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Minggang Fang


Assistant Professor
   
Ph.D.: 2008, University of British Columbia
Postdoctoral research: University of Massachusetts Medical School
   
Office: University of Massachusetts Medical School
364 Plantation Street, LRB-670-B
Worcester, MA 01605
Phone: 508-856-5335
Email: Minggang.Fang@umassmed.edu


Research

My research interests are focused on understanding epigenetic and transcriptional dysregulation in 13 human disease. Mis-regulated expression of a specific gene is the underlying cause of several monogenic rare genetic disorders. In some instances, the mis-regulated gene is transcriptionally repressed through a process called epigenetic silencing. In these cases, reactivation of the epigenetically silenced gene represents a potential therapeutic approach. As a first step toward developing therapeutics that can reactivate expression of an epigenetically silenced gene, I have developed experimental approaches to first identify the factors responsible for transcriptional repression, and then based upon this information, find small molecule inhibitors of these factors that can reactivate expression of the silenced gene. I have used this general approach to identify small molecule inhibitors that can reactivate specific genes whose silencing underlie neurodevelopmental diseases including Fragile X Syndrome and Friedreich ataxia.