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Selected Publications

Peer-reviewed publications

1. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, & Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell 29: 739 (2020).

2. Bulow U, Govindan R, Munro JB. Acidic pH triggers lipid mixing mediated by Lassa virus GP. Viruses 12: 716 (2020).

3. Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathogens 16: e1008577 (2020).

4. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses 12: 1 (2020).

5. Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biology 18: e3000626 (2020).

6. Howard AR, & Munro JB. Developments in single-molecule and single-particle fluorescence-based approaches for studying viral envelope glycoproteins and membrane fusion. Advances in Virus Research 104: 124-146 (2019).

7. Brigham BS, Kitzrow JP, Reyes JPC, Musier-Forsyth, & Munro JB. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5’ UTR. 2019. Proceedings of the National Academy of Sciences of the USA 116: 10372-10381 (2019).

8. Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Delgado GGO, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, & Munro JB. An asymmetric opening of HIV-1 Env is required for anti-cluster A antibody binding. Cell Host & Microbe 25: 578-587 (2019).

9. Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature 568: 415-419 (2019).

10. Munro JB. HIV Env on lockdown. Cell Host & Microbe 23: 699-701 (2018).

11. Das DK, Govindan R, Nikic-Spiegel I, Krammer F, Lemke EA, & Munro JB. Direct visualization of the conformational dynamics of single hemagglutinin trimers. Cell 174: 926-937 (2018).

12. Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB*, & Mothes W*. HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. eLife 7: e34271 (2018). *corresponding authors

13. Munro JB*, & Lee KK*. Probing structural variation and dynamics in the HIV-1 Env fusion glycoprotein. Current HIV Research 16: 5-12 (2018). *corresponding authors

14. Herschhorn A, Ma X, Gu C, Castillo-Menendez L, Melillo B, Smith AB, Blanchard SC, Munro JB, Finzi A, Mothes W, Sodroski J. An Intermediate state of the HIV-1 envelope glycoproteins on the virus entry pathway. mBio 7: e01598 (2016).

15. Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O’Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GBE, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Crystal structure, conformational fixation, and receptor interactions of mature unliganded HIV-1 Env. Nature Structural and Molecular Biology 22: 522-531 (2015).

16. Munro JB*, & Mothes W*. Structure and dynamics of the native HIV-1 Env trimer. Journal of Virology 89: 5752-5755 (2015). *corresponding authors

17. Munro JB*, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Coulter JC, Smith AB, Kwong PD, Blanchard SC*, & Mothes W*. 2014. Conformational dynamics of single HIV-1 Env trimers on the surface of native virions. Science 346: 759-763 (2014). *corresponding authors

18. Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Acharya P, Ofek G, Stewart-Jones GBE, Stuckey J, Bailer RT, Chuang GY, Joyce MG, Yang Y, Zhang B, Louder MK, Mascola JR, Cohen MS, Morris L, Tumba N, Haynes BF, Huang J, Connors M, Munro JB, Blanchard SC, Mothes W, & Kwong PD. Structure and immune recognition of a mature HIV-1 Env trimer. Nature 514: 455-461 (2014).

19. Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Fang H, Floyd RW, Yang H, Xiong Y, Bewersdorf J, & Mothes W. 2014. TRIM15 is a focal adhesion protein required focal adhesion disassembly. Journal of Cell Science 127: 3928-3942 (2014).

20. Munro JB*, & Mothes W*. The HIV-1 Env trimer in HD. Structure 22: 935 (2014). *corresponding authors

21. Agosto LM, Zhong P, Munro JB, & Mothes W. Highly active anti-retroviral therapies are effective against the high multiplicity of infection observed during HIV-1 cell-to-cell transmission. PLoS Pathogens 10: e1003982 (2014).

22. Munro JB*, Nath A, Farber M, Datta SAK, Rein A, Rhoades E, & Mothes W*. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. Journal of Virology 88: 3577-3585 (2014). *corresponding authors

23. Zhong P, Agosto LM, Munro JB, & Mothes W. Cell-to-cell transmission of viruses. Current Opinion in Virology 1, 44-50 (2013).

24. Budkevich T, Giesebrech J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, & Spahn CMT. Structure and dynamics of the mammalian ribosomal pre-translocation complex. Molecular Cell 44: 214-224 (2011).

25. Fu J, Munro JB, Blanchard SC, & Frank J. Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proceedings of the National Academy of Sciences of the USA 108: 4817-4821 (2011).

26. Munro JB, Wasserman MW, Altman RB, Wang L, & Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation. Nature Structural & Molecular Biology 17: 1470-1477 (2010).

27. Geggier PE, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, & Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. Journal of Molecular Biology 399: 576-595 (2010).

28. Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, & Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome. The EMBO Journal

29: 709-714 (2010). 29. Munro JB, Altman RB, Tung CS, Cate JHD, Sanbonmatsu KY, & Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proceedings of the National Academy of Sciences of the USA 107: 709-714 (2010).

30. Munro JB, Sanbonmatsu KY, Spahn CMT, & Blanchard SC. Navigating the ribosome’s metastable free energy landscape. Trends in Biochemical Sciences 34: 390-400 (2009).

31. Dave R, Terry DS, Munro JB, & Blanchard SC. Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophysical Journal 96: 2371-2381 (2009).

32. Munro JB, Vaiana A, Sanbonmatsu KY, & Blanchard SC. A new view of protein synthesis: Mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers 89: 565-577 (2008).

33. Munro JB, Altman RB, O’Connor N, & Blanchard SC. Identification of two distinct hybrid state intermediates on the ribosome. Molecular Cell 25: 505-517 (2007).

34. Bleuit JS, Ma Y, Munro JB, & Morrical SW. Mutations in a conserved motif inhibit single-stranded DNA binding and recombination mediator activities of bacteriophage T4 UvsY protein. Journal of Biological Chemistry 279: 6077-6086 (2004).

Books & Chapters

1. Whitford PC, Altman RB, Geggier PE, Terry DS, Munro JB, Onuchic JN, Spahn CMT, Sanbonmatsu KY, & Blanchard SC. Dynamic views of ribosome function: energy landscapes and ensembles. In The Ribosome: Structure, Function, and Dynamics. Eds. Rodnina, M.V., Wintermeyer, W., & Green, R. Springer (2011).

2. Dave R, Altman RB, Terry DS, Munro JB, Geggier PE, Feldman MB, & Blanchard SC. Single-molecule studies of biomolecules. In Wiley Encyclopedia of Chemical Biology, Vol. 4. Ed. Begley, T. P. Wiley (2009).