Shaw Lab Research
The Shaw lab is interested in understanding how growth factor receptor signaling pathways drive breast cancer progression. We study how receptor regulation and function are altered in tumor cells to overcome normal controls and checkpoints to facilitate metastasis. We have had a longstanding interest in the insulin (IR) and IGF-1 receptors (IGF-1R) and their mechanisms of action. IR/IGF-1R signaling is associated with poor outcomes in breast cancer, in particular in the context of obesity and other hyperinsulinemic conditions when the activity of these receptors is upregulated. Ongoing projects in the lab focus on understanding differential signaling of the IR and IGF-1R and the unique roles of the Insulin Receptor Substrate (IRS) adaptor proteins which link the IR/IGF-1R to intracellular signals and determine functional cellular outcomes. We are also studying how Beclin 1 regulates endosomal trafficking to control the expression and signaling of the IR/IGF-1R and other growth regulatory receptors. The goal of our work is to elaborate novel approaches for improved therapy and breast cancer outcomes.
Shaw Lab News
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May 2023 |
Dr. Shaw was awarded the Dean's Award for Outstanding Faculty Contributions to Graduate Education at the Education Recognition Awards and Last Lecture held on May 3, 2023. CONGRATULATIONS!!!! |
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March 2023 |
Leslie, Ji-Sun, Claire, and Michael attended the "IGF and Insulin Systems in Physiology and Disease" Gordon Conference in California. Ji-Sun gave a great talk, and Claire, Michael, and Ji-Sun presented posters. |
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January 2023 |
Welcome to our new Postdoctoral Fellow, Quyen Thu Bui |
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December 2022 |
Congratulations to Jose Mercado-Matos MD,PhD on his match for a Heme-Onc/Clinical-Med Oncology Fellowship at NCI! |
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December 2022 |
Shaw lab publishes in Cell Reports "The Insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC." |
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November 2022 |
Shaw lab publishes a review in Life "The Insulin-like Growth Factor Signaling Pathway in Breast Cancer:An Elusive Therapeutic Target" |
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July 2022 |
Welcome Jeannie Karwowski to the Shaw Lab as a Research Volunteer! |
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April 2022 |
Welcome Minjeong Jo to the Shaw Lab as a new Research Associate! |
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September 2021 |
Welcome MD/PhD GS1 student Claire Tocheny to the Shaw Lab. |
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June 2021 |
Welcome summer student Caroline Moore to the Shaw Lab. |
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May 2021 |
Shaw lab publishes review in J. Mol. Endocrinology: “Diversity of insulin and IGF signaling in breast cancer: Implications for therapy” |
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April 2021 |
Congratulations to James on his acceptance into the University of Colorado, Boulder Biochemistry PhD program! |
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March 2021 |
Congratulations to Michael for passing his Qualifying Exam! |
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January 2021 |
Congratulations to Maira on her acceptance into the Brandeis University MCB PhD program! |