31, 2013..

De-identified data sets are available for use by interested investigators. All investigators must follow the TRACE-CORE publications and presentation policies, which are available here. Additional information about the data request process is available here. If you are interested in exploring the possibility of using TRACE-CORE data, please contact Rick McManus at

For a schematic of how we arrived at our final number of participants (N=2187), please review this document.  

About the Cohort

Total Participants 2,187
Participants from Massachusetts 1223 (55.9%)
Participants from Georgia 952 (43.5)
Mean Age 61.3
Median Age 61.0
% Female 33.4
% Non-white 19.1
ACS Type  
            %STEMI 15.1
            %NSTEMI 55.0
            %Unstable Angina 29.9
Average SF-36 Score at Baseline  
            PCS 41.1
            MCS 47.4
% Surviving to December 2013 94.4


Data Request Process

All investigators wishing to use TRACE-CORE data must complete a paper proposal form that will be reviewed by the TRACE-CORE Publications and Presentations Committee. Before starting the data request process, we recommend that all investigators review the data request/access process.

Contact: Rebecca Gigliello at

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