Fazzio Lab

The Fazzio lab uses deep sequencing approaches to probe regulation of the epigenome and transcriptome in normal and cancerous cells.  In the context of this work, they have collaborated with the MCCB bioinformatics group to develop novel techniques and computational approaches, such as RED-Seq, which measures DNA accessibility throughout the genome in an unbiased manner. The lab continues to combine molecular and computational approaches to uncover mechanisms by which chromatin structure regulates gene expression networks.  

  • Yildirim et al. (2011) Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.  Cell, 147(7):1498-510. 
  • Chen et al. (2014) Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo.  BMC Genomics, 15:1104