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Total: displaying 10 out of 35 results

NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2

Saturday, January 08, 2022

Author(s): Heidi Erlandsen,Anne M Jecrois,Jeffry C Nichols,James L Cole,William E Royer

Source: FEBS letters
NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)

Monday, February 01, 2021

Author(s): Jeffry C Nichols,Celia A Schiffer,William E Royer

Source: The Journal of biological chemistry
Cryo-EM structure of CtBP2 confirms tetrameric architecture

Wednesday, December 02, 2020

Author(s): Anne M Jecrois,M Michael Dcona,Xiaoyan Deng,Dipankar Bandyopadhyay,Steven R Grossman,Celia A Schiffer,William E Royer

Source: Structure (London, England : 1993)
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures

Friday, March 06, 2020

Author(s): Gordon J Lockbaum,Florian Leidner,William E Royer,Nese Kurt Yilmaz,Celia A Schiffer

Source: Acta crystallographica. Section D, Structural biology
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

Wednesday, May 01, 2019

Author(s): M Michael Dcona,Priyadarshan K Damle,Francisco Zarate-Perez,Benjamin L Morris,Zaid Nawaz,Michael J Dennis,Xiaoyan Deng,Sudha Korwar,Sahib J Singh,Keith C Ellis,William E Royer,Dipankar Bandyopadhyay,C...

Source: Molecular pharmacology
Assembly of human C-terminal binding protein (CtBP) into tetramers

Saturday, April 28, 2018

Author(s): Andrew G Bellesis,Anne M Jecrois,Janelle A Hayes,Celia A Schiffer,William E Royer

Source: The Journal of biological chemistry
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Saturday, April 29, 2017

Author(s): Takahide Kouno,Tania V Silvas,Brendan J Hilbert,Shivender M D Shandilya,Markus F Bohn,Brian A Kelch,William E Royer,Mohan Somasundaran,Nese Kurt Yilmaz,Hiroshi Matsuo,Celia A Schiffer

Source: Nature communications
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP)

Monday, May 09, 2016

Author(s): Sudha Korwar,Benjamin L Morris,Hardik I Parikh,Robert A Coover,Tyler W Doughty,Ian M Love,Brendan J Hilbert,William E Royer,Glen E Kellogg,Steven R Grossman,Keith C Ellis

Source: Bioorganic & medicinal chemistry
Structure-guided design of a high affinity inhibitor to human CtBP

Saturday, January 31, 2015

Author(s): Brendan J Hilbert,Benjamin L Morris,Keith C Ellis,Janet L Paulsen,Celia A Schiffer,Steven R Grossman,William E Royer

Source: ACS chemical biology
Insight into the allosteric mechanism of Scapharca dimeric hemoglobin

Friday, October 31, 2014

Author(s): Jennifer M Laine,Miguel Amat,Brittany R Morgan,William E Royer,Francesca Massi

Source: Biochemistry
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

Tuesday, March 25, 2014

Author(s): Brendan J Hilbert,Steven R Grossman,Celia A Schiffer,William E Royer

Source: FEBS letters
Resolution of structural heterogeneity in dynamic crystallography

Thursday, May 23, 2013

Author(s): Zhong Ren,Peter W Y Chan,Keith Moffat,Emil F Pai,William E Royer,Vukica Šrajer,Xiaojing Yang

Source: Acta crystallographica. Section D, Biological crystallography
Tertiary and quaternary allostery in tetrameric hemoglobin from Scapharca inaequivalvis

Wednesday, March 06, 2013

Author(s): Luca Ronda,Stefano Bettati,Eric R Henry,Tara Kashav,Jeffrey M Sanders,William E Royer,Andrea Mozzarelli

Source: Biochemistry
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures

Friday, December 16, 2011

Author(s): Zhong Ren,Vukica Srajer,James E Knapp,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Friday, November 19, 2010

Author(s): Keith P Romano,Akbar Ali,William E Royer,Celia A Schiffer

Source: Proceedings of the National Academy of Sciences of the United States of America
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces

Tuesday, February 16, 2010

Author(s): Shivender M D Shandilya,Madhavi N L Nalam,Ellen A Nalivaika,Phillip J Gross,Johnathan C Valesano,Keisuke Shindo,Ming Li,Mary Munson,William E Royer,Elena Harjes,Takahide Kono,Hiroshi Matsuo,Reuben S H...

