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Publications

Total: 1004 results
  • International Controlled Study of Revascularization and Outcomes Following COVID-Positive Mechanical Thrombectomy

    julio 12, 2022
    Author(s): Adam A. Dmytriw, Anna L. Kuhn, Ajit S. Puri, Pascal Jabbour
    Source: European journal of neurology; This article is protected by copyright. All rights reserved. Accepted manuscript posted after 12 months as allowed by the publisher's self-archiving policy at https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This arti...
    BACKGROUND: Previous studies suggest that the mechanisms and outcomes in COVID-19-associated stroke differ from those with non-COVID-19 strokes, but there is limited comparative evidence focusing on these populations. Therefore, we aimed to determine if a significant association exists between COVID-19 status with revascularization and functional outcomes following thrombectomy for large vessel occlusion (LVO), after adjustm...
  • Super large-bore ingestion of clot (SLIC) leads to high first pass effect in thrombectomy for large vessel occlusion

    junio 22, 2022
    Author(s): Francesco Massari, Guilherme Dabus, Gustavo M. Cortez, Jasmeet Singh, Anna L. Kuhn, Varun Naragum, Vania Anagnostakou, Ricardo A. Hanel, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Super large-bore aspiration (SLBA) has shown high rates of complete clot ingestion. OBJECTIVE: To report the initial clinical feasibility, safety, and efficacy of this novel SLBA insert combination-super large-bore ingestion of clot (SLIC) technique for stroke. METHODS: We performed a retrospective review of three comprehensive stroke center databases. The SLIC technique entails a triaxial assembly of an 8 Fr 0.1...
  • Interventional oncology update

    junio 20, 2022
    Author(s): Alex Newbury, Chantal M. Ferguson, Daniel Alvarez Valero, Roberto Kutcher-Diaz, Lacey J. McIntosh, Ara Karamanian, Aaron Harman
    Source: European journal of radiology open; Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Interventional Oncology (IO) is a subspecialty field of Interventional Radiology bridging between diagnostic radiology and the clinical oncology team, addressing the diagnosis and treatment of cancer. There have been many exciting advancements in the field of IO in recent years; far too many to cover in a single paper. To give each topic sufficient attention, we have limited the scope of this review article to four topics wh...
  • Clinical Diagnoses and Outcomes After Diagnostic Breast Ultrasound by Nurses and General Practitioner Physicians in Rural Rwanda

    junio 20, 2022
    Author(s): Lydia E. Pace, Jean-Marie Vianney Dusengimana, Vedaste Hategekimana, Vestine Rugema, Aline Umwizerwa, Elisabeth Frost, Dylan Kwait, Lauren E. Schleimer, ChuanChin Huang, Cyprien Shyirambere, Jean Bosco Bigirimana, Lawrence N. Shulman, Tharcisse Mpunga, Sughra Raza
    Source: Journal of the American College of Radiology
    PURPOSE: To scale up early detection of breast cancer in low- and middle-income countries, research is needed to inform the role of diagnostic breast ultrasound performed by nonradiologists in resource-constrained settings. The authors examined 2-year clinical follow-up and outcomes among women who underwent diagnostic breast ultrasound performed by nonradiologist clinicians participating in a breast ultrasound training and ...
  • Imaging response assessment for oncology: An algorithmic approach

    junio 07, 2022
    Author(s): Kathleen Ruchalski, Rohit Dewan, Victor Sai, Lacey J. McIntosh, Marta Braschi-Amirfarzan
    Source: European journal of radiology open; © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Treatment response assessment by imaging plays a vital role in evaluating changes in solid tumors during oncology therapeutic clinical trials. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 is the reference standard imaging response criteria and provides details regarding image acquisition, image interpretation and categorical response classification. While RECIST 1.1 is applied for the majority of clinical trials...
  • Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study

    mayo 20, 2022
    Author(s): Oana Madalina Mereuta, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Platelets and von Willebrand factor (vWF) are key components of acute ischemic stroke (AIS) emboli. We aimed to investigate the CD42b (platelets)/vWF expression, its association with stroke etiology and the impact these components may have on the clinical/procedural parameters. METHODS: CD42b/vWF immunostaining was performed on 288 emboli collected as part of the multicenter STRIP Registry. CD42b/VWF expression a...
  • Dual gating myocardial perfusion SPECT denoising using a conditional generative adversarial network

    mayo 08, 2022
    Author(s): Jingzhang Sun, Qi Zhang, Yu Du, Duo Zhang, P. Hendrik Pretorius, Michael A. King, Greta S. P. Mok
    Source: Medical physics
    PURPOSE: Dual respiratory-cardiac gating reduces respiratory and cardiac motion blur in myocardial perfusion single-photon emission computed tomography (MP-SPECT). However, image noise is increased as detected counts are reduced in each dual gate (DG). We aim to develop a denoising method for dual gating MP-SPECT images using a 3D conditional generative adversarial network (cGAN). METHODS: Twenty extended cardiac-torso phant...
  • Intravascular lithotripsy for severely calcified carotid artery stenosis - A new frontier in carotid artery stenting

    mayo 03, 2022
    Author(s): Jasmeet Singh, Anna L. Kuhn, Francesco Massari, Marwa Elnazeir, Roberto Kutcher-Diaz, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Carotid stenosis due to severely calcified plaque can pose a significant therapeutic challenge. Extremely calcified scars/stenosis plaques can be challenging from an endovascular treatment perspective as severely calcified lesions are prone to technical failure, stent re-coil and restenosis. Intravascular lithotripsy, approved for treatment of severely calcified coronary lesions, can be used for breaking up the calcium build...
  • Retreatment of Residual and Recurrent Aneurysms After Embolization With the Woven EndoBridge Device: Multicenter Case Series

    mayo 01, 2022
    Author(s): Visish M. Srinivasan, Ajit S. Puri, Francesco Massari, Peter Kan
    Source: Neurosurgery
    BACKGROUND: The Woven EndoBridge (WEB) device (Terumno Corp. [parent company of Microvention]) was approved by the U.S. Food and Drug Administration as the first intrasaccular device for intracranial aneurysm treatment in December 2018. Its use has become more common since then, but both trial results and postmarket experiences have raised questions about the efficacy in achieving complete aneurysm obliteration. Retreatment ...
  • Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device

    abril 28, 2022
    Author(s): Nimer Adeeb, Anna L. Kuhn, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: The Woven EndoBridge (WEB) device has Food and Drug Administration approval for treatment of wide-necked intracranial bifurcation aneurysms. The WEB device has been shown to result in adequate occlusion in bifurcation aneurysms overall, but its usefulness in the individual bifurcation locations has been evaluated separately only in few case series, which were limited by small sample sizes. OBJECTIVE: To compare a...
  • Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT

    abril 26, 2022
    Author(s): Xiongchao Chen, P. Hendrik Pretorius, Bo Zhou, Hui Liu, Karen L. Johnson, Yi-Hwa Liu, Michael A. King, Chi Liu
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    It has been proved feasible to generate attenuation maps (mu-maps) from cardiac SPECT using deep learning. However, this assumed that the training and testing datasets were acquired using the same scanner, tracer, and protocol. We investigated a robust generation of CT-derived mu-maps from cardiac SPECT acquired by different scanners, tracers, and protocols from the training data. We first pre-trained a network using 120 stu...
  • Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge (WEB)

    abril 19, 2022
    Author(s): Nimer Adeeb, Anna L. Kuhn, Ajit S. Puri
    Source: Radiology
    Background The Woven EndoBridge (WEB) device was explicitly designed for wide-neck intracranial bifurcation aneurysms. Small-scale reports have evaluated the off-label use of WEB devices for the treatment of sidewall aneurysms, with promising outcomes. Purpose To compare the angiographic and clinical outcomes of the WEB device for the treatment of sidewall aneurysms compared with the treatment of bifurcation aneurysms. Mater...
  • Peer learning in emergency radiology: effects on learning, error identification, and radiologist experience

    abril 07, 2022
    Author(s): Eric Schmidt, Hao S. Lo, Amina Saghir
    Source: Emergency radiology
    PURPOSE: We established and evaluated a peer learning program in an emergency radiology (ER) division. Peer learning is an alternative to peer review focusing on non-punitive error reporting to mitigate consequences of inevitable human error. The central component is the peer learning conference, where cases are presented, key teaching points are discussed, and process improvement ideas are solicited. METHODS: We established...
  • Acute ischaemic stroke associated with SARS-CoV-2 infection in North America

    abril 01, 2022
    Author(s): Adam A. Dmytriw, Anna L. Kuhn, Ajit S. Puri
    Source: Journal of neurology, neurosurgery, and psychiatry
    BACKGROUND: To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome. METHODS: Multicentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at di...
  • Detection of Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction Using Quantitative Chest CT

    abril 01, 2022
    Author(s): Hiroto Hatabu, Maria Barile
    Source: JACC. Cardiovascular imaging
    Comment on: Jain CC, Tschirren J, Reddy YNV, Melenovsky V, Redfield M, Borlaug BA. Subclinical Pulmonary Congestion and Abnormal Hemodynamics in Heart Failure With Preserved Ejection Fraction. JACC Cardiovasc Imaging. 2022 Apr;15(4):629-637. doi: 10.1016/j.jcmg.2021.09.017. Epub 2021 Nov 17. PMID: 34801461; PMCID: PMC8995316.
  • Downstream Mammary and Extramammary Cascade Services and Spending Following Screening Breast Magnetic Resonance Imaging vs Mammography Among Commercially Insured Women

    abril 01, 2022
    Author(s): Ishani Ganguli, Nancy l. Keating, Nitya Thakore, Joyce Lii, Sughra Raza, Lydia E. Pace
    Source: JAMA Network Open; Copyright 2022 Ganguli I et al. JAMA Network Open. This is an open access article distributed under the terms of the CC-BY License.
    Importance: Increasing use of screening breast magnetic resonance imaging (MRI), including among women at low or average risk of breast cancer, raises concerns about resulting mammary and extramammary cascades (downstream services and new diagnoses) of uncertain value. Objective: To estimate rates of cascade events (ie, laboratory tests, imaging tests, procedures, visits, hospitalizations, and new diagnoses) and associated s...
  • Traumatic Intracranial Hemorrhage on CT After Ground-Level Fall in Adult Patients on Antithrombotic Therapy: A Retrospective Case-Control Study

    marzo 23, 2022
    Author(s): Zeynep Vardar, Hao S. Lo, Matthew Mariyampillai, Hemang M. Kotecha
    Source: AJR. American journal of roentgenology
    Background: Antithrombotic medications may increase risk and severity of traumatic intracranial hemorrhage (tICH) after minor head trauma. Objective: To determine the frequency, distribution, and clinical course of tICH in patients on antithrombotic therapy who present with good neurological status after ground-level fall. Methods: This retrospective study included 1630 patients (mean age 80+/-12 years; 693 female, 937 male)...
  • Novel Oxygen Carrier Slows Infarct Growth in Large Vessel Occlusion Dog Model Based on Magnetic Resonance Imaging Analysis

    marzo 21, 2022
    Author(s): Mohammed S. Shazeeb, Robert M. King, Vania Anagnostakou, Zeynep Vardar, Afif M. Kraitem, Josephine Kolstad, Christopher M. Raskett, Natacha Le Moan, Jonathan A. Winger, Lauren Kelly, Ana Krtolica, Nils Henninger, Matthew J. Gounis
    Source: Stroke
    BACKGROUND: Tissue hypoxia plays a critical role in the events leading to cell death in ischemic stroke. Despite promising results in preclinical and small clinical pilot studies, inhaled oxygen supplementation has not translated to improved outcomes in large clinical trials. Moreover, clinical observations suggest that indiscriminate oxygen supplementation can adversely affect outcome, highlighting the need to develop novel...
  • Interacting-heads motif explains the X-ray diffraction pattern of relaxed vertebrate skeletal muscle

    marzo 19, 2022
    Author(s): Natalia A. Koubassova, Andrey K. Tsaturyan, Sergey Y. Bershitsky, Michael A. Ferenczi, Raul A. Padron, Roger W. Craig
    Source: Biophysical journal
    Electron microscopy (EM) shows that myosin heads in thick filaments isolated from striated muscles interact with each other and with the myosin tail under relaxing conditions. This "interacting-heads motif" (IHM) is highly conserved across the animal kingdom and is thought to be the basis of the super-relaxed state. However, a recent X-ray modeling study concludes, contrary to expectation, that the IHM is not present in rela...
  • Teaching cancer imaging in the era of precision medicine: Looking at the big picture

    marzo 15, 2022
    Author(s): Christopher N. Chin, Ty Subhawong, James Grosso, Jeremy R. Wortman, Lacey J. McIntosh, Ryan Tai, Marta Braschi-Amirfarzan, Patricia Castillo, Francesco Alessandrino
    Source: European journal of radiology open; © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    The role of imaging in cancer diagnosis and treatment has evolved at the same rapid pace as cancer management. Over the last twenty years, with the advancement of technology, oncology has become a multidisciplinary field that allows for researchers and clinicians not only to create individualized treatment options for cancer patients, but also to evaluate patients' response to therapy with increasing precision. Familiarity w...
  • Prospective study on embolization of intracranial aneurysms with the pipeline device (PREMIER study): 3-year results with the application of a flow diverter specific occlusion classification

    marzo 15, 2022
    Author(s): Ricardo A. Hanel, Ajit S. Puri
    Source: Journal of neurointerventional surgery; © Author(s) (or their employer(s)) 2022. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is giv...
    BACKGROUND: The pipeline embolization device (PED; Medtronic) has presented as a safe and efficacious treatment for small- and medium-sized intracranial aneurysms. Independently adjudicated long-term results of the device in treating these lesions are still indeterminate. We present 3-year results, with additional application of a flow diverter specific occlusion scale. METHODS: PREMIER (prospective study on embolization of ...
  • Characteristics of a COVID-19 Cohort With Large Vessel Occlusion: A Multicenter International Study

    marzo 07, 2022
    Author(s): Pascal Jabbour, Anna L. Kuhn, Ajit S. Puri
    Source: Neurosurgery
    BACKGROUND: The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke. OBJECTIVE: To describe the efficacy and outcomes of acute revascularization of large vessel occlusion (LVO) in the setting of COVID-19 in an international cohort. METHODS: We conducted an international multicenter retrospective study of consecutively admitted patients with COVID-19 with co...
  • Flow Diverter Reconstruction of Internal Carotid Artery (Loop) Dissections with or without Associated Pseudoaneurysms

    febrero 22, 2022
    Author(s): Anna L. Kuhn, Jasmeet Singh, Francesco Massari, Katyucia de Macedo Rodrigues, Matthew J. Gounis, Ajit S. Puri
    Source: World neurosurgery
    OBJECTIVE: Endovascular treatment of cervical internal carotid artery (ICA) loop dissections in acute stroke interventions can be challenging. Flow diverters can effectively reconstruct vessel loops and treat the injured vessel and provide a safe conduit for intracranial catheterization. METHODS: We retrospectively reviewed our neurointerventional database and identified all patients with ICA loop dissections treated with fl...
  • Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker

    febrero 17, 2022
    Author(s): Pin-Tsun Justin Lee, Zachary C. Kennedy, Yuzhen Wang, Yimeng Lu, Carolina Cefaliello, Ozgun Uyan, Chun-Qing Song, Bruno M. D. C. Godinho, Zuoshang Xu, Mary Rusckowski, Wen Xue, Robert H. Brown Jr.
    Source: Annals of neurology; © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
    OBJECTIVE: The objective of this study is to develop a novel method for monitoring the integrity of motor neurons in vivo by quantifying net retrograde axonal transport. METHODS: The method uses single photon emission computed tomography to quantify retrograde transport to spinal cord of tetanus toxin fragment C ((125) I-TTC) following intramuscular injection. We characterized the transport profiles in 3 transgenic mouse mod...
  • Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use

    febrero 17, 2022
    Author(s): Waleed Brinjikji, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    BACKGROUND AND PURPOSE: Given recent evidence suggesting the clot composition may be associated with revascularization outcomes and stroke etiology, clot composition research has been a topic of growing interest. It is currently unclear what effect, if any, pre-thrombectomy thrombolysis has on clot composition. Understanding this association is important as it is a potential confounding variable in clot composition research....
  • Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use

    febrero 15, 2022
    Author(s): Aladdin Taha, Matthew J. Gounis, Heleen M. M. van Beusekom
    Source: Stroke
    Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been rec...
  • Value of BI-RADS 3 Audits

    febrero 14, 2022
    Author(s): Prithwijit Roychowdhury, Gopal Vijayaraghavan, John G. Roubil, Imani M. Williams, Efaza Siddiqui, Srinivasan Vedantham
    Source: Biomedical journal of scientific and technical research; Copyright @ Srinivasan Vedantham. This work is licensed under Creative Commons Attribution 4.0 License.
    Objectives: BI-RADS 3 is an established assessment category in which the probability of malignancy is equal to or less than 2%. However, monitoring adherence to imaging criteria can be challenging and there are few established benchmarks for auditing BI-RADS 3 assignments. In this study, we explore some parameters that could serve as useful tools for quality control and clinical practice management. Materials and Methods: Th...
  • AAV gene therapy for Tay-Sachs disease

    febrero 10, 2022
    Author(s): Terence R. Flotte, Oguz Cataltepe, Ajit S. Puri, Ana Rita Batista, Richard P. Moser, Diane McKenna-Yasek, Catherine Douthwright, Gwladys Gernoux, Meghan Blackwood, Christian Mueller, Phillip W. L. Tai, Scot T. Bateman, Spiro G. Spanakis, Julia Parzych, Allison M. Keeler, Aly Abayazeed, Saurabh Rohatgi, Laura L. Gibson, Robert W. Finberg, Bruce A. Barton, Zeynep Vardar, Mohammed S. Shazeeb, Matthew J. Gounis, Robert H. Brown Jr...
    Source: Nature medicine
    Tay-Sachs disease (TSD) is an inherited neurological disorder caused by deficiency of hexosaminidase A (HexA). Here, we describe an adeno-associated virus (AAV) gene therapy expanded-access trial in two patients with infantile TSD (IND 18225) with safety as the primary endpoint and no secondary endpoints. Patient TSD-001 was treated at 30 months with an equimolar mix of AAVrh8-HEXA and AAVrh8-HEXB administered intrathecally ...
  • Transradial versus transfemoral access for embolization of intracranial aneurysms with the Woven EndoBridge device: a propensity score-matched study

    febrero 04, 2022
    Author(s): Mahmoud Dibas, Anna L. Kuhn, Ajit S. Puri, Adam A. Dmytriw
    Source: Journal of neurosurgery
    OBJECTIVE: Transradial access (TRA) is commonly utilized in neurointerventional procedures. This study compared the technical and clinical outcomes of the use of TRA versus those of transfemoral access (TFA) for intracranial aneurysm embolization with the Woven EndoBridge (WEB) device. METHODS: This is a secondary analysis of the Worldwide WEB Consortium, which comprises multicenter data related to adult patients with intrac...
  • Transvascular in vivo microscopy of the subarachnoid space

    febrero 03, 2022
    Author(s): Vania Anagnostakou, Mark Epshtein, Giovanni J. Ughi, Robert M. King, Antonios Valavanis, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: The micro-architectonics of the subarachnoid space (SAS) remain partially understood and largely ignored, likely the result of the inability to image these structures in vivo. We explored transvascular imaging with high-frequency optical coherence tomography (HF-OCT) to interrogate the SAS. METHODS: In vivo HF-OCT was performed in 10 dogs in both the posterior and anterior cerebral circulations. The conduit vesse...
  • About artificial intelligence...

    febrero 01, 2022
    Author(s): Sarwat Hussain
    Source: JPMA. The Journal of the Pakistan Medical Association
  • MR and fluorescence imaging of gadobutrol-induced optical clearing of red fluorescent protein signal in an in vivo cancer model

    febrero 01, 2022
    Author(s): Natalia I. Kazachkina, Victoria V. Zherdeva, Irina G. Meerovich, Asiya N. Saydasheva, Ilya D. Solovyev, Daria K. Tuchina, Alexander P. Savitsky, Valery V. Tuchin, Alexei A. Bogdanov Jr.
    Source: NMR in biomedicine
    Multimodality registration of optical and MR images in the same tissue volume in vivo may be enabled by MR contrast agents with an optical clearing (OC) effect. The goals of this study were to (a) investigate the effects of clinical MR contrast agent gadobutrol (GB) and its combinations as a potential OC agent assisting in fluorescence intensity (FI) imaging in vivo and (b) evaluate MRI as a tool for imaging of topical or sy...
  • Impaired pulmonary ventilation beyond pneumonia in COVID-19: A preliminary observation

    enero 25, 2022
    Author(s): Shohei Inui, Soon Ho Yoon, Ozkan Doganay, Fergus V. Gleeson, Minsuok Kim
    Source: PloS one; Copyright: © 2022 Inui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    BACKGROUND: Coronavirus disease 2019 (COVID-19) may severely impair pulmonary function and cause hypoxia. However, the association of COVID-19 pneumonia on CT with impaired ventilation remains unexplained. This pilot study aims to demonstrate the relationship between the radiological findings on COVID-19 CT images and ventilation abnormalities simulated in a computational model linked to the patients' symptoms. METHODS: Twen...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Suspected Upper-Extremity Deep Vein Thrombosis

    enero 25, 2022
    Author(s): Sandra V. Kotsis, Tasneem K. Lalani
    Source: Journal of the American College of Radiology : JACR
    The ACR Committee on Appropriateness Criteria and its expert panels have developed criteria for determining appropriate imaging examinations for diagnosis and treatment of specified medical condition(s). These criteria are intended to guide radiologists, radiation oncologists and referring physicians in making decisions regarding radiologic imaging and treatment.
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Nontraumatic Chest Wall Pain

    enero 22, 2022
    Author(s): Emily Chu, Tasneem K. Lalani
    Source: Journal of the American College of Radiology : JACR
    The ACR Committee on Appropriateness Criteria and its expert panels have developed criteria for determining appropriate imaging examinations for diagnosis and treatment of specified medical condition(s). These criteria are intended to guide radiologists, radiation oncologists and referring physicians in making decisions regarding radiologic imaging and treatment.
  • Novel gamma-sarcoglycan interactors in murine muscle membranes

    enero 22, 2022
    Author(s): Tara C. Smith, Georgios Vasilakos, Scott A. Shaffer, Jason M. Puglise, Chih-Hsuan Chou, Elisabeth R. Barton, Elizabeth J. Luna
    Source: Skeletal muscle; Copyright © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other t...
    BACKGROUND: The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across the sarcolemma. The SC coordinates changes in phosphorylation and Ca(++)-flux during mechanical deformation, and these processes are disrupted with loss-of-function mutations in gamma-sarcoglycan (Sgcg) that cause Limb girdle muscular dystrophy 2C/R5. METHODS: To gain insight into how the SC me...
  • Consensus nomenclature for dyneins and associated assembly factors

    enero 10, 2022
    Author(s): Bryony Braschi, Heymut Omran, George B. Witman, Gregory J. Pazour, K. Kevin Pfister, Elspeth A. Bruford, Stephen M. King
    Source: The Journal of cell biology; © 2021 Braschi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
    Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility. Variants in multiple genes encoding dyneins, outer dynein arm (ODA) docking complex subunits, and cytoplasmic factors involved in axonemal dynein preassembly (DNAAFs) are associated...
  • S184: preoperative sarcopenia is associated with worse short-term outcomes following transanal total mesorectal excision (TaTME) for rectal cancer

    enero 06, 2022
    Author(s): Jeremy E. Springer, Catherine Beauharnais, Derek Chicarilli, Danielle Coderre, Allison Crawford, Jennifer A. Baima, Lacey J. McIntosh, Jennifer S. Davids, Paul R. Sturrock, Justin A. Maykel, Karim Alavi
    Source: Surgical endoscopy
    INTRODUCTION: Malnutrition and deconditioning impact postoperative morbidity and mortality. Computed tomography (CT) body composition variables are used as markers of nutritional status and sarcopenia. The objective of this study is to evaluate the impact of sarcopenia, using CT variables, on postoperative outcomes following transanal total mesorectal excision (TaTME) for rectal cancer. METHODS: This was an institutional ret...
  • Nontraumatic brain parenchymal hemorrhage: The usual suspects and more

    enero 05, 2022
    Author(s): Sathish Kumar Dundamadappa
    Source: Clinical imaging
    Brain parenchymal hemorrhage is a common neuroimaging finding in an emergency room. It is considered primary in the absence of an underlying lesion or coagulopathy. Secondary hemorrhages are caused by various structural causes and pathologies. The goals of imaging are to identify the hematoma, assess factors that have prognostic significance, assess associated complications, identify an underlying etiology whenever possible,...
  • Acutely Symptomatic Hypoperfusion Through an Occluded Subclavian to Internal Carotid Artery Bypass Graft: Salvage Mechanical Thrombectomy and Graft Revascularization

    enero 02, 2022
    Author(s): Jose Marino Granados, Anna L. Kuhn, Ajit S. Puri, Francesco Massari, Jasmeet Singh
    Source: Cureus; Copyright © 2022, Marino Granados et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    This middle-aged patient had undergone surgical placement of a left subclavian to internal carotid artery bypass graft five years ago for treatment of symptomatic, chronic, bilateral carotid occlusions. The patient was neurologically intact after the procedure and until the day of presentation with symptoms of an acute left anterior circulation stroke. Initial workup confirmed acute occlusion of the graft as the cause of the...
  • Health Care Disparities in Radiology - A Review of the Current Literature

    enero 01, 2022
    Author(s): Carolynn M. DeBenedectis, Lucy B. Spalluto, Lisa Americo, Casey Bishop, Asim Mian, David Sarkany, Nolan J. Kagetsu, Priscilla J. Slanetz
    Source: Journal of the American College of Radiology : JACR
    INTRODUCTION: Health care disparities exist in all medical specialties, including radiology. Raising awareness of established health care disparities is a critical component of radiology's efforts to mitigate disparities. Our primary objective is to perform a comprehensive review of the last 10 years of literature pertaining to disparities in radiology care. Our secondary objective is to raise awareness of disparities in rad...
  • Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

    diciembre 23, 2021
    Author(s): Helene Tran, Michael P. Moazami, Huiya Yang, Diane Mckenna-Yasek, Catherine Douthwright, Courtney Pinto, Jake P. Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit S. Puri, Alexandra Weiss, Nicholas Wightman, Heather L. Gray-Edwards, Miklos G. Marosfoi, Robert M. King, Jonathan K. Watts, Robert H. Brown Jr.
    Source: Nature medicine
    Expansions of a G4C2 repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Using C9-ALS/FTD patient-derived cells and C9ORF72 BAC transgenic mice, we generated and optimized antisense oligonucleotides (ASOs) that selectively blunt expression of G4C2 repeat-containing transcripts and effect...
  • Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

    diciembre 22, 2021
    Author(s): Chantal M. Ferguson, Bruno M. D. C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew R. Hassler, Dimas Echeverria, James W. Gilbert, Emily G. Knox, Jillian Caiazzi, Reka A. Haraszti, Robert M. King, Toloo Taghian, Ajit S. Puri, Richard P. Moser, Matthew J. Gounis, Neil Aronin, Heather L. Gray-Edwards, Anastasia Khvorova
    Source: JCI insight; Copyright: © 2021, Ferguson et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
    siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term efficacy in rodent and nonhuman primate brains upon direct cerebrospinal fluid (CSF) administration. Oligonucleotide distribution in the CNS is nonuniform, limiting clinical applications. The contribution of CSF infusion pla...
  • International Study of Intracranial Aneurysm Treatment Using Woven EndoBridge: Results of the WorldWideWEB Consortium

    diciembre 17, 2021
    Author(s): Adam A. Dmytriw, Anna L. Kuhn, Ajit S. Puri
    Source: Stroke
  • Quantification of clot spatial heterogeneity and its impact on thrombectomy

    diciembre 15, 2021
    Author(s): Yang Liu, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Compositional and structural features of retrieved clots by thrombectomy can provide insight into improving the endovascular treatment of ischemic stroke. Currently, histological analysis is limited to quantification of compositions and qualitative description of the clot structure. We hypothesized that heterogeneous clots would be prone to poorer recanalization rates and performed a quantitative analysis to test...
  • Data-driven respiratory signal estimation from temporally finely sampled projection data in conventional cardiac perfusion SPECT imaging

    diciembre 13, 2021
    Author(s): P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    PURPOSE: The aim of this work was to revisit the data-driven approach of axial center-of-mass (COM) measurements to recover a surrogate respiratory signal from finely sampled (100 ms) single photon emission computed tomography (SPECT) projection data derived from list-mode acquisitions. METHODS: For our initial evaluation, we acquired list-mode projection data from an anthropomorphic cardiac phantom mounted on a Quasar respi...
  • Structural basis of the super- and hyper-relaxed states of myosin II

    diciembre 10, 2021
    Author(s): Roger W. Craig, Raul A. Padron
    Source: The Journal of general physiology; © 2021 Craig and Padrón. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommo...
    Super-relaxation is a state of muscle thick filaments in which ATP turnover by myosin is much slower than that of myosin II in solution. This inhibited state, in equilibrium with a faster (relaxed) state, is ubiquitous and thought to be fundamental to muscle function, acting as a mechanism for switching off energy-consuming myosin motors when they are not being used. The structural basis of super-relaxation is usually taken ...
  • Preclinical modeling of mechanical thrombectomy

    diciembre 08, 2021
    Author(s): Vania Anagnostakou, Mark Epshtein, Anna L. Kuhn, Robert M. King, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of biomechanics
    Mechanical thrombectomy to treat large vessel occlusions (LVO) causing a stroke is one of the most effective treatments in medicine, with a number needed to treat to improve clinical outcomes as low as 2.6. As the name implies, it is a mechanical solution to a blocked artery and modeling these mechanics preclinically for device design, regulatory clearance and high-fidelity physician training made clinical applications possi...
  • American Association for Women in Radiology

    diciembre 01, 2021
    Author(s): Carolynn M. DeBenedectis, Chelsea Schmitt, Kristin K. Porter, Carol Rumack
    Source: Clinical imaging
    For the past 40 years the American Association for Women in Radiology (AAWR) has continued to support efforts to achieve its founding goals of improving the visibility of women in radiology, advancing the professional and academic standing of women in radiology, and identifying and addressing issues faced by women in radiology. In the past 5 years, the AAWR has made great strides to support women in radiology through amplify...
  • Paramagnetic Rim Lesions in Multiple Sclerosis: Comparison of Visualization at 1.5-T and 3-T MRI

    diciembre 01, 2021
    Author(s): Christopher C. Hemond, Daniel S. Reich, Sathish Kumar Dundamadappa
    Source: AJR. American journal of roentgenology
    Background: Multiple sclerosis (MS) is characterized by both acute and chronic intrathecal inflammation. A subset of MS lesions show paramagnetic rims on susceptibility-weighted MRI sequences, reflecting iron accumulation in microglia. These paramagnetic rim lesions (PRLs) have been proposed as a marker of compartmentalized smoldering disease. PRLs have been demonstrated at 7 T and, more recently, at 3 T. As susceptibility e...
  • Tissue Adequacy and Safety of Percutaneous Transthoracic Needle Biopsy for Molecular Analysis in Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis

    diciembre 01, 2021
    Author(s): Bo Da Nam, Soon Ho Yoon, Hyunsook Hong, Jung Hwa Hwang, Jin Mo Goo, Suyeon Park
    Source: Korean journal of radiology; Copyright © 2021 The Korean Society of Radiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    OBJECTIVE: We conducted a systematic review and meta-analysis of the tissue adequacy and complication rates of percutaneous transthoracic needle biopsy (PTNB) for molecular analysis in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We performed a literature search of the OVID-MEDLINE and Embase databases to identify original studies on the tissue adequacy and complication rates of PTNB for molecular...
  • Ultrasonographic evaluation of patients with abnormal liver function tests in the emergency department

    noviembre 18, 2021
    Author(s): Baran Umut Vardar, Carolyn S. Dupuis, Alan J. Goldstein, Zeynep Vardar, Young H. Kim
    Source: Ultrasonography (Seoul, Korea); Copyright © 2022 Korean Society of Ultrasound in Medicine (KSUM). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Ultrasonography is often the initial modality used to evaluate patients found to have abnormal liver function tests (LFTs) in the emergency department. While an assessment for biliary ductal dilatation and obstruction remains one of the main questions to answer, radiologists should also be aware of the ultrasonographic appearance of other conditions that can cause abnormal LFTs. This may be crucial for the management and dis...
  • ACR Appropriateness Criteria(R) Epigastric Pain

    noviembre 15, 2021
    Author(s): Abhinav Vij, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Epigastric pain can have multiple etiologies including myocardial infarction, pancreatitis, acute aortic syndromes, gastroesophageal reflux disease, esophagitis, peptic ulcer disease, gastritis, duodenal ulcer disease, gastric cancer, and hiatal hernia. This document focuses on the scenarios in which epigastric pain is accompanied by symptoms such as heartburn, regurgitation, dysphagia, nausea, vomiting, and hematemesis, whi...
  • Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

    noviembre 08, 2021
    Author(s): Thanh N. Nguyen, Ajit S. Puri, Anna L. Kuhn, Raul G. Nogueira
    Source: JAMA neurology
    Importance: Advanced imaging for patient selection in mechanical thrombectomy is not widely available. Objective: To compare the clinical outcomes of patients selected for mechanical thrombectomy by noncontrast computed tomography (CT) vs those selected by computed tomography perfusion (CTP) or magnetic resonance imaging (MRI) in the extended time window. Design, Setting, and Participants: This multinational cohort study inc...
  • CT Examinations for COVID-19: A Systematic Review of Protocols, Radiation Dose, and Numbers Needed to Diagnose and Predict

    noviembre 04, 2021
    Author(s): Jong Hyuk Lee, Hyunsook Hong, Hyungjin Kim, Chang Hyun Lee, Jin Mo Goo, Soon Ho Yoon
    Source: Journal of the Korean Society of Radiology; Copyrights © 2021 The Korean Society of Radiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Purpose Although chest CT has been discussed as a first-line test for coronavirus disease 2019 (COVID-19), little research has explored the implications of CT exposure in the population. To review chest CT protocols and radiation doses in COVID-19 publications and explore the number needed to diagnose (NND) and the number needed to predict (NNP) if CT is used as a first-line test. Materials and Methods We searched nine highl...
  • Endoluminal flow diverting stents for middle cerebral artery bifurcation aneurysms: multicenter cohort

    noviembre 03, 2021
    Author(s): Mohamed M. Salem, Anna L. Kuhn, Francesco Massari, Ajit S. Puri, Ajith J. Thomas
    Source: Journal of neurointerventional surgery
    BACKGROUND: Data regarding the safety and efficacy of flow diverting stents (FDS) in the treatment of middle cerebral artery (MCA) bifurcation aneurysms are scarce and limited to small single center series, with particular concern for increased risk of ischemic complications with jailing one of the M2 branches. METHODS: Prospectively-maintained databases at six North American and European centers were queried for patients ha...
  • Structural organization of the C1b projection within the ciliary central apparatus

    noviembre 01, 2021
    Author(s): Kai Cai, Yanhe Zhao, Lei Zhao, Nhan Phan, Yuqing Hou, Xi Cheng, George B. Witman, Daniela Nicastro
    Source: Journal of cell science
    Motile cilia have a '9+2' structure containing nine doublet microtubules and a central apparatus (CA) composed of two singlet microtubules with associated projections. The CA plays crucial roles in regulating ciliary motility. Defects in CA assembly or function usually result in motility-impaired or paralyzed cilia, which in humans causes disease. Despite their importance, the protein composition and functions of most CA pro...
  • Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing

    noviembre 01, 2021
    Author(s): Arda Konik, Navid Zeraatkar, Kesava S. Kalluri, Benjamin Auer, Timothy J. Fromme, Yulun He, Micaehla May, Lars R. Furenlid, Phillip H. Kuo, Michael A. King
    Source: IEEE transactions on radiation and plasma medical sciences
    SPECT imaging of dopamine transporters (DAT) in the brain is a widely utilized study to improve the diagnosis of Parkinsonian syndromes, where conventional (parallel-hole and fan-beam) collimators on dual-head scanners are commonly employed. We have designed a multi-pinhole (MPH) collimator to improve the performance of DAT imaging. The MPH collimator focuses on the striatum and hence offers a better trade-off for sensitivit...
  • Disability: An Important Dimension of Diversity

    noviembre 01, 2021
    Author(s): Juan D. Guerrero-Calderon, Kay Lozano, Carolynn M. DeBenedectis, LeAnn Shannon, Chitra Viswanathan, Nolan J. Kagetsu
    Source: Journal of the American College of Radiology : JACR
    We want to encourage people with disabilities to join the field of medicine, especially radiology. Radiologists should embrace disability as a dimension of diversity and should mentor students with disabilities. Appreciating the contributions of people with disabilities in our workforce will make us as radiologists more empathetic and active in removing barriers and ensuring equal access for patients, staff, and physicians w...
  • Carotid artery revascularization using the Walrus balloon guide catheter: safety and feasibility from a US multicenter experience

    octubre 22, 2021
    Author(s): Mohamed M. Salem, Anna L. Kuhn, Ajit S. Puri, Jan-Karl Burkhardt
    Source: Journal of neurointerventional surgery
    INTRODUCTION: The Walrus balloon guide catheter (BGC) is a new generation of BGC, designed to eliminate conventional limitations during mechanical thrombectomy. OBJECTIVE: To report a multi-institutional experience using this BGC for proximal flow control (PFC) in the setting of carotid artery angioplasty/stenting (CAS) in elective (eCAS) and tandem strokes (tCAS). METHODS: Prospectively maintained databases at 8 North Ameri...
  • Stratifying the early radiologic trajectory in dyspneic patients with COVID-19 pneumonia

    octubre 22, 2021
    Author(s): Jin Young Kim, Keum Ji. Jung, Seung-Jin Yoo, Soon Ho Yoon
    Source: PloS one; Copyright © 2021 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    OBJECTIVE: This study aimed to stratify the early pneumonia trajectory on chest radiographs and compare patient characteristics in dyspneic patients with coronavirus disease 2019 (COVID-19). MATERIALS AND METHODS: We retrospectively included 139 COVID-19 patients with dyspnea (87 men, 62.7+/-16.3 years) and serial chest radiographs from January to September 2020. Radiographic pneumonia extent was quantified as a percentage u...
  • Repeat Flow Diversion for Cerebral Aneurysms Failing Prior Flow Diversion: Safety and Feasibility From Multicenter Experience

    octubre 12, 2021
    Author(s): Mohamed M. Salem, Anna L. Kuhn, Ajit S. Puri, Ajith J. Thomas
    Source: Stroke
    BACKGROUND AND PURPOSE: Aneurysmal persistence after flow diversion (FD) occurs in 5% to 25% of aneurysms, which may necessitate retreatment. There are limited data on safety/efficacy of repeat FD-a frequently utilized strategy in such cases. METHODS: A series of consecutive patients undergoing FD retreatment from 15 centers were reviewed (2011-2019), with inclusion criteria of repeat FD for the same aneurysm at least 6 mont...
  • A clinical perspective on endovascular stroke treatment biomechanics

    octubre 11, 2021
    Author(s): Johanna M. Ospel, Aad van der Lugt, Matthew J. Gounis, Mayank Goyal, Charles B. L. M. Majoie
    Source: Journal of biomechanics
    Acute ischemic stroke (AIS) is caused by blockage of an arterial blood vessel in the brain by a thrombus, which interrupts oxygen supply to the brain parenchyma. The goal of endovascular stroke treatment (mechanical thrombectomy) is to restore blood flow as quickly and completely as possible. There are numerous factors that influence endovascular treatment success. They can be broadly grouped into a) factors related to blood...
  • Artificial Intelligence in Healthcare Explained for Computer-Non-Experts

