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Overview

Overview

MCCB offers top-notch facilities and resources, as well as state-of-the-art equipment, that significantly enhance the research programs of MCCB faculty.

Members of MCCB labs have full access to the UMass Research Core Facilities, which are shared resources available to all internal investigators for research enhancement. The facilities offer a wide range of services to the research community including cutting-edge technologies, high-end instrumentation and technical support for basic, translational and clinical research. These services are provided on a fee-for-service basis, but the cores are subsidized by UMMS such that rates are inexpensive. The Cores are directed by faculty members with specific expertise in the relevant technology.

Shared Equipment and Resources

MCCB has a substantial amount of common equipment available to its researchers (see Appendix 13A for a list of shared major equipment items). These equipment items, which can be freely used by researchers, include additional spare freezers and routinely used items (such as shakers, high-speed centrifuges, sonicators, microvolume spectrophotometers, real-time PCR machines, plate readers and digital imaging systems) and major equipment items (such as epifluorescence and confocal microscopes and cameras). The overall operations of the shared equipment are overseen by the Facilities Manager, who maintains the inventory list of all shared equipment items, coordinates preventative maintenance and service on shared equipment, monitors and maintains adequate gas/supply levels for equipment, and trains new employees on equipment. MCCB has a budget to purchase major shared equipment items, and faculty have a large say regarding the specific items purchased.

Furthermore, individual labs have major equipment items that are available for use with permission and are closely monitored by the lab that houses the item (see Appendix 13B for a list of individual lab major equipment items). These equipment items include a 10X Genomics Chromium Single Cell Controller for single cell applications, Bio-Rad TC10 Automated Cell Counter, Guava EasyCyte HT Flow Cytometer, Beckman Coulter Biomek NX Laboratory Automation Workstation for automated liquid handling, MED64 Presto Amplifier multielectrode array system, Bio-Rad BioLogic DuoFlow liquid chromatography system, AKTA Pure25M FPLC, NEON Transfection System, NEPA21 Electro-Kinetic Transfection System for in vivo transfection, and several additional microscopes (including Zeiss fluorescence, inverted, confocal and stereo microscopes).

In addition to the shared equipment items, MCCB has access to a large collection of ~400 mammalian cells lines that are shared between researchers in MCCB and the Program in Molecular Medicine. The collection includes numerous human cancer, mouse tumor, embryonic stem, neural stem and cancer stem cell lines, as well as various other immortalized mammalian cell lines. The inventory list of cell lines is curated by MCCB faculty member Dohoon Kim.