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Co-director, Humanized Mouse Core Facility, University of Massachusetts Medical School

Dr. Brehm works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer.  Brehm's laboratory studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.  The ultimate objective is to understand the etiology and pathogenesis of autoimmune T1D, in order to develop new therapies and drugs for personalized medicine.

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