    octubre 06, 2021
    Author(s): Sarwat Hussain
    Source: Annals of King Edward Medical University; This work is licensed under a Creative Commons Attribution 4.0 International License.
    It is human nature to find ways to do more with less and faster. This instinct is at the root of all advances and inventions that resulted in the Industrial Revolutions (IR). The first industrial revolution in 1760 marked the development of the steam engine. Then the mass industrial production and electricity, automation, and electronics denoted the second and the third industrial revolutions. Currently, the 4th industrial r...
  • The Lancet Commission on diagnostics: transforming access to diagnostics

    octubre 06, 2021
    Author(s): Kenneth A. Fleming, Susan Horton, Sarwat Hussain
    Source: Lancet (London, England)
    At the end of 2019, the first reports of a new respiratory virus appeared in China. The subsequent COVID-19 pandemic has affected every person, in every country, in the world. One early lesson was the crucial importance of timely accurate diagnosis. A second lesson was the widespread scarcity of such diagnostic capacity and capability. The second lesson supported the findings of the 2018 Lancet Series on Pathology and Labor...
  • Qualifying Certainty in Radiology Reports through Deep Learning-Based Natural Language Processing

    octubre 01, 2021
    Author(s): Feifan Liu, Peng Zhou, Steven J. Baccei, Mark J. Masciocchi, Nita Amornsiripanitch, Catarina I. Kiefe, Max P. Rosen
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Communication gaps exist between radiologists and referring physicians in conveying diagnostic certainty. We aimed to explore deep learning-based bidirectional contextual language models for automatically assessing diagnostic certainty expressed in the radiology reports to facilitate the precision of communication. MATERIALS AND METHODS: We randomly sampled 594 head MR imaging reports from an academic...
  • Impact of Computed Tomography-Based, Artificial Intelligence-Driven Volumetric Sarcopenia on Survival Outcomes in Early Cervical Cancer

    septiembre 24, 2021
    Author(s): Qingling Han, Se Ik Kim, Soon Ho Yoon, Taek Min Kim, Hyun-Cheol Kang, Hak Jae Kim, Jeong Yeon Cho, Jae-Weon Kim
    Source: Frontiers in oncology; Copyright © 2021 Han, Kim, Yoon, Kim, Kang, Kim, Cho and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted acade...
    The purpose of this study was to investigate the impact of sarcopenia and body composition change during primary treatment on survival outcomes in patients with early cervical cancer. We retrospectively identified patients diagnosed with 2009 International Federation of Gynecology and Obstetrics stage IB1-IIA2 cervical cancer who underwent primary radical hysterectomy between 2007 and 2019. From pre-treatment CT scans (n = 3...
  • Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner

    septiembre 22, 2021
    Author(s): Navid Zeraatkar, Kesava S. Kalluri, Benjamin Auer, Micaehla May, R. Garrett Richards, Lars R. Furenlid, Phillip H. Kuo, Michael A. King
    Source: Biomedical physics and engineering express
    Application of multi-pinhole collimator in pinhole-based SPECT increases detection sensitivity. The presence of multiplexing in projection images due to the usage of multiple pinholes can further improve the sensitivity at the cost of adding data ambiguity. We are developing a next-generation adaptive brain-dedicated SPECT system -AdaptiSPECT-C. The AdaptiSPECT-C can adapt the multiplexing level and system sensitivity using ...
  • Intravascular Wrap for Treatment of Basilar Artery Perforator Aneurysm

    septiembre 16, 2021
    Author(s): Anna L. Kuhn, Ajit S. Puri, Francesco Massari, Jasmeet Singh
    Source: Cureus; © Copyright 2021 Kuhn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Basilar artery perforator aneurysms are very rare and usually present with subarachnoid hemorrhage. High-quality imaging systems with digital subtraction angiography and three-dimensional rotational angiography are crucial for the detection of these posterior circulation vascular lesions, which may still be missed on the initial angiogram. We present the first use of a Flow Re-Direction Endoluminal Device (Microvention, Alis...
  • Optimizing integrated imaging service delivery by tier in low-resource health systems

    septiembre 16, 2021
    Author(s): Kristen DeStigter, Kara-Lee Pool, Abimbola Leslie, Sarwat Hussain, Bien Soo Tan, Lluis Donoso-Bach, Savvas Andronikou
    Source: Insights into imaging; Copyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or o...
    Access to imaging diagnostics has been shown to result in accurate treatment, management, and optimal outcomes. Particularly in low-income and low-middle-income countries (LICs, LMICs), access is limited due to a lack of adequate resources. To achieve Sustainable Development Goal (SDG) 3, access to imaging services is critical at every tier of the health system. Optimizing imaging services in low-resource settings is best ac...
  • Biophysical targeting of high-risk cerebral aneurysms

    septiembre 16, 2021
    Author(s): Mark Epshtein, Moran Levi, Afif M. Kraitem, Hikaia Zidan, Robert M. King, Meinrad Gawaz, Matthew J. Gounis, Netanel Korin
    Source: Bioengineering and translational medicine; © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Localized delivery of diagnostic/therapeutic agents to cerebral aneurysms, lesions in brain arteries, may offer a new treatment paradigm. Since aneurysm rupture leading to subarachnoid hemorrhage is a devastating medical emergency with high mortality, the ability to noninvasively diagnose high-risk aneurysms is of paramount importance. Moreover, treatment of unruptured aneurysms with invasive surgery or minimally invasive ne...
  • Use of Artificial Intelligence-Based Software as Medical Devices for Chest Radiography: A Position Paper from the Korean Society of Thoracic Radiology

    septiembre 13, 2021
    Author(s): Eui Jin Hwang, Jin Mo Goo, Soon Ho Yoon, Kyongmin Sarah Beck, Joon Beom Seo, Byoung Wook Choi, Myung Jin Chung, Chang Min Park, Kwang Nam Jin, Sang Min Lee
    Source: Korean journal of radiology; Copyright © 2021 The Korean Society of Radiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Chest radiography (CR) is the primary examination for the evaluation and follow-up of various thoracic diseases. The number of examinations is steadily on the increase, as is evidenced by the national health insurance data in Korea. However, due to the relative shortage of experienced radiologists, many institutions cannot provide timely interpretation of CRs or depend on outsourcing for interpretation. In this background, ...
  • Ultrasound Imaging Morphology is Associated with Biological Behavior in Invasive Ductal Carcinoma of the Breast

    septiembre 02, 2021
    Author(s): Gopal Vijayaraghavan, Matthew Kona, Abiramy Maheswaran, Dina Kandil, Madhavi Toke, Srinivasan Vedantham
    Source: Journal of clinical imaging science; Copyright © 2021 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the i...
    Objectives: Ultrasound (US) is commonly used for diagnostic evaluation of breast lesions. The objective of this study was to investigate the association between US imaging morphology from routine radiologists' interpretation and biological behavior such as receptor status and tumor grade determined from histopathology in invasive ductal carcinoma (IDC). Material and Methods: This retrospective study included 453 patients wit...
  • A single-institution analysis of reflector-guided localization using SAVI SCOUT(R) in nonpalpable breast carcinoma compared to traditional wire localization

    septiembre 01, 2021
    Author(s): Nicholas Bercovici, Vladislav Makarenko, Gopal Vijayaraghavan, Anne C. Larkin, Jennifer Clark, Dina Kandil
    Source: The breast journal
    Breast-conservation therapy (BCT), now considered standard of care, was introduced as an alternative to total mastectomy in patients with early-stage breast cancer. Preoperative image-guided wire localization (WL) has traditionally been used to help surgeons localize these nonpalpable tumors.1 WL is typically performed on the day of surgery, which may lead to scheduling conflicts with the surgical and radiology teams. In add...
  • Lung Physiological Variations in COVID-19 Patients and Inhalation Therapy Development for Remodeled Lungs

    septiembre 01, 2021
    Author(s): Jinxiang Xi, Brendan Walfield, Xiuhua April Si, Alexander A. Bankier
    Source: SciMedicine Journal; Copyright (c) 2021 Jinxiang Xi, Brendan Walfield, Xiuhua April Si, Alexander A Bankier. This is an open access article under the CC-BY license (https://creativecommons.org/licenses/by/4.0/).
    In response to the unmet need for effective treatments for symptomatic patients, research efforts of inhaled therapy for COVID-19 patients have been pursued since the pandemic began. However, inhalation drug delivery to the lungs is sensitive to the lung anatomy and physiology, which can be significantly altered due to the viral infection. The ensued ventilation heterogeneity will change distribution and thus dosimetry of in...
  • Real-time MR tracking of AAV gene therapy with betagal-responsive MR probe in a murine model of GM1-gangliosidosis

    agosto 26, 2021
    Author(s): Toloo Taghian, Ana Rita Batista, Paola Rodriguez, Katerina Mesa, Shaokuan Zheng, Robert M. King, Matthew J. Gounis, Sophia H. Todeasa, Miguel Sena-Esteves, Thomas J. Meade, Heather L. Gray-Edwards
    Source: Molecular therapy. Methods and clinical development; Copyright 2021 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber's congenital amaurosis led to approval of the first two AAV products in the United States to treat these diseases. These extraordinary results led to a dramatic increase in the number and type of AAV gene-therapy programs. However, the field lacks non-invasive means to assess levels and duration of therapeut...
  • LI-RADS treatment response assessment of combination locoregional therapy for HCC

    agosto 01, 2021
    Author(s): Marielia Gerena, Christopher Molvar, Mark Masciocchi, Sadhna Nandwana, Carl Sabottke, Bradley Spieler, Rishi Sharma, Leo Tsai, Ania Kielar
    Source: Abdominal radiology (New York)
    HCC incidence continues to increase worldwide and is most frequently discovered at an advanced stage when limited curative options are available. Combination locoregional therapies have emerged to improve patient survival and quality of life or downstage patients to curative options. The increasing options for locoregional therapy combinations require an understanding of the expected post-treatment imaging appearance in orde...
  • Improving detection accuracy of perfusion defect in standard dose SPECT-myocardial perfusion imaging by deep-learning denoising

    julio 19, 2021
    Author(s): Junchi Liu, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Piotr J. Slomka, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: We previously developed a deep-learning (DL) network for image denoising in SPECT-myocardial perfusion imaging (MPI). Here we investigate whether this DL network can be utilized for improving detection of perfusion defects in standard-dose clinical acquisitions. METHODS: To quantify perfusion-defect detection accuracy, we conducted a receiver-operating characteristic (ROC) analysis on reconstructed images with an...
  • Mechanical thrombectomy beyond the circle of Willis: efficacy and safety of different techniques for M2 occlusions

    julio 05, 2021
    Author(s): Leonardo Renieri, Iacopo Valente, Ajit S. Puri, Jasmeet Singh, Anna L. Kuhn
    Source: Journal of neurointerventional surgery
    BACKGROUND: M2 segment occlusions represent approximately one-third of non-lacunar ischemic stroke and can lead to permanent neurological deficits. Various techniques are available for mechanical thrombectomy beyond the circle of Willis, but data evaluating their effectiveness and safety are lacking. METHODS: A retrospective review of patients with ischemic stroke undergoing mechanical thrombectomy for M2 occlusions from 13 ...
  • Age and Acute Ischemic Stroke Outcome in North American Patients With COVID-19

    julio 03, 2021
    Author(s): Adam A. Dmytriw, Anna L. Kuhn, Ajit S. Puri
    Source: Journal of the American Heart Association; Copyright © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are...
    Background: Acute ischemic stroke (AIS) in the context of COVID-19 has received considerable attention for its propensity to affect patients of all ages. We aimed to evaluate the effect of age on functional outcome and mortality following an acute ischemic event. Methods and Results: A prospectively maintained database from comprehensive stroke centers in Canada and the United States was analyzed for patients with AIS from M...
  • Integration of clinical anatomical sciences in medical education: Design, development and implementation strategies

    julio 01, 2021
    Author(s): Mohammed K. Khalil, Eustathia Lela Giannaris, Vaughan Lee, Dolgor Baatar, Saskia Richter, Krista S. Johansen, Priti L. Mishall
    Source: Clinical anatomy (New York, N.Y.)
    For the last 20 years, undergraduate medical education has seen a major curricular reform movement toward integration of basic and clinical sciences. The rationale for integrated medical school curricula focuses on the application of knowledge in a clinical context and the early ability to practice key skills such as critical thinking and clinical problem-solving. The method and extent of discipline integration can vary wide...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Crohn Disease

    julio 01, 2021
    Author(s): Kristin Jordan Moore, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Crohn disease (CD) is a chronic condition caused by inflammation of the bowel. The small bowel, the colon, or both can be involved. Individuals may have periods with frequent flare-ups and periods of remission. CD is usually diagnosed by colonoscopy along with clinical symptoms, laboratory tests, and imaging. Imaging is helpful to evaluate the extent of involvement on initial diagnosis, to evaluate for residual inflammation,...
  • Family and Medical Leave for Diagnostic Radiology, Interventional Radiology, and Radiation Oncology Residents in the United States: A Policy Opportunity

    julio 01, 2021
    Author(s): Kirti Magudia, Carolynn M. DeBenedectis
    Source: Radiology
    The American Board of Medical Specialties recently announced that effective July 1, 2021, member boards with training programs of 2 years or more must “establish requirements for candidates to become eligible for Initial Certification, including standards for training” and have “policies that accommodate reasonable leaves of absence from residency and fellowship training for personal or familial needs”. In preparation for th...
  • Artificial intelligence in medical ultrasonography: driving on an unpaved road

    julio 01, 2021
    Author(s): Young H. Kim
    Source: Ultrasonography (Seoul, Korea); Copyright © 2021 Korean Society of Ultrasound in Medicine (KSUM). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Recent advances in deep-learning technology have brought revolutionary changes to artificial intelligence (AI) research and application across industries, yielding major innovations such as facial recognition and self-driving cars. Medicine is no exception, and radiology, which is based on the interpretation of image data obtained through various methods-and has often been compared with computer vision using pattern analysis...
  • Addressing the ACGME Mandate for Healthcare Disparities Education in Residency Programs: A Needs Assessment

    julio 01, 2021
    Author(s): Alexander Song, Lisa Americo, Hannah Myers, Carolynn M. DeBenedectis, Priscilla J. Slanetz, David Sarkany
    Source: Academic radiology
    PURPOSE: To assess current opinions and efforts from radiology residency program leadership regarding healthcare disparities (HCD) education for residents. METHODS: Radiology residency program directors across the United States were sent a 10-item survey and asked a series of qualitative questions regarding their opinions about HCD and current methods of implementation into their residency curriculum, in addition to demograp...
  • Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model

    julio 01, 2021
    Author(s): Tobias Bauerle, Suresh Gupta, Shaokuan Zheng, Lisa Seyler, Anita M. Leporati, Miklos G. Marosfoi, Simone Maschauer, Olaf Prante, Peter Caravan, Alexei A. Bogdanov Jr.
    Source: Radiology. Imaging cancer
    Purpose: To develop multimodality imaging techniques for measuring epidermal growth factor receptor (EGFR) as a therapy-relevant and metastasis-associated molecular marker in triple-negative mammary adenocarcinoma metastases. Materials and Methods: An orthotopic bone metastasis EGFR-positive, triple-negative breast cancer (TNBC) model in rats was used for bioluminescence imaging, SPECT/CT, PET/CT, and MRI with quantitative a...
  • Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a

    junio 28, 2021
    Author(s): Yuqing Hou, Lei Zhao, Tomohiro Kubo, Xi Cheng, Nathan A. McNeill, Toshiyuki Oda, George B. Witman
    Source: Journal of cell science; Copyright © 2021. Published by The Company of Biologists Ltd. Publisher PDF posted with 12 month embargo as allowed by the publisher's self-archiving policy at https://journals.biologists.com/jcs/pages/rights-permissions.
    Cilia are essential organelles required for cell signaling and motility. Nearly all motile cilia have a '9+2' axoneme composed of nine outer doublet microtubules plus two central microtubules; the central microtubules together with their projections are termed the central apparatus (CA). In Chlamydomonas reinhardtii, a model organism for studying cilia, 30 proteins are known CA components, and approximately 36 more are predi...
  • Comprehensive Assessment of Fine-Grained Wound Images Using a Patch-Based CNN With Context-Preserving Attention

    junio 24, 2021
    Author(s): Ziyang Liu, Emmanuel Agu, Peder Pedersen, Clifford Lindsay, Bengisu Tulu, Diane Strong
    Source: IEEE open journal of engineering in medicine and biology; This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. For more information see https://creativecommons.org/licenses/by-nc-nd/4.0/
    Goal: Chronic wounds affect 6.5 million Americans. Wound assessment via algorithmic analysis of smartphone images has emerged as a viable option for remote assessment. Methods: We comprehensively score wounds based on the clinically-validated Photographic Wound Assessment Tool (PWAT), which comprehensively assesses clinically important ranges of eight wound attributes: Size, Depth, Necrotic Tissue Type, Necrotic Tissue Amoun...
  • Left Ventricular Noncompaction Cardiomyopathy as a Potential Cause of Bilateral Posterior Cerebral Artery Stroke - a Rare and Unique Clinical Occurrence

    junio 22, 2021
    Author(s): Marwa Elnazeir, Lisa Nobel, Siddharth Narayanan, Fahed Darmoch, Francesco Massari, Timothy P. Fitzgibbons, Raphael A. Carandang, Adalia H. Jun-O'Connell
    Source: The American journal of case reports; Copyright © Am J Case Rep, 2021. This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
    BACKGROUND Bilateral posterior cerebral artery (PCA) occlusions are exceedingly rare, and are considered a devastating phenomenon that presents as cortical blindness. Predominant causes of PCA infarcts include cardiac and arterial embolisms. Left ventricular noncompaction (LVNC) cardiomyopathy is also an extremely rare cardiopathology. Several reports describe stroke as a potential manifestation of LVNC, but bilateral PCA in...
  • Optical Coherence Tomography for Neurovascular Disorders

    junio 12, 2021
    Author(s): Vania Anagnostakou, Giovanni J. Ughi, Ajit S. Puri, Matthew J. Gounis
    Source: Neuroscience
    Diagnosis of cerebrovascular disease includes vascular neuroimaging techniques such as computed tomography (CT) angiography, magnetic resonance (MR) angiography (with or without use of contrast agents) and catheter digital subtraction angiography (DSA). These techniques provide mostly information about the vessel lumen. Vessel wall imaging with MR seeks to characterize cerebrovascular pathology, but with resolution that is o...
  • Ensuring a Smooth Transition for Trainees Returning from Parental Leave - A Guide for Program Directors

    junio 06, 2021
    Author(s): Carolynn M. DeBenedectis, Ann K. Jay, Sheryl G. Jordan, Courtney P. Raybon, Jessica B. Robbins, Lori A. Deitte
    Source: Academic radiology
    Transitioning from parental leave during radiology residency training can be a time of stress and uncertainty. However, there are ways that program directors can help make the transition smoother and less overwhelming. Trainees report numerous stressors upon returning from leave involving childcare, lactation concerns and logistics, and discrimination. Program directors can help alleveate these stressors by counseling traine...
  • A case of distal limb arterial tortuosity and dilation: observations and potential clinical significance

    junio 01, 2021
    Author(s): Yasmin Carter, Desmond J. Bennett, Vadim Molla, Alexandra E. Wink, Amanda J. Collins, Eustathia Lela Giannaris
    Source: Folia morphologica; This article has been peer reviewed and published immediately upon acceptance. It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.
    Arterial tortuosity describes variation via bending of the arterial wall and has been noted in several arteries throughout the body. Tortuous blood vessels can cause nerve compression, as well as present difficulties to surgeons and radiologists. Here we present an unusual case of multi-vessel arterial tortuosity discovered in 78-year-old Hispanic male cadaver, independent of systemic pathology. The left ulnar and right tibi...
  • Mitigating Unconscious Bias in Recruitment and Hiring

    junio 01, 2021
    Author(s): Nikita Consul, Richard Strax, Carolynn M. DeBenedectis, Nolan J. Kagetsu
    Source: Journal of the American College of Radiology : JACR
    Unconscious biases in recruitment and hiring can limit the potential for building a diverse academic and private radiology practice. In the private practice environment of radiology, especially in smaller firms, in which a dysfunctional team can lead to a dysfunctional practice overall, it is especially essential to find the best candidates for the team. Many strategies for mitigating these biases can be employed strategical...
  • Up around the bend: progress and promise of intravascular imaging in neurointerventional surgery

    junio 01, 2021
    Author(s): Matthew J. Gounis, David A. Steinman
    Source: Journal of neurointerventional surgery
    Endovascular treatment in peripheral and coronary circulations has been greatly advanced with the aid of intravascular imaging such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS). Studies have shown that these technologies have a clinical impact, such as reducing in-hospital adverse events and improving long-term survival following coronary artery stenting. For the intracranial circulation, however...
  • Integrating art museum visits into the radiology curriculum: A program to encourage engagement, observation and analytic skills among millennial learners

    mayo 31, 2021
    Author(s): Andrew M. Singer, Carolynn M. DeBenedectis, Max P. Rosen
    Source: Clinical imaging
    Millennial learners have unique educational preferences and expectations, many of which vary significantly from those of their predecessors. To aid in the preparation and training of the next generation of radiologists, we have been exploring a teaching technique using an art observation training workshop to foster engagement of millennial radiology residents to pay closer attention to image detail, clearly state the observa...
  • Deep Learning-Based Quantification of Visceral Fat Volumes Predicts Posttransplant Diabetes Mellitus in Kidney Transplant Recipients

    mayo 25, 2021
    Author(s): Ji Eun Kim, Sang Joon Park, Yong Chul Kim, Sang-Il Min, Jongwon Ha, Yon Su Kim, Soon Ho Yoon, Seung Seok Han
    Source: Frontiers in medicine; Copyright © 2021 Kim, Park, Kim, Min, Ha, Kim, Yoon and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academ...
    Background: Because obesity is associated with the risk of posttransplant diabetes mellitus (PTDM), the precise estimation of visceral fat mass before transplantation may be helpful. Herein, we addressed whether a deep-learning based volumetric fat quantification on pretransplant computed tomographic images predicted the risk of PTDM more precisely than body mass index (BMI). Methods: We retrospectively included a total of 7...
  • Lack of Progression of Intraventricular Hemorrhage in Premature Infants: Implications for Head Ultrasound Screening

    mayo 19, 2021
    Author(s): Jaclyn Daigneault, Heather White, Alexandra Dube, Qiming Shi, Jean-Marc Gauguet, Lawrence M. Rhein
    Source: Global pediatric health; Copyright © The Author(s) 2021. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en...
    Very preterm infants are at risk for germinal matrix hemorrhage- intraventricular hemorrhage (GH-IVH). Severe GH-IVH may cause death or severe neurodevelopmental disability while mild GH-IVH is considered a static, non-progressive disease. This retrospective study aimed to determine if infants with no GH-IVH or mild GH-IVH on initial screening head ultrasound (HUS) advanced to severe GH-IVH. A total of 353 eligible infants w...
  • Myocarditis following COVID-19 vaccination

    mayo 18, 2021
    Author(s): Elisabeth Albert, Gerard P. Aurigemma, Jason Saucedo, David S. Gerson
    Source: Radiology Case Reports; © 2021 Published by Elsevier Inc. on behalf of University of Washington. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    The coronavirus disease 2019 (COVID-19) vaccination frequently leads to minor side-effects, that may be more intense after the second dose, but more serious side effects have been reported. We report a case of a 24-year-old man who presented to the hospital with acute substernal chest pain, 4 days after his second COVID-19 Moderna vaccination. Laboratory studies revealed elevated troponins and negative viral serologies. Card...
  • Prognostic Significance of Computed Tomography Findings in Pulmonary Vein Stenosis

    mayo 17, 2021
    Author(s): Laureen Sena, Ryan Callahan, Lynn A. Sleeper, Rebecca S. Beroukhim
    Source: Children (Basel, Switzerland); Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
    (1) Pulmonary vein stenosis (PVS) can be a severe, progressive disease with lung involvement. We aimed to characterize findings by computed tomography (CT) and identify factors associated with death; (2) Veins and lung segments were classified into five locations: right upper, middle, and lower; and left upper and lower. Severity of vein stenosis (0-4 = no disease-atresia) and lung segments (0-3 = unaffected-severe) were sco...
  • Analysis of Literature Regarding Health Care Disparities in Radiology: Is Radiology Falling Behind

    mayo 15, 2021
    Author(s): Lisa Americo, Alexander Song, Hannah Myers, Mudassir Mumtaz, Jordan Mercado, Carolynn M. DeBenedectis, David Sarkany
    Source: Academic radiology
    PURPOSE: To quantify the gap between radiology and other specialties regarding the amount of literature on healthcare disparities (HCD). METHODS: Four different searches were conducted to evaluate the amount of literature on HCD in radiology as compared to internal medicine and surgery. Initially, the Journal Citation Report was utilized to search for the five highest ranking journals in each field and a second search used i...
  • Postmarket American Experience With Woven EndoBridge Device: Adjudicated Multicenter Case Series

    mayo 14, 2021
    Author(s): Jacob Cherian, Stephen R. Chen, Ajit S. Puri, Kunal Vakharia, Elad Levy, Sheila Eshraghi, Brian M. Howard, Frank C. Tong, C. Michael Cawley, Bradley Gross, Matthew D. Alexander, Ramesh Grandhi, Visish M. Srinivasan, Jan-Karl Burkhardt, Jeremiah N. Johnson, Peter Kan
    Source: Neurosurgery
    BACKGROUND: The Woven EndoBridge (WEB) device was granted premarket approval in the United States following results of the Woven EndoBridge Intrasaccular Therapy (WEB-IT) study. WEB-IT reported excellent adequate angiographic occlusion of treated aneurysms with a high safety profile. These results were achieved, however, in the context of a prospective study with strict inclusion criteria and rigorous training support. OBJEC...
  • Coordination and optimization of FDG PET/CT and COVID-19 vaccination; Lessons learned in the early stages of mass vaccination

    mayo 11, 2021
    Author(s): Lacey J. McIntosh, Max P. Rosen, Kriti Mittal, Giles F. Whalen, Venu G. Bathini, Tasneem Ali, Kathryn L. Edmiston, William V. Walsh, Jonathan M. Gerber
    Source: Cancer Treatment Reviews
    As the world embarks on mass vaccination for COVID-19, we are beginning to encounter unintended dilemmas in imaging oncology patients; particularly with regards to FDG PET/CT. In some cases, vaccine-related lymphadenopathy and FDG uptake on PET/CT can mimic cancer and lead to confounding imaging results. These cases with findings overlapping with cancer pose a significant dilemma for diagnostic purposes, follow-up, and manag...
  • Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy

    mayo 11, 2021
    Author(s): Oana Madalina Mereuta, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Several animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following MT are difficult to determine. OBJECTIVE: To investigate the occurrence of VWI during MT by histological and immunohistochemical evaluation of AIS clots. METHODS: As part of the multicenter STRIP regist...
  • Determinants of Burnout and Well-Being in Women, Gender-Diverse Radiologists, and Radiologists of Other Underrepresented Minorities

    mayo 01, 2021
    Author(s): Carolynn M. DeBenedectis
    Source: Journal of the American College of Radiology : JACR
    There are many factors contributing to chronic stress at work, but one that most people do not think about is the stress related to being a woman, a person of an underrepresented minority group, or a gender-diverse or lesbian, gay, bisexual, and transgender (LGBTQ) person. In radiology, all these groups are underrepresented, and being a minority in a field can lead to stress on the job because of macro- and microaggressions,...
  • Role of the radiologist at HCC multidisciplinary conference and use of the LR-TR algorithm for improving workflow

    abril 27, 2021
    Author(s): Anuradha S. Shenoy-Bhangle, Leo L. Tsai, Mark J. Masciocchi, Sandeep Singh Arora, Ania Z. Kielar
    Source: Abdominal radiology (New York)
    Multidisciplinary conferences (MDCs) play a major role in management and care of oncology patients. Hepatocellular carcinoma (HCC) is a complex disease benefiting from multidisciplinary discussions to determine optimal patient management. A multitude of liver-directed locoregional therapies have emerged allowing for more options for treatment of HCC. A radiologist dedicated to HCC-MDC is an important member of the team contr...
  • Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction

    abril 27, 2021
    Author(s): Taejeong Song, James W. McNamara, Weikang Ma, Maicon Landim-Vieira, Kyounghwan Lee, Lisa A. Martin, Judith A. Heiny, John N. Lorenz, Roger W. Craig, Jose Renato Pinto, Thomas Irving, Sakthivel Sadayappan
    Source: Proceedings of the National Academy of Sciences of the United States of America
    Fast skeletal myosin-binding protein-C (fMyBP-C) is one of three MyBP-C paralogs and is predominantly expressed in fast skeletal muscle. Mutations in the gene that encodes fMyBP-C, MYBPC2, are associated with distal arthrogryposis, while loss of fMyBP-C protein is associated with diseased muscle. However, the functional and structural roles of fMyBP-C in skeletal muscle remain unclear. To address this gap, we generated a hom...
  • Walrus large bore guide catheter impact on recanalization first pass effect and outcomes: the WICkED study

    abril 15, 2021
    Author(s): Gustavo M. Cortez, Raymond D. Turner, Andre Monteiro, Ajit S. Puri, Adnan H. Siddiqui, J. Mocco, Jan Vargas, Anna L. Kuhn, Shahram Majidi, M. Imran Chaudry, Amin Aghaebrahim, Aquilla S. Turk, Eric Sauvageau, Ricardo A. Hanel
    Source: Journal of neurointerventional surgery
    BACKGROUND: The use of a balloon-guide catheter (BGC) in acute stroke treatment has been widely adopted after demonstrating optimized procedure metrics and outcomes. Initial technical constraints of previous devices included catheter stiffness and smaller inner diameters. We aim to evaluate the performance and safety of the Walrus BGC, a variable stiffness catheter with a large bore 0.087 inch inner diameter (ID), via the th...
  • Per pass analysis of thrombus composition retrieved by mechanical thrombectomy

    abril 07, 2021
    Author(s): Mehdi Abbasi, Matthew J. Gounis
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    BACKGROUND AND AIM: Mechanical thrombectomy (MT) for large vessel occlusion often requires multiple passes to retrieve the entire thrombus load. In this multi-institutional study we sought to examine the composition of thrombus fragments retrieved with each pass during MT. METHODS: Patients who required multiple passes during thrombectomy were included. Histopathological evaluation of thrombus fragments retrieved from each p...
  • A novel deep-learning-based approach for automatic reorientation of 3D cardiac SPECT images

    abril 02, 2021
    Author(s): Duo Zhang, P. Hendrik Pretorius, Kaixian Lin, Weibing Miao, Jingsong Li, Michael A. King, Wentao Zhu
    Source: European journal of nuclear medicine and molecular imaging
    PURPOSE: Reconstructed transaxial cardiac SPECT images need to be reoriented into standard short-axis slices for subsequent accurate processing and analysis. We proposed a novel deep-learning-based method for fully automatic reorientation of cardiac SPECT images and evaluated its performance on data from two clinical centers. METHODS: We used a convolutional neural network to predict the 6 rigid-body transformation parameter...
  • In Seas of Change, a Call to Action: 2021 American Board of Medical Specialties Policy on Parental, Caregiver, and Medical Leave During Training

    marzo 31, 2021
    Author(s): Courtney P. Raybon, Sheryl G. Jordan, Lori A. Deitte, Carolynn M. DeBenedectis, Ann K. Jay, Jessica B. Robbins
    Source: Academic radiology
    Institutional graduate medical education (GME) programs are guided by architecture built by the Accreditation Council for Graduate Medical Education (ACGME), the American Board of Medical Specialties (ABMS) and, as radiology programs, the American Board of Radiology (ABR). At its core, GME is dynamic and progressive, committed to enhancing resident education and improving the patient care that residents deliver. In 2019 and ...
  • Global Impact of COVID-19 on Stroke Care

    marzo 29, 2021
    Author(s): SVIN COVID-19 global registry, Raul Nogueira, Ajit S. Puri, Anna L. Kuhn, Thanh Nguyen
    Source: International journal of stroke : official journal of the International Stroke Society; Copyright © 2021 World Stroke Organization. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE a...
    BACKGROUND: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. AIMS: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy (MT), stroke, and intracranial hemorrhage (ICH) hospitalizations over a 3-month period at the height of the pandemic (March 1 to May 31, 2020) compared with two control 3-month periods (immediately prece...
  • Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

    marzo 26, 2021
    Author(s): Thanh N. Nguyen, Ajit S. Puri, Anna L. Kuhn, Raul G. Nogueira
    Source: Stroke and vascular neurology; Copyright © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the or...
    BACKGROUND: During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines. METHODS: We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stro...
  • Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility

    marzo 26, 2021
    Author(s): Thomas L. Lynch 4th, Kyounghwan Lee, Roger W. Craig, Sakthivel Sadayappan
    Source: Journal of molecular and cellular cardiology
    Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) regulates cardiac contraction through modulation of actomyosin interactions mediated by the protein's amino terminal (N')-region (C0-C2 domains, 358 amino acids). On the other hand, dephosphorylation of cMyBP-C during myocardial injury results in cleavage of the 271 amino acid C0-C1f region and subsequent contractile dysfunction. Yet, our current understanding of ...
  • A New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter Tiger Trial

    marzo 19, 2021
    Author(s): Rishi Gupta, Ajit S. Puri
    Source: Stroke
    Background and Purpose: The Tigertriever is a novel, radially adjustable, fully visible, stentriever that permits the operator to align radial expansion with target vessel diameters. This multicenter trial compared the Tigertriever's effectiveness and safety compared with established stent retrievers. Methods: Single arm, prospective, multicenter trial comparing the Tigertriever to efficacy and safety performance goals deriv...
  • Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology

    marzo 15, 2021
    Author(s): Waleed Brinjikji, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: We retrospectively evaluated the composition of retrieved clots from ischemic stroke patients to study the association between histological composition and stroke etiology METHODS: Consecutive patients enrolled in the Stroke Thromboembolism Registry of Imaging and Pathology (STRIP) were included in this study. All patients underwent mechanical thrombectomy and retrieved clots were sent to a central core lab for p...
  • Pivotal trial of the Neuroform Atlas stent for treatment of posterior circulation aneurysms: one-year outcomes

    marzo 15, 2021
    Author(s): Brian T. Jankowitz, Ajit S. Puri
    Source: Journal of neurointerventional surgery; © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the ori...
    BACKGROUND: Stent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results. OBJECTIVE: To present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs. METHODS: The ATLAS trial is a prospective, multicenter, single-arm, open-label study of unrupture...
  • Pseudoprogression of triple-hit diffuse large B-cell lymphoma following polatuzumab vedotin-based salvage therapy

    marzo 15, 2021
    Author(s): Xin Wang, Lacey J. McIntosh, William Selove, Jaroslav Zivny, Jan Cerny
    Source: Leukemia and lymphoma
    Our case highlights the importance of recognizing the atypical radiological response of patients with hematological malignancies treated with polatuzumab vedotin or other antibody-drug conjugates.
  • Role of Surgical Intervention for Intracranial Dural Arteriovenous Fistulas With Cortical Venous Drainage in an Endovascular Era: A Case Series

    marzo 15, 2021
    Author(s): Yosuke Akamatsu, Santiago Gomez-Paz, David Vergara-Garcia, Viraj M. Moholkar, Anna L. Kuhn, Kohei Chida, Jasmeet Singh, Katyucia de Macedo Rodrigues, Francesco Massari, Justin M. Moore, Ajit S. Puri, Christopher S. Ogilvy, Ajith J. Thomas
    Source: Operative neurosurgery (Hagerstown, Md.)
    BACKGROUND: Intracranial dural arteriovenous fistulae (dAVFs) with cortical venous drainage (CVD) require treatment because of their aggressive clinical presentation and natural history. Although endovascular treatment is effective for the majority of these lesions in the current endovascular era, surgical management has been required if the lesions are not amenable to or fail endovascular treatments. OBJECTIVE: To demonstra...
  • Stereotactic Body Radiotherapy for Palliation of Hematuria Arising From Urothelial Carcinoma of the Kidney in Unfavorable Surgical Candidates

    marzo 12, 2021
    Author(s): Jesse N. Aronowitz, Linda Ding, Jennifer K. Yates, Yang Zong, Larry Z. Zheng, Zhong Jiang, Jessica Yancey, Kriti Mittal, Thomas J. Fitzgerald
    Source: American journal of clinical oncology
    INTRODUCTION: Hematuria can be a distressing and debilitating complication of urothelial carcinoma (UC) of the kidney for patients who are not candidates for surgery or ureteroscopic ablation. We retrospectively assessed the efficacy, tolerability, and safety of stereotactic body radiotherapy (SBRT) for controlling gross hematuria in this patient population. MATERIALS AND METHODS: Institutional Review Board (IRB)-approved re...
  • Modelling the impact of clot fragmentation on the microcirculation after thrombectomy

    marzo 12, 2021
    Author(s): Wahbi K. El-Bouri, Andrew MacGowan, Tamas I. Jozsa, Matthew J. Gounis, Stephen J. Payne
    Source: PLoS computational biology; Copyright: © 2021 El-Bouri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this 'no-reperfusion' phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model b...
  • Review of Artificial Intelligence Training Tools and Courses for Radiologists

    marzo 10, 2021
    Author(s): Michael L. Richardson, Hao S. Lo
    Source: Academic radiology
    Artificial intelligence (AI) systems play an increasingly important role in all parts of the imaging chain, from image creation to image interpretation to report generation. In order to responsibly manage radiology AI systems and make informed purchase decisions about them, radiologists must understand the underlying principles of AI. Our task force was formed by the Radiology Research Alliance (RRA) of the Association of Un...
  • Preventing Inadvertent Foreign Body Injection in Angiography

    marzo 09, 2021
    Author(s): Omid Nikoubashman, Afif Kraitem, Rose Arslanian, Matthew J. Gounis, Thorsten Sichtermann, Martin Wiesmann
    Source: Radiology
    Background: Inadvertent injection of foreign material during angiography, particularly neuroangiography, should be avoided to reduce the risk of embolic complications. Woven gauze and cotton fabrics have been identified as sources of inadvertent foreign body embolization. Purpose: To find the source of particles that contaminate injections on an angiography table and to identify measures for their reduction. Materials and Me...
  • Long-term GH Therapy Does Not Advance Skeletal Maturation in Children and Adolescents

    marzo 05, 2021
    Author(s): Benjamin U. Nwosu, Gabrielle Jasmin, Sadichchha Parajuli, Alan D. Rogol, Ellen C. Wallace, Austin F. Lee
    Source: Journal of the Endocrine Society; Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original wor...
    Context: There is no consensus on the effect of recombinant human GH (rhGH) therapy on skeletal maturation in children despite the current practice of annual monitoring of skeletal maturation with bone age in children on rhGH therapy. Aims: To investigate the effects of long-term rhGH therapy on skeletal age in children and explore the accuracy of bone age-predicted adult height (BAPAH) at different ages based on 13 years of...
  • Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms

    marzo 01, 2021
    Author(s): Weikang Ma, Sebastian Duno-Miranda, Thomas Irving, Roger W. Craig, Raul A. Padron
    Source: The Journal of general physiology; © 2021 Ma et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/l...
    Myosin molecules in the relaxed thick filaments of striated muscle have a helical arrangement in which the heads of each molecule interact with each other, forming the interacting-heads motif (IHM). In relaxed mammalian skeletal muscle, this helical ordering occurs only at temperatures 20 degrees C and is disrupted when temperature is decreased. Recent x-ray diffraction studies of live tarantula skeletal muscle have suggest...
  • COVID-19 Vaccination-Related Uptake on FDG PET/CT: An Emerging Dilemma and Suggestions for Management

