Dietary intervention alters the microbiota and its byproducts improving patient’s outcomes
Principal investigators: Beth McCormick, Ph.D.; Ana Maldonado-Contreras, Ph.D.; and Barbara Olendzki, RD MPH
Objective: Determine the microbiota shifts due to a dietary regimen that increase nutrient absorption, decrease symptomatology and improve quality of life in patients suffering of IBD.
Inflammatory bowel diseases are chronic recurrent inflammatory disorders of the gastrointestinal tract that may be caused by inappropriate inflammatory responses to normal intestinal microbes in a genetically susceptible host. In this project we seek to test the hypothesis that specific dietary modification of the diet may significantly alter the microbiome and improve nutrient absorption, which in turn alters the immune response in such a way as to reduce disease activity and improve outcomes for patients suffering with IBD.