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Phage DNA recombination systems have been instrumental in the development of bacterial genome engineering technologies over the last 20 years. My lab was the first to recognize that the phage lambda Red system, when expressed in E. coli, leads to high levels of gene replacement via electroporation of linear DNA substrates (J. Bacteriology (1998),180(8):2063-71), a process that later became known as “Recombineering”. My lab is focused on (1) the development of recombineering technologies for important pathogens, focused most recently on Mycobacterium tuberculosis and (2) the study of the molecular mechanisms of homologous recombination and DNA mismatch repair.

If interested in joining the lab, or for more information on opportunities to study bacterial pathogenesis or DNA repair, please contact me by email at kenan.murphy@umassmed.edu.