    marzo 01, 2021
    Author(s): Lacey J. McIntosh, Alexander A. Bankier, Gopal R. Vijayaraghavan, Robert Licho, Max P. Rosen
    Source: AJR. American journal of roentgenology
    As mass COVID-19 vaccination is underway, radiologists are encountering transient FDG uptake in normal or enlarged axillary, supraclavicular, and cervical lymph nodes after ipsilateral deltoid vaccination. This phenomenon may confound interpretation in oncology patients undergoing FDG PET/CT. In this article, we present our institutional approach for management of COVID-19 vaccine-related lymphadenopathy on FDG PET/CT based ...
  • Implementation of a Novel Hands-on Advanced Radiology Elective

    marzo 01, 2021
    Author(s): Alex Newbury, Christopher A. Cerniglia, Hao S. Lo
    Source: Current problems in diagnostic radiology
    Despite the use of imaging in many medical and surgical practices, no universal mandatory radiology component is required by the Liaison Committee on Medical Education. In contrast, United States medical students are required to complete at least one core subinternship during their final year of medical school in medicine, surgery, pediatrics, or family medicine, regardless of their chosen field of interest. Students are exp...
  • Building a Learning Community for Radiology Quality and Safety in Massachusetts: Confronting Challenges and Creating Opportunities

    marzo 01, 2021
    Author(s): Jennifer C. Broder, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Radiologists in quality and safety (QS) leadership positions often arrive with little to no formal training in QS. Their determination and practical problem-solving skills have allowed them to succeed in local QS initiatives; however, they now must develop and manage practice-wide comprehensive programs and face challenges that typically lack single, straightforward solutions. Resources for QS training and program management...
  • POSITIVE: Perfusion imaging selection of ischemic stroke patients for endovascular therapy

    febrero 25, 2021
    Author(s): J. Mocco, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: The PerfusiOn imaging Selection of Ischemic sTroke patIents for endoVascular thErapy (POSITIVE) trial was designed to evaluate functional outcome in patients with emergent large vessel occlusion (ELVO) presenting within 0-12 hours with pre-specified bifurcated arms of early and late window presentation, who were selected for endovascular thrombectomy with non-vendor specific commercially available perfusion imagi...
  • Deficient spermiogenesis in mice lacking Rlim

    febrero 23, 2021
    Author(s): Feng Wang, Maria Gracia Gervasi, Ana Boskovic, Fengyun Sun, Vera D. Rinaldi, Jun Yu, Mary C. Wallingford, Darya A. Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J. Rando, Pablo E. Visconti, Lara Strittmatter, Ingolf Bach
    Source: eLife; Copyright © 2021, Wang et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
    The X-linked gene Rlim plays major roles in female mouse development and reproduction, where it is crucial for the maintenance of imprinted X chromosome inactivation in extraembryonic tissues of embryos. However, while females carrying a systemic Rlim knockout (KO) die around implantation, male Rlim KO mice appear healthy and are fertile. Here, we report an important role for Rlim in testis where it is highly expressed in po...
  • Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System [preprint]

    febrero 15, 2021
    Author(s): Michael P. Moazami, Julia M. Rembetsy-Brown, Feng Wang, Pranathi Meda Krishnamurthy, Alexandra Weiss, Miklos G. Marosfoi, Robert M. King, Mona Motwani, Heather L. Gray-Edwards, Katherine A. Fitzgerald, Robert H. Brown Jr., Jonathan K. Watts
    Source: bioRxiv; The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
    Antisense oligonucleotides (ASOs) are emerging as a promising class of therapeutics for neurological diseases. When injected directly into the cerebrospinal fluid, ASOs distribute broadly across brain regions and exert long-lasting therapeutic effects. However, many phosphorothioate (PS)-modified gapmer ASOs show transient motor phenotypes when injected into the cerebrospinal fluid, ranging from reduced motor activity to ata...
  • CT Angiogram Area Stenosis Calculations Overestimate the Degree of Carotid Stenosis Compared to NASCET Diameter Stenosis Calculations

    febrero 03, 2021
    Author(s): Edward J. Arous, Dejah R. Judelson, Anushree Agrawal, Sathish Kumar Dundamadappa, Allison S. Crawford, Kimberly T. Malka, Jessica P. Simons, Andres Schanzer
    Source: Journal of vascular surgery
    OBJECTIVE: The degree of carotid artery stenosis, as calculated by catheter-based angiography using NASCET methodology, has been shown to predict stroke risk in several large randomized controlled trials. In the current era, patients are increasingly being evaluated with CT-angiography (CTA) prior to carotid artery revascularization, especially as transcarotid artery revascularization (TCAR) adoption grows. Interpretation of...
  • The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle

    febrero 01, 2021
    Author(s): Sheema Rahmanseresht, Kyoung H. Lee, Thomas S. O'Leary, James W. McNamara, Sakthivel Sadayappan, Jeffrey Robbins, David M. Warshaw, Roger W. Craig, Michael J. Previs
    Source: The Journal of general physiology; © 2021 Rahmanseresht et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativeco...
    Myosin and actin filaments are highly organized within muscle sarcomeres. Myosin-binding protein C (MyBP-C) is a flexible, rod-like protein located within the C-zone of the sarcomere. The C-terminal domain of MyBP-C is tethered to the myosin filament backbone, and the N-terminal domains are postulated to interact with actin and/or the myosin head to modulate filament sliding. To define where the N-terminal domains of MyBP-C ...
  • Safety of the APOLLO Onyx delivery microcatheter for embolization of brain arteriovenous malformations: results from a prospective post-market study

    febrero 01, 2021
    Author(s): Philip M. Meyers, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Catheter retention and difficulty in retrieval have been observed during embolization of brain arteriovenous malformations (bAVMs) with the Onyx liquid embolic system (Onyx). The Apollo Onyx delivery microcatheter (Apollo) is a single lumen catheter designed for controlled delivery of Onyx into the neurovasculature, with a detachable distal tip to aid catheter retrieval. This study evaluates the safety of the Apo...
  • Robust breast cancer detection in mammography and digital breast tomosynthesis using an annotation-efficient deep learning approach

    febrero 01, 2021
    Author(s): William Lotter, Abdul Rahman Diab, Bryan Haslam, Jiye G. Kim, Giorgia Grisot, Eric Wu, Kevin Wu, Jorge Onieva Onieva, Yun Boyer, Jerrold L. Boxerman, Meiyun Wang, Mack Bandler, Gopal Vijayaraghavan, A. Gregory Sorensen
    Source: Nature medicine
    Breast cancer remains a global challenge, causing over 600,000 deaths in 2018 (ref. (1)). To achieve earlier cancer detection, health organizations worldwide recommend screening mammography, which is estimated to decrease breast cancer mortality by 20-40% (refs. (2,3)). Despite the clear value of screening mammography, significant false positive and false negative rates along with non-uniformities in expert reader availabili...
  • Absence of post-traumatic bone marrow edema in the setting of preeclampsia

    febrero 01, 2021
    Author(s): Tina Shiang, Ryan Tai, George J. Watts
    Source: Journal of the American Podiatric Medical Association
    Magnetic resonance imaging (MRI) is a powerful tool in the diagnosis of missed or occult fractures on radiographic and computed tomography (CT) imaging, through the detection of bone marrow edema. While radiologists often rely on bone marrow edema as a guide for diagnosing subtle underlying fractures, it is important to recognize its limitations as a diagnostic metric. We present a rare case demonstrating the absence of bone...
  • UPR(mt) scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans

    enero 20, 2021
    Author(s): Tomer Shpilka, Yunguang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Sookyung Kim, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara Strittmatter, Cole M. Haynes
    Source: Nature communications; Copyright © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or ...
    As organisms develop, individual cells generate mitochondria to fulfill physiological requirements. However, it remains unknown how mitochondrial network expansion is scaled to cell growth. The mitochondrial unfolded protein response (UPR(mt)) is a signaling pathway mediated by the transcription factor ATFS-1 which harbors a mitochondrial targeting sequence (MTS). Here, using the model organism Caenorhabditis elegans we demo...
  • Deletions in CWH43 cause idiopathic normal pressure hydrocephalus

    enero 18, 2021
    Author(s): Hong Wei Yang, Dejun Yang, Huijun Dai, Yan Zhang, Sijun Zhao, Shuo Zhang, Yan Ma, George Wang, Shaokuan Zheng, Rona S. Carroll, Mark D. Johnson
    Source: EMBO molecular medicine; Copyright 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder that occurs in about 1% of individuals over age 60 and is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and cognitive decline. The cause and pathophysiology of iNPH are largely unknown. We performed whole exome sequencing of DNA obtained from 53 unrelated iNPH patients. Two recurrent heterozygous loss of function deleti...
  • Enabling Your Radiology Business to Thrive Strategic Lessons Learned During the Initial and Subsequent Surges of the Covid-19 Pandemic

    enero 13, 2021
    Author(s): Jonathan B. Kruskal, Max P. Rosen, Amy K. Hara, Cheri Canon, Christoph Wald
    Source: Academic radiology
    The Covid-19 pandemic surges of 2020 resulted in major operational, personal, and financial impacts on US radiology practices. In response, a series of strategic and intentional operational changes were implemented, varying by practice size, structure and model. In reviewing the many business lessons that we learned during the pandemic, it became clear that for a business to be successful, a host of additional supportive fac...
  • Representation of Women in Diagnostic Radiology Residency Programs: Does National Institutes of Health Program Ranking Matter?

    enero 01, 2021
    Author(s): Grace Wang, Molly Huggett, Bruce A. Barton, Lucy B. Spalluto, Carolynn M. DeBenedectis
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: Women are consistently underrepresented in the radiology workforce. The authors examined recent trends in the gender distribution of residents entering diagnostic radiology residency programs. METHODS: A retrospective review was performed of residents entering US diagnostic radiology residency programs for graduate medical education years 2009 to 2018. Demographic and program data were obtained from the Association ...
  • Regional Variations in Diagnostic Radiology Residency Stipends Are Accentuated When Correlated With Cost of Living

    diciembre 30, 2020
    Author(s): Marco Ertreo, David Field, Dominique Rowcroft, Peter O'Halloran
    Source: Journal of the American College of Radiology : JACR
    Teaching hospitals in the United States are reimbursed for educating residents by CMS through Direct and Indirect Graduate Medical Education Payments, which are based on the number of residents, hospital beds, Medicare patients discharged, costs associated with resident education, and a federally adjusted balanced budget multiplier. Despite visibility into these standardized payments to teaching hospitals from the federal go...
  • Cryo-EM structure of the inhibited (10S) form of myosin II

    diciembre 02, 2020
    Author(s): Shixin Yang, Prince Tiwari, Kyounghwan Lee, Osamu Sato, Mitsuo Ikebe, Raul A. Padron, Roger W. Craig
    Source: Nature
    Myosin II is the motor protein that enables muscle cells to contract and nonmuscle cells to move and change shape(1). The molecule has two identical heads attached to an elongated tail, and can exist in two conformations: 10S and 6S, named for their sedimentation coefficients(2,3). The 6S conformation has an extended tail and assembles into polymeric filaments, which pull on actin filaments to generate force and motion. In 1...
  • Impact of the COVID-19 pandemic on emergency department CT for suspected diverticulitis

    diciembre 01, 2020
    Author(s): Averi L. Gibson, Byron Y. Chen, Max P. Rosen, S. Nicolas Paez, Hao S. Lo
    Source: Emergency radiology
    PURPOSE: This study examined the impact of the COVID-19 pandemic on emergency department CT use for acute nontraumatic abdominal pain, to better understand why imaging volume so drastically decreased during the COVID-19 pandemic. METHODS: This was a retrospective review of emergency imaging volumes from January 5 to May 30, 2020. Weekly volume data were collected for total imaging studies, abdominopelvic CT, and abdominopelv...
  • Cervical spondylosis is a risk factor for localized spinal cord lesions in multiple sclerosis

    diciembre 01, 2020
    Author(s): Roberto Bomprezzi, Andrew P. Chen, Christopher C. Hemond
    Source: Clinical neurology and neurosurgery
    OBJECTIVES: To answer the question whether cervical spondylosis would increase the incidence of cord lesions in MS patients, we investigated the statistical association between the two pathologies. METHODS: We extracted demographics, basic disease characteristics and MRI data of a cohort of 304 consecutive MS patients. For a subset of 176 patients, a detailed analysis independently assessed for each cervical level the co-exi...
  • Extracting signature responses from respiratory flows: Low-dimensional analyses on Direct Numerical Simulation-predicted wakes of a flapping uvula

    diciembre 01, 2020
    Author(s): Jinxiang Xi, Junshi Wang, Xiuhua April Si, Shaokuan Zheng, Ramesh Donepudi, Haibo Dong
    Source: International journal for numerical methods in biomedical engineering
    Uvula-induced snoring and associated obstructive sleep apnea is a complex phenomenon characterized by vibrating structures and highly transient vortex dynamics. This study aimed to extract signature features of uvula wake flows of different pathological origins and develop a linear reduced-order surrogate model for flow control. Six airway models were developed with two uvula kinematics and three pharynx constriction levels....
  • Mitigating Asian American Bias and Xenophobia in Response to the Coronavirus Pandemic: How You Can Be an Upstander

    diciembre 01, 2020
    Author(s): Christopher P. Ho, Alice Chong, Anand Narayan, Erin A. Cooke, Francis Deng, Vikas Agarwal, Carolynn M. DeBenedectis, Lori A. Deitte, Ann K. Jay, Nolan J. Kagetsu
    Source: Journal of the American College of Radiology : JACR
    Imagine finishing a long shift in the operating room performing aerosolizing procedures on high-risk patients with coronavirus disease 2019 (COVID-19). You are walking home, and the next thing you know, a stranger confronts you on the sidewalk shouting, “Why are you Chinese people killing everyone? What is wrong with you? Why the [expletive] are you killing us?” This is exactly what happened to an Asian American anesthesia r...
  • Natural history study of glycan accumulation in large animal models of GM2 gangliosidoses

    diciembre 01, 2020
    Author(s): Catlyn Cavender, Linley Mangini, Jeremy L. Van Vleet, Carley Corado, Emma McCullagh, Heather L. Gray-Edwards, Douglas R. Martin, Brett E. Crawford, Roger Lawrence
    Source: PloS one; Copyright: © 2020 Cavender et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    beta-hexosaminidase is an enzyme responsible for the degradation of gangliosides, glycans, and other glycoconjugates containing beta-linked hexosamines that enter the lysosome. GM2 gangliosidoses, such as Tay-Sachs and Sandhoff, are lysosomal storage disorders characterized by beta-hexosaminidase deficiency and subsequent lysosomal accumulation of its substrate metabolites. These two diseases result in neurodegeneration and ...
  • Modelling the impact of clot fragmentation on the microcirculation after thrombectomy [preprint]

    noviembre 30, 2020
    Author(s): Wahbi K. El-Bouri, Andrew MacGowan, Tamás I. Józsa, Matthew J. Gounis, Stephen J. Payne
    Source: bioRxiv; The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
    Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this ‘no-reperfusion’ phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model b...
  • Radiology podcasting as a model for asynchronous remote learning in the COVID-19 era

    noviembre 26, 2020
    Author(s): Tina Shiang, Christopher Cerniglia, Hannah Lin, Hao S. Lo
    Source: Clinical imaging
    RATIONALE AND OBJECTIVES: We aimed to create an open access online radiology podcast to educate listeners at any time, from anywhere. To meet learner needs and improve the likelihood of successful implementation and utilization, we assessed radiology trainee attitudes and experiences of podcasts. MATERIALS AND METHODS: We developed an educational podcast, From the Viewbox, focused on evergreen themes and practical approaches...
  • Prognostic relevance of temporal muscle thickness as a marker of sarcopenia in patients with glioblastoma at diagnosis

    noviembre 17, 2020
    Author(s): Riccardo Muglia, Matteo Simonelli, Federico Pessina, Emanuela Morenghi, Pierina Navarria, Pasquale Persico, Elena Lorenzi, Angelo Dipasquale, Marco Grimaldi, Marta Scorsetti, Armando Santoro, Letterio S. Politi
    Source: European radiology
    OBJECTIVES: Temporal muscle thickness (TMT) is a surrogate marker of sarcopenia, correlated with survival expectancy in patients suffering from brain metastases and recurrent or treated glioblastoma. We evaluated the prognostic relevance of TMT measured on brain MRIs acquired at diagnosis in patients affected by glioblastoma. METHODS: We retrospectively enrolled 51 patients in our Institution affected by methylated MGMT prom...
  • Quantitative Characterization of Recanalization and Distal Emboli with a Novel Thrombectomy Device

    noviembre 11, 2020
    Author(s): Juyu Chueh, Miklos G. Marosfoi, Vania Anagnostakou, Rose Arslanian, Michael P. Marks, Matthew J. Gounis
    Source: Cardiovascular and interventional radiology
    PURPOSE: The first-pass effect during mechanical thrombectomy improves clinical outcomes regardless of first-line treatment approach, but current success rates for complete clot capture with one attempt are still less than 40%. We hypothesize that the ThrombX retriever (ThrombX Medical Inc.) can better engage challenging clot models during retrieval throughout tortuous vasculature in comparison with a standard stent retrieve...
  • Deep learning with noise-to-noise training for denoising in SPECT myocardial perfusion imaging

    noviembre 03, 2020
    Author(s): Junchi Liu, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    PURPOSE: Post-reconstruction filtering is often applied for noise suppression due to limited data counts in myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT). We study a deep learning (DL) approach for denoising in conventional SPECT-MPI acquisitions, and investigate whether it can be more effective for improving the detectability of perfusion defects compared to traditional postfilte...
  • Still Coming Out of the Dark: Enduring Effects of Simulation-Based Communication Skills Training for Radiology Residents-Four-Year Follow-Up

    noviembre 01, 2020
    Author(s): Sana Majid, Jean-Marc Gauguet, Lacey J. McIntosh, George Watts, Max P. Rosen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    PURPOSE: To evaluate the long-term efficacy of simulation-based communication skills training for radiology residents. METHOD AND MATERIALS: The simulation-based communication skills training curriculum was developed in 2014. The curriculum included a teaching module based on the essential elements of communication. Two sets of 6 communication scenarios encountered by radiologist were created. First and fourth year radiology...
  • ACR Appropriateness Criteria(R) Liver Lesion-Initial Characterization

    noviembre 01, 2020
    Author(s): Expert Panel on Gastrointestinal Imaging, Victoria Chernyak, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Incidental liver masses are commonly identified on imaging performed for other indications. Since the prevalence of benign focal liver lesions in adults is high, even in patients with primary malignancy, accurate characterization of incidentally detected lesions is of paramount clinical importance. This document reviews utilization of various imaging modalities for characterization of incidentally detected liver lesions, dis...
  • Distal radial artery (Snuffbox) access for intracranial aneurysm treatment using the Woven EndoBridge (WEB) device

    noviembre 01, 2020
    Author(s): Anna L. Kuhn, Jasmeet Singh, Katyucia de Macedo Rodrigues, Francesco Massari, Viraj M. Moholkar, Suroop K. Marwah, Danyal Unar, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
    Preliminary experience with distal radial artery (dRA) access for diagnostic cerebral angiography and some neurointerventional procedures has proved to be promising with good technical results and a reliable safety profile. Vascular access via the dRA may further improve minimally invasive treatment of intracranial aneurysms. Between July 2019 and June 2020 we identified 11 patients (9 females) with a mean age of 63.5 years ...
  • Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients

    noviembre 01, 2020
    Author(s): Jason Levy, Thomas Hopkins, Jonathan Morris, Nam D. Tran, Elizabeth David, Francesco Massari, Hamed Farid, Alexander Vogel, William G. O'Connell, Peter Sunenshine, Robert Dixon, Afshin Gangi, Nicolas von der Hoh, Sandeep Bagla
    Source: Journal of vascular and interventional radiology : JVIR; © SIR, 2020. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    PURPOSE: To evaluate the effectiveness of radiofrequency (RF) ablation as measured by change in worst pain score from baseline to 3 mo after RF ablation for the palliative treatment of painful bone metastases. MATERIALS AND METHODS: One hundred patients (mean age, 64.6 y) underwent RF ablation for metastatic bone disease and were followed up to 6 mo. Subjects' pain and quality of life were measured before RF ablation and pos...
  • Pulmonary Edema: A Pictorial Review of Imaging Manifestations and Current Understanding of Mechanisms of Disease

    octubre 30, 2020
    Author(s): Maria Barile
    Source: European journal of radiology open; © 2020 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
    Pulmonary edema is a common clinical entity caused by the extravascular movement of fluid into the pulmonary interstitium and alveoli. The four physiologic categories of edema include hydrostatic pressure edema, permeability edema with and without diffuse alveolar damage (DAD), and mixed edema where there is both an increase in hydrostatic pressure and membrane permeability. As radiographic manifestations and etiologies are ...
  • Simple quantitative chest CT for pulmonary edema

    octubre 30, 2020
    Author(s): Maria Barile, Tomoyuki Hida, Mark Hammer, Hiroto Hatabu
    Source: European journal of radiology open; © 2020 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Purpose: To determine the accuracy of quantitative CT to diagnose pulmonary edema compared to qualitative CT and CXR and to determine a threshold Hounsfield unit (HU) measurement for pulmonary edema on CT examinations. Method: Electronic medical records were searched for patients with a billing diagnosis of heart failure and a Chest CT and CXR performed within three hours between 1/1/2016 to 10/1/2016, yielding 100 patients....
  • Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives

    octubre 29, 2020
    Author(s): Yang Zong, Rodolfo Montironi, Francesco Massari, Zhong Jiang, Antonio Lopez-Beltran, Thomas M. Wheeler, Marina Scarpelli, Matteo Santoni, Alessia Cimadamore, Liang Cheng
    Source: European urology focus
    Intraductal carcinoma of the prostate (IDC-P), a clinicopathological entity characterized by malignant prostatic epithelial cells growing within ducts and/or acini, has a distinct architectural pattern, cytological features, and biological behavior. Whereas most IDC-P tumors could be derived from adjacent high-grade invasive cancer via retrograde spreading of cancer cells along benign ducts and acini, a small subset of IDC-P...
  • The radiologist empowerment through virtual multidisciplinary tumor boards: The commitment of oncologic care during COVID-19 pandemic

    octubre 21, 2020
    Author(s): Nicolo Gennaro, Andrea Marrari, Alexia F. Bertuzzi, Luca Balzarini, Armando Santoro, Letterio S. Politi
    Source: Clinical imaging
    Highlights: Implementing a virtual tumor board program should represent a feasible goal for every health-care provider pursuing clinical excellence; even in time of COVID-19, the multidisciplinary commitment to oncologic care should remain imperative, as cancer may not forgive delays; working daily with advanced computer technologies, radiologists should lead virtual multidisciplinary tumor boards by present key images.
  • Lipophilic dye-compatible brain clearing technique allowing correlative magnetic resonance/high-resolution fluorescence imaging in rat models of glioblastoma

    octubre 21, 2020
    Author(s): Marco Peviani, Giorgia Spano, Antonella Pagani, Gianluca Brugnara, Cesare Covino, Rossella Galli, Alessandra Biffi, Letterio S. Politi
    Source: Scientific reports; Copyright © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or othe...
    In this work we optimized a novel approach for combining in vivo MRI and ex vivo high-resolution fluorescence microscopy that involves: (i) a method for slicing rat brain tissue into sections with the same thickness and spatial orientation as in in vivo MRI, to better correlate in vivo MRI analyses with ex-vivo imaging via scanning confocal microscope and (ii) an improved clearing protocol compatible with lipophilic dyes tha...
  • Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance

    octubre 16, 2020
    Author(s): Benjamin Auer, Navid Zeraatkar, Justin C. Goding, Arda Konik, Timothy J. Fromme, Kesava S. Kalluri, Lars R. Furenlid, Phillip H. Kuo, Michael A. King
    Source: Physics in medicine and biology; © 2020 Institute of Physics and Engineering in Medicine. As the Version of Record of this article is going to be/has been published on a subscription basis, this Accepted Manuscript will be available for reuse under a CC BY-NC-ND 3.0 licence after a 12 month embargo period.
    With brain-dedicated multi-detector systems employing pinhole apertures the usage of detectors facing the top of the patient's head (i.e., quasi-vertex views) can provide the advantage of additional viewing from close to the brain for improved detector coverage. In this paper, we report the results of simulation and reconstruction studies to investigate the impact of the quasi-vertex views on the imaging performance of Adapt...
  • Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke

    octubre 06, 2020
    Author(s): Jan Vargas, Jonathan Blalock, Anand Venkatraman, Vania Anagnostakou, Robert M. King, Joseph A. Ewing, Matthew J. Gounis, Raymond D. Turner, Imran Chaudry, Aquilla Turk
    Source: Journal of neurointerventional surgery; © Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is giv...
    BACKGROUND: Direct aspiration thrombectomy techniques use large bore aspiration catheters for mechanical thrombectomy. Several aspiration catheters are now available. We report a bench top exploration of a novel beveled tip catheter and our experience in treating large vessel occlusions (LVOs) using next-generation aspiration catheters. METHODS: A retrospective analysis from a prospectively maintained database comparing the ...
  • In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling

    octubre 05, 2020
    Author(s): Robert M. King, Jildaz Caroff, Erin T. Langan, Anita M. Leporati, Aurora Rodriguez-Rodriguez, Christopher M. Raskett, Suresh Gupta, Ajit S. Puri, Peter Caravan, Matthew J. Gounis, Alexei A. Bogdanov
    Source: Journal of neurointerventional surgery
    OBJECTIVE: To investigate in situ decellularization of a large animal model of saccular aneurysm as a strategy for achieving aneurysmal growth and lasting inflammation. METHODS: 18 New Zealand White rabbits were randomized 2:1 to receive endoluminal sodium dodecyl sulfate infusion (SDS, 1% solution, 45 min) following elastase or elastase-only treatment (control). All aneurysms were measured by digital subtraction angiography...
  • The clinical utilities of multi-pinhole single photon emission computed tomography

    octubre 01, 2020
    Author(s): Ilker Ozsahin, Ling Chen, Arda Konik, Michael A. King, Freek J. Beekman, Greta S. P. Mok
    Source: Quantitative imaging in medicine and surgery; Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to bot...
    Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very successful application in small animal imaging, there has been a resurgence of the use...
  • High-resolution image-guided WEB aneurysm embolization by high-frequency optical coherence tomography

    septiembre 28, 2020
    Author(s): Zeynep Vardar, Robert M. King, Afif Kraitem, Erin T. Langan, Lindsy M. Peterson, Benjamin H. Duncan, Christopher M. Raskett, Vania Anagnostakou, Matthew J. Gounis, Ajit S. Puri, Giovanni J. Ughi
    Source: Journal of neurointerventional surgery
    BACKGROUND: High-frequency optical coherence tomography (HF-OCT) is an intra-vascular imaging technique capable of assessing device-vessel interactions at spatial resolution approaching 10 microm. We tested the hypothesis that adequately deployed Woven EndoBridge (WEB) devices as visualized by HF-OCT lead to higher aneurysm occlusion rates. METHODS: In a leporine model, elastase-induced aneurysms (n=24) were treated with the...
  • Thermus thermophilus Argonaute Functions in the Completion of DNA Replication

    septiembre 17, 2020
    Author(s): Samson M. Jolly, Ildar Gainetdinov, , Han Zhang, Lara Strittmatter, Shannon M. Bailey, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, Phillip D. Zamore
    Source: Cell
    In many eukaryotes, Argonaute proteins, guided by short RNA sequences, defend cells against transposons and viruses. In the eubacterium Thermus thermophilus, the DNA-guided Argonaute TtAgo defends against transformation by DNA plasmids. Here, we report that TtAgo also participates in DNA replication. In vivo, TtAgo binds 15- to 18-nt DNA guides derived from the chromosomal region where replication terminates and associates w...
  • Outcomes After Stereotactic Body Radiation Therapy as a Bridging Modality to Liver Transplantation for Hepatocellular Carcinoma

    septiembre 14, 2020
    Author(s): Rashi Garg, Kim Foley, Babak Movahedi, Mark Masciocchi, Jacob R. Bledsoe, Linda Ding, Paul Rava, Thomas J. Fitzgerald, Shirin Sioshansi
    Source: Advances in radiation oncology; Copyright © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Purpose: For patients with hepatocellular carcinoma awaiting liver transplantation (LT), stereotactic body radiation therapy (SBRT) has emerged as a bridging treatment to ensure patients maintain priority status and eligibility per Milan criteria. In this study, we aimed to determine the efficacy and safety of SBRT in such situations. Methods and Materials: A retrospective analysis was conducted of the outcomes of 27 patient...
  • Distal radial artery (snuffbox) access for carotid artery stenting - Technical pearls and procedural set-up

    septiembre 13, 2020
    Author(s): Anna L. Kuhn, Jasmeet Singh, Viraj M. Moholkar, Sudhakar R. Satti, Katyucia de Macedo Rodrigues, Francesco Massari, Matthew J. Gounis, Archie McGowen, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    PURPOSE: To report use of distal radial artery (dRA) access for carotid artery stenting (CAS) and to discuss procedural setup and technical considerations for a successful intervention. METHODS: A retrospective review of our prospective neurointerventional database of CAS was conducted between May 2019 and March 2020. All CAS cases via dRA in the anatomical snuffbox were identified. Patient demographics, clinical information...
  • Impact of the COVID-19 pandemic on emergency department CT for suspected diverticulitis: A natural experiment to explain patients’ and clinicians’ assessment of risk and willingness to undergo CT scanning? [preprint]

    septiembre 11, 2020
    Author(s): Averi L. Gibson, Byron Y. Chen, Max P. Rosen, S. Nicolas Paez, Hao S. Lo
    Source: Research Square; This work is a preprint. Preprints are preliminary reports that have not undergone peer review. It is licensed under a Creative Commons Attribution 4.0 International License.
    Purpose: This study examined the impact of the COVID-19 pandemic on emergency department CT use for acute non-traumatic abdominal pain, to better understand why imaging volume so drastically decreased during the COVID-19 pandemic. Methods: This was a retrospective review of emergency imaging volumes from January 5 to May 30, 2020. Weekly volume data were collected for total imaging studies, abdominopelvic CT, and abdominopel...
  • Diffusion rather than intraflagellar transport likely provides most of the tubulin required for axonemal assembly in Chlamydomonas

    septiembre 11, 2020
    Author(s): Julie Craft Van De Weghe, J. Aaron Harris, Tomohiro Kubo, George B. Witman, Karl F. Lechtreck
    Source: Journal of cell science; © 2020. Published by The Company of Biologists Ltd. Publisher PDF posted after 12 months as allowed by publisher's author rights policy at https://www.biologists.com/user-licence-1-1/.
    Tubulin enters the cilium by diffusion and motor-based intraflagellar transport (IFT). However, the respective contribution of each route in providing tubulin for axonemal assembly remains unknown. Using Chlamydomonas, we attenuated IFT-based tubulin transport of GFP-beta-tubulin by altering the IFT74N-IFT81N tubulin-binding module and the C-terminal E-hook of tubulin. E-hook-deficient GFP-beta-tubulin was incorporated into ...
  • Assessing invasiveness of subsolid lung adenocarcinomas with combined attenuation and geometric feature models

    septiembre 03, 2020
    Author(s): Constance de Margerie-Mellon, Ritu R. Gill, Pascal Salazar, Anastasia Oikonomou, Elsie T. Nguyen, Benedikt H. Heidinger, Mayra A. Medina, Paul A. VanderLaan, Alexander A. Bankier
    Source: Scientific reports; Copyright © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or oth...
    The aim of this study was to develop and test multiclass predictive models for assessing the invasiveness of individual lung adenocarcinomas presenting as subsolid nodules on computed tomography (CT). 227 lung adenocarcinomas were included: 31 atypical adenomatous hyperplasia and adenocarcinomas in situ (class H1), 64 minimally invasive adenocarcinomas (class H2) and 132 invasive adenocarcinomas (class H3). Nodules were segm...
  • Patient Friendly Summary of the ACR Appropriateness Criteria: Acute Mental Status Change, Delirium, and New Onset Psychosis

    septiembre 01, 2020
    Author(s): Susan Anemone, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Changes in mental status can be caused by a variety of factors, including intoxication, infection, stroke, bleeding, tumor, fluid, trauma or brain injury, and inflammation. This can show up as changes in behavior, alertness, agitation, confusion, and seizures. When there is high suspicion of bleeding, stroke, infection, or tumor or if the individual has extremely high blood pressure, CT or MRI without intravenous (IV) contra...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Radiologic Management of Venous Thromboembolism-Inferior Vena Cava Filters

    septiembre 01, 2020
    Author(s): Susan Anemone, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Deep vein thrombosis is caused by blood clots in the veins in the legs. These can travel to the lungs, causing pulmonary embolism (PE). These conditions are referred to as venous thromboembolism (VTE). VTE is usually treated with anticoagulants (medicines that decrease blood clotting). It may also be appropriate to put a permanent or retrievable device within the inferior vena cava (IVC) to stop the clot from going into the...
  • COVID-19 and its Mimics: What the Radiologist Needs to Know

    agosto 25, 2020
    Author(s): Sameer H. Hanfi, Tasneem K. Lalani, Amina Saghir, Lacey J. McIntosh, Hao S. Lo, Hemang M. Kotecha
    Source: Journal of thoracic imaging
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current outbreak of Coronavirus disease 2019 (COVID-19). Although imaging should not be used for first-line screening or diagnosis, radiologists need to be aware of its imaging features, and those of common conditions that may mimic COVID-19 pneumonia. In this Pictorial Essay, we review frequently encountered conditions with imaging features ...
  • Endovascular treatment of anterior cranial fossa dural arteriovenous fistula: a multicenter series

    agosto 25, 2020
    Author(s): Guilherme Dabus, Peter Kan, Carlos Diaz, Boris Pabon, Juan Andres-Mejia, Italo Linfante, Jonathan A. Grossberg, Brian M. Howard, Civan Islak, Naci Kocer, Osman Kizilkilic, Ajit S. Puri, Anna L. Kuhn, Viraj M. Moholkar, Santiago Ortega-Gutierrez, Edgar A. Samaniego, Michael W. McDermott
    Source: Neuroradiology
    PURPOSE: We report a multicenter experience using endovascular embolization as the first line approach for treatment of anterior cranial fossa (ACF) dural arteriovenous fistula (DAVF). METHODS: All patients with DAVFs located in the anterior cranial fossa who were treated with endovascular technique as a first line approach were included. Demographics, clinical presentation, angioarchitecture, strategy, complications, immedi...
  • Extracellular Vesicles from Pseudomonas aeruginosa Suppress MHC-Related Molecules in Human Lung Macrophages

    agosto 20, 2020
    Author(s): David A. Armstrong, Min Kyung. Lee, Haley F. Hazlett, John A. Dessaint, Diane L. Mellinger, Daniel S. Aridgides, Gregory M. Hendricks, Moemen A. K. Abdalla, Brock C. Christensen, Alix Ashare
    Source: ImmunoHorizons; Copyright © 2020 The Authors. This article is distributed under the terms of the CC BY-NC 4.0 Unported license.
    Pseudomonas aeruginosa, a Gram-negative bacterium, is one of the most common pathogens colonizing the lungs of cystic fibrosis patients. P. aeruginosa secrete extracellular vesicles (EVs) that contain LPS and other virulence factors that modulate the host's innate immune response, leading to an increased local proinflammatory response and reduced pathogen clearance, resulting in chronic infection and ultimately poor patient ...
  • Ischaemic stroke associated with COVID-19 and racial outcome disparity in North America

    agosto 13, 2020
    Author(s): Adam A. Dmytriw, Anna L. Kuhn, Ajit S. Puri
    Source: Journal of neurology, neurosurgery, and psychiatry
    A retrospective study from the COVID-19 outbreak in Wuhan, China demonstrated an incidence of acute ischaemic stroke of approximately 5% in hospitalised patients with severe disease. However, there has been limited evidence on the influence of racial background in stroke outcomes in this pandemic. We report 69 cases of acute stroke in patients positive for SARS-CoV-2, including 27 of African–American background and 42 of oth...
  • "What Program Directors Think" V: Results of the 2019 Spring Survey of the Association of Program Directors in Radiology (APDR)

    agosto 07, 2020
    Author(s): Anna Rozenshtein, Brent D. Griffith, Priscilla J. Slanetz, Carolynn M. DeBenedectis, Jennifer E. Gould, Jennifer R. Kohr, Tan-Lucien Mohammed, Angelisa M. Paladin, Paul J. Rochon, Monica Sheth, Ernest F. Wiggins III, Jonathan O. Swanson
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: The Association of Program Directors in Radiology (APDR) surveys its membership annually on hot topics and new developments in radiology residency training. Here we report the results of that annual survey. MATERIALS AND METHODS: A web-based survey was posed to the APDR membership in the Fall of 2018. Members were asked 43 questions on program staffing, resident education resources/funding, impact o...
  • Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

    agosto 07, 2020
    Author(s): Navid Zeraatkar, Kesava S. Kalluri, Benjamin Auer, Arda Konik, Timothy J. Fromme, Lars R. Furenlid, Phillip H. Kuo, Michael A. King
    Source: IEEE transactions on medical imaging; (c) 2020 IEEE. Accepted manuscript posted as allowed by the publisher's policy at https://www.ieee.org/publications/rights/author-posting-policy.html.
    We designed a dedicated multi-detector multi-pinhole brain SPECT scanner to generate images of higher quality compared to general-purpose systems. The system, AdaptiSPECT-C, is intended to adapt its sensitivity-resolution trade-off by varying its aperture configurations allowing both high-sensitivity dynamic and high-spatial-resolution static imaging. The current system design consists of 23 detector heads arranged in a trun...
  • USMLE Step 3 Scores Have Value in Predicting ABR Core Examination Outcome and Performance: A Multi-institutional Study

    agosto 06, 2020
    Author(s): Maitray D. Patel, Carolynn M. DeBenedectis
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: We analyzed multi-institutional data to determine if Step 3 performance tiers can identify radiology residents with increased risk of Core examination failure and submean performance. MATERIALS AND METHODS: We collected Step 3 scores (USMLE Step 3 or COMLEX Level 3) and American Board of Radiology (ABR) Core examination outcomes and scores for anonymized residents from 13 different Diagnostic Radiol...
  • Semantic Segmentation of Smartphone Wound Images: Comparative Analysis of AHRF and CNN-Based Approaches

    agosto 06, 2020
    Author(s): Ameya Wagh, Shubham Jain, Apratim Mukherjee, Emmanuel Agu, Peder Pedersen, Diane Strong, Bengisu Tulu, Clifford Lindsay, Ziyang Liu
    Source: IEEE access : practical innovations, open solutions; This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/.
    Smartphone wound image analysis has recently emerged as a viable way to assess healing progress and provide actionable feedback to patients and caregivers between hospital appointments. Segmentation is a key image analysis step, after which attributes of the wound segment (e.g. wound area and tissue composition) can be analyzed. The Associated Hierarchical Random Field (AHRF) formulates the image segmentation problem as a gr...
  • A case of solitary kidney with duplex collecting systems and renal vascular variants in an adult male cadaver

    agosto 04, 2020
    Author(s): Mehdi S. Salimy, Gabrielle A. Luiselli, Megan Yuen, Rose C. Healy, S. G. Shah, Eustathia Lela Giannaris, Manas Das, Alexandra E. Wink
    Source: Folia morphologica; This article has been peer reviewed and published immediately upon acceptance. It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.
    We describe a unique solitary kidney with duplex collecting system and vascular variation observed in an 86-year-old White male formaldehyde- and phenol-fixed cadaver during routine academic dissection. The left renal fossa was empty with an intact adrenal gland, and the right renal fossa contained a fused renal mass with apparent polarity between the superior and inferior regions and two renal pelves converging into a singl...
  • Analysis of Recombinant Adeno-Associated Virus (rAAV) Sample Morphology Using Negative Staining and High-Resolution Electron Microscopy