Source: Structure (London, England : 1993)
Structural insights into interferon regulatory factor activation

Saturday, January 02, 2010

Author(s): Weijun Chen,William E Royer

Source: Cellular signalling
Protein conformational dynamics of homodimeric hemoglobin revealed by combined time-resolved spectroscopic probes

Friday, November 20, 2009

Author(s): Jungkweon Choi,Srinivasan Muniyappan,John T Wallis,William E Royer,Hyotcherl Ihee

Source: Chemphyschem : a European journal of chemical physics and physical chemistry
Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis

Tuesday, November 17, 2009

Author(s): James E Knapp,Reinhard Pahl,Jordi Cohen,Jeffry C Nichols,Klaus Schulten,Quentin H Gibson,Vukica Srajer,William E Royer

Source: Structure (London, England : 1993)
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Tuesday, October 07, 2008

Author(s): Weijun Chen,Suvana S Lam,Hema Srinath,Zhaozhao Jiang,John J Correia,Celia A Schiffer,Katherine A Fitzgerald,Kai Lin,William E Royer

Source: Nature structural & molecular biology
Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3

Tuesday, April 29, 2008

Author(s): Weijun Chen,Hema Srinath,Suvana S Lam,Celia A Schiffer,William E Royer,Kai Lin

Source: Journal of molecular biology
Time-resolved x-ray crystallography of heme proteins

Friday, April 25, 2008

Author(s): Vukica Srajer,William E Royer

Source: Methods in enzymology
Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis

Friday, November 16, 2007

Author(s): Karin Nienhaus,James E Knapp,Pasquale Palladino,William E Royer,G Ulrich Nienhaus

Source: Biochemistry
Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling

Wednesday, February 07, 2007

Author(s): Weijun Chen,Suvana S Lam,Hema Srinath,Celia A Schiffer,William E Royer,Kai Lin

Source: The Journal of biological chemistry
An optical signal correlated with the allosteric transition in Scapharca inaequivalvis HbI

Thursday, December 21, 2006

Author(s): Jeffry C Nichols,William E Royer,Quentin H Gibson

Source: Biochemistry
Low resolution crystal structure of Arenicola erythrocruorin: influence of coiled coils on the architecture of a megadalton respiratory protein

Tuesday, November 07, 2006

Author(s): William E Royer,Michael N Omartian,James E Knapp

Source: Journal of molecular biology
Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex

Tuesday, July 18, 2006

Author(s): William E Royer,Hitesh Sharma,Kristen Strand,James E Knapp,Balaji Bhyravbhatla

Source: Structure (London, England : 1993)
Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin

Thursday, May 11, 2006

Author(s): James E Knapp,Reinhard Pahl,Vukica Srajer,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin

Thursday, November 03, 2005

Author(s): James E Knapp,Michele A Bonham,Quentin H Gibson,Jeffry C Nichols,William E Royer

Source: Biochemistry
Allosteric hemoglobin assembly: diversity and similarity

Saturday, June 04, 2005

Author(s): William E Royer,Hao Zhu,Thomas A Gorr,Jason F Flores,James E Knapp

Source: The Journal of biological chemistry
Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin

Wednesday, February 16, 2005

Author(s): Jason F Flores,Charles R Fisher,Susan L Carney,Brian N Green,John K Freytag,Stephen W Schaeffer,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Crystal structure of the hemoglobin dodecamer from Lumbricus erythrocruorin: allosteric core of giant annelid respiratory complexes

Wednesday, October 27, 2004

Author(s): Kristen Strand,James E Knapp,Balaji Bhyravbhatla,William E Royer

Source: Journal of molecular biology
Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments

Wednesday, March 24, 2004

Author(s): James E Knapp,Vukica Srajer,Reinhard Pahl,William E Royer

Source: Micron (Oxford, England : 1993)
Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis

Wednesday, November 05, 2003

Author(s): Eric J Bennett,Jens Bjerregaard,James E Knapp,David A Chavous,Alan M Friedman,William E Royer,Clare M O'Connor

Source: Biochemistry
Ligand-linked structural transitions in crystals of a cooperative dimeric hemoglobin

Wednesday, April 23, 2003

Author(s): James E Knapp,William E Royer

Source: Biochemistry

In the News

Latest BMB news as reported by the UMass Chan Communications Office

PhD student among first to join UMass Chan program focused on quantitative skills

December 09, 2024
UMass Chan community invited to ponder meaning of ‘advancing together’ at art exhibit

September 25, 2024
UMass Memorial Health gift, with matching funds from UMass Foundation, to fund five new endowed chairs at UMass Chan

September 19, 2024
Convocation 2024: UMass Chan racing toward ambitious future

September 13, 2024
Morningside Graduate School of Biomedical Sciences celebrates largest class at qualifying exam ceremony

September 12, 2024
UMass Chan kicks off 2024 academic year with weeklong Convocation celebration

August 30, 2024
UMass Chan neuroscientist receives $4.1 million Transformative Research Award to study Down syndrome

July 16, 2024
UMass Chan BRIDGE Fund commits $2M in six faculty projects

July 03, 2024
Morningside Graduate School of Biomedical Sciences celebrates milestones of IMSD, PREP students

June 18, 2024
Advancing gender equity, importance of mentoring highlighted at Women’s Faculty Awards

May 24, 2024
Twenty rising faculty members graduate from Junior Faculty Development Program

May 17, 2024
Celia A. Schiffer elected to National Academy of Sciences

May 03, 2024
Mary Munson, Craig Peterson named American Association for the Advancement of Science fellows

April 18, 2024
Zhiping Weng named inaugural chair of the Department of Genomics & Computational Biology

November 03, 2023
Celebrating collaboration, UMass Chan launches ‘Advancing Together’ brand

September 06, 2023
Kirschstein award to fund PhD candidate’s research on HTLV-1

August 16, 2023