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Craig Mello, PhD

Professor, RNA Therapeutics Institute, Investigator, Howard Hughes Medical Institute, and Blais Chair of Molecular Medicine

Research Focus - Mechanisms of Small-RNA-directed Search Pathways

  • Investigation of the mechanism of RNA interference
  • Investigation of how embryonic cells differentiate and communicate during development

Representative Publications

  • 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-Pérez JA, Sontheimer EJ, Watts JK, Mello CC.Elife. 2021 Oct 19;10:e72216. doi: 10.7554/eLife.72216.PMID: 34665130 Read Publication

In the News

  • Biomedical sciences student works toward a future in genetic engineering
    Education News, Media

    Biomedical sciences student works toward a future in genetic engineering

    PhD student Katya Makeyeva investigates how small RNA pathways regulate gene expression of reproductive cells in the lab of Nobel Laureate Craig Mello, PhD.

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  • Atalanta Therapeutics founded by UMass Medical School and three faculty members
    Research News

    Atalanta Therapeutics founded by UMass Medical School and three faculty members

    Atalanta Therapeutics, a biotech founded by UMass Medical School and three faculty research scientists to pioneer treatment options for neurodegenerative diseases, has launched with financing by venture capital fund F-Prime Capital and strategic collaborations with Biogen and Genentech.

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  • Inside the new mRNA vaccines for COVID-19
    Research News

    Inside the new mRNA vaccines for COVID-19

    The new vaccines by Pfizer/BioNTech and Moderna use messenger RNA to stimulate the immune system to protect against COVID-19. These vaccines are the first of their kind and researchers at UMass Medical School are among the leading RNA biologists in the world.

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  • Biomedical sciences student studying fertility in Mello lab
    Education News, Media

    Biomedical sciences student studying fertility in Mello lab

    Movies piqued PhD candidate Humberto Ochoa’s interest in science. He’s conducting RNA research in the lab of Nobel Laureate Craig C. Mello, PhD, to understand the national decline in fertility.

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