    agosto 03, 2020
    Author(s): Gregory M. Hendricks, Miguel Sena-Esteves, Guangping Gao
    Source: Cold Spring Harbor protocols
    Negative staining is a simple and rapid method for studying the morphology and ultrastructure of small particulate specimens (e.g., viruses, bacteria, cell fragments, and isolated macromolecules such as proteins and nucleic acids). The technique described in this protocol involves allowing particles or fragments of cells to settle onto a support film, then applying a drop of metal salt solution to the adherent particulate sp...
  • COVID-19 Impact on Well-Being and Education in Radiology Residencies: A Survey of the Association of Program Directors in Radiology

    agosto 01, 2020
    Author(s): Jessica B. Robbins, Eric England, Maitray D. Patel, Carolynn M. DeBenedectis, David S. Sarkany, Darel E. Heitkamp, James M. Milburn, Vivek Kalia, Kamran Ali, Glenn C. Gaviola, Christopher P. Ho, Ann K. Jay, Seng Ong, Sheryl G. Jordan
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: The COVID-19 pandemic has forced rapid evolution of the healthcare environment. Efforts to mitigate the spread of the virus through social distancing and shelter-at-home edicts have unintended consequences upon clinical and educational missions and mental well-being of radiology departments. We sought to understand the impact of the COVID-19 pandemic on radiology residencies with respect to the educ...
  • Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging

    agosto 01, 2020
    Author(s): Nicolo Gennaro, Andrea Marrari, Salvatore Lorenzo Renne, Ferdinando Carlo Maria Cananzi, Vittorio Lorenzo Quagliuolo, Lucia Di Brina, Marta Scorsetti, Giovanna Pepe, Arturo Chiti, Armando Santoro, Luca Balzarini, Letterio S. Politi, Alexia Francesca Bertuzzi
    Source: The British journal of radiology
    Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, st...
  • Loss of supervillin causes myopathy with myofibrillar disorganization and autophagic vacuoles

    agosto 01, 2020
    Author(s): Carola Hedberg-Oldfors, Elizabeth J. Luna, Anders Oldfors, Cordula Knopp
    Source: Brain : a journal of neurology; © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. F...
    The muscle specific isoform of the supervillin protein (SV2), encoded by the SVIL gene, is a large sarcolemmal myosin II- and F-actin-binding protein. Supervillin (SV2) binds and co-localizes with costameric dystrophin and binds nebulin, potentially attaching the sarcolemma to myofibrillar Z-lines. Despite its important role in muscle cell physiology suggested by various in vitro studies, there are so far no reports of any h...
  • A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy

    julio 31, 2020
    Author(s): Giovanni J. Ughi, Miklos G. Marosfoi, Robert M. King, Jildaz Caroff, Lindsy M. Peterson, Benjamin H. Duncan, Erin T. Langan, Amanda J. Collins, Anita M. Leporati, Serge Rousselle, Demetrius K. Lopes, Matthew J. Gounis, Ajit S. Puri
    Source: Nature communications; Copyright © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or ...
    Intravascular imaging has emerged as a valuable tool for the treatment of coronary and peripheral artery disease; however, no solution is available for safe and reliable use in the tortuous vascular anatomy of the brain. Endovascular treatment of stroke is delivered under image guidance with insufficient resolution to adequately assess underlying arterial pathology and therapeutic devices. High-resolution imaging, enabling s...
  • Molecular Assessment of Epiretinal Membrane: Activated Microglia, Oxidative Stress and Inflammation

    julio 23, 2020
    Author(s): Sushma Vishwakarma, Rishikesh Kumar Gupta, Saumya Jakati, Mudit Tyagi, Rajeev Reddy Pappuru, Keith Reddig, Gregory M. Hendricks, Michael R. Volkert, Hemant Khanna, Jay Chhablani, Inderjeet Kaur
    Source: Antioxidants (Basel, Switzerland); © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    Fibrocellular membrane or epiretinal membrane (ERM) forms on the surface of the inner limiting membrane (ILM) in the inner retina and alters the structure and function of the retina. ERM formation is frequently observed in ocular inflammatory conditions, such as proliferative diabetic retinopathy (PDR) and retinal detachment (RD). Although peeling of the ERM is used as a surgical intervention, it can inadvertently distort th...
  • Magnetic resonance contrast agents in optical clearing: Prospects for multimodal tissue imaging

    julio 20, 2020
    Author(s): Daria K. Tuchina, Irina G. Meerovich, Olga A. Sindeeva, Victoria V. Zherdeva, Alexander P. Savitsky, Alexei A. Bogdanov, Valery V. Tuchin
    Source: Journal of biophotonics
    Skin optical clearing effect ex vivo and in vivo was achieved by topical application of low molecular weight paramagnetic magnetic resonance contrast agents. This novel feature has not been explored before. By using collimated transmittance the diffusion coefficients of three clinically used magnetic resonance contrast agents, that is Gadovist, Magnevist and Dotarem as well as X-ray contrast agent Visipaque in mouse skin wer...
  • Trapped Embolic Protection Device: A Salvage Technique

    julio 16, 2020
    Author(s): Anna L. Kuhn, Ajit S. Puri, Katyucia de Macedo Rodrigues, Francesco Massari, Jasmeet Singh
    Source: Cureus; Copyright 2020 Kuhn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    After carotid artery stenting, retrieval of the embolic protection device can sometimes be difficult due to incomplete stent expansion, stent fracture, vasospasm, and vessel tortuosity. In this technical report, we describe a novel rescue technique used in a patient with diffuse calcific atherosclerosis of the left common and proximal left internal carotid arteries who underwent left internal carotid artery stenting with cer...
  • The rates of second lung cancers and the survival of surgically-resected second primary lung cancers in patients undergoing resection of an initial primary lung cancer

    julio 15, 2020
    Author(s): John M. Varlotto, Paul Rava, Thomas J. FitzGerald, Mark W. Maxfield, Feiran Lou, Paulo Oliveira, Rahul N. Sood, Jennifer Baima, J. Zhang, Lacey J. McIntosh, William Walsh, Debra Maddox, Karl Fabian Uy
    Source: Lung cancer (Amsterdam, Netherlands)
    BACKGROUND: The Lung Cancer Screening Trial demonstrated improved overall survival (OS) and lung cancer specific survival (LCSS), likely due to finding early-stage NSCLC. The purpose of our investigation is to evaluate whether long-term surveillance strategies (4+ years after surgical resection of the initial lung cancer(1LC)) would be beneficial in NSCLC patients by assessing the rates of second lung cancers(2LC) and the OS...
  • Evolving Role of Radiology in COVID-19 Pandemic: A Review

    julio 11, 2020
    Author(s): Sarwat Hussain
    Source: Annals of King Edward Medical University; This work is licensed under a Creative Commons Attribution 4.0 International License. This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Background: This worldwide outbreak has disrupted a steady world of healthcare. Until now, diagnostic radiology and laboratory tests had been reasonably accurate in confirmed disease. Methods: The review article used data bases, published literature, radiological guidelines issued from societies related to COVID-19 and large number of research journals to find out the latest evidence for the evolving role of radiology in COV...
  • Impact of Coronavirus Disease 2019 (COVID-19) on the Practice of Clinical Radiology

    julio 09, 2020
    Author(s): Max P. Rosen, Alexander Norbash, Jonathan Kruskal, Carolyn C. Meltzer, Judy Yee, James Thrall
    Source: Journal of the American College of Radiology : JACR
    The speed at which coronavirus disease 2019 (COVID-19) spread quickly fractured the radiology practice model in ways that were never considered. In March 2020, most practices saw an unprecedented drop in their volume of greater than 50%. The profound changes that have interrupted the arc of the radiology narrative may substantially dictate how health care and radiology services are delivered in the future. We examine the imp...
  • Optimization of Endovascular Therapy in the Neuroangiography Suite to Achieve Fast and Complete (Expanded Treatment in Cerebral Ischemia 2c-3) Reperfusion

    julio 01, 2020
    Author(s): Ryan A. McTaggart, Johanna M. Ospel, Marios-Nikos Psychogios, Ajit S. Puri, Christian Maegerlein, Kendall M. Lane, Mahesh V. Jayaraman, Mayank Goyal
    Source: Stroke
    The first part of this review provides a step-by-step guide to optimize endovascular therapy (EVT) for your patients, whereas the second part describes management strategies for frequently encountered challenging situations, which might require additional steps or modification of the thrombectomy approach.
  • Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist

    julio 01, 2020
    Author(s): Vanessa Fiorini Furtado, Kira Melamud, Khalid Hassan, Saurabh Rohatgi, Karen Buch
    Source: Clinical imaging
    Immune checkpoint inhibitors are monoclonal antibodies directed against cellular pathways on T-cells to treat different types of malignancies. This new therapy can cause immune-related adverse events that can involve almost any organ system. This article will review clinical presentations, molecular mechanisms and imaging manifestations of adverse events caused by checkpoint inhibitors and also illustrate the pseudoprogressi...
  • Clinical evaluation of three respiratory gating schemes for different respiratory patterns on cardiac SPECT

    junio 24, 2020
    Author(s): Duo Zhang, Jingzhang Sun, P. Hendrik Pretorius, Michael A. King, Greta S. P. Mok
    Source: Medical physics
    PURPOSE: Respiratory gating reduces respiratory blur in cardiac single photon emission computed tomography (SPECT). It can be implemented as three gating schemes: (a) equal amplitude-based gating (AG); (b) phase or time-based gating (TG); or (c) equal count-based gating (CG), that is, a variant of amplitude-based method. The goal of this study is to evaluate the effectiveness of these respiratory gating methods for patients ...
  • Factors Associated with Mortality After Undergoing Thrombectomy for Acute Ischemic Stroke

    junio 12, 2020
    Author(s): Hannah Lin
    Source: Morningside Graduate School of Biomedical Sciences Dissertations and Theses; Licensed under a Creative Commons license
    Background: Mechanical thrombectomy is the gold standard for treating patients with certain acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, even with major advancements and increasing procedural volumes, acute endovascular therapy remains a high-risk procedure with a considerable 90-day mortality rate, affected by a variety of factors. Purpose: To investigate various clinical and procedural factors ...
  • The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms

    junio 02, 2020
    Author(s): Raul Padron, Weikang Ma, Sebastian Duno-Miranda, Natalia Koubassova, Kyounghwan Lee, Antonio Pinto, Lorenzo Alamo, Pura Bolanos, Andrey Tsaturyan, Thomas Irving, Roger W. Craig
    Source: Proceedings of the National Academy of Sciences of the United States of America; © 2020. PDF posted with 6-month embargo to author's website as allowed by publisher's default license at https://www.pnas.org/page/authors/licenses.
    Striated muscle contraction involves sliding of actin thin filaments along myosin thick filaments, controlled by calcium through thin filament activation. In relaxed muscle, the two heads of myosin interact with each other on the filament surface to form the interacting-heads motif (IHM). A key question is how both heads are released from the surface to approach actin and produce force. We used time-resolved synchrotron X-ra...
  • Volume and Infusion Rate Dynamics of Intraparenchymal Central Nervous System Infusion in a Large Animal Model

    junio 01, 2020
    Author(s): Toloo Taghian, Erin Horn, Mohammed S. Shazeeb, Lindsey J. Bierfeldt, Susan M. Tuominen, Jennifer Koehler, Deborah Fernau, Stephanie Bertrand, Stephen Frey, Oguz Cataltepe, Matthew J. Gounis, Aly Abayazeed, Terence R. Flotte, Miguel Sena-Esteves, Heather Gray-Edwards
    Source: Human gene therapy
    Thalamic infusion of adeno-associated viral (AAV) vectors has been shown to have therapeutic effects in neuronopathic lysosomal storage diseases. Preclinical studies in sheep model of Tay-Sachs disease demonstrated that bilateral thalamic injections of AAV gene therapy are required for maximal benefit. Translation of thalamic injection to patients carries risks in that (1) it has never been done in humans, and (2) dosing sca...
  • Alveolar size effects on nanoparticle deposition in rhythmically expanding-contracting terminal alveolar models

    junio 01, 2020
    Author(s): Jinxiang Xi, Mohamed Talaat, Xiuhua April Si, Pan Han, Haibo Dong, Shaokuan Zheng
    Source: Computers in biology and medicine
    Significant differences in alveolar size exist in humans of different ages, gender, health, and among different species. The effects of alveolar sizes, as well as the accompanying breathing frequencies, on regional and local dosimetry of inhaled nanoparticles have not been sufficiently studied. Despite a well-accepted qualitative understanding of the advection-diffusion-sedimentation mechanism in the acinar region, a quantit...
  • Sarcopenia is associated with longer hospital stay and multiorgan dysfunction in alcoholic hepatitis

    junio 01, 2020
    Author(s): Yasir Al-Azzawai, Betty Albo, Matthew Fasullo, Jennifer A. Coukos, George J. Watts, Ryan Tai, David Radcliffe, Aimee Kroll-Desrosiers, Deepika Devuni, Gyongyi Szabo
    Source: European journal of gastroenterology and hepatology
    INTRODUCTION: Excessive alcohol consumption has steadily risen to become the third leading cause of preventable death in the USA. One consequence of heavy alcohol use recently under considerable investigation is alcoholic hepatitis. Although many risk factors for developing alcoholic hepatitis have been documented, our aim in this study was to examine the potential association between sarcopenia and severity, mortality, 30 d...
  • Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion

    junio 01, 2020
    Author(s): Mohammed S. Shazeeb, Robert M. King, Olivia W. Brooks, Ajit S. Puri, Nils Henninger, Johannes Boltze, Matthew J. Gounis
    Source: Translational stroke research
    Mechanical thrombectomy for the treatment of ischemic stroke shows high rates of recanalization; however, some patients still have a poor clinical outcome. A proposed reason for this relates to the fact that the ischemic infarct growth differs significantly between patients. While some patients demonstrate rapid evolution of their infarct core (fast evolvers), others have substantial potentially salvageable penumbral tissue ...
  • Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia

    mayo 29, 2020
    Author(s): Letterio S. Politi, Ettore Salsano, Marco Grimaldi
    Source: JAMA neurology
    The neurotropism of human coronaviruses has already been demonstrated in small animals, and in autoptic studies the severe acute respiratory syndrome coronavirus (SARS-CoV), which was responsible for the SARS outbreak during 2002 to 2003, was found in the brains of patients with infection. It has been proposed that the neuroinvasive potential of the novel SARS-CoV-2, responsible for coronavirus disease 2019 (COVID-19), may b...
  • The Relationship Between ACR Diagnostic Radiology In-Training Examination Scores and ABR Core Examination Outcome and Performance: A Multi-Institutional Study

    mayo 29, 2020
    Author(s): Maitray D. Patel, Katie N. Hunt, Thad Benefield, Kamran Ali, Carolynn M. DeBenedectis, Eric England, Christopher P. Ho, Ann K. Jay, James M. Milburn, Jessica B. Robbins, David S. Sarkany, Courtney M. Tomblinson, Darel E. Heitkamp, Sheryl G. Jordan
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: We analyzed multi-institutional data to understand the relationship of ACR Diagnostic Radiology In-Training Examination (DXIT) scores to ABR Core Examination performance. METHODS: We collected DXIT rank scores and ABR Core Examination outcomes and scores for anonymized residents from 12 different diagnostic radiology residency programs taking the ABR Core Examination between 2013 and 2019. DXIT scores were grouped i...
  • Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography

    mayo 28, 2020
    Author(s): Jildaz Caroff, Robert M. King, Giovanni J. Ughi, Miklos G. Marosfoi, Erin T. Langan, Christopher M. Raskett, Ajit S. Puri, Matthew J. Gounis
    Source: Neurosurgery
    BACKGROUND: Tissue growth over covered branches is a leading cause of delayed thrombotic complications after flow-diverter stenting (FDS). Due to insufficient resolution, no imaging modality is clinically available to monitor this phenomenon. OBJECTIVE: To evaluate high-frequency optical coherence tomography (HF-OCT), a novel intravascular imaging modality designed for the cerebrovascular anatomy with a resolution approachin...
  • The Incidence of Node-Positive Non-small-Cell Lung Cancer Undergoing Sublobar Resection and the Role of Radiation in Its Management

    mayo 26, 2020
    Author(s): John M. Varlotto, Isabel Cristina Martins Emmerick, Debra Maddox, Christine Herbert, Molly Griffin, Paul Rava, Thomas J. Fitzgerald, Paulo Oliveira, Jennifer Baima, Rahul N. Sood, William Walsh, Lacey J. McIntosh, Feiran Lou, Mark W. Maxfield
    Source: Frontiers in oncology; Copyright © 2020 Varlotto, Emmerick, Voland, DeCamp, Flickinger, Maddox, Herbert, Griffin, Rava, Fitzgerald, Oliveira, Baima, Sood, Walsh, McIntosh, Lou, Maxfield, Rassaei and Uy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyrig...
    Purpose: To identify the incidence, preoperative risk factors, and prognosis associated with pathologically positive lymph node (pN+) in patients undergoing a sub-lobar resection (SLR). Methods: This is a retrospective study using the National Cancer Database (NCDB) from 2004 to 2014 analyzing SLR excluding those with any preoperative chemotherapy and/or radiation, follow-up 1 tumor nodule. Multivariable modeling (MVA) was ...
  • Strategies to Reach Gender Equity in Radiology

    mayo 25, 2020
    Author(s): Priscilla J. Slanetz, Lucy Spalluto, Maria Jesus Diaz Candamio, Carolynn M. DeBenedectis
    Source: Journal of the American College of Radiology : JACR
    For decades, women have comprised only 25% of practicing radiologists in the United States, even though women now represent approximately 50% of medical students. Even fewer women in the United States rise into radiology leadership positions, with only 17% currently serving as a department chair. In contrast, globally, women represent over 33% of radiologists, with Thailand having the highest female representation at 85%. De...
  • Biomechanics and hemodynamics of stent-retrievers

    mayo 19, 2020
    Author(s): Anna L. Kuhn, Zeynep Vardar, Afif Kraitem, Robert M. King, Vania Anagnostakou, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    In 2015, multiple randomized clinical trials showed an unparalleled treatment benefit of stent-retriever thrombectomy as compared to standard medical therapy for the treatment of a large artery occlusion causing acute ischemic stroke. A short time later, the HERMES collaborators presented the patient-level pooled analysis of five randomized clinical trials, establishing class 1, level of evidence A for stent-retriever thromb...
  • Primary Care Providers Underutilize Breast Screening MRI for High-Risk Women

    mayo 17, 2020
    Author(s): Nita Amornsiripanitch, Sarah M. Ameri, Robert J. Goldberg
    Source: Current problems in diagnostic radiology
    OBJECTIVE: Supplemental MRI screening for women at high risk for breast cancer is underutilized. Our study assessed how primary care providers in our healthcare network identify high-risk women and recommend high-risk screening breast MRI. METHODS: An electronic survey was distributed to providers in OB/GYN, family, and internal medicine departments between 1/14/19 and 3/22/19. The survey inquired about methods used to asses...
  • Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke

    mayo 15, 2020
    Author(s): Zimbul Albo, Jose Marino, Muhammad Nagy, Dilip K. Jayaraman, Muhammad U. Azeem, Ajit S. Puri, Nils Henninger
    Source: Journal of neurointerventional surgery
    BACKGROUND: White matter lesions (WML) are associated with poor outcome after mechanical thrombectomy (MT) for large vessel stroke; the reasons are uncertain. To elucidate this issue we sought to determine the association of WML with multiple early and late outcome measures after MT. METHODS: We retrospectively analyzed 181 MT patients prospectively included in our local stroke registry (January 2012 to November 2016). Using...
  • TIM, a targeted insertional mutagenesis method utilizing CRISPR/Cas9 in Chlamydomonas reinhardtii

    mayo 13, 2020
    Author(s): Tyler Picariello, Yuqing Hou, Tomohiro Kubo, Nathan A. McNeill, Haru-Aki Yanagisawa, Toshiyuki Oda, George B. Witman
    Source: PloS one; Copyright: © 2020 Picariello et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Generation and subsequent analysis of mutants is critical to understanding the functions of genes and proteins. Here we describe TIM, an efficient, cost-effective, CRISPR-based targeted insertional mutagenesis method for the model organism Chlamydomonas reinhardtii. TIM utilizes delivery into the cell of a Cas9-guide RNA (gRNA) ribonucleoprotein (RNP) together with exogenous double-stranded (donor) DNA. The donor DNA contain...
  • Acute Thrombus Burden on Coated Flow Diverters Assessed by High Frequency Optical Coherence Tomography

    mayo 08, 2020
    Author(s): Robert M. King, Erin T. Langan, Giovanni J. Ughi, Christopher M. Raskett, Ajit S. Puri, Hans Henkes, Matthew J. Gounis
    Source: Cardiovascular and interventional radiology
    PURPOSE: The implantation of flow diverters requires administration of dual anti-platelet therapy, posing the potential for complications. The p48MW HPC (phenox, Bochum, Germany) hydrophilic-coated flow diverting stent is designed to be anti-thrombotic, thus opening the potential for single anti-platelet therapy. We deploy a novel intravascular high-resolution imaging technique, high-frequency optical coherence tomography (H...
  • Impact of Age, Race, and Socioeconomic Status on Women's Perceptions and Preferences Regarding Communication of Estimated Breast Cancer Risk

    mayo 03, 2020
    Author(s): Nita Amornsiripanitch, Sarah M. Ameri, Robert Goldberg
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: Performing breast cancer risk assessment at the time of screening mammography has potential to increase high-risk identification, appropriate supplemental screening, and risk management. The study's goal is to investigate women's interest in risk assessment and preferred method of risk communication in a diverse patient population. MATERIALS AND METHODS: Surveys in English and five non-English langu...
  • Promoting Well-Being in Radiology Residency: A Primer for Program Directors

    mayo 01, 2020
    Author(s): Eric England, Maitray D. Patel, Sheryl Jordan, Vivek Kalia, Kamran Ali, Carolynn M. DeBenedectis, Glenn C. Gaviola, Christopher P. Ho, James M. Milburn, Seng Ong, David S. Sarkany, Ann K. Jay, Jessica B. Robbins, Darel E. Heitkamp
    Source: Academic radiology
    Radiology trainees devote 5 to 7 years after medical school to gain the knowledge and skills necessary for independent radiology practice. The length and intensity of this training can negatively impact residents’ well-being in a variety of ways, ultimately affecting their sleep, exercise, family interactions, religious activities, and major life events. Declining resident well-being often contributes to burnout, manifesting...
  • ACR Appropriateness Criteria(R) Chronic Liver Disease

    mayo 01, 2020
    Author(s): Expert Panel on Gastrointestinal Imaging, Mustafa R. Bashir, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    The liver fibrosis stage is the most important clinical determinate of morbidity and mortality in patients with chronic liver diseases. With newer therapies, liver fibrosis can be stabilized and possibly reversed, thus accurate diagnosis and staging of liver fibrosis are clinically important. Ultrasound, CT, and conventional MRI can be used to establish the diagnosis of advanced fibrosis/cirrhosis but have limited utility fo...
  • ACR Appropriateness Criteria(R) Pancreatic Cyst

    mayo 01, 2020
    Author(s): Expert Panel on Gastrointestinal Imaging, Kelly Fabrega-Foster, Ihab R. Kamel, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Incidental pancreatic cysts are increasingly detected on imaging studies performed for unrelated indications and may be incompletely characterized on these studies. Adequate morphological characterization is critical due to the small risk of malignant degeneration associated with neoplastic pancreatic cysts, as well as the risk of associated pancreatic adenocarcinoma. For all pancreatic cysts, both size and morphology determ...
  • The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

    abril 24, 2020
    Author(s): Yosra A. Helmy, Mohamed Fawzy, Ahmed Elaswad, Ahmed Sobieh, Scott P. Kenney, Awad A. Shehata
    Source: Journal of clinical medicine; © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market. The causative agent of the outbreak was identified by the WHO as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), producing the disease named coronavirus disease-2019 (COVID-19). The virus is closely related (96.3%) to bat coronavirus RaTG13, based on...
  • The Radiology Department during the COVID-19 pandemic: a challenging, radical change

    abril 21, 2020
    Author(s): Letterio S. Politi, Luca Balzarini
    Source: European radiology
    Since the first cases of SARS-CoV-2 pneumonia reported in Wuhan in December 2019, the Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, and Radiology Departments have to face significant changes in order to cope with this sanitary emergency. We would like to share our experience with the outbreak of COVID-19 in our Radiology Department at the Humanitas Clinical and Research University Hospital, a tertiary lev...
  • Using Quality Improvement Methodology to Reduce Costs while Improving Efficiency and Provider Satisfaction in a Busy, Academic Musculoskeletal Radiology Division

    abril 21, 2020
    Author(s): Steven J. Baccei, Scott Henderson, Hao S. Lo, Kevin Reynolds
    Source: Journal of medical systems
    Within an everchanging healthcare system, continuous evaluation of standard operating procedures must be performed to ensure optimization of system level organization, communication, and efficiency. Using the Lean management approach, our institution introduced modifications to our musculoskeletal (MSK) radiology workflow in order to facilitate beneficial change that improved clinical workflow efficiency, reduced moonlightin...
  • Society of NeuroInterventional Surgery recommendations for the care of emergent neurointerventional patients in the setting of covid-19

    abril 15, 2020
    Author(s): Justin F. Fraser, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    The global pandemic of coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented challenge to our healthcare system.1 As the number of identified COVID-19 patients exponentially increases, protocols for the safe delivery of care of both patients and providers are vital. This is especially true, given the number of healthcare providers wh...
  • JAOCR at the Viewbox: Calcific Tendinitis of the Longus Colli Muscle

    abril 14, 2020
    Author(s): Tina Shiang, Christopher A. Cerniglia
    Source: Journal of the American Osteopathic College of Radiology
    A 50-year-old man presented with acute neck pain and limited range of motion.
  • Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma in Patients With Child-Pugh B or C Cirrhosis

    abril 09, 2020
    Author(s): Peter L. Lee, Yunsheng Ma, Isabel Zacharias, Adel Bozorgzadeh, Sean Wilson, Kim Foley, Paul Rava, Mark Masciocchi, Linda Ding, Jacob R. Bledsoe, Thomas J. Fitzgerald, Shirin Sioshansi
    Source: Advances in radiation oncology; Copyright 2020 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Purpose: Our purpose was to report outcomes in patients with Child-Pugh B or C (CP B/C) hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT). Methods and Materials: Patients with HCC suitable for SBRT were prospectively enrolled in the study from 2012 to 2018. Outcomes in patients with CP B/C were analyzed. Cox proportional hazard models were used to compare survival outcomes between baselin...
  • Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting

    abril 01, 2020
    Author(s): Venkatesh A. Murugan, Bryan O'Sullivan Murphy, Carolyn S. Dupuis, Alan J. Goldstein, Young H. Kim
    Source: Ultrasonography (Seoul, Korea); Copyright © 2020 Korean Society of Ultrasound in Medicine (KSUM). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    In patients presenting for an evaluation of pregnancy in the first trimester, transvaginal ultrasound is the modality of choice for establishing the presence of an intrauterine pregnancy; evaluating pregnancy viability, gestational age, and multiplicity; detecting pregnancy-related complications; and diagnosing ectopic pregnancy. In this pictorial review article, the sonographic appearance of a normal intrauterine gestation ...
  • Abdominal wall and pelvic hernias: classic and unusual hernias and their mimics

    abril 01, 2020
    Author(s): Arash Bedayat, Cameron Hassani, Jason Chiang, Frank Hebroni, Saeed Ghandili, Hamid Chalian, Pegah Khoshpouri, Hao S. Lo, Adib R. Karam
    Source: Clinical imaging
    Abdominal and pelvic wall hernias are classically defined as a weakness or opening of the muscular wall through which abdominal or pelvic tissues protrude. The aim of this manuscript is to review the imaging findings of abdominal and pelvic wall hernias and their mimics and to discuss pearls and pitfalls for accurately diagnosing and classifying these entities.
  • The Relationship Between US Medical Licensing Examination Step Scores and ABR Core Examination Outcome and Performance: A Multi-institutional Study

    marzo 24, 2020
    Author(s): Maitray D. Patel, Courtney M. Tomblinson, Thad Benefield, Kamran Ali, Carolynn M. DeBenedectis, Eric England, Glenn C. Gaviola, Christopher P. Ho, Ann K. Jay, James M. Milburn, Seng Ong, Jessica B. Robbins, David S. Sarkany, Darel E. Heitkamp, Sheryl G. Jordan
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: We analyzed multi-institutional data to understand the relationship of US Medical Licensing Examination (USMLE) Step scores to ABR Core examination performance to identify Step score tiers that stratify radiology residents into different Core performance groups. METHODS: We collected USMLE Step scores and ABR Core examination outcomes and scores for anonymized residents from 13 different diagnostic radiology residen...
  • How Radiologists Are Paid: An Economic History, Part II: Advanced Imaging and Radiologists' Incomes

    marzo 24, 2020
    Author(s): Frank Levy, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    The advent of the CT scanner in the early 1970s removed much, if not all, of the morbidity and discomfort previously associated with diagnostic imaging studies. Throughout the 1970s and 1980s, advances in CT technology allowed radiologists to scan "better and faster." The professional fee for reading a CT study was higher than for reading a radiograph, an uncontroversial policy. But estimating the technical fee for using CT ...
  • How Radiologists Are Paid: An Economic History, Part IV: End of the Bubble

    marzo 24, 2020
    Author(s): Frank Levy, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    During the first decade of the 21st century, the imaging bubble began to burst. The combination of digitized images, the DICOM standard, and affordable PACS sharply increased radiologists' productivity but also allowed an imaging study to be read from anywhere, creating the field of teleradiology and increased competition for radiologists. Increasing numbers of insurers contracted with radiology benefits managers to help con...
  • How Radiologists Are Paid: An Economic History, Part I: The Fight for Independent Billing

    marzo 20, 2020
    Author(s): Frank Levy, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    In this four-part work, the authors review the economic history of how radiologists are paid, from the fight for independent billing in the 1960s to the impact of advanced imaging technologies on radiologists' incomes in the 1980s to the "bubble years" of the 1990s and to the end of the bubble in the first decade of the 21 century. The authors begin in this first part with the connections among a radiologist from Arkansas, a...
  • How Radiologists Are Paid: An Economic History, Part III: The Bubble Years

    marzo 17, 2020
    Author(s): Frank Levy, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    With the collapse of the Clinton health care reforms, advanced imaging entered an economic bubble. Between 1995 and 2006, the number of CT and MRI studies almost tripled, from 21 million to 62 million and from 9.1 to 26.6 million, respectively. The increase reflected increases in both the number of scanners and the number of scans generated per CT or MRI scanner. Without restrictions, the profits generated by CT and MR owner...
  • Feasibility of Robot-Assisted Ultrasound Imaging with Force Feedback for Assessment of Thyroid Diseases

    marzo 16, 2020
    Author(s): Jakub T. Kaminski, Khashayar Rafatzand, Haichong K. Zhang
    Source: Proceedings of SPIE--the International Society for Optical Engineering
    Medical ultrasound is extensively used to define tissue textures and to characterize lesions, and it is the modality of choice for detection and follow-up assessment of thyroid diseases. Classical medical ultrasound procedures are performed manually by an occupational operator with a hand-held ultrasound probe. These procedures require high physical and cognitive burden and yield clinical results that are highly operator-dep...
  • Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

    marzo 14, 2020
    Author(s): Michael D. Hill, Ajit S. Puri, Mayank Goyal, Bijoy K. Menon, Raul G. Nogueira, Ryan A. McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian H. Buck, Thalia S. Field, Dar Dowlatshahi, Brian A. van Adel, Richard H. Swartz, Ruchir A. Shah, Eric Sauvageau
    Source: Lancet (London, England)
    BACKGROUND: Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke. METHODS: For this multicentre, double-blind, r...
  • Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases

    marzo 11, 2020
    Author(s): Brett D. Story, Matthew E. Miller, Allison M. Bradbury, Emily D. Million, Dongsheng Duan, Toloo Taghian, Dominik Faissler, Deborah Fernau, Sidney J. Beecy, Heather Gray-Edwards
    Source: Frontiers in veterinary science; Copyright © 2020 Story, Miller, Bradbury, Million, Duan, Taghian, Faissler, Fernau, Beecy and Gray-Edwards. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in ...
    Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or livestock because of their emotional or economic value to modern society and, unlike mice, often...
  • Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

    marzo 10, 2020
    Author(s): Christopher N. Toepfer, Raul Padron, Christine E. Seidman
    Source: Circulation; © 2020 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
    BACKGROUND: Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart and increased patient risks for arrhythmias and heart failure. Recent studies show that pathogenic missense variants in myosin, the molecular motor of the sarcomere, are clustered in residues that participate in dynamic conforma...
  • Improving Diagnostic Accuracy in Low-Dose SPECT Myocardial Perfusion Imaging with Convolutional Denoising Networks

    marzo 10, 2020
    Author(s): Albert Juan Ramon, Yongyi Yang, P. Hendrik Pretorius, Karen L. Johnson, Michael A. King, Miles N. Wernick
    Source: IEEE transactions on medical imaging
    Lowering the administered dose in SPECT myocardial perfusion imaging (MPI) has become an important clinical problem. In this study we investigate the potential benefit of applying a deep learning (DL) approach for suppressing the elevated imaging noise in low-dose SPECT-MPI studies. We adopt a supervised learning approach to train a neural network by using image pairs obtained from full-dose (target) and low-dose (input) acq...
  • Flow Diversion for Treatment of Partially Thrombosed Aneurysms: A Multicenter Cohort

    marzo 01, 2020
    Author(s): Paul M. Foreman, Mohamed M. Salem, Christoph J. Griessenauer, Adam A. Dmytriw, Carmen Parra-Farinas, Patrick Nicholson, Nicola Limbucci, Anna Luisa. Kuhn, Ajit S. Puri, Leonardo Renieri, Sergio Nappini, Kimberly P. Kicielinski, Alejandro Bugarini, Vitor Mendes. Pereira, Thomas R. Marotta
    Source: World neurosurgery
    BACKGROUND: Partially thrombosed intracranial aneurysms (PTIA) represent a unique subset of intracranial aneurysms with an ill-defined natural history, posing challenges to standard management strategies. This study aims to assess the efficacy of flow diversion in the treatment of this pathology. METHODS: A retrospective review of patients with flow-diverted PTIA at 6 cerebrovascular centers was performed. Clinical and radio...
  • First Pass Effect in Patients Treated With the Trevo Stent-Retriever: A TRACK Registry Study Analysis

    febrero 18, 2020
    Author(s): Maxim Mokin, Ajit S. Puri
    Source: Frontiers in neurology; Copyright © 2020 Mokin, Primiani, Castonguay, Nogueira, Haussen, English, Satti, Chen, Farid, Borders, Veznedaroglu, Binning, Puri, Vora, Budzik, Dabus, Linfante, Janardhan, Alshekhlee, Abraham, Edgell, Taqi, Khoury, Majjhoo, Kabbani, Froehler, Finch, Ansari, Novakovic, Nguyen and Zaidat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The ...
    Background and Objective: The first pass effect (FPE; achieving complete recanalization with a single thrombectomy device pass) has been shown to be associated with higher rates of good clinical outcomes in patients with acute ischemic stroke. Here, we investigate clinical and radiographic factors associated with FPE in a large U.S. post-marketing registry (TRACK, Trevo Stent-Retriever Acute Stroke). Methods: We analyzed the...
  • Noninterpretive Uses of Artificial Intelligence in Radiology

    febrero 12, 2020
    Author(s): Michael L. Richardson, Elisabeth R. Garwood, Yueh Lee, Matthew D. Li, Hao S. Lo, Arun Nagaraju, Xuan V. Nguyen, Linda Probyn, Prabhakar Rajiah, Jessica Sin, Ashish P. Wasnik, Kali Xu
    Source: Academic radiology
    We deem a computer to exhibit artificial intelligence (AI) when it performs a task that would normally require intelligent action by a human. Much of the recent excitement about AI in the medical literature has revolved around the ability of AI models to recognize anatomy and detect pathology on medical images, sometimes at the level of expert physicians. However, AI can also be used to solve a wide range of noninterpretive ...
  • CT diagnosis of bucket handle meniscus tear

    febrero 11, 2020
    Author(s): Tina Shiang, Hemang M. Kotecha
    Source: Emergency radiology; Bucket handle, Computed tomography (CT), Knee, Magnetic resonance imaging (MRI), Meniscus tear, Trauma
    Bucket handle meniscus tears are difficult to diagnosis and are one of the most frequently missed tear patterns on magnetic resonance imaging (MR). However, this meniscal injury often requires arthroscopic intervention and preoperative characterization of the tear is important to orthopedic surgeons for treatment planning. MR is currently the best imaging modality for evaluating meniscal tears, but trauma patients in the eme...
  • Breaking the Stereotype: Interventions Aimed at Changing Medical Student Misperceptions of Radiology and Increasing the Female Match Rate

    febrero 10, 2020
    Author(s): Victoria Podsiadlo, Carolynn M. DeBenedectis
    Source: Academic radiology
    BACKGROUND: Although nearly half of medical students are female there is still a significant discrepancy in the number of women specializing in radiology. In 2013, 26.9% of US diagnostic radiology residents were female, a 1% increase in 20 years from 25.5% in 1990. PURPOSE: The purpose of this project is to determine the effectiveness of the interventions implemented at a single medical school at decreasing negative attitude...
  • Reconstructive vs Deconstructive Endovascular Approach to Intradural Vertebral Artery Aneurysms: A Multicenter Cohort Study

    febrero 05, 2020
    Author(s): Ashish Kumar, Adam A. Dmytriw, Mohamed M. Salem, Anna L. Kuhn, Kevin Phan, Aditya Bharatha, Julian Spears, Ajith Thomas, Ajit S. Puri, Thomas R. Marotta
    Source: Neurosurgery
    BACKGROUND: Parent vessel sacrifice (PVS) has been a traditional way of treating complex aneurysms of the intradural vertebral artery (VA). Flow diversion (FD) has emerged as an alternative reconstructive option. OBJECTIVE: To compare the long-term clinical and radiographic outcomes of intradural VA aneurysms following PVS or FD. METHODS: We retrospectively reviewed and evaluated 43 consecutive patients between 2009 and 2018...
  • Imaging Musculoskeletal Manifestations of Pediatric Hematologic Malignancies

    febrero 01, 2020
    Author(s): Melissa F. Tannenbaum, Sakura Noda, Sara Cohen, Julia G. Rissmiller, Anna M. Golja, Daniel M. Schwartz
    Source: AJR. American journal of roentgenology
    OBJECTIVE. The purpose of this article is to describe imaging findings of common and uncommon musculoskeletal manifestations, posttreatment changes, and complications of pediatric hematologic malignancies. CONCLUSION. Many pediatric patients with leukemia and lymphoma present with or experience musculoskeletal symptoms over the course of the disease. Imaging can depict bone and soft-tissue signs of pediatric hematologic mali...
  • The Use of Artificial Intelligence in the Evaluation of Knee Pathology

    febrero 01, 2020
    Author(s): Elisabeth R. Garwood, Ryan Tai, Ganesh Joshi, George J. Watts
    Source: Seminars in musculoskeletal radiology
    Artificial intelligence (AI) holds the potential to revolutionize the field of radiology by increasing the efficiency and accuracy of both interpretive and noninterpretive tasks. We have only just begun to explore AI applications in the diagnostic evaluation of knee pathology. Experimental algorithms have already been developed that can assess the severity of knee osteoarthritis from radiographs, detect and classify cartilag...
  • Impact of Leukoaraiosis Severity on the Association of Time to Successful Reperfusion with 90-Day Functional Outcome After Large Vessel Occlusion Stroke

