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Publications

  1. Kingsley SF, Seo Y, Allen C, Ghanta KS, Finkel S, Tissenbaum HA. Bacterial processing of glucose modulates C. elegans lifespan and healthspan. Sci Rep. 2021 Mar 15;11(1):5931. doi: 10.1038/s41598-021-85046-3.
  2. Seo Y, Kingsley S, Walker G, Mondoux MA, Tissenbaum HA. Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans. Proc Natl Acad Sci USA. 2018 Mar 20; 10.1073/pnas.1714178115
  3. Tissenbaum, HA. DAF-16: FOXO in the Context of C. elegans. Curr Top Dev Biol. 2018. 10.1016/bs.ctdb.2017.11.007.
  4. Martell J, Seo Y, Bak DW, Kingsley SF, Tissenbaum HA, Weerapana E. Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. Cell Chemical Biology. 2016 Aug 18; 23(8):955-66. doi: 10.1016/j.chembiol.2016.06.015.
  5. Tissenbaum, HA. Using C. elegans for aging research. Invertebrate Reproduction and Development. 2015; 59. 10.1080/07924259.2014.940470.
  6. Bansal A, Zhu LJ, Yen K, Tissenbaum HA. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E277-86.
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  7. Bansal A, Kwon ES, Conte D, Liu H, Gilchrist MJ, MacNeil LT, Tissenbaum HA. Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan. Longev Healthspan. 2014; 3:5.
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  8. Viswanathan M, Tissenbaum HA. C. elegans sirtuins. Methods Mol Biol. 2013; 1077:39-56.
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  9. Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. Integration of ß-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J Neurosci. 2012 Sep 5; 32(36):12630-40.
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  10. Perrin AJ, Gunda M, Yu B, Yen K, Ito S, Forster S, Tissenbaum HA, Derry WB. Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death Differ. 2013 Jan; 20(1):97-107.
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  11. Tissenbaum HA. Genetics, life span, health span, and the aging process in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2012 May; 67(5):503-10.
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  12. Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA. PDP-1 links the TGF-ß and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet. 2011 Apr; 7(4):e1001377.
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  13. Yen K, Narasimhan SD, Tissenbaum HA. DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxid Redox Signal. 2011 Feb 15; 14(4):623-34.
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  14. Yen K, Le TT, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One. 2010; 5(9).
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  15. Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Dietary restriction: standing up for sirtuins. Science. 2010 Aug 27; 329(5995):1012-3; author reply 1013-4.
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  16. Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA. A new DAF-16 isoform regulates longevity. Nature. 2010 Jul 22; 466(7305):498-502.
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  17. Narasimhan SD, Mukhopadhyay A, Tissenbaum HA. InAKTivation of insulin/IGF-1 signaling by dephosphorylation. Cell Cycle. 2009 Dec; 8(23):3878-84.
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  18. Narasimhan SD, Yen K, Tissenbaum HA. Converging pathways in lifespan regulation. Curr Biol. 2009 Aug 11; 19(15):R657-66.
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  19. Padmanabhan S, Mukhopadhyay A, Narasimhan SD, Tesz G, Czech MP, Tissenbaum HA. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell. 2009 Mar 6; 136(5):939-51.
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  20. Barber LJ, Youds JL, Ward JD, McIlwraith MJ, O'Neil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB, Auclair M, Tissenbaum H, West SC, Rose AM, Boulton SJ. RTEL1 maintains genomic stability by suppressing homologous recombination. Cell. 2008 Oct 17; 135(2):261-71.
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  21. Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA. Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat Protoc. 2008; 3(4):698-709.
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  22. Mukhopadhyay A, Pan X, Lambright DG, Tissenbaum HA. An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep. 2007 Oct; 8(10):931-8.
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  23. Mukhopadhyay A, Tissenbaum HA. Reproduction and longevity: secrets revealed by C. elegans. Trends Cell Biol. 2007 Feb; 17(2):65-71.
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  24. Tissenbaum HA. Serotonin's SOS signal. Cell Metab. 2006 Dec; 4(6):415-7.
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  25. Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev. 2006 Sep; 127(9):741-7.
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  26. Mukhopadhyay A, Oh SW, Tissenbaum HA. Worming pathways to and from DAF-16/FOXO. Exp Gerontol. 2006 Oct; 41(10):928-34.
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  27. Deplancke B, Mukhopadhyay A, Ao W, Elewa AM, Grove CA, Martinez NJ, Sequerra R, Doucette-Stamm L, Reece-Hoyes JS, Hope IA, Tissenbaum HA, Mango SE, Walhout AJ. A gene-centered C. elegans protein-DNA interaction network. Cell. 2006 Jun 16; 125(6):1193-205.
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  28. Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet. 2006 Feb; 38(2):251-7.
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  29. Wang Y, Tissenbaum HA. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev. 2006 Jan; 127(1):48-56.
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  30. Grabowski MM, Svrzikapa N, Tissenbaum HA. Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans. Mech Ageing Dev. 2005 Dec; 126(12):1314-21.
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  31. Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA. C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metab. 2005 Jul; 2(1):35-42.
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  32. Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4494-9.
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  33. Tissenbaum HA, Guarente L. Model organisms as a guide to mammalian aging. Dev Cell. 2002 Jan; 2(1):9-19.
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  34. McVey M, Kaeberlein M, Tissenbaum HA, Guarente L. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics. 2001 Apr; 157(4):1531-42.
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  35. Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001 Mar 8; 410(6825):227-30.
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  36. Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000 Jan 4; 97(1):460-5.
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  37. Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 1998 Feb; 148(2):703-17.
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  38. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997 Oct 30; 389(6654):994-9.
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  39. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997 Aug 15; 277(5328):942-6.
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  40. Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996 Aug 8; 382(6591):536-9.
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  41. Tissenbaum HA, Parry DJ. The effect of partial denervation of tibialis anterior (TA) muscle on the number and sizes of motorneurons in TA motornucleus of normal and dystrophic (C57BL dy2j/dy2j) mice. Can J Physiol Pharmacol. 1991 Nov; 69(11):1769-73.
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