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Michael Purcaro, MD PhD

Michael Purcaro, MD PhD - UMMS Radiology Resident

  Michael Purcaro, MD PhD

Internship: University Of Massachusetts Chan, Internal Medicine
 
Medical School: University Of Massachusetts Chan Medical School, MD/PhD
 

Post-Baccalaureate: Harvard Extension School, Diploma in Pre-Medical Studies

Graduate School: Worcester Polytechnic Institute, MS, Computer Science

Undergraduate College: Yale University, BA, Computer Science
 
Hometown: Watertown, CT
 
Clinical Interests: Neuroimaging, research applications of machine learning, bioinformatics
 
Personal Interests: High-performance computing, 3d printing, electronics, engineering, woodworking, machining, travel
 

Publications:

The ENCODE Project Consortium, Moore J, Purcaro M, Pratt H, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, Kaul R, Halow J, Nostrand EL, Freese P, Gorkin DU, Shen Y, He Y, Mackiewicz M, Pauli-Behn F, Williams BA, Keller CA, Zhang X, Huey J, Dickel DE, Snetkova V, Wei X, Wang X, Rivera-Mulia JC, Rozowsky J, Zhang J, Chhetri SB, Zhang J, Victorsen A, White KP, Visel A, Yeo GW, Burge CB, Lécuyer E, Gilbert DM, Dekker J, Rinn J, Mendenhall EM, Ecker JR, Kellis M, Klein RJ, Noble WS, Kundaje A, Guigó R, Farnham PJ, Cherry JM*, Myers RM*, Ren B*, Graveley BR*, Gerstein MB*, Pennacchio LA*, Snyder MP*, Bernstein BE*, Wold B*, Hardison RC*, Gingeras TR*, Stamatoyannopoulos JA*, Weng Z*. (2020) Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. PMID: 32728249. (Authors contributed equally, *Co-corresponding)

Moore J, Pratt H, Purcaro M, Weng Z. (2020) A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods. Genome Biology. PMCID: PMC6977301

Fu S, Wang Q, Moore J, Purcaro M, Pratt H, Fan K, Gu C, Jiang C, Zhu R, Kundaje A, Lu A, Weng Z. (2018) Differential Analysis of Chromatin Accessibility and Histone Modifications for Predicting Mouse Developmental Enhancers. Nucleic Acids Research 46(21): 11184-11201. PMCID: PMC6265487

Borrman T, Cimons J, Cosiano M, Purcaro M, Pierce B, Baker B, Weng Z. (2017) ATLAS: a database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes. Proteins 85(5): 908-916. PMCID: PMC5860664

Akbarian, S., et al. (2015). The PsychENCODE project. Nature Neuroscience.18(12): 1707-1712. PMCID: PMC4675669

Kim JS, Greene MJ, Zlateski A, Lee K, Richardson M, Turaga SC, Purcaro M, Balkam M, Robinson A, Behabadi BF, Campos M, Denk W, Seung HS & the EyeWirers. (2014) Space–time wiring specificity supports direction selectivity in the retina. Nature, 509(7500), 331-336. PMCID: PMC4074887

Mishra A, Ellens D, Schridde U, Motelow J, Purcaro M, DeSalvo M, Enev M, Sanganahalli B, Hyder F, Blumenfeld H (2011) Where fMRI and electrophysiology agree to disagree: corticothalamic and striatal activity patterns in the WAG/Rij rat. Journal of Neuroscience. 31(42), 15053-15064. PMCID: PMC3432284

Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro M, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MCF, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. (2010) Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain, 133(12), 3764-3777. PMCID: PMC2995886

Berman R, Negishi M, Vestal M, Spann M, Chung M, Bai X, Purcaro M, Motelow JE, Danielson N, Dix-Cooper L, Enev M, Novotny EJ, Constable RT, Blumenfeld H. (2010). Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures. Epilepsia, 51(10), 2011-2022. PMCID: PMC2953613

Yang L, Morland T, Schmits K, Rawson E, Narasimhan P, Motelow J, Purcaro M, Peng K; Raouf R, DeSalvo M, Oh T, Wilkerson J, Bod J, Srinivasan J, Kurashvili P, Anaya J, ManzaP, Danielson N, Ransom C, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Fattahi P, Astur R, Xiao B, Duckrow R, Blumenfeld H.; (2010) A Prospective Study of Loss of Consciousness in Epilepsy Using Virtual Reality Driving Simulation and Other Video Games. Epilepsy Behav, 18(3), 238-246. PMCID: PMC2914099

Varghese G, Purcaro M, Motelow J, Enev M, McNally K, Levin A, Hirsch L, Tikofsky R, Paige A, Zubal I, Spencer S, Blumenfeld H. (2009). Clinical use of ictal SPECT in secondarily generalized tonic-clonic seizures. Brain, 132(Pt 8), 2102-2113. PMCID: PMC2714057

DeSalvo M, Schridde U, Mishra A, Motelow J, Purcaro M, Danielson N , Hyder F, Blumenfeld H., (2010) Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat. NeuroImage 50(3), 902-909. PMCID: PMC2830359

Purcaro M, Blumenfeld H (2008) SPECT in epilepsy research. In: Philip A. Schwartzkroin, editors Encyclopedia of Basic Epilepsy Research, Vol 2. Oxford: Academic Press; 2009. p. 558-564.

Chahboune H, Mishra AM, Desalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. (2009). DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. Neuroimage. 47(2), 459-466. PMCID: PMC2712639

Blumenfeld H, Varghese G, Purcaro M, Motelow J, Enev M, McNally K, Levin A, Hirsch L, Tikofsky R, Zubal I, Paige A, Spencer S. (2009). Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures. Brain, 132(Pt 4), 999-1012. PMCID: PMC2724910

Awards:

  • UMMS MD/PhD MSTP (Medical Scientist Training Program) Grant (2018 – 2019)
  • NIH Cloud Credits Model Pilot Grant (2017-2018)
  • UMASS: Fuller Foundation Scholarship (2014-2015)
  • Harvard University Certificate of Distinction in Teaching (Spring 2010)
  • Yale Club of Northwestern Connecticut Scholarship (2002 – 2004)
  • Admiral Paul E. Phil (Class of 1920) Scholarship (2002 – 2004)

Presentations (selected):

  • Purcaro M*, Pratt H*, Moore J, Weng Z. ENCODE Encyclopedia: Featuring a Registry of Candidate Regulatory Elements and the Visualization Tool SCREEN for Searching Them: Kent Lab, UC Santa Cruz (February 2018, Santa Cruz, California)
  • Moore J*, Purcaro M*, Pratt H, Weng Z. ASHG Interactive Workshop: Navigating the ENCODE Encyclopedia: Exploring candidate regulatory elements, linked genes, and genetic variation with SCREEN: American Society of Human Genetics (October 2017, Orlando, Florida)
  • Moore J*, Purcaro M*, Pratt H, Weng Z. Visualizing Elements of the ENCODE Encyclopedia. ENCODE Consortium Meeting (June 2016, La Jolla, California)
  • Purcaro M, Pratt H, Moore J, Weng Z. ENCODE Encyclopedia and Factorbook: First International Epigenomics Conference, Fudan University (October 2015, Shanghai, China)
  • Purcaro M, Moore J, Pratt H, Weng Z. ENCODE Encyclopedia and Factorbook: ENCODE 2015: Research Applications and Users Meeting 2015 (June 2015, Potomac, Maryland)