    febrero 01, 2020
    Author(s): Abdul Ghani Mikati, Max Mandelbaum, Shweta Sapnar, Ajit S. Puri, Brian Silver, Richard P. Goddeau Jr, Diogo C. Haussen, Majaz Moonis, Adalia H. Jun-O'Connell, Nils Henninger
    Source: Translational stroke research
    The chance for a favorable outcome after mechanical thrombectomy (MT) for large vessel occlusion stroke decreases with the symptom onset-to-reperfusion time (OTR). Patients with severe leukoaraiosis are at increased risk for a poor outcome after MT. However, whether leukoaraiosis modulates to the association between OTR and 90-day functional outcome is uncertain. We retrospectively analyzed 144 consecutive patients with succ...
  • Tales of Mentoring in Radiology: The Experience of Residents and Mentors at a Single Academic Program

    enero 20, 2020
    Author(s): Joelle Wazen, Alan J. Goldstein, Helen H. Kim, Ryan Tai, George Watts, Carolynn M. Debenedictis
    Source: Current problems in diagnostic radiology
    PURPOSE: To investigate the utility of mentoring groups in radiology residency. METHODS: Five assistant professors of Radiology and 20 radiology residents were divided into 5 groups. One resident from each academic year was randomly paired with a mentor group. Three 1-hour group mentoring sessions took place over the year. Upon completion of the project an anonymous Quality Improvement survey of 20 questions were sent out to...
  • Distal radial access in the anatomical snuffbox for neurointerventions: a feasibility, safety, and proof-of-concept study

    enero 08, 2020
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Jasmeet Singh, Francesco Massari, Ajit S. Puri
    Source: Journal of Neurointerventional Surgery
    PURPOSE: To report the first use of distal radial artery (dRA) access for a variety of neurointerventions and to demonstrate the safety and feasibility of this approach. METHODS: A retrospective review of our prospective neurointerventional database of endovascular interventions was conducted and, between May and October 2019, all patients in whom the intervention was performed via dRA in the anatomical snuffbox were identif...
  • Introduction: History and Development of Flow Diverter Technology and Evolution

    enero 01, 2020
    Author(s): Anna Luisa Kuhn, Matthew J. Gounis, Ajit S. Puri
    Source: Neurosurgery
    The introduction of flow diverter technology to the field of neurointervention has revolutionized the treatment of intracranial aneurysms. The therapy approach has shifted from intrasaccular aneurysm treatment to exclusion of the aneurysm from the blood circulation with remodeling of the parent artery. Previously, "difficult"-to-treat aneurysms including fusiform and blister aneurysms, but also aneurysms arising from a disea...
  • Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms

    enero 01, 2020
    Author(s): Valeriy G. Metelev, Alexei A. Bogdanov
    Source: Theranostics; © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
    The use of various oligonucleotide (ON) syntheses and post-synthetic strategies for targeted chemical modification enables improving their efficacy as potent modulators of gene expression levels in eukaryotic cells. However, the search still continues for new approaches designed for increasing internalization, lysosomal escape, and tissue specific delivery of ON. In this review we emphasized all aspects related to the synthe...
  • Imaging NF-kappaB activity in a murine model of early stage diabetes

    enero 01, 2020
    Author(s): Toloo Taghian, Valeriy G. Metelev, Surong Zhang, Alexei A. Bogdanov Jr.
    Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    Early pro-inflammatory signaling in the endocrine pancreas involves activation of NF-kappaB, which is believed to be important for determining the ultimate fate of beta-cells and hence progression of type 1 diabetes (T1D). Thus, early non-invasive detection of NF-kappaB in pancreatic islets may serve as a potential strategy for monitoring early changes in pancreatic endocrine cells eventually leading to T1D. We investigated ...
  • Pulsed field gradient signal attenuation of restricted anomalous diffusions in plate, sphere, and cylinder with wall relaxation

    enero 01, 2020
    Author(s): Xinli Liao, Shaokuan Zheng, Guoxing Lin
    Source: Physical review. E
    The effect of boundary relaxation on pulsed field gradient (PFG) anomalous restricted diffusion is investigated in this paper. The PFG signal attenuation expressions of anomalous diffusion in plate, sphere, and cylinder are derived based on fractional calculus. In addition, approximate expressions for boundary relaxation induced short time signal attenuation under zero gradient field and boundary relaxation affected short ti...
  • Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B

    enero 01, 2020
    Author(s): Ana Rita Batista, Oliver D. King, Christopher P. Reardon, Crystal Davis, FNU Shankaracharya, Vivek Philip, Heather Gray-Edwards, Neil Aronin, Cathleen Lutz, John E. Landers, Miguel Sena-Esteves
    Source: Human gene therapy
    Adeno-associated virus (AAV) gene therapy for neurological diseases was revolutionized by the discovery that AAV9 crosses the blood-brain barrier (BBB) after systemic administration. Transformative results have been documented in various inherited diseases, but overall neuronal transduction efficiency is relatively low. The recent development of AAV-PHP.B with ∼60-fold higher efficiency than AAV9 in transducing the adult mou...
  • The unity and diversity of the ciliary central apparatus

    diciembre 30, 2019
    Author(s): Lei Zhao, Yuqing Hou, Nathan A. McNeill, George B. Witman
    Source: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    Nearly all motile cilia and flagella (terms here used interchangeably) have a '9+2' axoneme containing nine outer doublet microtubules and two central microtubules. The central pair of microtubules plus associated projections, termed the central apparatus (CA), is involved in the control of flagellar motility and is essential for the normal movement of '9+2' cilia. Research using the green alga Chlamydomonas reinhardtii, an ...
  • The mesa trail and the interacting heads motif of myosin II

    diciembre 13, 2019
    Author(s): John Leslie Woodhead, Roger Craig
    Source: Archives of biochemistry and biophysics
    Myosin II molecules in the thick filaments of striated muscle form a structure in which the heads interact with each other and fold back onto the tail. This structure, the "interacting heads motif" (IHM), provides a mechanistic basis for the auto-inhibition of myosin in relaxed thick filaments. Similar IHM interactions occur in single myosin molecules of smooth and nonmuscle cells in the switched-off state. In addition to th...
  • Primary, scatter, and penetration characterizations of parallel-hole and pinhole collimators for I-123 SPECT

    diciembre 13, 2019
    Author(s): Arda Konik, Benjamin Auer, Jan De Beenhouwer, Kesava S. Kalluri, Navid Zeraatkar, Lars R. Furenlid, Michael A. King
    Source: Physics in medicine and biology
    Multi-pinhole (MPH) collimators are known to provide better trade-off between sensitivity and resolution for preclinical, as well as for smaller regions in clinical SPECT imaging compared to conventional collimators. In addition to this geometric advantage, MPH plates typically offer better stopping power for penetration than the conventional collimators, which is especially relevant for I-123 imaging. The I-123 emits a seri...
  • A DNA-guided Argonaute Protein Functions in DNA Replication in Thermus thermophilus [preprint]

    diciembre 09, 2019
    Author(s): Samson M. Jolly, Ildar Gainetdinov, , Han Zhang, Lara Strittmatter, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, Phillip D. Zamore
    Source: bioRxiv; The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
    Argonaute proteins use nucleic acid guides to protect organisms against transposons and viruses. In the eubacterium Thermus thermophilus, the DNA-guided Argonaute TtAgo defends against transformation by DNA plasmids. Here, we report that TtAgo also participates in DNA replication. TtAgo binds small DNA guides derived from the chromosomal region where replication terminates and associates with proteins known to act in DNA rep...
  • Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots

    diciembre 05, 2019
    Author(s): Sean Fitzgerald, Shunli Wang, Daying Dai, Dennis H. Murphree Jr., Abhay Pandit, Andrew Douglas, Asim Rizvi, Ramanathan Kadirvel, Michael Gilvarry, Ray McCarthy, Manuel Stritt, Matthew J. Gounis, Waleed Brinjikji, David F. Kallmes, Karen M. Doyle
    Source: PloS one; Copyright: © 2019 Fitzgerald et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical thrombectomy procedures. Following HandE staining, quantification of clot components was performed by two different methods: a pathologist using a reference standard method (Adobe Photoshop CC) and an ex...
  • Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle

    diciembre 02, 2019
    Author(s): Weikang Ma, Kyounghwan Lee, Shixin Yang, Thomas C. Irving, Roger Craig
    Source: The Journal of general physiology; © 2019 Ma et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/l...
    The thick (myosin-containing) filaments of vertebrate skeletal muscle are arranged in a hexagonal lattice, interleaved with an array of thin (actin-containing) filaments with which they interact to produce contraction. X-ray diffraction and EM have shown that there are two types of thick filament lattice. In the simple lattice, all filaments have the same orientation about their long axis, while in the superlattice, nearest ...
  • Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment

    noviembre 28, 2019
    Author(s): Sarah Johnson, Juyu Chueh, Matthew J. Gounis, Ray McCarthy, J. Patrick McGarry, Peter E. McHugh, Michael Gilvarry
    Source: Journal of neurointerventional surgery
    BACKGROUND: Clot mechanical properties are influenced by composition and the arrangement of components within the clot. This work investigates the effects of platelet-driven contraction on blood clot microstructure and mechanical behavior, and provides insight into some implications for mechanical thrombectomy. METHODS: Platelet-contracted clot analogues (PCCs) and non-contracted clot analogues (NCCs) were prepared from bloo...
  • Global Radiology Training Prevalence Among Radiology Residency Programs

    noviembre 18, 2019
    Author(s): Hana L. Haver, Max P. Rosen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    OBJECTIVE: Global Radiology aims to enhance access to medical imaging services and education, worldwide. To date, few reports have evaluated Global Radiology Training (GRT) in radiology residency programs. Here, we examined how radiology residency programs perceive and incorporate GRT into their curriculum, and how this information is promoted online. METHODS: Two methods were used to examine the current state of GRT. First,...
  • Positive Predictive Value of Tomosynthesis-guided Biopsies of Architectural Distortions Seen on Digital Breast Tomosynthesis and without an Ultrasound Correlate

    noviembre 18, 2019
    Author(s): Gopal Vijayaraghavan, Adrienne Newburg, Srinivasan Vedantham
    Source: Journal of clinical imaging science; © 2019 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical t...
    Objective: The objective of the study was to determine the positive predictive value (PPV) of architectural distortions (AD) observed on digital breast tomosynthesis (DBT) and without an ultrasound (US) correlate. Materials and Methods: In this single-institution, retrospective study, patients who underwent DBT-guided biopsies of AD without any associated findings on digital mammography (DM) or DBT, and without a correlate o...
  • A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna

    noviembre 16, 2019
    Author(s): Toloo Taghian, Miklos G. Marosfoi, Ajit S. Puri, Oguz Cataltepe, Robert M. King, Deborah Fernau, Ana Rita Batista, Terence R. Flotte, Diane McKenna-Yasek, Phillip W. L. Tai L, Neil Aronin, Matthew J. Gounis, Miguel Sena-Esteves, Heather L. Gray-Edwards
    Source: Molecular therapy : the journal of the American Society of Gene Therapy
    Global gene delivery to the CNS has therapeutic importance for the treatment of neurological disorders that affect the entire CNS. Due to direct contact with the CNS, cerebrospinal fluid (CSF) is an attractive route for CNS gene delivery. A safe and effective route to achieve global gene distribution in the CNS is needed, and administration of genes through the cisterna magna (CM) via a suboccipital puncture results in broad...
  • Early postmarket results with PulseRider for treatment of wide-necked intracranial aneurysms: a multicenter experience

    noviembre 08, 2019
    Author(s): Visish M. Srinivasan, Ajit S. Puri, Peter Kan
    Source: Journal of neurosurgery
    OBJECTIVE: Traditionally, stent-assisted coiling and balloon remodeling have been the primary endovascular treatments for wide-necked intracranial aneurysms with complex morphologies. PulseRider is an aneurysm neck reconstruction device that provides parent vessel protection for aneurysm coiling. The objective of this study was to report early postmarket results with the PulseRider device. METHODS: This study was a prospecti...
  • ACR Appropriateness Criteria(R) Acute Pancreatitis

    noviembre 01, 2019
    Author(s): Expert Panel on Gastrointestinal Imaging, Kristin K. Porter, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Acute pancreatitis (AP) is divided into two types: interstitial edematous and necrotizing. AP severity is classified clinically into mild, moderately severe, and severe, depending on the presence and persistence of organ failure and local or systemic complications. The revised Atlanta classification divides the clinical course of AP into an early (first week) and late phase (after first week) and the clinical phase determine...
  • Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus

    octubre 31, 2019
    Author(s): Gang Fu, Lei Zhao, Erin Dymek, Yuqing Hou, Kangkang Song, Nhan Phan, Zhiguo Shang, Elizabeth F. Smith, George B. Witman, Daniela Nicastro
    Source: The Journal of cell biology; © 2019 Fu et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/license...
    Nearly all motile cilia contain a central apparatus (CA) composed of two connected singlet microtubules with attached projections that play crucial roles in regulating ciliary motility. Defects in CA assembly usually result in motility-impaired or paralyzed cilia, which in humans causes disease. Despite their importance, the protein composition and functions of the CA projections are largely unknown. Here, we integrated bioc...
  • SF-Assemblin genes in Paramecium: phylogeny and phenotypes of RNAi silencing on the ciliary-striated rootlets and surface organization

    octubre 29, 2019
    Author(s): Ashikun Nabi, Junji Yano, Megan S. Valentine, Tyler Picariello, Judith L. Van Houten
    Source: Cilia; © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Crea...
    Background: Cilia emanate from basal bodies just underneath the cell membrane. Basal bodies must withstand torque from the ciliary beat and be appropriately spaced for cilia to beat in metachronal waves. Basal body rootlets provide stability for motile cilia. Paramecium has three. Our focus is on the largest one, the striated rootlet (SR). Paramecium basal bodies align in straight rows. Previously we found a potential role f...
  • Dense motion propagation from sparse samples

    octubre 21, 2019
    Author(s): Rhodri L. Smith, Paul K. R. Dasari, Clifford Lindsay, Michael A. King, Kevin Wells
    Source: Physics in medicine and biology
    There are many applications for which sparse, or partial sampling of dynamic image data can be used for articulating or estimating motion within the medical imaging area. In this new work, we propose a generalized framework for dense motion propagation from sparse samples which represents an example of transfer learning and manifold alignment, allowing the transfer of knowledge across imaging sources of different domains whi...
  • Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy

    octubre 08, 2019
    Author(s): Ju-Yu Chueh, Dong-Hun Kang, Byung Moon Kim, Matthew J. Gounis
    Source: Journal of Korean Neurosurgical Society; Copyright © 2019 The Korean Neurosurgical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Proximal flow control achieved with a balloon guide catheter (BGC) during endovascular treatment of acute ischemic stroke is reviewed in this article. In clinical practice, BGCs offer a multi-faceted approach for clot retrieval by creating proximal flow arrest, reducing embolic burden, and shortening procedure time. Evaluation of frontline thrombectomy procedures with BGCs revealed advantages of combined use over the convent...
  • Association of Varus Knee Thrust During Walking With Worsening Western Ontario and McMaster Universities Osteoarthritis Index Knee Pain: A Prospective Cohort Study

    octubre 01, 2019
    Author(s): Alexandra E. Wink, K. Douglas Gross, Carrie A. Brown, Cora E. Lewis, James Torner, Michael C. Nevitt, Irina Tolstykh, Leena Sharma, David T. Felson
    Source: Arthritis care and research
    OBJECTIVE: To investigate the 2-year association of varus knee thrust observed during walking to the odds of worsening Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain in older adults with or at risk of osteoarthritis (OA). METHODS: Video recordings of self-paced walking trials of Multicenter Osteoarthritis Study participants were assessed for the presence of varus thrust at baseline. Knee pai...
  • Flow Diversion for Treatment of Intracranial Aneurysms in Pediatric Patients: Multicenter Case Series

    septiembre 26, 2019
    Author(s): Jacob Cherian, Ajit S. Puri, Peter Kan
    Source: Neurosurgery
    BACKGROUND: Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. OBJECTIVE: To report technical, angiographic, and clinical outcomes in patients aged 21 or below undergoing...
  • The central role of the tail in switching off 10S myosin II activity

    septiembre 02, 2019
    Author(s): Shixin Yang, Kyounghwan Lee, John L. Woodhead, Osamu Sato, Mitsuo Ikebe, Roger Craig
    Source: The Journal of general physiology; © 2019 Yang et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org...
    Myosin II is a motor protein with two heads and an extended tail that plays an essential role in cell motility. Its active form is a polymer (myosin filament) that pulls on actin to generate motion. Its inactive form is a monomer with a compact structure (10S sedimentation coefficient), in which the tail is folded and the two heads interact with each other, inhibiting activity. This conformation is thought to function in cel...
  • Opioid Use and Respiratory Compromise in the Interventional Suite: A Wake-up Call

    septiembre 01, 2019
    Author(s): Max P. Rosen, J. Matthias Walz
    Source: Radiology
    The study by Urman et al (1) in this issue of Radiology addresses the effect of respiratory compromise among inpatients undergoing interventional radiology (IR) procedures performed with moderate sedation. The study was conducted by using a national all-payer database and included data from over 500 000 patients across 853 hospitals, collected during a 3-year period. The results demonstrated that, among a wide range of varia...
  • Site Experience and Outcomes in the Trevo Acute Ischemic Stroke (TRACK) Multicenter Registry

    septiembre 01, 2019
    Author(s): Raul G. Nogueira, Ajit S. Puri
    Source: Stroke
    Background and Purpose- It remains unclear how experience influences outcomes after the advent of stent retriever technology. We studied the relationship between site experience and outcomes in the Trevo Acute Ischemic Stroke multicenter registry. Methods- The 24 sites that enrolled patients in the Trevo Acute Ischemic Stroke registry were trichotomized into low-volume ( 4 cases/month). Baseline features, imaging, and clini...
  • Abbreviated MRI of the foot in patients with suspected osteomyelitis

    agosto 28, 2019
    Author(s): Hemang M. Kotecha, Hao S. Lo, Srinivasan Vedantham, Heeseop Shin, Christopher Cerniglia
    Source: Emergency radiology
    PURPOSE: To determine the diagnostic accuracy of an abbreviated magnetic resonance imaging (MRI) protocol of the foot for the diagnosis of osteomyelitis in patients with acute foot infection. METHODS: This retrospective study evaluated adult patients (age 18 and over) visiting an academic medical center from 1 January 2013 to 31 December 2015 who were imaged with MRI for suspected acute pedal osteomyelitis. Examinations were...
  • A Program Director's Guide to Cultivating Diversity and Inclusion in Radiology Residency Recruitment

    agosto 28, 2019
    Author(s): Carolynn M. DeBenedectis, Darel E. Heitkamp, Eric England, Glenn C. Gaviola, Joshua A. Hirsch, Christopher P. Ho, Ann K. Jay, Nolan Kagetsu, Vivek Kalia, James Milburn, Seng Ong, Angelisa M. Paladin, Maitray D. Patel, Jonathan Swanson, David S. Sarkany
    Source: Academic radiology
    Diversity and inclusion are vital elements to the success of any group. Indeed, evidence from the business world indicates that a group's overall talent level is a function of its collective cognitive diversity. The ability to effectively problem solve, innovate, and adapt to change all depend to a large degree on the biases and life experiences of an organization's constituent members. As other industries have come to embra...
  • Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival

    agosto 27, 2019
    Author(s): Chandana Javvaji, Jacob R. Bledsoe, Lloyd Hutchinson, Ediz F. Cosar, Lacey J. McIntosh, Venu G. Bathini
    Source: Journal of gastrointestinal cancer
    Ampulla of Vater tumors are uncommon, with an incidence of approximately four to six cases per million population. Incidence of ampullary cancer is higher in Caucasian and African-American men than in women [Fig. 1]. Among the periampullary tumors, they account for around 6% of lesions. Signet ring cell pathology is a rare finding in ampulla of Vater carcinoma.
  • Flow diversion treatment for acutely ruptured aneurysms

    agosto 24, 2019
    Author(s): Michelle F. M. Ten Brinck, Maike Jager, Joost de Vries, J. Andre Grotenhuis, Rene Aquarius, Svein H. Morkve, Riitta Rautio, Jussi Numminen, Rahul Raj, Ajay K. Wakhloo, Ajit S. Puri, Christian A. Taschner, Hieronymus D. Boogaarts
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Flow diverters are sometimes used in the setting of acutely ruptured aneurysms. However, thromboembolic and hemorrhagic complications are feared and evidence regarding safety is limited. Therefore, in this multicenter study we evaluated complications, clinical, and angiographic outcomes of patients treated with a flow diverter for acutely ruptured aneurysms. METHODS: We conducted a retrospective obser...
  • Overview on Percutaneous Therapies of Disc Diseases

    agosto 12, 2019
    Author(s): Salvatore Masala, Fabio Salimei, Adriano Lacche, Stefano Marcia, Francesco Massari
    Source: Medicina (Kaunas, Lithuania); Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    Low back pain is an extremely common pathology affecting a great share of the population, in particular, young adults. Many structures can be responsible for pain such as intervertebral discs, facet joints, nerve roots, and sacroiliac joints. This review paper focuses on disc pathology and the percutaneous procedures available to date for its treatment. For each option, we will assess the indications, technical aspects, adva...
  • Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

    agosto 09, 2019
    Author(s): Aurora Rodriguez-Rodriguez, Sergey Shuvaev, Nicholas Rotile, Chloe M. Jones, Clemens K. Probst, Diego Dos Santos Ferreira, Katherine Graham-O Regan, Eszter Boros, Rachel S. Knipe, Jason W. Griffith, Andrew M. Tager, Alexei A. Bogdanov Jr., Peter Caravan
    Source: ACS sensors
    An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of...
  • Intraoperative Aneurysm Rupture during Resection for Presumed Metastasis

    agosto 09, 2019
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Ajit S. Puri
    Source: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    A 54-year-old male with metastatic melanoma, including a presumed brain metastasis underwent elective surgery when there was sudden onset of extensive bleeding upon resection. An emergent cerebral angiogram revealed a fusiform left posterior cerebral artery aneurysm. Malignant melanoma commonly metastasizes to the brain and has shown to assume a wide variety of appearances with involvement of almost any intracranial structur...
  • A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

    agosto 02, 2019
    Author(s): Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Chantal M. Ferguson, Dimas Echeverria, Ellen Sapp, Reka A. Haraszti, Andrew H. Coles, Faith Conroy, Rachael Miller, Loic Roux, Paul Yan, Emily G. Knox, Anton A. Turanov, Robert M. King, Gwladys Gernoux, Christian Mueller, Heather Gray-Edwards, Richard P. Moser, N Bishop, Samer M. Jaber, Matthew J. Gounis, Miguel Sena-Esteves, Athma A. Pai, Marian DiFiglia, Neil Aro...
    Source: Nature biotechnology
    Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustained gene silencing in the central nervous system (CNS) of mice and nonhuman primates following a single injection into the cerebrospinal fluid. Di-siRNAs are composed of two fully chemically modified, phosphoroth...
  • Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept

    julio 30, 2019
    Author(s): Jildaz Caroff, Robert M. King, Jennifer E. Mitchell, Miklos G. Marosfoi, Joseph R. Licwinko, Heather L. Gray-Edwards, Ajit S. Puri, Thomas L. Merrill, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    INTRODUCTION: The neuroprotective benefit of therapeutic hypothermia (TH) has been demonstrated, but systemic side effects and time required to achieve effective TH in acute ischemic stroke (AIS) care limits clinical use. We investigate rapid and localized cooling using a novel insulated catheter in an ischemia-reperfusion model. METHODS: In phase I (n=4), cold saline was delivered to the canine internal carotid artery via a...
  • Prospective study on embolization of intracranial aneurysms with the pipeline device: the PREMIER study 1 year results

    julio 15, 2019
    Author(s): Ricardo A. Hanel, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Preliminary clinical studies on the safety and efficacy of the pipeline embolization device (PED) for the treatment of small/medium aneurysms have demonstrated high occlusion rates with low complications. OBJECTIVE: To evaluate the safety and effectiveness of the PED for treatment of wide necked small and medium intracranial aneurysms. METHODS: PREMIER is a prospective, multicenter, single arm trial. Patients wer...
  • The Association of Program Directors in Radiology Well-Being 2019 Survey: Identifying Residency Gaps and Offering Solutions

    julio 11, 2019
    Author(s): Sheryl G. Jordan, Jessica B. Robbins, David Sarkany, Eric England, Vivek Kalia, Maitray D. Patel, Kamran Ali, Carolynn M. DeBenedectis, Christopher P. Ho, James M. Milburn, Seng Ong, Ann K. Jay, Glenn C. Gaviola, Darel E. Heitkamp
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: The Well-Being subcommittee of the Association of Program Directors in Radiology (APDR) Common Program Requirements (CPR) Ad Hoc Committee and the APDR Academic Output Task Force jointly conducted a study of APDR members' current level of understanding and implementation of the 2017 ACGME CPR regarding well-being. METHODS: A survey instrument consisting of 10 multiple-choice and open-ended questions was distributed ...
  • TARGET(R) Intracranial Aneurysm Coiling Prospective Multicenter Registry: Final Analysis of Peri-Procedural and Long-Term Safety and Efficacy Results

    julio 09, 2019
    Author(s): Osama O. Zaidat, Ajit S. Puri
    Source: Frontiers in neurology; Copyright © 2019 Zaidat, Castonguay, Rai, Badruddin, Mack, Alshekhlee, Shah, Hussain, Kabbani, Bulsara, Taqi, Janardhan, Patterson, Nordhaus, Elijovich and Puri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are c...
    Background and Purpose: To describe the final results of the TARGET Registry, a multicenter, real-world study of patients with intracranial aneurysms treated with new generation TARGET Coils. . Methods: The TARGET Registry is a prospective, single-arm study with independent medical event monitoring and core-lab adjudication. Patients with de novo intracranial aneurysms were embolized with either TARGET-360 degrees or helical...
  • Sarcopenia in lung cancer: Could chest imaging help?

    julio 02, 2019
    Author(s): Jennifer Baima, Elke Sarah Schipani, Wasih Kamran, John M. Varlotto, Lacey J. McIntosh, Karl Uy, Isabel Emmerick, Mathew J. Most
    Source: Prehabilitation World Congress 2019; Copyright 2019 The Author(s)
    Introduction: Fifteen to seventy percent of cancer patients demonstrate sarcopenia.1-6,[i],[ii],[iii],[iv],[v],[vi],[vii],[viii],[ix],[x],[xi],[xii],[xiii] Analysis of iliopsoas cross-sectional area, a non-invasive surrogate measure for sarcopenia in patients with cancer has been associated with survival.[xiv],[xv],[xvi],[xvii] The pectoralis muscle may be a more accessible target for measuring sarcopenia in lung cancer pati...
  • Impact of age on cerebral aneurysm occlusion after flow diversion

    julio 01, 2019
    Author(s): Anna Luisa Kuhn, Peter Kan, Nils Henninger, Visish Srinivasan, Katyucia de Macedo Rodrigues, Ajay K. Wakhloo, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
    The purpose of this study was to evaluate safety and efficacy of the pipeline embolization device (PED) in different patient age groups with unruptured intracranial aneurysms (UIA). All patients with UIA treated with the PED between 2011 and 2017 were included. Based on their age, patients were trichotomized to: young ( /=65years) groups. Patient's vascular risk factors, presenting symptoms and mRS on admission were collect...
  • Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source

    julio 01, 2019
    Author(s): Sean Fitzgerald, Matthew J. Gounis, Juyu Chueh, Ajit S. Puri, Waleed Brinjikji
    Source: Stroke
    Background and Purpose- Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and investigated correlations between clot composition and stroke pathogenesis. Methods- As part of the multi-institutional STRIP registry (Stroke Thromboembolism Registry of Imaging and Pathology), consecutive emboli...
  • Introduction. Formation, growth, and rupture: the biology and physics of cerebral aneurysms

    julio 01, 2019
    Author(s): Charles J. Prestigiacomo, Matthew J. Gounis, L. Fernando Gonzalez, Juhana Frosen
    Source: Neurosurgical focus
    his issue of Neurosurgical Focus addresses several of the important biological and genetic aspects of aneurysm formation. The reader will be exposed to the latest theories of aneurysm formation that invoke genetic predispositions and the role of inflammation and matrix metalloproteinases in the genesis of a cerebral aneurysm. Observational studies provide additional insight into the role of estrogen and other female sex ster...
  • Shortened cataract surgery by standardisation of the perioperative protocol according to the Joint Commission International accreditation: a retrospective observational study

    junio 14, 2019
    Author(s): Yuichi Okumura, Takenori Inomata, Masao Iwagami, Atsuko Eguchi, Ju Mizuno, Tina Shiang, Shiori Kawasaki, Akie Shimada, Eiichi Inada, Atsushi Amano, Akira Murakami
    Source: BMJ open; Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on differe...
    OBJECTIVES: To investigate the impact of standardisation of the perioperative protocol based on the Joint Commission International (JCI) accreditation guidelines for operating time in cataract surgery. DESIGN: Retrospective observational study. SETTING: Single centre in Japan. PARTICIPANTS: Between March 2014 and June 2016, 3127 patients underwent cataract surgery under topical anaesthesia including 2581 and 546 patients bef...
  • Proteome of the central apparatus of a ciliary axoneme

    junio 03, 2019
    Author(s): Lei Zhao, Yuqing Hou, Tyler Picariello, Branch Craige, George B. Witman
    Source: The Journal of cell biology; © 2019 Zhao et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licen...
    Nearly all motile cilia have a "9+2" axoneme containing a central apparatus (CA), consisting of two central microtubules with projections, that is essential for motility. To date, only 22 proteins are known to be CA components. To identify new candidate CA proteins, we used mass spectrometry to compare axonemes of wild-type Chlamydomonas and a CA-less mutant. We identified 44 novel candidate CA proteins, of which 13 are cons...
  • Lithium-Induced Chronic Kidney Disease in a Pediatric Patient

    junio 03, 2019
    Author(s): Neena Gupta, Meghan Gibson, Ellen C. Wallace
    Source: Case reports in pediatrics; Copyright © 2019 Neena Gupta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Lithium-induced nephropathy usually manifests in adulthood as it develops slowly after many years of cumulative exposure. There is very limited information available in pediatric patients. Renal function monitoring and timely intervention is the key in preventing lithium-induced chronic kidney disease in these patients. We report a case of a 14-year-old boy who was on lithium for almost 9 years for his complex psychiatric il...
  • Benign Breast Cyst in a Young Male

    junio 03, 2019
    Author(s): Nima Azimi, Azniv Azar, Ashraf Khan, Carolynn M. DeBenedectis
    Source: Cureus; © Copyright 2019. Azimi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Simple benign breast cysts are commonly diagnosed in female breasts and may present as palpable masses. However, they are extremely uncommon in the male breast and are rarely reported in the literature. Here, we report a case of a simple benign cyst of the breast in a relatively healthy 37-year-old man. The patient initially presented with a palpable 2-3 mm tender left breast lump. Further evaluation with mammography and ult...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria ((R)): Radiologic Management of Central Venous Access

    mayo 28, 2019
    Author(s): Roberta Savo, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Venous access is a procedure in which a catheter is placed into a vein for medical diagnosis or therapy. The type of device used depends on the patient and the type of illness being treated. There are two main types of venous access devices: peripheral and central catheters. A peripheral catheter is usually placed into a small vein, often in the arm, and is usually used up to 96 hours. A central catheter can be placed into a...
  • A canine model of mechanical thrombectomy in stroke

    mayo 18, 2019
    Author(s): Olivia W. Brooks, Robert M. King, Erez Nossek, Miklos G. Marosfoi, Jildaz Caroff, Juyu Chueh, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    PURPOSE: To develop a preclinical model of stroke with a large vessel occlusion treated with mechanical thrombectomy. MATERIALS AND METHODS: An ischemic stroke model was created in dogs by the introduction of an autologous clot into the middle cerebral artery (MCA). A microcatheter was navigated to the clot and a stent retriever thrombectomy was performed with the goal to achieve Thrombolysis in Cerebral Ischemia (TICI) 2b/3...
  • Retrospective fractional dose reduction in Tc-99m cardiac perfusion SPECT/CT patients: A human and model observer study

    mayo 10, 2019
    Author(s): P. Hendrik Pretorius, Albert Juan Ramon, Michael A. King, Arda Konik, Seth T. Dahlberg, Matthew Parker, Naomi F. Botkin, Karen L. Johnson, Yongyi Yang, Miles N. Wernick
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: In the ongoing efforts to reduce cardiac perfusion dose (injected radioactivity) for conventional SPECT/CT systems, we performed a human observer study to confirm our clinical model observer findings that iterative reconstruction employing OSEM (ordered-subset expectation-maximization) at 25% of the full dose (quarter-dose) has a similar performance for detection of hybrid cardiac perfusion defects as FBP at full...
  • Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy

    mayo 03, 2019
    Author(s): Diederik W.D. Kuster, Thomas L. Lynch, David Y. Barefield, Mayandi Sivaguru, Gina Kuffel, Michael J. Zilliox, Kyounghwan Lee, Roger Craig, Rajasekaran Namakkal-Soorappan, Sakthivel Sadayappan
    Source: Cardiovascular research
    AIMS: A 25-base pair (bp) deletion in the cardiac myosin binding protein-C (cMyBP-C) gene (MYBPC3), proposed to skip exon 33, modifies the C10 domain (cMyBP-CDeltaC10mut) and is associated with hypertrophic cardiomyopathy (HCM) and heart failure, affecting approximately 100 million South Asians. However, the molecular mechanisms underlying the pathogenicity of cMyBP-CDeltaC10mutin vivo are unknown. We hypothesized that expre...
  • Unconventional myosins muscle into myofibrils

    mayo 03, 2019
    Author(s): Elizabeth J. Luna
    Source: The Journal of biological chemistry; © 2019 Luna. Publisher's PDF posted after 12 months as allowed by the publisher's author rights policy at http://www.jbc.org/site/misc/edpolicy.xhtml#copyright.
    "Myosin" is famous as a component of muscle fibrils, but the majority of myosin family members act elsewhere with roles unrelated to muscle contraction. The biological functions of a relatively new family of these unconventional myosins, myosins 18A and 18B, are poorly understood. New research from Horsthemke et al. describes a new isoform (Myo18Agamma) that is essential for heart function and viability in mice. Their findin...
  • Segmental Distribution of Hepatocellular Carcinoma Correlates with Microvascular Invasion in Liver Explants Undergoing Transplantation

    mayo 02, 2019
    Author(s): Yasir Al-Azzawai, Eva Rouanet, Ryan J. Hendrix, Lidia Spaho, Hesham Malik, Deepika Devuni, Gyongyi Szabo, Graham Barnard
    Source: Journal of cancer epidemiology; Copyright © 2019 Yasir Al-Azzawi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Introduction: Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients is a poor prognostic factor after liver transplantation and/or resection. Any correlation between MVI and segmental location of HCC has yet to be studied. Our aim is to evaluate the segmental location of HCC and any correlation with the presence of MVI, portal vein thrombosis (PVT) in explanted livers, and the recurrence of HCC after transp...
  • ACR Appropriateness Criteria ((R)) Jaundice

    mayo 01, 2019
    Author(s): Expert Panel on Gastrointestinal Imaging, Nicole M. Hindman, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Jaundice is the end result of myriad causes, which makes the role of imaging in this setting particularly challenging. In the United States, the most common causes of all types of jaundice fall into four categories including hepatitis, alcoholic liver disease, blockage of the common bile duct by a gallstone or tumor, and toxic reaction to a drug or medicinal herb. Clinically, differentiating between the various potential eti...
  • ACR Appropriateness Criteria ((R)) Nonatherosclerotic Peripheral Arterial Disease

    mayo 01, 2019
    Author(s): Expert Panels on Vascular Imaging, Christopher J. Francois, Erik P. Skulborstad, Sanjeeva P. Kalva, Bill S. Majdalany, Jeremy D. Collins, Jens Eldrup-Jorgensen, Maros Ferencik, Suvranu Ganguli, A. Tuba Kendi, Minhajuddin S. Khaja, Piotr Obara, Thomas Ptak, Stephen P. Reis, Patrick D. Sutphin, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    A broad range of nonatherosclerotic diseases affect the peripheral arteries. The appropriate initial diagnostic imaging studies vary, depending upon the clinical presentation and suspicion of disease. Accurate vascular imaging relies upon visualization of the vessel lumen, vessel wall, and surrounding soft-tissue structures, with some modalities also offering the ability to characterize blood flow direction and velocity. Fur...
  • ACR Appropriateness Criteria ((R)) Right Upper Quadrant Pain

    mayo 01, 2019
    Author(s): Expert Panel on Gastrointestinal Imaging, Christine M. Peterson, Alan J. Goldstein
    Source: Journal of the American College of Radiology : JACR
    Although right upper quadrant pain is a very common clinical presentation, it can be nonspecific. However, acute cholecystitis is very often the diagnosis of exclusion. This review focuses on the recommended imaging evaluation in the most commonly encountered clinical scenarios presenting with right upper quadrant abdominal pain, including suspected biliary disease, suspected acute cholecystitis, and suspected acalculous cho...
  • ACR Appropriateness Criteria ((R)) Abdominal Aortic Aneurysm Follow-up (Without Repair)

    mayo 01, 2019
    Author(s): Expert Panel on Vascular Imaging, Michael Collard, Patrick D. Sutphin, Sanjeeva P. Kalva, Bill S. Majdalany, Jeremy D. Collins, Jens Eldrup-Jorgensen, Christopher J. Francois, Suvranu Ganguli, Andrew J. Gunn, A. Tuba Kendi, Minhajuddin S. Khaja, Piotr Obara, Stephen P. Reis, Kanupriya Vijay, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Abdominal aortic aneurysm (AAA) is defined as aneurysmal dilation of the abdominal aorta to 3 cm or greater. A high degree of morbidity and mortality is associated with AAA rupture, and imaging surveillance plays an essential role in mitigating the risk of rupture. Aneurysm size and growth rate are factors associated with the risk of rupture, thus surveillance imaging studies must be accurate and reproducible to characterize...
  • Should Radiology Delay the Start of Fellowships? A Survey of the APDR

    abril 29, 2019
    Author(s): James Michael Milburn, Darel E. Heitkamp, Ann K. Jay, David Sarkany, Kamran Ali, Carolynn M. DeBenedectis, Eric England, Christopher P. Ho, Vivek Kalia, Todd R. Kumm, Seng Ong, Angelisa M. Paladin, Maitray D. Patel, Jonathan O. Swanson, Joshua A. Hirsch
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: Several major medical specialties have recently considered delaying the start date of their fellowship training programs to allow for completion of their trainees' residency obligations. Radiology program directors (PDs) have voiced the need for a similar solution, as fellowship start dates at some institutions now occur well before the end of residency training. The objectives of this study are to ...
  • High frequency optical coherence tomography assessment of homogenous neck coverage by intrasaccular devices predicts successful aneurysm occlusion

    abril 29, 2019
    Author(s): Robert M. King, Miklos G. Marosfoi, Jildaz Caroff, Giovanni J. Ughi, Dale M. Groth, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: High frequency optical coherence tomography (HF-OCT) is a novel intravascular imaging technology developed for use in the cerebral vasculature. We hypothesize that HF-OCT characterization of intrasaccular device neck coverage can prognosticate exclusion of the aneurysm from the circulation. METHODS: Bifurcation and sidewall aneurysms were made in six dogs. Seven aneurysms were treated with next generation intrasa...
  • Microaggression in Radiology

