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Laam (Magnolia) Pak


Instructor
   
Ph.D.: 2012, University of British Columbia
Postdoctoral research: University of Massachusetts Medical School
   
Office: University of Massachusetts Medical School
364 Plantation Street, LRB-670-C
Worcester, MA 01605
Phone: 508-856-5318
Email: Magnolia.Pak@umassmed.edu


Research

My research focuses on investigating the epigenetic and transcriptional regulatory mechanisms underlying the epithelial-mesenchymal transition (EMT) using breast cancer as a model system. Using a candidate-based RNAi screening strategy, I have identified the histone acetyltransferase EP300 as a suppressor of EMT in human breast epithelial cells and shown that it suppresses EMT by repressing expression of TGFB1, a known key EMT inducer. My work has provided insight into the epigenetic regulation of gene expression during EMT.