    abril 08, 2019
    Author(s): Carolynn M. Debenedictis, Ann K. Jay, James Milburn, Judy Yee, Nolan J. Kagetsu
    Source: Journal of the American College of Radiology : JACR
    A microaggression is a comment or an action that subtly and often unconsciously or unintentionally expresses a prejudiced attitude toward a member of a marginalized group (such as a racial minority). Microaggressions can be seen in all aspects of society in everyday life. As members of the Association of Program Directors in Radiology and/or the ACR Diversity Committee, we want to raise awareness about microaggressions in ev...
  • Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT

    abril 05, 2019
    Author(s): Sean T. Fitzgerald, Matthew J. Gounis, Juyu Chueh, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize clot composition using the Martius Scarlet Blue stain and assess associations between platelet density and CT density. MATERIALS AND METHOD: Histopathological analysis of the clots collected as part of the m...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Staging of Pancreatic Ductal Adenocarcinoma

    abril 01, 2019
    Author(s): Frank J. Rybicki Jr., Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Pancreatic ductal adenocarcinoma, cancer of the pancreas, usually causes only vague symptoms until the pancreatic duct is blocked. Surgery with complete removal of the tumor is curative. Thus, it is important to find out if the tumor has spread outside of the pancreas or whether it remains confined to the pancreas and can be completely resected (surgically removed).
  • Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application

    marzo 27, 2019
    Author(s): Anita M. Leporati, Suresh Gupta, Elijah Bolotin, Gerardo Castillo, Joshua Alfaro, Marina B. Gottikh, Alexei A. Bogdanov Jr.
    Source: Pharmaceutical research
    PURPOSE: Developing and testing of microbicides for pre-exposure prophylaxis and post-exposure protection from HIV are on the list of major HIV/AIDS research priorities. To improve solubility and bioavailability of highly potent anti-retroviral drugs, we explored the use of a nanoparticle (NP) for formulating a combination of two water-insoluble HIV inhibitors. METHODS: The combination of a non-nucleoside HIV reverse transcr...
  • Transitioning from Radiology Training to Academic Faculty: Defining Your Role and Interests

    marzo 07, 2019
    Author(s): Joseph R. Grajo, Michele Retrouvey, Omer Awan, Tara Catanzano, Li Hsia Cheong Alicia, David Mankoff, Jonathan H. Burdette, Mishal Mendiratta-Lala, Lucy B. Spalluto, Richard A. Bronen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    Transitioning from radiology training to academic faculty presents many challenges. In this review, we discuss strategies to navigate this process and to facilitate success through appropriate selection of career tracks. Various modern avenues include roles as a Clinician-Educator, Clinician-Investigator, and Clinician-Administrator. Selection of the appropriate career track based on personal interests and institutional cult...
  • Impact of Balloon Guide Catheter Use on Clinical and Angiographic Outcomes in the STRATIS Stroke Thrombectomy Registry

    marzo 01, 2019
    Author(s): Osama O. Zaidat, Ajit S. Puri
    Source: Stroke
    Background and Purpose- Mechanical thrombectomy has been shown to improve clinical outcomes in patients with acute ischemic stroke. However, the impact of balloon guide catheter (BGC) use is not well established. Methods- STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter study of patients with large vessel occlusion treated with the Sol...
  • Transitioning From Radiology Training to Academic Faculty: The Importance of Mentorship

    febrero 27, 2019
    Author(s): Michele Retrouvey, Joseph R. Grajo, Omer Awan, Tara Catanzano, Li Hsia Cheong Alicia, David Mankoff, Jonathan H. Burdette, Mishal Mendiratta-Lala, Lucy B. Spalluto, Richard A. Bronen, Carolynn M. DeBenedectis
    Source: Current problems in diagnostic radiology
    Transitioning from radiology residency to academic faculty presents many challenges. In this review, we discuss the importance of introspection and mentorship to successfully navigate this process. Key points include alignment of goals with those of the institution, formation of a mentorship program, and periodic reassessment of career goals. These tips and tools can help make the transition from residency to academic facult...
  • Getting into the thick (and thin) of it

    febrero 21, 2019
    Author(s): Thomas C. Irving, Roger Craig
    Source: The Journal of general physiology; © 2019 Irving and Craig. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommo...
    The heart is a highly regulated system in which a combination of mechanisms work together to match cardiac output to the needs of the body. Loss of this regulation characterizes many cardiomyopathies, where muscle is either hypo- or hypercontractile. For many years, x-ray diffraction has been used to study the structural basis of myofilament length-dependent activation...
  • Cardiac motion correction for improving perfusion defect detection in cardiac SPECT at standard and reduced doses of activity

    febrero 20, 2019
    Author(s): Chao Song, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Piotr J. Slomka, Michael A. King
    Source: Physics in medicine and biology
    In cardiac SPECT perfusion imaging, cardiac motion can lead to motion blurring of anatomical detail and perfusion defects in the reconstructed myocardium. In this study, we investigated the potential benefit of cardiac motion correction for improving the detectability of perfusion defects. We considered a post-reconstruction motion correction (PMC) approach in which the image motion between two cardiac gates is obtained with...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria Imaging After Total Knee Arthroplasty

    febrero 18, 2019
    Author(s): Casey Quinlan, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Knee replacement, or total knee arthroplasty, is the most common joint replacement procedure in the United States. Most patients do not require any imaging after discharge other than the x-rays at the first postoperative follow-up appointment.
  • Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

    febrero 13, 2019
    Author(s): Anne-Laure Papa, Amanda Jiang, Netanel Korin, Michelle B. Chen, Erin T. Langan, Anna Waterhouse, Emma Nash, Jildaz Caroff, Amanda Graveline, Andyna Vernet, Akiko Mammoto, Tadanori Mammoto, Abhishek Jain, Roger D. Kamm, Matthew J. Gounis, Donald E. Ingber
    Source: Science translational medicine
    Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platelet activation cascades. Here, we describe the development of detergent-extracted human modified platelets (pl...
  • A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia

    febrero 11, 2019
    Author(s): Tyler Picariello, Jason M. Brown, Yuqing Hou, Gregory Swank, Deborah A. Cochran, Oliver D. King, Karl Lechtreck, Gregory J. Pazour, George B. Witman
    Source: Journal of cell science; © 2019. Published by The Company of Biologists Ltd. Publisher PDF posted after 12 months as allowed by publisher's author rights policy at https://www.biologists.com/user-licence-1-1/.
    Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most organisms, is the trafficking of IFT trains (i.e. assemblies of IFT particles) that carry cargo within the cilium. Defects in IFT cause several human diseases. IFT trains contain the complexes IFT-A and IFT-B. To dissect the functions of these complexes, we studied a Chlamydomonas mutant that is null for the IFT-A protein IFT14...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Lower Extremity Arterial Revascularization-Post-Therapy Imaging

    febrero 11, 2019
    Author(s): Frank Jr. Rybicki, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    The goal of endovascular angioplasty and of surgical bypass is to restore normal blood flow to the diseased arteries in the legs for individuals with peripheral artery disease. Both procedures need imaging follow-up to check for lesions, typically narrowing of arteries that may come back and cause symptoms. Often, noninvasive testing is done first to help choose the appropriate imaging test. The first test is usually measure...
  • Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

    febrero 07, 2019
    Author(s): Andrea M. Herrmann, Stephan Meckel, Matthew J. Gounis, Leona Kringe, Edith Motschall, Christoph Mulling, Johannes Boltze
    Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular...
  • Complete clot ingestion with cyclical ADAPT increases first-pass recanalization and reduces distal embolization

    febrero 04, 2019
    Author(s): Rose Arslanian, Miklos G. Marosfoi, Jildaz Caroff, Robert M. King, Christopher M. Raskett, Ajit S. Puri, Matthew J. Gounis, Juyu Chueh
    Source: Journal of neurointerventional surger
    BACKGROUND: Evidence is mounting that first-pass complete recanalization during mechanical thrombectomy is associated with better clinical outcomes in patients presenting with an emergent large vessel occlusion. We hypothesize that aspiration achieving complete clot ingestion results in higher first-pass successful recanalization with quantitative reduction in distal emboli. METHODS: A patient-specific cerebrovascular replic...
  • Effect of balloon guide catheter on clinical outcomes and reperfusion in Trevo thrombectomy

    febrero 02, 2019
    Author(s): Thanh N. Nguyen, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    INTRODUCTION: The Solitaire stent retriever registry showed improved reperfusion, faster procedure times, and better outcome in acute stroke patients with large vessel occlusion treated with a balloon guide catheter (BGC) and Solitaire stent retriever compared with a conventional guide catheter. The goal of this study was to evaluate whether use of a BGC with the Trevo stent retriever improves outcomes compared with a conven...
  • Mortality Associated With Opioid Overdose: A Review of Clinical Characteristics and Health Services Received in the Year Prior to Death

    febrero 01, 2019
    Author(s): Christian Rose, Abtin Shahanaghi, Mauricio Romero-Gonzalez, Jorge Yarzebski, Michael Andre, Gregory J. DiGirolamo, Alan P. Brown, Gerardo Gonzalez
    Source: Psychiatric services (Washington, D.C.)
    OBJECTIVE:: To assess missed opportunities for reducing fatal opioid overdoses, characteristics of decedents by opioid overdose with and without problematic opioid use who received health care services within one year of death were examined. METHODS:: Of 157 decedents in the Worcester, Massachusetts, area between 2008 and 2012, 112 had contact with the health care system. Electronic medical records were reviewed for clinical...
  • A2, M2, P2 aneurysms and beyond: results of treatment with pipeline embolization device in 65 patients

    enero 23, 2019
    Author(s): Christopher T. Primiani, Ajit S. Puri, Maxim Mokin
    Source: Journal of neurointerventional surgery
    BACKGROUND: Intracranial aneurysms located in the distal vessels are rare and remain a challenge to treat through surgical or endovascular interventions. OBJECTIVE: To describe a multicenter approach with flow diversion using the pipeline embolization device (PED) for treatment of distal intracranial aneurysms. METHODS: Cases of distal intracranial aneurysms defined as starting on or beyond the A2 anterior cerebral artery, M...
  • Neuroform Atlas Stent System for the treatment of intracranial aneurysm: primary results of the Atlas Humanitarian Device Exemption cohort

    enero 22, 2019
    Author(s): Brian T. Jankowitz, Ricardo Hanel, Ashutosh P. Jadhav, David N. Loy, Donald Frei, Adnan H. Siddiqui, Ajit S. Puri, Ahmad Khaldi, Aquilla S. Turk, Adel M. Malek, Eric Sauvageau, Steven W. Hetts, Osama O. Zaidat
    Source: Journal of neurointerventional surgery; © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the ori...
    BACKGROUND AND OBJECTIVE: Stent-assisted coil embolization is a well-established treatment of intracranial wide-necked aneurysms. The Neuroform Atlas Stent System is a new generation microstent designed to enhance coil support, conformability, deliverability, and improve deployment accuracy. We present the 1-year efficacy and angiographic results of the Humanitarian Device Exemption (HDE) cohort from the Atlas Investigationa...
  • Towards Drug Safety Surveillance and Pharmacovigilance: Current Progress in Detecting Medication and Adverse Drug Events from Electronic Health Records

    enero 16, 2019
    Author(s): Feifan Liu, Abhyuday Jagannatha, Hong Yu
    Source: Drug safety
    Large-scale drug safety surveillance and pharmacovigilance are key components of effective drug regulation systems, clinical practice, and public health programs. Although the efficacy and safety of a drug must be demonstrated in a series of clinical trials prior to approval, many adverse drug events (ADEs) are detected only after a drug has been marketed when it is used by a larger and more diverse population than during cl...
  • Overview of the First Natural Language Processing Challenge for Extracting Medication, Indication, and Adverse Drug Events from Electronic Health Record Notes (MADE 1.0)

    enero 16, 2019
    Author(s): Abhyuday Jagannatha, Feifan Liu, Weisong Liu, Hong Yu
    Source: Drug safety
    INTRODUCTION: This work describes the Medication and Adverse Drug Events from Electronic Health Records (MADE 1.0) corpus and provides an overview of the MADE 1.0 2018 challenge for extracting medication, indication, and adverse drug events (ADEs) from electronic health record (EHR) notes. OBJECTIVE: The goal of MADE is to provide a set of common evaluation tasks to assess the state of the art for natural language processing...
  • Outcomes after coverage of lenticulostriate vessels by flow diverters: a multicenter experience

    enero 11, 2019
    Author(s): Kathryn M. Wagner, Visish M. Srinivasan, Aditya Srivatsan, Michael G. Ghali Z, Ajith J. Thomas, Alejandro Enriquez-Marulanda, Abdulrahman Y. Alturki, Christopher S. Ogilvy, Maxim Mokin, Anna L. Kuhn, Ajit Puri, Ramesh Grandhi, Stephen Chen, Jeremiah Johnson, Peter Kan
    Source: Journal of neurosurgery; Publisher's PDF posted as allowed by publisher's copyright policy at: https://jns.msubmit.net/html/JNSPG_Editorial_and_Publishing_Policies.pdf
    OBJECTIVE: With the increasing use of flow diversion as treatment for intracranial aneurysms, there is a concomitant increased vigilance in monitoring complications. The low porosity of flow diverters is concerning when the origins of vessels are covered, whether large circle of Willis branches or critical perforators. In this study, the authors report their experience with flow diverter coverage of the lenticulostriate vess...
  • Incorporating Patient- and Family-Centered Care Into Radiology Residency Training Through an Experiential Curriculum

    enero 08, 2019
    Author(s): Carolynn M. DeBenedectis, David Sarkany, Michael Morrow, Danielle Del Re, Devon DiVito, Stephen D. Brown, Priscilla J. Slanetz
    Source: Journal of the American College of Radiology : JACR
    The intention of this article is to introduce the Communication Curriculum for Radiology Residents developed by the ACR PFCC Committee, as well as to describe the research behind it and how radiology residency program directors can use it.
  • Improving Communication of Actionable Findings in Radiology Imaging Studies and Procedures Using an EMR-Independent System

    enero 05, 2019
    Author(s): Steven J. Baccei, Cole DiRoberto, Janet Greene, Max P. Rosen
    Source: Journal of medical systems
    The primary purpose of this study is to determine if the implementation of an actionable findings communication system (PeerVue) with explicitly defined criteria for the classification of critical results, leads to an increase in the number of actionable findings reported by radiologists. Secondary goals are to 1) analyze the adoption rate of PeerVue and 2) assess the accuracy of the classification of actionable findings wit...
  • Patient-Friendly Summary of the ACR Appropriateness Criteria: Prostate Cancer-Pretreatment Detection, Surveillance, and Staging

    enero 01, 2019
    Author(s): David B. Andrews, Tasneem Lalani
    Source: Journal of the American College of Radiology : JACR
    Regular screening is recommended for men beginning about age 55. The first sign of cancer comes from either a blood test for a protein specific to prostate cancer (PSA) or by a digital examination of the prostate through the rectum to assess enlargement or firmness. Neither of these is perfectly accurate. Suspicion of cancer warrants additional testing.
  • Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases

    enero 01, 2019
    Author(s): Alexei A. Bogdanov Jr., I. D. Solovyev, A P. Savitsky
    Source: Biochemistry. Biokhimiia
    Various sensors designed for optical and photo(opto)acoustic imaging in living systems are becoming essential components of basic and applied biomedical research. Some of them including those developed for determining enzyme activity in vivo are becoming commercially available. These sensors can be used for various fluorescent signal detection methods: from whole body tomography to endoscopy with miniature cameras. Sensor mo...
  • 19F MRI Imaging of Polymer Nanogels Aided by Improved Segmental Mobility of Embedded Fluorine Moieties

    diciembre 18, 2018
    Author(s): Oyuntuya Munkhbat, Mine Canakci, Shaokuan Zheng, Weiguo Hu, Barbara Osborne, Alexei A. Bogdanov, S. Thayumanavan
    Source: Biomacromolecules
    Using fluorinated probes for 19F MRI imaging is an emerging field with potential utility in cellular imaging and cell tracking in vivo, which complements conventional 1H MRI. An attractive feature of 19F-based imaging is that this is a bio-orthogonal nucleus and the naturally abundant isotope is NMR active. A significant hurdle however in the 19F MRI arises from the tendency of organic macromolecules, with multiple fluorocar...
  • A Revisit to the Pretargeting Concept - A Target Conversion

    diciembre 17, 2018
    Author(s): Guozheng Liu
    Source: Frontiers in pharmacology; Copyright © 2018 Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution o...
    Pretargeting is often used as a tumor targeting strategy that provides much higher tumor to non-tumor ratios than direct-targeting using radiolabeled antibody. Due to the multiple injections, pretargeting is investigated less than direct targeting, but the high T/NT ratios have rendered it more useful for therapy. While the progress in using this strategy for tumor therapy has been regularly reviewed in the literature, this ...
  • Personalized Models for Injected Activity Levels in SPECT Myocardial Perfusion Imaging

    diciembre 06, 2018
    Author(s): Albert Juan Ramon, Yongyi Yang, P. Hendrik Pretorius, Karen L. Johnson, Michael A. King, Miles N. Wernick
    Source: IEEE transactions on medical imaging
    We propose a patient-specific ("personalized") approach for tailoring the injected activities to individual patients in order to achieve dose reduction in SPECT-myocardial perfusion imaging (MPI). First, we develop a strategy to determine the minimum dose levels required for each patient in a large set of clinical acquisitions (857 subjects) such that the reconstructed images are sufficiently similar to that obtained at conv...
  • Intravascular Optical Coherence Tomography for Neurointerventional Surgery

    noviembre 29, 2018
    Author(s): Matthew J. Gounis, Giovanni J. Ughi, Miklos G. Marosfoi, Demetrius K. Lopes, David Fiorella, Hiram G. Bezerra, Conrad W. Liang, Ajit S. Puri
    Source: Stroke
    Optical coherence tomography (OCT) is a high-resolution imaging modality that uses backscattered light to produce cross-sectional images of biological tissue with micrometer resolution. The first publication using the term OCT appeared in 1991 and arose as a collaboration between the Massachusetts Institute of Technology (MIT) and Harvard University. The high-spatial resolution makes it an optimal modality for imaging pathol...
  • Endovascular techniques for achievement of better flow diverter wall apposition

    noviembre 28, 2018
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Flow diverter malapposition has been described as a technical complication during endovascular procedures and can be associated with, potentially delayed, life-threatening aneurysm rupture or ischemic events. We performed a retrospective review of our flow diverter database to identify all patients in whom device malapposition was detected on follow-up angiogram immediately after device deployment. Feasibility and technical ...
  • Performance analysis of a high-sensitivity multi-pinhole cardiac SPECT system with hemi-ellipsoid detectors

    noviembre 08, 2018
    Author(s): Narayan Bhusal, Joyoni Dey, Jingzhu Xu, Kesava S. Kalluri, Arda Konik, Joyeeta M. Mukherjee, P. Hendrik Pretorius
    Source: Medical physics
    PURPOSE: Single-photon emission computed tomography (SPECT) is a noninvasive imaging modality, used in myocardial perfusion imaging. The challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. This improvement can be us...
  • Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT

    noviembre 07, 2018
    Author(s): Albert Juan Ramon, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Karen L. Johnson, Piotr J. Slomka, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function. METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with...
  • Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation

    noviembre 01, 2018
    Author(s): Yumi Uetake, Greenfield Sluder
    Source: Molecular biology of the cell; © 2018 Uetake and Sluder. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). Publisher PDF posted as allowed by the publisher's author rights policy at...
    When untransformed human cells spend 1.5 hr. in prometaphase under standard culture conditions, all daughters arrest in G1 despite normal division of their mothers. We investigate what happens during prolonged prometaphase that leads to daughter cell arrest in the absence of DNA damage. We find that progressive loss of anti-apoptotic MCL-1 activity and oxidative stress act in concert to partially activate the apoptosis pathw...
  • ACR Appropriateness Criteria((R)) Imaging of Mesenteric Ischemia

    noviembre 01, 2018
    Author(s): Michael Ginsburg, Piotr Obara, Drew L. Lambert, Michael Hanley, Michael L. Steigner, Marc A. Camacho, Ankur Chandra, Kevin J. Chang, Kenneth L. Gage, Christine M. Peterson, Thomas Ptak, Nupur Verma, David H. Kim, Laura R. Carucci, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Mesenteric ischemia is an uncommon condition resulting from decreased blood flow to the small or large bowel in an acute or chronic setting. Acute ischemia is associated with high rates of morbidity and mortality; however, it is difficult to diagnose clinically. Therefore, a high degree of suspicion and prompt imaging evaluation are necessary. Chronic mesenteric ischemia is less common and typically caused by atherosclerotic...
  • ACR Appropriateness Criteria((R)) Suspected Lower Extremity Deep Vein Thrombosis

    noviembre 01, 2018
    Author(s): Michael Hanley, Michael L. Steigner, Osmanuddin Ahmed, Ezana M. Azene, Shelby J. Bennett, Ankur Chandra, Benoit Desjardins, Kenneth L. Gage, Michael Ginsburg, David M. Mauro, Isabel B. Oliva, Thomas Ptak, Richard Strax, Nupur Verma, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Suspected lower extremity deep venous thrombosis is a common clinical scenario which providers seek a reliable test to guide management. The importance of confidently making this diagnosis lies in the 50% to 60% risk of pulmonary embolism with untreated deep vein thrombosis and subsequent mortality of 25% to 30%, balanced with the risks of anticoagulation. The ACR Appropriateness Criteria Expert Panel on Vascular Imaging rev...
  • Name That Nephrogram: Asymmetric Renal Enhancement in the Acute Care Setting

    octubre 19, 2018
    Author(s): Staci M. Gagne, Alex Newbury, Kristina M. Nowitzki, Byron Y. Chen, Hao S. Lo
    Source: Current problems in diagnostic radiology
    Disorders of the kidney and urinary collecting system are common encountered in the acute care setting. Computed tomography has progressively replaced intravenous pyelography for the evaluation of most urinary tract pathology including acute flank pain, suspected malignancy, congenital abnormalities, anatomical variants, and inflammatory/vascular conditions through evaluation of the "nephrogram" produced by intravenous contr...
  • Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms

    octubre 17, 2018
    Author(s): Tara C. Smith, Richard G. Saul, Elisabeth R. Barton, Elizabeth J. Luna
    Source: PloS one; Copyright: © 2018 Smith et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Supervillin isoforms have been implicated in cell proliferation, actin filament-based motile processes, vesicle trafficking, and signal transduction. However, an understanding of the roles of these proteins in cancer metastasis and physiological processes has been limited by the difficulty of obtaining specific antibodies against these highly conserved membrane-associated proteins. To facilitate research into the biological ...
  • Association Between Sarcopenia and Functional Status in Liver Transplant Patients

    octubre 05, 2018
    Author(s): Natasha H. Dolgin, Andrew J. Smith, Samantha G. Harrington, Babak Movahedi, Paulo N.A. Martins, Adel Bozorgzadeh
    Source: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation; Copyright © Başkent University 2018
    OBJECTIVES: A growing body of evidence shows that frailty and functional performance predict liver transplant outcomes. The Organ Procurement and Transplant Network uses the Karnofsky Performance Status scale to adjust for transplant center case mix in assessing quality measures. This study explores the strength of the relationship between Karnofsky Performance Status scores and objective measures of frailty. MATERIALS AND M...
  • Creating a Radiology Quality and Safety Program: Principles and Pitfalls

    octubre 01, 2018
    Author(s): Jennifer C. Broder, Scott F. Cameron, William T. Korn, Steven J. Baccei
    Source: Radiographics : a review publication of the Radiological Society of North America, Inc
    All radiology departments are now expected to create organized and comprehensive quality and safety (QS) programs. No matter the department size, there are fundamental principles that should be at the core of each program. "Just culture" and culture of safety are essential principles in establishing effective programs. Physician leaders of QS programs must involve stakeholders, define program goals, and develop an effective ...
  • Advances in Breast Localization Techniques: An Opportunity to Improve Quality of Care and Patient Satisfaction

    octubre 01, 2018
    Author(s): Lucy B. Spalluto, Carolynn M. Debenedectis, Michael Morrow, Ana P. Lourenco
    Source: Seminars in roentgenology
    We will review imaging modalities used for localization in addition to current localization techniques for nonpalpable breast lesions.
  • Women's response to state-mandated language in dense breast notification

    septiembre 25, 2018
    Author(s): Lucy B. Spalluto, Christianne L. Roumie, Kemberlee R. Bonnett, David G. Schlundt, Carolynn M. Debenedectis, Consuelo H. Wilkins
    Source: The breast journal
    Many states require radiologists to notify women of dense breast status. Our aim was to elicit women's response to state-mandated dense breast notification language. Of respondents, 82% report that current notification does not inform them of additional screening studies available, and 41% report notification does not inform them of next steps. Open-ended responses indicate three main areas of patient concern: Decisional Nee...
  • The impact of Joint Commission International accreditation on time periods in the operating room: A retrospective observational study

    septiembre 21, 2018
    Author(s): Takenori Inomata, Ju Mizuno, Masao Iwagami, Shiori Kawasaki, Akie Shimada, Eiichi Inada, Tina Shiang, Atsushi Amano
    Source: PloS one; Copyright: © 2018 Inomata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    The Joint Commission International (JCI) is responsible for upholding standards in healthcare and organizations in compliance receive accreditation. JCI requires quality improvement on patient safety goals, but requirements may prolong the total procedure/surgery time and reduce efficiency. Here, we evaluate the impact of JCI requirements on time periods in the operating room. We included patients who received elective and e...
  • Validation of Adult Relative Radiation Levels Using the ACR Dose Index Registry: Report of the ACR Appropriateness Criteria Radiation Exposure Subcommittee

    septiembre 20, 2018
    Author(s): David W. Jordan, Murray D. Becker, Samuel Brady, Mary Ann Keenan, Max P. Rosen, Debapriya Sengupta, Keith J. Strauss, Dianna D. Cody, Subcommittee on Appropriateness Criteria Radiation Exposure
    Source: Journal of the American College of Radiology : JACR
    The ACR Dose Index Registry (DIR) provides a new source of clinical radiation exposure data that has not been used previously to establish or update the relative radiation level (RRL) values in the ACR Appropriateness Criteria (AC). The results of a recent review of DIR data for 10 common CT examinations were compared with current ACR AC RRL values for the same procedures. The AC RRL values were previously determined by cons...
  • Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease

    septiembre 07, 2018
    Author(s): Takenori Inomata, Masao Iwagami, Yoshimune Hiratsuka, Keiichi Fujimoto, Yuichi Okumura, Tina Shiang, Akira Murakami
    Source: Scientific reports; © The Author(s) 2018. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third p...
    The prevalence of dry eye disease (DED) is increasing worldwide, and its diagnosis often needs dedicated reagents and machines. We investigated the usefulness of maximum blink interval (MBI) (the length of time that participants could keep their eyes open) in screening for DED. This cross-sectional study included 292 patients (194 with DED and 98 without DED) recruited between September 2016 and September 2017. We compared t...
  • Microcatheter navigation through the clot: does size matter

    septiembre 03, 2018
    Author(s): Jildaz Caroff, Robert M. King, Rose Arslanian, Miklos G. Marosfoi, Erin T. Langan, Matthew J. Gounis, Juyu Chueh
    Source: Journal of neurointerventional surgery
    BACKGROUND: Despite high recanalization rates achieved with endovascular treatment of acute ischemic strokes, around 50% of eligible patients will not achieve a good outcome. Parameters that may determine patient outcomes include: time from puncture to recanalization, the collateral status, the anesthesia regimen, blood pressure management, and distal emboli. Characterization of distal emboli generated during mechanical thro...
  • Spinal cord involvement in adult-onset metabolic and genetic diseases

    agosto 27, 2018
    Author(s): Cecilia Marelli, Ettore Salsano, Letterio S. Politi, Pierre Labauge
    Source: Journal of neurology, neurosurgery, and psychiatry
    In adulthood, spinal cord MRI abnormalities such as T2-weighted hyperintensities and atrophy are commonly associated with a large variety of causes (inflammation, infections, neoplasms, vascular and spondylotic diseases). Occasionally, they can be due to rare metabolic or genetic diseases, in which the spinal cord involvement can be a prominent or even predominant feature, or a secondary one. This review focuses on these rar...
  • Evaluation of different respiratory gating schemes for cardiac SPECT

    agosto 07, 2018
    Author(s): Duo Zhang, P. Hendrik Pretorius, Michael Ghaly, Qi Zhang, Michael A. King, Greta S. P. Mok
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: Respiratory gating reduces motion blurring in cardiac SPECT. Here we aim to evaluate the performance of three respiratory gating strategies using a population of digital phantoms with known truth and clinical data. METHODS: We analytically simulated 60 projections for 10 XCAT phantoms with (99m)Tc-sestamibi distributions using three gating schemes: equal amplitude gating (AG), equal count gating (CG), and equal t...
  • Flow diverter for endovascular treatment of intracranial mirror segment internal carotid artery aneurysms

    agosto 06, 2018
    Author(s): Anna L. Kuhn, Peter Kan, Visish Srinivasan, David E. Rex, Katyucia de Macedo Rodrigues, Mary Howk, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background: To evaluate the feasibility and efficacy of the pipeline embolization device in the treatment of unruptured intracranial mirror segment aneurysms. Methods: Out of a total of 338 subjects, 14 were identified harboring a total of 32 internal carotid artery mirror segment aneurysms that were treated with the pipeline embolization device and were consecutively enrolled into our study. We collected data on patient dem...
  • Bypass for Innominate artery occlusive disease

    agosto 01, 2018
    Author(s): Anna L. Kuhn, Ajit S. Puri, David E. Rex
    Source: World neurosurgery
    The innominate artery, also known as the brachiocephalic artery, is the first vessel off the aortic arch and provides blood to the right arm, neck and head. Occlusion of the innominate artery can be treated with endarterectomy, angioplasty and stenting as well as bypass grafting. Bypass grafting describes a surgical procedure during which a bypass from the ascending aorta to the innominate artery is created. Our case depicts...
  • Imaging of Spine Fractures With Emphasis on the Craniocervical Junction

    agosto 01, 2018
    Author(s): Gabriela Santos-Nunez, Hao S. Lo, Hemang Kotecha, Joe Jose, Aly Abayazeed
    Source: Seminars in ultrasound, CT, and MR
    Spinal cord injury often times is a catastrophic result of trauma. Delay in diagnosis may result in increased morbidity and mortality. Cross-sectional imaging is now increasingly used as a first-line diagnostic modality in the setting of trauma for recognition of spine fractures and ligamentous injuries that might be missed on routine radiographs. The learning objectives of this article are to review the anatomy of the spine...
  • Imaging and Management of Thoracic Trauma

    agosto 01, 2018
    Author(s): Alex Newbury, Jon D. Dorfman, Hao S. Lo
    Source: Seminars in ultrasound, CT, and MR
    Thoracic injury results from penetrating and blunt trauma and is a major contributor to overall trauma morbidity and mortality in the United States. Modern imaging algorithms utilize ultrasound, chest radiograph, and computed tomography with intravenous contrast to accurately diagnose and effectively treat patients with acute thoracic trauma. This review focuses on the etiologies, signs and symptoms, imaging, and management ...
  • Pancreaticobiliary Trauma: A Multimodality Imaging Update

    agosto 01, 2018
    Author(s): Staci M. Gagne, Bryan O'Sullivan-Murphy, Hao S. Lo, Lacey J. McIntosh
    Source: Seminars in ultrasound, CT, and MR
    Pancreaticobiliary injury is an uncommon entity which more often occurs in the setting of blunt than penetrating trauma. We present cases of pancreaticobiliary traumatic injuries from our Level 1 trauma center to illustrate an imaging update on the spectrum of injuries and correlation with current grading systems.
  • Pediatric Elbow Injuries

    agosto 01, 2018
    Author(s): Helen H. R. Kim, Jean-Marc Gauguet
    Source: Seminars in ultrasound, CT, and MR
    Elbow trauma in children is one of the most commonly encountered musculoskeletal injuries in pediatric radiology. However, elbow injuries in children can be misdiagnosed due to secondary ossification centers unique to pediatric patients. Familiarity of the normal elbow anatomy in children is crucial for an accurate diagnosis. This article seeks to improve diagnostic accuracy of these elbow injuries by reviewing the secondary...
  • Soft Tissue Injuries of the Finger and Thumb

    agosto 01, 2018
    Author(s): Juliann Giese, Christopher Cerniglia
    Source: Seminars in ultrasound, CT, and MR
    Soft tissue digital injury of the hand is a common presenting complaint in the emergency setting. Although initial work-up requires physical examination and radiographs, many of these entities may be radiographically occult and solely appreciated on ultrasound (US) or magnetic resonance imaging (MRI). If undiagnosed, these conditions may lead to sequela of untreated disease including early osteoarthritis, pain, permanent def...
  • Improving perfusion defect detection with respiratory motion correction in cardiac SPECT at standard and reduced doses

    julio 30, 2018
    Author(s): Chao Song, Yongyi Yang, Albert Juan Ramon, Miles N. Wernick, P. Hendrik Pretorius, Karen L. Johnson, Piotr J. Slomka, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: In cardiac SPECT perfusion imaging, respiratory motion can cause non-uniform blurring in the reconstructed myocardium. We investigate the potential benefit of respiratory correction with respiratory-binned acquisitions, both at standard dose and at reduced dose, for defect detection and for left ventricular (LV) wall resolution. METHODS: We applied two reconstruction methods for respiratory motion correction: pos...
  • Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology

    julio 27, 2018
    Author(s): Gopal Vijayaraghavan, Srinivasan Vedantham, Gabriela Santos-Nunez, Rebecca Hultman
    Source: Clinical breast cancer
    BACKGROUND: We systematically analyzed the extent of disease in unifocal invasive lobular carcinoma (ILC) using ultrasonography, with the histopathologic findings as the reference standard. PATIENTS AND METHODS: In the present single-institution retrospective study, 128 cases of ILC were identified during a 5-year period. After exclusions, the analyzed cohort included 66 cases. Ultrasound measurements of the tumor extent alo...
  • Size matters... but how do I know what size it is

    julio 24, 2018
    Author(s): Patrick A. Brouwer, Leonard L. Yeo, Matthew J. Gounis, Vamsi Krishna Gontu
    Source: Journal of neurointerventional surgery
    One of the challenges that doctors, nurses, and technologists in the field of neurointervention face is the differing definitions regarding the sizes of the materials we use, or more specifically the nomenclature by which these sizes are communicated. In this field, where practitioners have grown accustomed to ‘odd’ units of measurement, such as mm Hg for blood pressure and cm H2O for intracranial pressure, the neurovascular...
  • Development and validation of a new MRI simulation technique that can reliably estimate optimal in vivo scanning parameters in a glioblastoma murine model

    julio 23, 2018
    Author(s): Andrea Protti, Kristen L. Jones, Dennis M. Bonal, Lei Qin, Letterio S. Politi, Sasha Kravets, Quang-De Nguyen, Annick D. Van den Abbeele
    Source: PloS one; Copyright: © 2018 Protti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    BACKGROUND: Magnetic Resonance Imaging (MRI) relies on optimal scanning parameters to achieve maximal signal-to-noise ratio (SNR) and high contrast-to-noise ratio (CNR) between tissues resulting in high quality images. The optimization of such parameters is often laborious, time consuming, and user-dependent, making harmonization of imaging parameters a difficult task. In this report, we aim to develop and validate a compute...
  • Teaching Radiologists Who Perform Image Guided Interventions Effective Communication Skills Through Simulation

    julio 05, 2018
    Author(s): Carolynn M. DeBenedectis, Max P. Rosen
    Source: Current Problems in Diagnostic Radiology; © 2018 Elsevier Inc. Author's accepted manuscript posted after 12 months with a Creative Commons Attribution Non-Commercial No Derivatives License as allowed by the publisher's author rights policy at https://www.elsevier.com/about/policies/sharing.
    The purpose of this project is to teach radiologists who perform image guided interventions effective communication skills. Complaints related to communication errors between Radiologists and patients during interventional procedures are not uncommon. Communication for Radiologists performing IR procedures can be challenging since they are meeting the patient for the first time on the day of the procedure. Good communication...
  • The Association of Program Directors in Radiology Academic Output Task Force: Assisting Today's Busy Radiology Educators

    julio 01, 2018
    Author(s): Darel E. Heitkamp, Kamran Ali, Carolynn M. Debenedectis, Eric England, Glenn C. Gaviola, Christopher P. Ho, Vivek Kalia, James M. Milburn, Seng Ong, Maitray D. Patel, Mary H. Scanlon, David S. Sarkany
    Source: Journal of the American College of Radiology : JACR
    This report describes the mission and structure of the Academic Output Task Force (AOTF) so that APDR (Association of Program Directors in Radiology) members and radiology educators can use this new resource to its fullest potential.
  • Metachromatic Leukodystrophy: Too Frequent (Mis)Diagnosis

    junio 18, 2018
    Author(s): Letterio S. Politi, Ettore Salsano, Alessandra Biffi
    Source: JAMA neurology
    Recently, Wu et al1 reported the case of an adult patient with late-onset cobalamin C disease who received an incorrect diagnosis of adult metachromatic leukodystrophy (MLD). In this patient, the disease onset was characterized by acute psychiatric symptoms and spastic paraparesis. A brain magnetic resonance imagining (MRI) scan performed 2 months after the onset showed an area of hyperintensity on fluid-attenuated inversion...
  • A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

    junio 18, 2018
    Author(s): Young C. Shin, Georg F. Bischof, William A. Lauer, Lucas Gonzalez-Nieto, Eva G. Rakasz, Gregory M. Hendricks, David I. Watkins, Mauricio A. Martins, Ronald C. Desrosiers
    Source: PLoS pathogens; Copyright: © 2018 Shin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    The properties of the human immunodeficiency virus (HIV) pose serious difficulties for the development of an effective prophylactic vaccine. Here we describe the construction and characterization of recombinant (r), replication-competent forms of rhesus monkey rhadinovirus (RRV), a gamma-2 herpesvirus, containing a near-full-length (nfl) genome of the simian immunodeficiency virus (SIV). A 306-nucleotide deletion in the pol ...
  • Robotic Assisted MRI-Guided Interventional Interstitial MR Guided Focused Ultrasound Ablation in a Swine Model

    junio 14, 2018
    Author(s): Jacquelyn MacDonell, Matthew J. Gounis, Robert M. King, Gene Bogdanov, Olivia W. Brooks, Erin T. Langan, Julie G. Pilitsis
    Source: Neurosurgery
    BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS). OBJECTIVE: To describe our experience wit...
  • Varicosities affecting the lower limb veins consequent to a unique variant drainage pattern of the small saphenous vein

    junio 06, 2018
    Author(s): Shauna Mary Rice, Elke Sarah Schipani, Ana Maleesa Rae Santos, Katherine Anais Sadaniantz, Prithwijit Roychowdhury, Eustathia Lela Giannaris, Manas Das
    Source: International Journal of Anatomical Variations; This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact repr...
    We report varicosities affecting the right deep femoral vein and the right femoral vein consequent to a unique unilateral variation in the course of the small saphenous vein. The right small saphenous vein, instead of draining into the popliteal vein at the popliteal fossa, expanded considerably in girth and thickness and continued as the deep femoral vein. The deep femoral vein then pierced the adductor magnus muscle, appea...
  • Educating Radiology Residents About Patient- and Family-Centered Care: The Time Has Come

    junio 01, 2018
    Author(s): David Sarkany, Carolynn M. Debenedectis, Michael Morrow, Susan Sotardi, Danielle Del Re, Devon DiVito, Priscilla J. Slanetz
    Source: Journal of the American College of Radiology : JACR
    Introduction: Patient- and family-centered care (PFCC) has gained increased attention in recent years, especially with the current focus on value over volume and improving the patient experience, but it is not a new concept in medicine or radiology. After a recent New York Times article highlighted how a radiology department failed to provide a radiologist’s husband timely results, it is more critical than ever that radiolog...
  • Health Care Disparities in Radiology: A Primer for Resident Education

    mayo 31, 2018
    Author(s): Lisa Americo, Amit Ramjit, Michelle Wu, Leif Jensen, Drew Caplin, Joseph Mazzie, Glenn C. Gaviola, James Milburn, Christopher P. Ho, Maitray D. Patel, Carolynn M. Debenedectis, Darel E. Heitkamp, David Sarkany
    Source: Current problems in diagnostic radiology
    As the population of the United States grows increasingly diverse, health care disparities become vital to understand and mitigate. The ethical and financial implications of how groups of Americans gain access to health care have evolved into some of today's most challenging socioeconomic problems. Educators in radiology are just beginning to tackle the concepts of health care disparities, unconscious bias, and cultural comp...
  • High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease

    mayo 16, 2018
    Author(s): Youssef Z. Wadghiri, Dung Minh. Hoang, Anita M. Leporati, Matthew J. Gounis, Aurora Rodriguez-Rodriguez, Mary L. Mazzanti, John P. Weaver, Ajay K. Wakhloo, Peter Caravan, Alexei A. Bogdanov Jr
    Source: Scientific reports; © The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third p...
    Progress in clinical development of magnetic resonance imaging (MRI) substrate-sensors of enzymatic activity has been slow partly due to the lack of human efficacy data. We report here a strategy that may serve as a shortcut from bench to bedside. We tested ultra high-resolution 7T MRI (microMRI) of human surgical histology sections in a 3-year IRB approved, HIPAA compliant study of surgically clipped brain aneurysms. microM...
  • A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1)

    mayo 01, 2018
    Author(s): Tomohiro Kubo, Yuqing Hou, Deborah A. Cochran, George B. Witman, Toshiyuki Oda
    Source: Molecular biology of the cell; © 2018 Kubo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
    Motility of cilia/flagella is generated by a coordinated activity of thousands of dyneins. Inner dynein arms (IDAs) are particularly important for the formation of ciliary/flagellar waveforms, but the molecular mechanism of IDA regulation is poorly understood. Here, we show using cryo-electron tomography and biochemical analyses of Chlamydomonas flagella that a conserved protein FAP44 forms a complex that tethers IDA f (I1 d...
  • ACR Appropriateness Criteria((R)) Suspected Thoracic Aortic Aneurysm

    mayo 01, 2018
    Author(s): Shelby J. Bennett, Karin E. Dill, Michael Hanley, Osmanuddin Ahmed, Benoit Desjardins, Kenneth L. Gage, Michael Ginsburg, Ali Khoynezhad, Isabel B. Oliva, Michael L. Steigner, Richard Strax, Nupur Verma, Frank J. Rybicki
    Source: Journal of the American College of Radiology : JACR
    Although the incidence of thoracic aortic aneurysm is on the rise, initial imaging diagnosis can present a challenge for many clinicians. Providers are faced with many imaging choices as part of the initial workup. Considering level of invasiveness, relative radiation level, and quality of associated diagnostic data, CT angiography and MR angiography are believed to be the most appropriate options for radiological diagnosis ...
  • Motion-compensated image reconstruction vs postreconstruction correction in respiratory-binned SPECT with standard and reduced-dose acquisitions

    abril 21, 2018
    Author(s): Chao Song, Yongyi Yang, Wenyuan Qi, Miles N. Wernick, P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    PURPOSE: Cardiac perfusion images in single-photon emission computed tomography (SPECT) can suffer from respiratory motion blur. We investigated a reconstruction approach for correcting respiratory motion in respiratory-binned acquisitions and assessed the benefit of this approach in both standard dose and reduced dose. METHODS: We modeled the acquired data from different respiratory bins by a joint probability distribution ...
  • The Importance of Wall Apposition in Flow Diverters

    abril 04, 2018
    Author(s): Rene Aquarius, Antonius de Korte, Debby Smits, Matthew J. Gounis, Kiek Verrijp, Leon Driessen, William Leenders, Joost de Vries
    Source: Neurosurgery
    BACKGROUND: It is assumed that high pore densities in flow diverters (FDs) are beneficial for intracranial aneurysm (IA) healing. However, various animal studies are not conclusive on the issue, suggesting that other factors are in play. One important factor might be wall apposition. OBJECTIVE: To (1) determine the relationship between FD pore density and aneurysm occlusion, and (2) determine the relationship between FD wall...
  • To be or not 2b? To see or not 2c? Alas, the clock is ticking on TICI

    abril 01, 2018
    Author(s): David F. Kallmes, Alejandro A. Rabinstein, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    The time has come to throw the flag on the Thrombolysis in Cerebral Infarction (TICI) scale. Conceived in surrogacy from our cardiology brethren and sistren’s Thrombolysis in Myocardial Infarction (TIMI) score,1 TICI’s birth was anything but smooth. However, even though plagued by internal inconsistencies,2 confusing nomenclature,3 unclear pronunciation (are you a ‘tissy’ or ‘tiki’ person?), and modifications and more modifi...
  • Population-based differences in the outcome and presentation of lung cancer patients based upon racial, histologic, and economic factors in all lung patients and those with metastatic disease

    abril 01, 2018
    Author(s): John M. Varlotto, Richard Voland, Kerrie McKie, John C. Flickinger, Malcolm M. DeCamp, Debra Maddox, Paul Rava, Thomas J. Fitzgerald, Geoffrey Graeber, Negar Rassaei, Paulo Oliveira, Suhail Ali, Chandra Belani, Jonathan Glanzman, Heather A. Wakelee, Manali Patel, Jennifer Baima, Jianying Zhang, William Walsh
    Source: Cancer medicine; © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    To investigate the interrelation between economic, marital, and known histopathologic/therapeutic prognostic factors in presentation and survival of patients with lung cancer in nine different ethnic groups. A retrospective review of the SEER database was conducted through the years 2007-2012. Population differences were assessed via chi-square testing. Multivariable analyses (MVA) were used to detect overall survival (OS) d...
  • Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia

    marzo 06, 2018
    Author(s): Jildaz Caroff, Takamitsu Tamura, Robert M. King, Pedro N. Lylyk, Erin T. Langan, Olivia W. Brooks, Frederic Clarencon, John Michael. Wainwright, Laurent Spelle, Miklos G. Marosfoi, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Optical coherence tomography (OCT) is a high-resolution, intra-vascular diagnostic technique widely used for the characterization of vascular pathologies and optimization of stent implantation during percutaneous coronary intervention. OCT was used to investigate the in vivo vascular response to a new phosphorylcholine surface modified flow diverter (sPED). METHODS: In an in vivo rabbit aneurysmal model, we used ...
  • Treatment of blood blister aneurysms of the internal carotid artery with flow diversion

    febrero 24, 2018
    Author(s): Maxim Mokin, Ajit S. Puri, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND: Blood blister aneurysms (BBA) are a rare subset of intracranial aneurysms that represent a therapeutic challenge from both a surgical and endovascular perspective. OBJECTIVE: To report multicenter experience with flow diversion exclusively for BBA, located at non-branching segments along the anteromedial wall of the supraclinoidal internal carotid artery (ICA). METHODS: Consecutive cases of BBA located at non-bra...
  • Flow-diverter stents for endovascular management of non-fetal posterior communicating artery aneurysms-analysis on aneurysm occlusion, vessel patency, and patient outcome

    febrero 22, 2018
    Author(s): Anna L. Kuhn, Guilherme Dabus, Peter Kan, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background Use of flow-diversion technology in the treatment of incidental and recanalized posterior communicating artery (PComA) aneurysms. Methods Patients treated with the Pipeline embolization device (PED) for PComA aneurysms were identified and included in our retrospective analysis. We evaluated aneurysm characteristics, modified Rankin Scale score (mRS) on admission, angiography follow-up, and patient clinical outcome...
  • Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca(2+)-dependent manner

    febrero 08, 2018
    Author(s): Brian Leei Lin, Amy Li, Ji Young Mun, Michael J. Previs, Samantha Beck. Previs, Stuart G. Campbell, Cristobal G. Dos Remedios, Pieter de P. Tombe, Roger Craig, David M. Warshaw, Sakthivel Sadayappan
    Source: Scientific reports; © The Author(s) 2018. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third p...
    Muscle contraction, which is initiated by Ca(2+), results in precise sliding of myosin-based thick and actin-based thin filament contractile proteins. The interactions between myosin and actin are finely tuned by three isoforms of myosin binding protein-C (MyBP-C): slow-skeletal, fast-skeletal, and cardiac (ssMyBP-C, fsMyBP-C and cMyBP-C, respectively), each with distinct N-terminal regulatory regions. The skeletal MyBP-C is...
  • (18)F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis

    febrero 05, 2018
    Author(s): Sara Belloli, Lucia Zanotti, Valentina Murtaj, Cristina Mazzon, Giuseppe Di Grigoli, Cristina Monterisi, Valeria Masiello, Leonardo Iaccarino, Andrea Cappelli, Pietro Luigi Poliani, Letterio S. Politi, Rosa Maria Moresco
    Source: Journal of neuroinflammation; © The Author(s). 2018. Open Access.This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and ind...
    BACKGROUND: Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders, including multiple sclerosis (MS). The aim of this study was to evaluate neuroinflammation in a mouse MS model (EAE) using TSPO-PET with (18)F-VC701, in combination with magnetic resonance imaging (MRI). METHODS: MOG35-55/CFA and pertussis toxin protocol was u...
  • Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

    febrero 01, 2018
    Author(s): Kyounghwan Lee, Guidenn Sulbaran, Shixin Yang, Ji Young Mun, Lorenzo Alamo, Antonio Pinto, Osamu Sato, Mitsuo Ikebe, Xiong Liu, Edward D. Korn, Floyd Sarsoza, Sanford I. Bernstein, Raul Padron, Roger Craig
    Source: Proceedings of the National Academy of Sciences of the United States of America; © 2018. Published under the PNAS license, http://www.pnas.org/page/authors/licenses.
    Electron microscope studies have shown that the switched-off state of myosin II in muscle involves intramolecular interaction between the two heads of myosin and between one head and the tail. The interaction, seen in both myosin filaments and isolated molecules, inhibits activity by blocking actin-binding and ATPase sites on myosin. This interacting-heads motif is highly conserved, occurring in invertebrates and vertebrates...
  • Letter from the Guest Editor

    febrero 01, 2018
    Author(s): Gopal Vijayaraghavan
    Source: Seminars in ultrasound, CT, and MR
    The field of breast imaging is constantly evolving and has seen rapid advances in technology over the last 2 decades. Controversies surrounding breast cancer screening have also been gaining ground, despite unequivocal benefits and a decline in mortality of nearly 30%. There is talk of a paradigm shift in thinking from “population-based” screening to “personalized risk based” screening.
  • A Prospective Multicenter Trial of the TransForm Occlusion Balloon Catheter: Trial Design and Results

    febrero 01, 2018
    Author(s): M. Asif Taqi, Syed A. Quadri, Ajit S. Puri, Brian F. Fitzsimmons, Jianhua Nancy Jin, Ansaar T. Rai, Curtis A. Given 2nd, Javier Masso, Ciaran J. Powers, Joey D. English, Osama O. Zaidat
    Source: Interventional neurology
    Background and Purpose: Adjunctive treatments like balloon-assisted coil embolization (BACE) and stent-assisted coil embolization play a major role in the treatment of wide-neck and large intracranial aneurysms. The TransForm Occlusion Balloon Catheter (TOBC) registry is intended to evaluate the safety, efficacy, and efficiency of BACE using the TOBC. Method and Study Design: The TOBC registry is a prospective multicenter re...
  • A stereotaxic breed-averaged, symmetric T2w canine brain atlas including detailed morphological and volumetrical data sets

    enero 31, 2018
    Author(s): Bjorn Nitzsche, Johannes Boltze, Eberhard Ludewig, Thomas Flegel, Martin J. Schmidt, Johannes Seeger, Henryk Barthel, Olivia W. Brooks, Matthew J. Gounis, Michael H. Stoffel, Sabine Schulze
    Source: NeuroImage
    Stereotaxic systems and automatic tissue segmentation routines enable neuronavigation as well as reproducible processing of neuroimage datasets. Such systems have been developed for humans, non-human-primates, sheep, and rodents, but not for dogs. Although dogs share important neurofunctional and -anatomical features with humans, and in spite of their importance in translational neuroscience, little is known about the variab...
  • A Review of Resources and Methodologies Available for Teaching and Assessing Patient-Related Communication Skills in Radiology

    enero 18, 2018
    Author(s): David Sarkany, Carolynn M. Debenedectis, Stephen D. Brown
    Source: Academic radiology
    ACGME expectations for radiology trainees' proficiencies in communication skills pose a challenge to program directors who wish to develop curricula addressing these competencies. Numerous educational resources and pedagogical approaches have emerged to address such competencies specifically for radiology, but have yet to be systematically catalogued. In this paper, we review and compile these resources into a toolkit that w...
  • Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model

    enero 15, 2018
    Author(s): Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei A. Bogdanov Jr., Friederike Lammer, Claire Delbridge, Kaspar Matiasek, Benedikt J. Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S. Gersing
    Source: Scientific reports; © The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third p...
    After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obta...
  • System-Level Process Change Improves Communication and Follow-Up for Emergency Department Patients With Incidental Radiology Findings

    enero 03, 2018
    Author(s): Steven J. Baccei, Sneha A. Chinai, Martin A. Reznek, Scott Henderson, Kevin Reynolds, David Eric Brush
    Source: Journal of the American College of Radiology : JACR
    The appropriate communication and management of incidental findings on emergency department (ED) radiology studies is an important component of patient safety. Guidelines have been issued by the ACR and other medical associations that best define incidental findings across various modalities and imaging studies. However, there are few examples of health care facilities designing ways to manage incidental findings. Our instit...
  • Fostering Patient- and Family-Centered Care in Radiology Practice

    enero 02, 2018
    Author(s): Priscilla J. Slanetz, Cheri L. Canon, Lucy Spalluto, Carolynn M. Debenedectis, Andrea Borondy-Kitts, Lori A. Deitte
    Source: Journal of the American College of Radiology : JACR
    Patient- and family-centered care (PFCC) is “a model of providing care in which the patient and family are partners with the provider and care team”. With reimbursement linked to health care outcomes and patient satisfaction, radiology has an opportunity to add value to the health care system by fostering partnerships with patients and families.
  • Clinical Applications of 3D Printing: Primer for Radiologists

    enero 01, 2018
    Author(s): David H. Ballard, Anthony Paul Trace, Sayed Ali, Taryn Hodgdon, Matthew E. Zygmont, Carolynn M. Debenedectis, Stacy E. Smith, Michael L. Richardson, Midhir J. Patel, Summer J. Decker, Leon Lenchik
    Source: Academic radiology
    Three-dimensional (3D) printing refers to a number of manufacturing technologies that create physical models from digital information. Radiology is poised to advance the application of 3D printing in health care because our specialty has an established history of acquiring and managing the digital information needed to create such models. The 3D Printing Task Force of the Radiology Research Alliance presents a review of the ...
  • Logistics of Three-dimensional Printing: Primer for Radiologists

    enero 01, 2018
    Author(s): Taryn Hodgdon, Raman Danrad, Midhir J. Patel, Stacy E. Smith, Michael L. Richardson, David H. Ballard, Sayed Ali, Anthony Paul Trace, Carolynn M. Debenedectis, Matthew E. Zygmont, Leon Lenchik, Summer J. Decker
    Source: Academic radiology
    The Association of University Radiologists Radiology Research Alliance Task Force on three-dimensional (3D) printing presents a review of the logistic considerations for establishing a clinical service using this new technology, specifically focused on implications for radiology. Specific topics include printer selection for 3D printing, software selection, creating a 3D model for printing, providing a 3D printing service, r...
  • Pediatric intracranial aneurysms: considerations and recommendations for follow-up imaging

    enero 01, 2018
    Author(s): Michael George Zaki Ghali, Visish M. Srinivasan, Jacob Cherian, Louis Kim, Adnan Siddiqui, M. Ali Aziz-Sultan, Michael Froehler, Ajay K. Wakhloo, Eric Savageau, Ansaar Rai, Stephen R. Chen, Jeremiah Johnson, Sandi K. Lam, Peter Kan
    Source: World neurosurgery
    BACKGROUND: Pediatric intracranial aneurysms (IAs) are rare. Compared to adult IAs, they are more commonly giant, fusiform, or dissecting. Their treatment often proves more complex and recurrence rate and de novo aneurysmogenesis incidence is higher. A consensus regarding the most appropriate algorithm for following pediatric IAs is lacking. METHODS: We thus sought to generate recommendations based on the reported experience...
  • Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review

    enero 01, 2018
    Author(s): An Tang, Adib R. Karam, LI-RADS Evidence Working Group
    Source: Radiology
    The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC to imaging-detected liver observations based on major and ancillary imaging features. LI-RADS also includes imaging features suggesting malignancy other than HCC. S...
  • Increased signal intensity within glioblastoma resection cavities on fluid-attenuated inversion recovery imaging to detect early progressive disease in patients receiving radiotherapy with concomitant temozolomide therapy

    enero 01, 2018
    Author(s): Luke A. Perry, Panagiotis Korfiatis, Jay P. Agrawal, Bradley J. Erickson
    Source: Neuroradiology
    PURPOSE: Our study tested the diagnostic accuracy of increased signal intensity (SI) within FLAIR MR images of resection cavities in differentiating early progressive disease (ePD) from pseudoprogression (PsP) in patients with glioblastoma treated with radiotherapy with concomitant temozolomide therapy. METHODS: In this retrospective study approved by our Institutional Review Board, we evaluated the records of 122 consecutiv...
  • Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle - oligonucleotide nanoconstructs to head and neck cancer cells

    enero 01, 2018
    Author(s): Surong Zhang, Suresh Gupta, Thomas J. Fitzgerald, Alexei A. Bogdanov Jr.
    Source: Nanotheranostics; © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
    Constitutively activated signal transducer and activator of transcription 3 (STAT3) factor is an important therapeutic target in head and neck cancer (HNC). Despite early promising results, a reliable systemic delivery system for STAT3- targeted oligonucleotide (ODN) drugs is still needed for future clinical translation of anti-STAT3 therapies. We engineered and tested a novel ODN duplex/gold nanoparticle (AuNP)-based system...
  • 4D non-local means post-filtering for cardiac gated SPECT

    diciembre 28, 2017
    Author(s): Chao Song, Yongyi Yang, P. Hendrik Pretorius, Michael A. King
    Source: Physics in medicine and biology
    Cardiac gated images often suffer from increased noise in single photon emission computed tomography (SPECT) due to reduced data counts compared to non-gated studies. We investigate a spatiotemporal post-processing approach based on a non-local means (NLM) filter for suppressing the noise in gated SPECT images. In this filter, the output at a voxel location is computed from a weighted average of voxels in its 4D neighborhood...
  • Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research

    diciembre 19, 2017
    Author(s): Robert J. Duronio, Patrick H. O'Farrell, Greenfield Sluder, Tin Tin Su
    Source: Disease models and mechanisms; © 2017. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
    For hundreds of years, biologists have studied accessible organisms such as garden peas, sea urchins collected at low tide, newt eggs, and flies circling rotten fruit. These organisms help us to understand the world around us, attracting and inspiring each new generation of biologists with the promise of mystery and discovery. Time and time again, what we learn from such simple organisms has emphasized our common biological ...
  • Population representation among anatomical donors and the implication for medical student education

    diciembre 06, 2017
    Author(s): Amanda J. Collins, Whitney Smith, Eustathia Lela Giannaris, Elizabeth Aaker Orvek, Peter Lazar, Jan K. Carney, Anne M. Gilroy, Max P. Rosen
    Source: Clinical anatomy (New York, N.Y.)
    Dissection provides a unique opportunity to integrate anatomical and clinical education. Commonly, cadavers are randomly assigned to courses, which may result in skewed representation of patient populations. The primary aim of this study was to determine if the anatomical donors studied by students at the University of Massachusetts Medical School (UMMS) accurately represent the disease burden of the local patient population...
  • Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models

    diciembre 06, 2017
    Author(s): Silvia Valtorta, Alessia Lo. Dico, Isabella Raccagni, Daniela Gaglio, Sara Belloli, Letterio S. Politi, Cristina Martelli, Cecilia Diceglie, Marcella Bonanomi, Giulia Ercoli, Valentina Vaira, Luisa Ottobrini, Rosa Maria Moresco
    Source: Oncotarget; Copyright: Valtorta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor survival. Cytoreduction in association with radiotherapy and temozolomide (TMZ) is the standard therapy, but response is heterogeneous and life expectancy is limited. The combined use of chemotherapeutic agents with drugs targeting cell metabolism is becoming an interesting therapeutic option for cancer treatment. Here, we found that metformin...
  • Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up

    diciembre 01, 2017
    Author(s): Anna L. Kuhn, Katyucia de Macedo Rodrigues, Juan Diego Lozano, David E. Rex, Francesco Massari, Takamitsu Tamura, Mary Howk, Christopher Brooks, Jenna L'Heureux, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    OBJECTIVE: Evaluation of the safety and efficacy of the Pipeline embolization device (PED) when used as second-line treatment for recurrent or residual, pretreated ruptured and unruptured intracranial aneurysms (IAs). METHODS: Retrospective review of our database to include all patients who were treated with a PED for recurrent or residual IAs following surgical clipping or coiling. We evaluated neurological outcome and angi...
  • Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion

    noviembre 10, 2017
    Author(s): Robert M. King, Olivia W. Brooks, Erin T. Langan, Jildaz Caroff, Frederic Clarencon, Takamitsu Tamura, John Michael Wainwright, Matthew J. Gounis, Miklos G. Marosfoi, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Optical coherence tomography (OCT) is a high resolution intravascular imaging method that allows visualization of flow diverter struts and the vessel wall. In this study, malapposition of the flow diverter that continues into the neck of the aneurysm, named communicating malapposition (CM), was investigated as a potential factor for delayed aneurysm healing. METHODS: 40 New Zealand White rabbits underwent elastas...
  • Increased Depression and Anxiety Symptoms are Associated with More Breakdowns in Cognitive Control to Cocaine Cues in Veterans with Cocaine Use Disorder

    noviembre 09, 2017
    Author(s): Gregory J. DiGirolamo, Gerardo Gonzalez, David A. Smelson, Nathan Guevremont, Michael I. Andre, Pooja O. Patnaik, Zachary R. Zaniewski
    Source: Journal of dual diagnosis
    OBJECTIVE: Cue-elicited craving is a clinically important aspect of cocaine addiction directly linked to cognitive control breakdowns and relapse to cocaine-taking behavior. However, whether craving drives breakdowns in cognitive control toward cocaine cues in veterans, who experience significantly more co-occurring mood disorders, is unknown. The present study tests whether veterans have breakdowns in cognitive control beca...
  • ACR Appropriateness Criteria((R)) Thoracic Aorta Interventional Planning and Follow-Up

    noviembre 01, 2017
    Author(s): Expert Panels on Vascular Imaging and Interventional Radiology, Gregory Bonci, Michael L. Steigner, Michael Hanley, Aaron R. Braun, Benoit Desjardins, Ron C. Gaba, Kenneth L. Gage, Jon S. Matsumura, Eric E. Roselli, David M. Sella, Richard Strax, Nupur Verma, Clifford R. Weiss, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Thoracic endovascular aortic repair (TEVAR) has undergone rapid evolution and is now applied to a range of aortic pathologies. Imaging plays a vital role in the pre- and postintervention assessment of TEVAR patients. Accurate characterization of pathology and evaluation for high-risk anatomic features are necessary in the planning phase, and careful assessment for graft stability, aortic lumen diameter, and presence of endol...
  • ACR Appropriateness Criteria((R)) Renovascular Hypertension

    noviembre 01, 2017
    Author(s): Expert Panels on Urologic Imaging and Vascular Imaging, Howard J. Harvin, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Renovascular hypertension is the most common type of secondary hypertension and is estimated to have a prevalence between 0.5% and 5% of the general hypertensive population, and an even higher prevalence among patients with severe hypertension and end-stage renal disease, approaching 25% in elderly dialysis patients. Investigation for renal artery stenosis is appropriate when clinical presentation suggests secondary hyperten...
  • ACR Appropriateness Criteria((R)) Penetrating Neck Injury

    noviembre 01, 2017
    Author(s): Expert Panels on Neurologic and Vascular Imaging, Jason W. Schroeder, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    In patients with penetrating neck injuries with clinical soft injury signs, and patients with hard signs of injury who do not require immediate surgery, CT angiography of the neck is the preferred imaging procedure to evaluate extent of injury. Other modalities, such as radiography and fluoroscopy, catheter-based angiography, ultrasound, and MR angiography have their place in the evaluation of the patient, depending on the s...
  • ACR Appropriateness Criteria((R)) Imaging of Deep Inferior Epigastric Arteries for Surgical Planning (Breast Reconstruction Surgery)

    noviembre 01, 2017
    Author(s): Expert Panel on Vascular Imaging, Isabel B. Oliva, Kevin Day, Karin E. Dill, Michael Hanley, Osmanuddin Ahmed, Shelby J. Bennett, Benoit Desjardins, Kenneth L. Gage, Michael Ginsburg, Adam H. Hamawy, Michael L. Steigner, Richard Strax, Nupur Verma, Frank J. Rybicki
    Source: Journal of the American College of Radiology : JACR
    Breast cancer is the most common malignancy in women in the United States. Breast reconstruction surgery is a commonly used therapy for patients with breast cancer. The technique for the deep inferior epigastric perforator flap uses a preserved rectus muscle, which decreases donor site morbidity. Accurate identification and measurement of the perforator branches of the deep inferior epigastric artery is pivotal during pre-op...
  • ACR Appropriateness Criteria((R)) Imaging for Transcatheter Aortic Valve Replacement

    noviembre 01, 2017
    Author(s): Expert Panel on Cardiac Imaging and Vascular Imaging, Jonathon A. Leipsic, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Aortic stenosis is a common valvular condition with increasing prevalence in aging populations. When severe and symptomatic, the downstream prognosis is poor without surgical or transcatheter aortic valve replacement. Transcatheter aortic valve replacement is now considered a viable alternative to surgical aortic valve replacement in patients considered high and intermediate risk for surgery. Pre-intervention imaging with ec...
  • Flow diversion for anterior choroidal artery (AChA) aneurysms: a multi-institutional experience

    octubre 31, 2017
    Author(s): Visish M. Srinivasan, Michael George Zaki Ghali, Jacob Cherian, Maxim Mokin, Ajit S. Puri, Ramesh Grandhi, Stephen R. Chen, Jeremiah N. Johnson, Peter Kan
    Source: Journal of neurointerventional surgery
    BACKGROUND: Anterior choroidal artery (AChA) aneurysms represent a small subset of cerebral aneurysms. The Pipeline Embolization Device (PED) has been successfully applied to various aneurysms of the supraclinoid internal carotid artery (ICA). The treatment of these aneurysms requires special attention due to the eloquent territory supplied by the AChA. We report the largest and first dedicated series of flow diversion treat...
  • Flow diversion for the treatment of posterior inferior cerebellar artery aneurysms: a novel classification and strategies

    octubre 20, 2017
    Author(s): Visish M. Srinivasan, Michael George Zaki Ghali, Oleg E. Reznik, Jacob Cherian, Maxim Mokin, Travis M. Dumont, John R. Gaughen, Ramesh Grandhi, Ajit S. Puri, Stephen R. Chen, Jeremiah N. Johnson, Peter Kan
    Source: Journal of neurointerventional surgery
    BACKGROUND: The pipeline embolization device (PED) is frequently used in the treatment of anterior circulation aneurysms, especially around the carotid siphon, with generally excellent results. However, treatment of posterior inferior cerebellar artery (PICA) aneurysms with flow diversion (FD) has not been specifically described or discussed. While there are reports of treating PICA aneurysms using placement of FD stents in ...
  • Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

    octubre 20, 2017
    Author(s): Julia C. Meier, Hanna Witwicka, Sung-Yong Hwang, Mark J. Birnbaum, Stefan Knapp
    Source: ACS chemical biology; Copyright © 2017 American Chemical Society. ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
    Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1-3 in bone maintenance. We report three potent and selective inhibitors: one (PFI-4) with high selectivity for the BRPF1B isoform and two pan-BRPF bromo...
  • Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry

    octubre 01, 2017
    Author(s): Nils H. Mueller-Kronast, Ajit S. Puri, STRATIS Investigators
    Source: Stroke
    BACKGROUND AND PURPOSE: Mechanical thrombectomy with stent retrievers has become standard of care for treatment of acute ischemic stroke patients because of large vessel occlusion. The STRATIS registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) aimed to assess whether similar process timelines, technical, and functional outcomes could be achieved in a large real world...
  • Novel Distal Emboli Protection Technology: The EmboTrap

    octubre 01, 2017
    Author(s): Juyu Chueh, Miklos G. Marosfoi, Olivia W. Brooks, Robert M. King, Ajit S. Puri, Matthew J. Gounis
    Source: Interventional neurology
    Background: Over the course of the thrombectomy procedure, clot fragments may become dislodged and lead to downstream emboli due to manipulation of an endovascular device. The EmboTrap thrombectomy system features an inner stent channel with an outer stent trap design that may potentially reduce the risk of distal clot fragmentation during clot removal. We tested the hypothesis that distal emboli to both the same and new ter...
  • In situ tissue engineering: endothelial growth patterns as a function of flow diverter design

    octubre 01, 2017
    Author(s): Miklos G. Marosfoi, Erin T. Langan, Lara Strittmatter, Kajo van der Marel, Srinivasan Vedantham, Jennifer Arends, Ivan R. Lylyk, Siddharth Loganathan, Gregory M. Hendricks, Istvan Szikora, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: Vascular remodeling in response to implantation of a tissue engineering scaffold such as a flow diverter (FD) leads to the cure of intracranial aneurysms. We hypothesize that the vascular response is dependent on FD design, and CD34+ progenitor cells play an important role in the endothelialization of the implant. METHODS: Sixteen rabbit aneurysms were randomly treated with two different single-layer braided FDs ...
  • TREVO stent-retriever mechanical thrombectomy for acute ischemic stroke secondary to large vessel occlusion registry

    septiembre 29, 2017
    Author(s): Osama O. Zaidat, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Recent randomized clinical trials (RCTs) demonstrated the efficacy of mechanical thrombectomy using stent-retrievers in patients with acute ischemic stroke (AIS) with large vessel occlusions; however, it remains unclear if these results translate to a real-world setting. The TREVO Stent-Retriever Acute Stroke (TRACK) multicenter Registry aimed to evaluate the use of the Trevo device in everyday clinical practice....
  • Interhospital Transfer Prior to Thrombectomy is Associated with Delayed Treatment and Worse Outcome in the STRATIS Registry

    septiembre 24, 2017
    Author(s): Michael T. Froehler, Ajit S. Puri, STRATIS Investigators
    Source: Circulation
    Background -Endovascular treatment with mechanical thrombectomy (MT) is beneficial for acute stroke patients suffering a large vessel occlusion, though treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared to direct presentation. Methods -STRATIS was a prospective, multicenter, observationa...
  • Do Interventions Intended to Increase Female Medical Student Interest in Radiology Work? Preliminary Findings

    septiembre 12, 2017
    Author(s): Elizabeth D. Yuan, Joseph Makris, Carolynn M. Debenedectis
    Source: Current problems in diagnostic radiology
    PURPOSE: The purpose of this study is to share the preliminary findings after initiation of interventions at the medical school level, which have been suggested by the literature to increase female medical student interest in radiology at one institution. Additionally, the paper provides discussion of how to better future interventions for increasing female medical student interest. METHODS: Interventions to increase medical...
  • Live Cell Imaging: Assessing the Phototoxicity of 488 and 546 nm Light and Methods to Alleviate it

    septiembre 01, 2017
    Author(s): Stephen Douthwright, Greenfield Sluder
    Source: Journal of cellular physiology
    In live cell imaging of fluorescent proteins, phototoxicity of the excitation light can be problematical. Cell death is obvious, but reduced cell viability can make the interpretation of observations error prone. We characterized the phototoxic consequences of 488 and 546 nm light on untransformed human cells and tested methods that have or could be used to alleviate photodamage. Unlabeled RPE1 cells were given single 0.5-2....
  • Pancreatic Imaging

    septiembre 01, 2017
    Author(s): Mark Masciocchi
    Source: Endocrinology and metabolism clinics of North America
    Imaging of the endocrine pancreas is dominated by neuroendocrine tumors, a diverse category of neoplasms that may or may not cause symptoms from hormone hypersecretion. These tumors may also be evidence of several different genetic syndromes. Understanding the usefulness of different imaging modalities and entities that simulate neuroendocrine tumors is key for both radiologists and referring physicians.
  • The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16

    septiembre 01, 2017
    Author(s): Yuqing Hou, George B. Witman
    Source: Molecular biology of the cell; © 2017 Hou and Witman. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). Publisher PDF posted as allowed by the publisher's author rights policy at ht...
    Cilia are assembled via intraflagellar transport (IFT). The IFT machinery is composed of motors and multi-subunit particles, termed IFT-A and IFT-B, that carry cargo into the cilium. Knowledge of how the IFT subunits interact with their cargo is of critical importance for understanding how the unique ciliary domain is established. We previously reported a Chlamydomonas mutant, ift46-1, that fails to express the IFT-B protein...
  • Diagnosing ectopic pregnancy in the emergency setting

    agosto 19, 2017
    Author(s): Robert Lee, Carolyn S. Dupuis, Byron Y. Chen, Andrew Smith, Young H. Kim
    Source: Ultrasonography (Seoul, Korea); Copyright © 2017 Korean Society of Ultrasound in Medicine (KSUM). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Ectopic pregnancy is the implantation of a fertilized egg outside the uterine endometrial cavity. For women presenting to the emergency department with abdominal pain and/or vaginal bleeding, ectopic pregnancy is an important diagnostic consideration. The diagnosis is made based on laboratory values and ultrasound imaging findings. The ultrasound appearance of both normal early pregnancy and ectopic pregnancy are variable an...
  • Fluorocarbons Enhance Intracellular Delivery of Short STAT3-sensors and Enable Specific Imaging

    agosto 03, 2017
    Author(s): Valeriy G. Metelev, Surong Zhang, Shaokuan Zheng, Anand T. N. Kumar, Alexei A. Bogdanov
    Source: Theranostics; © Ivyspring International Publisher.
    Short oligonucleotide sequences are now being widely investigated for their potential therapeutic properties. The modification of oligonucleotide termini with short fluorinated residues is capable of drastically altering their behavior in complex in vitro and in vivo systems, and thus may serve to greatly enhance their therapeutic potential. The main goals of our work were to explore: 1) how modification of STAT3 transcripti...
  • Development of a Standardized Kalamazoo Communication Skills Assessment Tool for Radiologists: Validation, Multisource Reliability, and Lessons Learned

    agosto 01, 2017
    Author(s): Stephen D. Brown, Elizabeth A. Rider, Katherine Jamieson, Elaine C. Meyer, Michael J. Callahan, Carolynn M. Debenedectis, Sarah D. Bixby, Michele Walters, Sara F. Forman, Pamela H. Varrin, Peter Forbes, Christopher J. Roussin
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The purpose of this study was to develop and test a standardized communication skills assessment instrument for radiology. MATERIALS AND METHODS: The Delphi method was used to validate the Kalamazoo Communication Skills Assessment instrument for radiology by revising and achieving consensus on the 43 items of the preexisting instrument among an interdisciplinary team of experts consisting of five radiologists and ...
  • 4D Reconstruction with Respiratory Correction for Gated Myocardial Perfusion SPECT

    agosto 01, 2017
    Author(s): Wenyuan Qi, Yongyi Yang, Chao Song, Miles Wernick, P. Hendrik Pretorius, Michael A. King
    Source: IEEE transactions on medical imaging
    Cardiac SPECT images are known to suffer from both cardiac and respiratory motion blur. In this work, we investigate a 4D reconstruction approach to suppress the effect of respiratory motion in gated cardiac SPECT imaging. In this approach, the sequence of cardiac gated images is reconstructed with respect to a reference respiratory amplitude bin in the respiratory cycle. To combat the challenge of inherent high imaging nois...
  • Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions

    agosto 01, 2017
    Author(s): Matthew J. Gounis, Simon De Meyer
    Source: International journal of stroke : official journal of the International Stroke Society
    Limited data exist on clot composition and detailed characteristics of arterial thrombi associated with large vessel occlusion in acute ischemic stroke. Advances in endovascular thrombectomy and related imaging modalities have created a unique opportunity to analyze thrombi removed from cerebral arteries. Insights into thrombus composition, etiology, physical properties and neurovascular interactions may lead to future advan...
  • Histological Composition and the Origin of the Thrombus: A New Diagnostic Assay for Secondary Stroke Prevention?

    agosto 01, 2017
    Author(s): Matthew J. Gounis, Rene Chapot
    Source: Stroke
  • Use of a pressure sensing sheath: comparison with standard means of blood pressure monitoring in catheterization procedures

    agosto 01, 2017
    Author(s): Phillip D. Purdy, Charles South, Richard P. Klucznik, Kenneth C. Liu, Robin L. Novakovic, Ajit S. Puri, G. Lee Pride, Beverly Aagaard-Kienitz, Abishek Ray, Alan C. Elliott
    Source: Journal of neurointerventional surgery; This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/lice...
    PURPOSE: Monitoring of blood pressure (BP) during procedures is variable, depending on multiple factors. Common methods include sphygmomanometer (BP cuff), separate radial artery catheterization, and side port monitoring of an indwelling sheath. Each means of monitoring has disadvantages, including time consumption, added risk, and signal dampening due to multiple factors. We sought an alternative approach to monitoring duri...
  • Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort

    agosto 01, 2017
    Author(s): Muhib A. Khan, Grayson L. Baird, David Miller, Anand Patel, Shawn Tsekhan, Shadi Yaghi, Ajit S. Puri, Mahesh Jayaraman, Nils Henninger, Brian Silver
    Source: Journal of neurointerventional surgery
    BACKGROUND: Recent studies have demonstrated the superiority of endovascular therapy (EVT) for emergent large vessel occlusion. OBJECTIVE: To determine the effectiveness of EVT in nonagenarians, for whom data are limited. METHODS: We retrospectively reviewed clinical and imaging data of all patients who underwent EVT at two stroke centers between January 2012 and August 2014. The 90-day functional outcome (modified Rankin Sc...
  • 4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT

    agosto 01, 2017
    Author(s): Wenyuan Qi, Yongyi Yang, Chao Song, Miles N. Wernick, P. Hendrik Pretorius, Michael A. King
    Source: IEEE transactions on medical imaging
    Cardiac single photon emission computed tomography (SPECT) images are known to suffer from both cardiac and respiratory motion blur. In this paper, we investigate a 4-D reconstruction approach to suppress the effect of respiratory motion in gated cardiac SPECT imaging. In this approach, the sequence of cardiac gated images is reconstructed with respect to a reference respiratory amplitude bin in the respiratory cycle. To com...
  • Acute thrombus formation on phosphorilcholine surface modified flow diverters

    julio 08, 2017
    Author(s): Miklos G. Marosfoi, Frederic Clarencon, Erin T. Langan, Robert M. King, Olivia W. Brooks, Takamitsu Tamura, John M. Wainwright, Matthew J. Gounis, Srinivasan Vedantham, Ajit S. Puri
    Source: Journal of neurointerventional surgery; © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
    PURPOSE: Thromboembolic complications remain a limitation of flow diverting stents. We hypothesize that phosphorilcholine surface modified flow diverters (Pipeline Flex with Shield Technology, sPED) would have less acute thrombus formation on the device surface compared with the classic Pipeline Embolization device (cPED). METHODS: Elastase-induced aneurysms were created in 40 rabbits and randomly assigned to receive cPED or...
  • In vitro activity of a novel compound, Mul-1867, against clinically significant fungi Candida spp. and Aspergillus spp

    julio 01, 2017
    Author(s): George Tetz, Michael Cynamon, Gregory M. Hendricks, Daria Vikina, Victor Tetz
    Source: International journal of antimicrobial agents
    There is an urgent need for new antifungal compounds to treat various types of fungal infections, including pulmonary infections. This study was designed to investigate the potency of a novel compound (Mul-1867) against Candida spp. and Aspergillus spp. isolated from patients with fungal pneumonia, cystic fibrosis and chronic obstructive pulmonary disease. Mul-1867 was highly effective against susceptible control strains as ...
  • Results of the ANSWER Trial Using the PulseRider for the Treatment of Broad-Necked, Bifurcation Aneurysms

    julio 01, 2017
    Author(s): Alejandro M. Spiotta, Ajit S. Puri
    Source: Neurosurgery
    BACKGROUND: The safety and probable benefit of the PulseRider (Pulsar Vascular, Los Gatos, California) for the treatment of broad-necked, bifurcation aneurysms was studied in the context of the prospective, nonrandomized, single arm clinical trial-the Adjunctive Neurovascular Support of Wide-neck aneurysm Embolization and Reconstruction (ANSWER) Trial. OBJECTIVE: To present the results of the United States cases employing th...
  • Apocrine Metaplasia Found at MR Biopsy: Is There Something to be Learned

    julio 01, 2017
    Author(s): Yiming Gao, Vandana Dialani, Carolynn M. Debenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
    Source: The breast journal
    The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast l...
  • Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity

    junio 28, 2017
    Author(s): A. M. Ashique, L. S. Hart, C. D. L. Thomas, J. G. Clement, P. Pivonka, Yasmin Carter, D. D. Mousseau, D. M. L. Cooper
    Source: Bone reports; Copyright 2017 The Authors.
    The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, and are believed to serve as the mechanosensors that coordinate the processes of bone modeling and remodeling. Imbalances in remodeling, for example, are linked to bone disease, including fragility associated with aging. We have reported that there is a reduction in scale for one comp...
  • Two-year single-center experience with the 'Baby Trevo' stent retriever for mechanical thrombectomy in acute ischemic stroke

    junio 01, 2017
    Author(s): Anna L. Kuhn, Ajay K. Wakhloo, Juan Diego Lozano, Francesco Massari, Katyucia De Macedo Rodrigues, Miklos G. Marosfoi, Mary Perras, Christopher Brooks, Mary Howk, David E. Rex, Matthew J. Gounis, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    OBJECTIVE: To evaluate the safety and efficacy of the 'Baby Trevo' (Trevo XP ProVue 3x20 mm Retriever) stent retriever for large vessel occlusions (LVOs) in acute ischemic stroke (AIS). MATERIALS AND METHODS: We retrospectively analyzed our stroke database and included all patients treated with the Baby Trevo for distal LVOs in AIS. Patient gender, mean age, vascular risk factors, National Institutes of Health Stroke Scale (...
  • Aneurysms with persistent patency after treatment with the Pipeline Embolization Device

    junio 01, 2017
    Author(s): Peter Kan, Visish M. Srinivasan, Nnenna Mbabuike, Rabih G. Tawk, Vin Shen Ban, Babu G. Welch, Maxim Mokin, Bartley D. Mitchell, Ajit S. Puri, Mandy J. Binning, Edward Duckworth
    Source: Journal of neurosurgery
    The Pipeline Embolization Device (PED) was approved for the treatment of intracranial aneurysms from the petrous to the superior hypophyseal segment of the internal carotid artery. However, since its approval, its use for treatment of intracranial aneurysms in other locations and non-sidewall aneurysms has grown tremendously. The authors report on a cohort of 15 patients with 16 cerebral aneurysms that incorporated an end ve...
  • Prolapse of the Pipeline embolization device in aneurysms: incidence, management, and outcomes

    junio 01, 2017
    Author(s): Visish M. Srinivasan, Andrew P. Carlson, Maxim Mokin, Jacob Cherian, Stephen R. Chen, Ajit S. Puri, Peter Kan
    Source: Neurosurgical focus
    OBJECTIVE: The Pipeline embolization device (PED) is frequently used in the treatment of anterior circulation aneurysms, especially around the carotid siphon, with generally excellent results. However, the PED has its own unique technical challenges, including the occurrence of device foreshortening or migration leading to prolapse into the aneurysm. The authors sought to determine the incidence of this phenomenon, the rescu...
  • Direct Intracranial Injection of AAVrh8 Encoding Monkey beta-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain

    junio 01, 2017
    Author(s): Diane Golebiowski, Imramsjah M. J. van der Bom, Churl-Su Kwon, Andrew D. Miller, Keiko Petrosky, Allison M. Bradbury, Stacy A. Maitland, Anna L. Kuhn, Nina Bishop, Elizabeth Curran, Nilsa Silva, Dwijit Guhasarkar, Susan V. Westmoreland, Douglas R. Martin, Matthew J. Gounis, Wael F. Asaad, Miguel Sena-Esteves
    Source: Human gene therapy
    GM2 gangliosidoses, including Tay-Sachs disease and Sandhoff disease, are lysosomal storage disorders caused by deficiencies in beta-N-acetylhexosaminidase (Hex). Patients are afflicted primarily with progressive central nervous system (CNS) dysfunction. Studies in mice, cats, and sheep have indicated safety and widespread distribution of Hex in the CNS after intracranial vector infusion of AAVrh8 vectors encoding species-sp...
  • IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

    mayo 31, 2017
    Author(s): Jason M. Brown, Tyler Picariello, Deborah A. Cochran, George B. Witman, Karl Lechtreck
    Source: eLife; © 2017, Wingfield et al.
    Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFT proteins in Chlamydomonas reinhardtii. IFT-A and motor proteins are recruited from the cell body to the basal body pool, assembled into trains, move through the cilium, and disperse back into the cell body. In contrast to this 'open'...
  • Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy

    mayo 23, 2017
    Author(s): Albert Juan Ramon, Yongyi Yang, P. Hendrik Pretorius, Piotr J. Slomka, Karen L. Johnson, Michael A. King, Miles N. Wernick
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: We investigated the extent to which the administered dose (activity) level can be reduced without sacrificing diagnostic accuracy for three reconstruction strategies for SPECT-myocardial perfusion imaging (MPI). METHODS: We optimized the parameters of the three reconstruction strategies for perfusion-defect detection over a range of simulated administered dose levels using a set of hybrid studies (derived from 19...
  • Pipeline Embolization Device for Pericallosal Artery Aneurysms: A Retrospective Single Center Safety and Efficacy Study

    mayo 17, 2017
    Author(s): Katyucia De Macedo Rodrigues, Anna L. Kuhn, Takamitsu Tamura, Guilherme Dabus, Peter Kan, Miklos G. Marosfoi, Juan Diego Lozano, Mary Perras, Christopher Brooks, Mary Howk, Samuel Y. Hou, David E. Rex, Francesco Massari, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Operative neurosurgery (Hagerstown, Md.)
    BACKGROUND: Pericallosal artery aneurysm treatment may be challenging using traditional endovascular techniques. OBJECTIVE: To demonstrate the feasibility, efficacy, and safety of endovascular treatment of pericallosal artery aneurysm using flow diverters. METHODS: We performed a retrospective review of our institutional database from July 2013 through July 2016 and identified 7 subjects with a pericallosal artery aneurysm t...
  • The Relevance of Readmissions after Common IR Procedures: Readmission Rates and Association with Early Mortality

    mayo 01, 2017
    Author(s): Ammar Sarwar, Lujia Zhou, Nihara Chakrala, Olga R. Brook, Jeffrey L. Weinstein, Max P. Rosen, Muneeb Ahmed
    Source: Journal of vascular and interventional radiology : JVIR
    PURPOSE: To determine all-cause readmission rates for 12 IR procedures and association of time to readmission with risk-adjusted 90-day mortality. MATERIALS AND METHODS: Patients discharged after 12 inpatient IR procedures at a tertiary-care hospital between June 2008 and May 2013 (N = 4,163) were categorized as no readmission (n = 1,479; 40.5%) or readmission between 0 and 7 (n = 379; 10.4%), 8 and 30 (n = 650; 17.8%), 31 a...
  • A Private Investigation: Radiologic-Pathologic Correlation of Testicular Tumors

    mayo 01, 2017
    Author(s): Arash Bedayat, Byron Y. Chen, Morris Hayim, Larry Zheng, Staci M. Gagne, Lacey J. Mcintosh, April C. Deng, Hao S. Lo
    Source: Current problems in diagnostic radiology
    To review the classification of testicular tumors, describe the sonographic and pathologic features of each tumor type, and discuss the mimics, diagnostic pitfalls, and management of testicular tumors. Method consists of pictorial review. We review sonographic and pathologic findings of several testicular tumors and tumorlike entities. Although ultrasound is the first-line imaging modality to differentiate between intratesti...
  • ACR Appropriateness Criteria(R) Chronic Hip Pain

    mayo 01, 2017
    Author(s): Douglas N. Mintz, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Chronic hip pain is a common clinical problem whose cause is often elucidated by imaging. The ACR Appropriateness Criteria for chronic hip pain define best practices of image ordering. Clinical scenarios are followed by the imaging choices and their appropriateness. The information is in ordered tables with an accompanying narrative explanation to guide physicians to order the right test. The American College of Radiology Ap...
  • ACR Appropriateness Criteria(R) Chronic Extremity Joint Pain-Suspected Inflammatory Arthritis

    mayo 01, 2017
    Author(s): Jon A. Jacobson, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Evaluation for suspected inflammatory arthritis as a cause for chronic extremity joint pain often relies on imaging. This review first discusses the characteristic osseous and soft tissue abnormalities seen with inflammatory arthritis and how they may be imaged. It is essential that imaging results are interpreted in the context of clinical and serologic results to add specificity as there is significant overlap of imaging f...
  • ACR Appropriateness Criteria(R) Vascular Claudication-Assessment for Revascularization

    mayo 01, 2017
    Author(s): Osmanuddin Ahmed, Michael Hanley, Shelby J. Bennett, Ankur Chandra, Benoit Desjardins, Kenneth L. Gage, Marie D. Gerhard-Herman, Michael Ginsburg, Heather L. Gornik, Isabel B. Oliva, Michael L. Steigner, Richard Strax, Nupur Verma, Frank J. Rybicki, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Vascular claudication is a symptom complex characterized by reproducible pain and weakness in an active muscle group due to peripheral arterial disease. Noninvasive hemodynamic tests such as the ankle brachial index, toe brachial index, segmental pressures, and pulse volume recordings are considered the first imaging modalities necessary to reliably establish the presence and severity of arterial obstructions. Vascular imagi...
  • ACR Appropriateness Criteria(R) Stress (Fatigue/Insufficiency) Fracture, Including Sacrum, Excluding Other Vertebrae

    mayo 01, 2017
    Author(s): Jenny T. Bencardino, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Stress fractures, including both fatigue and insufficiency types, are frequently encountered in clinical practice as a source of pain in both athletes and patients with predisposing conditions. Radiography is the imaging modality of choice for baseline diagnosis. MRI has greatly improved our ability to diagnose radiographically occult stress fractures. Tc-99m bone scan and CT may also be useful as diagnostic tools. Although ...
  • ACR Appropriateness Criteria(R) Osteoporosis and Bone Mineral Density

    mayo 01, 2017
    Author(s): Robert J. Ward, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Osteoporosis is a considerable public health risk, with 50% of women and 20% of men 50 years of age experiencing fracture, with mortality rates of 20% within the first year. Dual x-ray absorptiometry (DXA) is the primary diagnostic modality by which to screen women 65 years of age and men 70 years of age for osteoporosis. In postmenopausal women fracture, DXA is recommended. Some patients with bone mineral density above t...
  • ACR Appropriateness Criteria(R) Nonvariceal Upper Gastrointestinal Bleeding

    mayo 01, 2017
    Author(s): Nimarta Singh-Bhinder, Karin E. Dill
    Source: Journal of the American College of Radiology : JACR
    Upper gastrointestinal bleeding (UGIB) remains a significant cause of morbidity and mortality with mortality rates as high as 14%. This document addresses the indications for imaging UGIB that is nonvariceal and unrelated to portal hypertension. The four variants are derived with respect to upper endoscopy. For the first three, it is presumed that upper endoscopy has been performed, with three potential initial outcomes: end...
  • Evaluation of the utility of 99m Tc-MDP bone scintigraphy versus MIBG scintigraphy and cross-sectional imaging for staging patients with neuroblastoma

    abril 27, 2017
    Author(s): Jean-Marc Gauguet, Tamara Pace-Emerson, Frederick D. Grant, Suzanne Shusterman, Steven G. DuBois, A. Lindsay Frazier, Stephan D. Voss
    Source: Pediatric blood and cancer
    PURPOSE: Accurate staging of neuroblastoma requires multiple imaging examinations. The purpose of this study was to determine the relative contribution of 99m Tc-methylene diphosphonate (MDP) bone scintigraphy (bone scan) versus metaiodobenzylguanidine scintigraphy (MIBG scan) for accurate staging of neuroblastoma. METHODS: A medical record search by the identified patients with neuroblastoma from 1993 to 2012 who underwent ...
  • Investigation of the physical effects of respiratory motion compensation in a large population of patients undergoing Tc-99m cardiac perfusion SPECT/CT stress imaging

    abril 21, 2017
    Author(s): P. Hendrik Pretorius, Karen L. Johnson, Seth T. Dahlberg, Michael A. King
    Source: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    BACKGROUND: Respiratory motion can deteriorate image fidelity in cardiac perfusion SPECT. We determined the extent of respiratory motion, assessed its impact on image fidelity, and investigated the existence of gender differences, thereby examining the influence of respiratory motion in a large population of patients. METHODS: One thousand one hundred and three SPECT/CT patients underwent visual tracking of markers on their ...
  • Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration

    abril 14, 2017
    Author(s): Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, Gregory J. Pazour
    Source: PLoS genetics
    Arf4 is proposed to be a critical regulator of membrane protein trafficking in early secretory pathway. More recently, Arf4 was also implicated in regulating ciliary trafficking, however, this has not been comprehensively tested in vivo. To directly address Arf4's role in ciliary transport, we deleted Arf4 specifically in either rod photoreceptor cells, kidney, or globally during the early postnatal period. Arf4 deletion in ...
  • Rosai-Dorfman Disease of the Breast

    abril 11, 2017
    Author(s): Eileen E. Delaney, Anne C. Larkin, Sue MacMaster, Ali Sakhdari, Carolynn M. Debenedectis
    Source: Cureus; Copyright 2017 Delaney et al.
    Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented with a palpable breast lump tha...
  • Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming

    abril 04, 2017
    Author(s): Jeffrey A. Nickerson, Qiong Wu, Anthony N. Imbalzano
    Source: Frontiers in oncology; Copyright: © 2017 Nickerson, Wu and Imbalzano.
    Tumor cells reprogram their metabolism to survive and grow in a challenging microenvironment. Some of this reprogramming is performed by epigenetic mechanisms. Epigenetics is in turn affected by metabolism; chromatin modifying enzymes are dependent on substrates that are also key metabolic intermediates. We have shown that the chromatin remodeling enzyme Brahma-related gene 1 (BRG1), an epigenetic regulator, is necessary for...
  • Revisiting the indirect signs of a temporal bone fracture: air, air, everywhere

    abril 03, 2017
    Author(s): Adam C. Ulano, Srinivasan Vedantham, Deepak Takhtani
    Source: Emergency radiology
    BACKGROUND AND PURPOSE: The standard head CT protocol makes detection of a temporal bone fracture difficult. The purposes of our study are to revisit the finding of air in various locations around the temporal bone as an indirect sign of fracture and determine if findings could predict fracture pattern. MATERIALS AND METHODS: We searched the radiology reports for the keyword "temporal bone fracture." We recorded the presence...
  • Gallbladder opacification on gadoxetate disodium-enhanced CT scan

    abril 01, 2017
    Author(s): Adib R. Karam, Eduardo Scortegagna, Byron Y. Chen, Carolyn S. Dupuis, Dennis D. Coughlin
    Source: Emergency radiology
    This study aimed to evaluate the radiologist's ability to identify excreted gadoxetate disodium within the gallbladder on CT scan. Thirty three healthy adults underwent imaging of the liver during work-up for potential liver donation. Three patients had undergone prior cholecystectomy and therefore were excluded. Imaging consisted of gadoxetate disodium-enhanced magnetic resonance cholangiography (MRC) and multiphase contras...
  • Use of Morpholino Oligomers for Pretargeting

    abril 01, 2017
    Author(s): Guozheng Liu
    Source: Methods in molecular biology (Clifton, N.J.)
    Differing from the conventional direct-targeting strategy in which a probe or payload is directly loaded onto a targeting molecule that binds to the native target, pretargeting is an improved targeting strategy. It converts the native target to an artificial target specific for a secondary targeting molecule loaded with the probe or payload (effector). The effector is small and does not accumulate in normal tissues, which ac...
  • Use of self-expanding stents for better intracranial flow diverter wall apposition

    abril 01, 2017
    Author(s): Anna L. Kuhn, Ajay K. Wakhloo, Matthew J. Gounis, Peter Kan, Katyucia de Macedo Rodrigues, Juan Diego Lozano, Miklos G. Marosfoi, Mary Perras, Christopher Brooks, Mary Howk, David E. Rex, Francesco Massari, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background Flow diverter (FD) malapposition is associated with stroke-related complications. We document the use of self-expanding nitinol stents to remove/reduce the ledge of a FD deployed for aneurysm treatment. Methods We identified five patients who were treated with the Pipeline embolization device (PED) in conjunction with a Neuroform EZ stent for inadequate wall apposition of the ends of the FD at our institution betw...
  • Characterization of a new oda3 allele, oda3-6, defective in assembly of the outer dynein arm-docking complex in Chlamydomonas reinhardtii

    marzo 14, 2017
    Author(s): Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, Maureen Wirschell
    Source: PloS one; Copyright: © 2017 Brown et al.
    We have used an insertional mutagenesis approach to generate new C. reinhardtii motility mutants. Of 56 mutants isolated, one is a new allele at the ODA3 locus, called oda3-6. Similar to the previously characterized oda3 alleles, oda3-6 has a slow-jerky swimming phenotype and reduced swimming speed. The oda3-6 mutant fails to assemble the outer dynein arm motor and outer dynein arm-docking complex (ODA-DC) in the ciliary axo...
  • Development of a high resolution MRI intracranial atherosclerosis imaging phantom

    marzo 09, 2017
    Author(s): Juyu Chueh, Kajo van der Marel, Matthew J. Gounis, Robert M. King, Shaokuan Zheng, Olivia W. Brooks, Jeff W. Rappleye
    Source: Journal of neurointerventional surgery
    BACKGROUND AND PURPOSE: Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD. MATERIALS AND METHODS: A patient specific injection mold was 3D printed to construct a ...
  • Towards standardization of x-ray beam filters in digital mammography and digital breast tomosynthesis: Monte Carlo simulations and analytical modelling

    marzo 07, 2017
    Author(s): Suman Shrestha, Srinivasan Vedantham, Andrew Karellas
    Source: Physics in medicine and biology
    In digital breast tomosynthesis and digital mammography, the x-ray beam filter material and thickness vary between systems. Replacing K-edge filters with Al was investigated with the intent to reduce exposure duration and to simplify system design. Tungsten target x-ray spectra were simulated with K-edge filters (50 microm Rh; 50 microm Ag) and Al filters of varying thickness. Monte Carlo simulations were conducted to quanti...
  • Tourniquet parent artery occlusion after flow diversion

    marzo 06, 2017
    Author(s): Visish M. Srinivasan, Maxim Mokin, Edward A. Duckworth M, Stephen Chen, Ajit S. Puri, Peter Kan
    Source: Journal of neurointerventional surgery
    BACKGROUND: The Pipeline Embolization Device (PED) is increasingly used for both on- and off-label purposes for treatment of intracranial aneurysms. The device gradually slows flow of blood into the aneurysm, but the high metal coverage of PED promotes endothelialization of the device. Occasionally, this leads to in-stent stenosis that is clinically well tolerated. We present a multi-institutional Pipeline series that includ...
  • Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms

    marzo 01, 2017
    Author(s): C. A. Taschner, Srinivasan Vedantham, J. de Vries, A. Biondi, J. Boogaarts, N. Sakai, P. Lylyk, I. Szikora, S. Meckel, H. Urbach, P. Kan, R. Siekmann, J. Bernardy, Matthew J. Gounis, Ajay K. Wakhloo
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Flow diverters for the treatment of posterior circulation aneurysms remain controversial. We aimed to identify factors contributing to outcome measures in patients treated with the Surpass flow diverter for aneurysms in this location. MATERIALS AND METHODS: We conducted an observational study of 53 patients who underwent flow-diverter treatment for posterior circulation aneurysms at 15 centers. Key ou...
  • Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry

    marzo 01, 2017
    Author(s): Larissa I. Estrada, Amy A. Robinson, Ana C. Amaral, Eustathia Lela Giannaris, Nadine C. Heyworth, Farzad Mortazavi, Laura B. Ngwenya, Debra E. Roberts, Howard J. Cabral, Ronald J. Killiany, Douglas L. Rosene
    Source: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society research, authorship, and/or publication of this article.
    Storage of tissue sections for long periods allows multiple samples, acquired over months or years, to be processed together, in the same reagents, for quantitative histochemical studies. Protocols for freezer storage of free-floating frozen sections using sucrose with different additives have been reported and assert that storage has no effect on histochemistry, but no quantitative support has been provided. The present stu...
  • The Relevance of Ultrasound Imaging of Suspicious Axillary Lymph Nodes and Fine-needle Aspiration Biopsy in the Post-ACOSOG Z11 Era in Early Breast Cancer

    marzo 01, 2017
    Author(s): Gopal Vijayaraghavan, Srinivasan Vedantham, Milliam Kataoka, Carolynn M. Debenedectis, Robert M. Quinlan
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: Evaluation of nodal involvement in early-stage breast cancers (T1 or T2) changed following the Z11 trial; however, not all patients meet the Z11 inclusion criteria. Hence, the relevance of ultrasound imaging of the axilla and fine-needle aspiration biopsy (FNA) in early-stage breast cancers was investigated. MATERIALS AND METHODS: In this single-center, retrospective study, 758 subjects had patholog...
  • Prioritizing the Protocol: Improving the Process of Scheduling Imaging Examinations in a Radiology Department With Partially Integrated IT Systems

    marzo 01, 2017
    Author(s): Cole DiRoberto, Scott Henderson, Crystal Lehto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    The final product of a diagnostic imaging study is the completed image set on the radiologists’ PACS and radiology information system worklist. Before the case is completed, multiple prior steps are required. The clinical provider must order the imaging study, the radiologist must complete the protocol, the administration must obtain insurance preauthorization, and the schedulers must book the imaging examination. Improving ...
  • Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform

    marzo 01, 2017
    Author(s): Kajo van der Marel, Srinivasan Vedantham, I. M. J. van der Bom, Mary Howk, T. Narain, Kimberly Ty, Andrew Karellas, Matthew J. Gounis, Ajit S. Puri, Ajay K. Wakhloo
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Advancements in medical device and imaging technology as well as accruing clinical evidence have accelerated the growth of the endovascular treatment of cerebrovascular diseases. However, the augmented role of these procedures raises concerns about the radiation dose to patients and operators. We evaluated patient doses from an x-ray imaging platform with radiation dose-reduction technology, which com...
  • Facial Drooping, Aphasia, and an Incidental Lung Mass in a Nonsmoker

    marzo 01, 2017
    Author(s): Justin K. Lui, Lacey J. McIntosh, Jorge Escobar Valle, Thomas J. Stockl, Stephen Summers
    Source: Journal of intensive care medicine
    BACKGROUND: Atrial fibrillation and atrial flutter are atrial tachycardias associated with embolic strokes. To date, there have only been a few reports highlighting the incidence of these atrial tachycardias due to mechanical compression of myocardial structures and the pulmonary vasculature in certain mediastinal masses and cysts. CASE: We present a case of a 75-year-old gentleman who is a nonsmoker with a history of hypert...
  • Magnetic Resonance Imaging-Directed Ultrasound Imaging of Non-Mass Enhancement in the Breast: Outcomes and Frequency of Malignancy

    marzo 01, 2017
    Author(s): Adrienne Newburg, Chloe M. Chhor, Leng Leng Young Lin, Samantha L. Heller, Jennifer Gillman, Hildegard K. Toth, Linda Moy
    Source: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
    OBJECTIVES: This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non-mass enhancement. METHODS: From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918 non-mass enhancing lesions for which follow-up or biopsy was recommended. Retrospective review of the images iden...
  • Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

    febrero 21, 2017
    Author(s): Robert W. Kensler, Roger Craig, Richard L. Moss
    Source: Proceedings of the National Academy of Sciences of the United States of America; Freely available online through the PNAS open access option.
    Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C accelerate cross-bridge kinetics remains unknown. In this study, we isolated thick filaments from the hearts of mice in which the three serine residues (Ser273, Ser282, and Ser302) that are phosphorylated by protein kinase A in the m-domain of cMyBP-C were replaced by e...
  • Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study

    febrero 08, 2017
    Author(s): Rene Aquarius, Debby Smits, Matthew J. Gounis, William P. Leenders, Joost de Vries
    Source: Journal of neurointerventional surgery
    BACKGROUND: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model. METHODS: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted. RESU...
  • Correction of hysteretic respiratory motion in SPECT myocardial perfusion imaging: Simulation and patient studies

    febrero 01, 2017
    Author(s): Paul K. R. Dasari, Arda Konik, P. Hendrik Pretorius, Karen L. Johnson, William P. Segars, Mohammed S. Shazeeb, Michael A. King
    Source: Medical physics
    PURPOSE: Amplitude-based respiratory gating is known to capture the extent of respiratory motion (RM) accurately but results in residual motion in the presence of respiratory hysteresis. In our previous study, we proposed and developed a novel approach to account for respiratory hysteresis by applying the Bouc-Wen (BW) model of hysteresis to external surrogate signals of anterior/posterior motion of the abdomen and chest wit...
  • An in vitro evaluation of distal emboli following Lazarus Cover-assisted stent retriever thrombectomy

    febrero 01, 2017
    Author(s): Juyu Chueh, Ajit S. Puri, Matthew J. Gounis
    Source: Journal of neurointerventional surgery
    BACKGROUND: Formation of clot fragments during mechanical thrombectomy for acute ischemic stroke can occlude the distal vasculature, which may reduce the rate of good clinical outcome. OBJECTIVE: To examine the hypothesis that distal embolization can be reduced using stent retriever thrombectomy in combination with Lazarus Cover technology. METHODS: Hard, fragment-prone clots were used to create middle cerebral artery occlus...
  • Treatment of complex anterior cerebral artery aneurysms with Pipeline flow diversion: mid-term results

    febrero 01, 2017
    Author(s): Guilherme Dabus, Jonathan A. Grossberg, C. Michael Cawley, Jacques E. Dion, Ajit S. Puri, Ajay K. Wakhloo, Douglas Gonsales, Pedro Aguilar-Salinas, Eric Sauvageau, Italo Linfante, Ricardo A. Hanel
    Source: Journal of neurointerventional surgery
    BACKGROUND: The off-label use of flow diverters in the treatment of distal aneurysms continues to be debated. OBJECTIVE: To report our multicenter experience in the treatment of complex anterior cerebral artery aneurysms with the Pipeline embolization device (PED). METHODS: The neurointerventional databases of the four participating institutions were retrospectively reviewed for aneurysms treated with PED between October 201...
  • Proceedings of the third international molecular pathological epidemiology (MPE) meeting

    febrero 01, 2017
    Author(s): P. T. Campbell, Alexei A. Bogdanov, Shuji Ogino
    Source: Cancer causes and control : CCC
    Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatme...
  • SPECT/CT: an update on technological developments and clinical applications

    enero 16, 2017
    Author(s): Michael Ljungberg, P. Hendrik Pretorius
    Source: The British journal of radiology
    Functional nuclear medicine imaging with single-photon emission CT (SPECT) in combination with anatomical CT has been commercially available since the beginning of this century. The combination of the two modalities has improved both the sensitivity and specificity of many clinical applications and CT in conjunction with SPECT that allows for spatial overlay of the SPECT data on good anatomy images. Introduction of diagnosti...
  • Apocrine Metaplasia Found at MR Biopsy: Is There Something to be Learned

    enero 12, 2017
    Author(s): Yiming Gao, Vandana Dialani, Carolynn M. Debenedectis, Nicole Johnson, Elena Brachtel, Priscilla Slanetz
    Source: The breast journal
    The purpose of this study was to determine (a) the frequency of apocrine metaplasia (ApoM) found on MR core biopsy of suspicious findings, and (b) to determine if there are specific MR imaging features that might obviate the need for biopsy. This HIPAA-compliant retrospective study was performed under IRB exemption for quality assurance studies. Patient demographics, MR imaging features, and pathology were reviewed. Breast l...
  • Emergent Endovascular Management of Long-Segment and Flow-Limiting Carotid Artery Dissections in Acute Ischemic Stroke Intervention with Multiple Tandem Stents

    enero 11, 2017
    Author(s): S. A. Ansari, Anna L. Kuhn, A. R. Honarmand, M. Khan, M. C. Hurley, M. B. Potts, B. S. Jahromi, A. Shaibani, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: AJNR. American journal of neuroradiology
    BACKGROUND AND PURPOSE: Although most cervical dissections are managed medically, emergent endovascular treatment may become necessary in the presence of intracranial large-vessel occlusions, flow-limiting and long-segment dissections with impending occlusion, and/or hypoperfusion-related ischemia at risk of infarction. We investigated the role of emergent endovascular stenting of long-segment carotid dissections in the acut...
  • T-Cell Non-Hodgkin Lymphomas: Spectrum of Disease and the Role of Imaging in the Management of Common Subtypes

    enero 05, 2017
    Author(s): Hye Sun Park, Lacey J. McIntosh, Marta Braschi-Amirfarzan, Atul B. Shinagare, Katherine M. Krajewski
    Source: Korean journal of radiology; Copyright © 2017 The Korean Society of Radiology.
    T-cell non-Hodgkin lymphomas (NHLs) are biologically diverse, uncommon malignancies characterized by a spectrum of imaging findings according to subtype. The purpose of this review is to describe the common subtypes of T-cell NHL, highlight important differences between cutaneous, various peripheral and precursor subtypes, and summarize imaging features and the role of imaging in the management of this diverse set of disease...
  • Molecular Imaging of Stems Cells: In Vivo Tracking and Clinical Translation

    enero 02, 2017
    Author(s): Stefania Rizzo, Francesco Petrella, Letterio S. Politi, Ping Wang
    Source: Stem cells international; Copyright © 2017 Stefania Rizzo et al.
    After further evaluation of different possibilities of tracking stem cells, we do expect that many clinical questions, raised from applications of stem cells-based therapies, will find an answer in molecular imaging. Therefore, we do believe that stem cell-based therapies and molecular imaging will live together happily ever after.
  • Coming Out of the Dark: A Curriculum for Teaching and Evaluating Radiology Residents' Communication Skills Through Simulation

    enero 01, 2017
    Author(s): Carolynn M. Debenedectis, Jean-Marc Gauguet, Joseph Makris, Stephen D. Brown, Max P. Rosen
    Source: Journal of the American College of Radiology : JACR
    Case report: The purpose of this pilot is to develop and implement a curriculum to teach radiology residents communication skills through simulation.
  • Open-cell stent and use of cone-beam CT enables a safe and effective coil embolization of true ophthalmic artery and anterior choroidal artery aneurysms with preservation of parent vessel: Clinical and angiographic results

    enero 01, 2017
    Author(s): Samuel Y. Hou, Anna L. Kuhn, Ajit S. Puri, Ajay K. Wakhloo
    Source: Interventional neuroradiology: journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    Background:Treatment of true ophthalmic artery (OA) or anterior choroidal artery (AChA) aneurysms with preservation of the parent vessel may be challenging. Flow diverters have limitations when dealing with branch vessels arising from the aneurysm sac. Visual loss or AChA territory infarcts have been reported both for surgical and endovascular treatment. Methods: We evaluated the safety and efficacy of an open-cell design, l...
  • What to Expect When They are Expecting: Magnetic Resonance Imaging of the Acute Abdomen and Pelvis in Pregnancy

    diciembre 15, 2016
    Author(s): Hemang M. Kotecha, Lacey J. McIntosh, Hao S. Lo, Byron Y. Chen, Carolyn S. Dupuis
    Source: Current problems in diagnostic radiology
    In this article, we discuss the challenges in the diagnosis of acute abdominopelvic pain in pregnant patients, role of imaging, and advantages of MRI over other modalities. Methods consist of pictorial review. We review the differential diagnoses and illustrate the MRI findings in pregnant patients with acute abdominopelvic pain, including gastrointestinal, gynecologic, urologic, and vascular etiologies.
  • Advantages of day-before lymphoscintigraphy and undiluted methylene blue dye injections for sentinel lymph node biopsies for melanoma

    diciembre 01, 2016
    Author(s): Kate Dinh, Ariana Harris, Jennifer LaFemina, Giles F. Whalen, Mary F. Sullivan, Robert Licho, Thomas Hill, Laura A. Lambert
    Source: Journal of surgical oncology
    BACKGROUND AND OBJECTIVES: Lymphatic mapping (LM) and blue dye injections are essential to identification of sentinel lymph nodes (SLN) for melanoma. LM is performed the day before (DB) or the same day (SD) of surgery, but the optimal timing is unknown. Similarly, methylene blue (MB), used during SLN biopsy (SLNB), is administered diluted (dMB) or undiluted (uMB), but the relative efficacies are unknown. METHODS: Patients wh...
  • Thoracic Spine Fracture in a Survivor of Out-of-Hospital Cardiac Arrest with Mechanical CPR

    diciembre 01, 2016
    Author(s): Robert Trevor. Marshall, Hemang M. Kotecha, Takuyo Chiba, Joseph Tennyson
    Source: Prehospital and disaster medicine
    This is a report of a thoracic vertebral fracture in a 79-year-old male survivor of out-of-hospital cardiac arrest with chest compressions provided by a LUCAS 2 (Physio-Control Inc.; Lund Sweden) device. This is the first such report in the literature of a vertebral fracture being noted in a survivor of cardiac arrest where an automated compression device was used.
  • Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome

    noviembre 01, 2016
    Author(s): Steven Schaub, Hartley M. Sirkis, Jonathan Kay
    Source: Rheumatic diseases clinics of North America
    Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region clas...
  • ACR Appropriateness Criteria Imaging After Shoulder Arthroplasty

    noviembre 01, 2016
    Author(s): Soterios Gyftopoulos, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    There has been a rapid increase in the number of shoulder arthroplasties, including partial or complete humeral head resurfacing, hemiarthroplasty, total shoulder arthroplasty, and reverse total shoulder arthroplasty, performed in the United States over the past two decades. Imaging can play an important role in diagnosing the complications that can occur in the setting of these shoulder arthroplasties. This review is divide...
  • Signal attenuation of PFG restricted anomalous diffusions in plate, sphere, and cylinder

    noviembre 01, 2016
    Author(s): Guoxing Lin, Shaokuan Zheng, Xinli Liao
    Source: Journal of magnetic resonance (San Diego, Calif. : 1997)
    Pulsed field gradient (PFG) NMR is a noninvasive tool to study anomalous diffusion, which exists widely in many systems such as in polymer or biological systems, in porous material, in single file structures and in fractal geometries. In a real system, the diffusion could be a restricted or a tortuous anomalous diffusion, rather than a free diffusion as the domains for fast and slow transport could coexist. Though there are ...
  • Cholecystostomy Treatment in an ICU Population: Complications and Risks

    octubre 01, 2016
    Author(s): Ann-Kristin U. Friedrich, Kevin P. Baratta, Joanne Lewis, Adib R. Karam, Margaret Hudlin, Demetrius E. M. Litwin, Mitchell A. Cahan
    Source: Surgical laparoscopy, endoscopy and percutaneous techniques
    BACKGROUND: Percutaneous cholecystostomy tube placement has widely been used as an alternative treatment to cholecystectomy, especially in advanced disease or critically ill patients. Reported postprocedural complication rates have varied significantly over the last decade. The goal of this study is to evaluate the safety of percutaneous cholecystostomy tube treatment in critically ill patients. STUDY DESIGN: We performed a ...
  • White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome

    octubre 01, 2016
    Author(s): Jatinder Patti, Johanna Helenius, Ajit S. Puri, Nils Henninger
    Source: Stroke
    BACKGROUND AND PURPOSE: There is increasing interest in defining stroke lesion volume thresholds to predict poststroke outcome. However, there is a paucity of data on factors that impact the association between critical infarct thresholds volume and outcome. We sought to determine whether lesion thresholds best predicting outcome depend on the degree of preexisting white matter hyperintensity (WMH) lesion burden. METHODS: Ma...
  • Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device

    octubre 01, 2016
    Author(s): Anna L. Kuhn, Peter Kan, Francesca Massi, Juan Diego Lozano, Samuel Y. Hou, Mary Howk, Matthew J. Gounis, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Dissecting aneurysms of the vertebral artery (VA) are difficult to treat using current surgical and endovascular techniques. OBJECTIVE: To analyze retrospectively the efficacy and safety of flow diverters in the treatment of dissecting aneurysms of the vertebral artery. METHODS: We identified six patients with six unruptured VA dissecting aneurysms either arising from the V4 or V3-V4 junction that were treated wi...
  • How to Effectively Implement a Peer Review Process for Interventional Radiology Procedures

    septiembre 01, 2016
    Author(s): Michael Caruso, Cole DiRoberto, John Howe Jr., Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    The purpose of this communication is to share our experience in creating an interventional radiology (IR)-specific peer review process, provide our initial results, and discuss future modifications and refinements to the system so that our institution— and others—can improve on the process of implementing peer review moving forward
  • Metastatic Renal Cell Carcinoma in a Hepatic Hemangioma: A Case Report and Review of the Literature

    septiembre 01, 2016
    Author(s): Joshua Cohen, Rashna Meunier, Sarah Jamshed, Adib R. Karam, Jennifer Yates, Xiaofei Wang, Jennifer LaFemina
    Source: International journal of surgical pathology
    We report the case of 55-year-old female with biopsy-proven clear cell renal cell carcinoma with a suspicious lesion found in the liver who presented for right radical nephrectomy and partial hepatectomy. Histologic evaluation of the hepatic specimen demonstrated metastatic renal cell carcinoma within a hepatic hemangioma. Herein we provide a review of the literature for this uncommon scenario.
  • Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography

    septiembre 01, 2016
    Author(s): Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Brian W. Pogue, Keith D. Paulsen, Steven P. Poplack
    Source: Journal of biomedical optics
    Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT).
  • Academic-industry Collaborations in Translational Stroke Research

    agosto 01, 2016
    Author(s): Johannes Boltze, Daniel-Christoph Wagner, Henryk Barthel, Matthew J. Gounis
    Source: Translational stroke research
    Academic-industry collaborations are an emerging format of translational stroke research. Next to classic contract research models, a multitude of collaboration models has been developed, some of which even allowing for multinational or intercontinental research programs. This development has recently been paralleled by first successful attempts to overcome the translational stroke research road block, such as the unpreceden...
  • Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT

    agosto 01, 2016
    Author(s): Kajo van der Marel, Matthew J. Gounis, John P. Weaver, Antonius M. de Korte, Robert M. King, Jennifer M. Arends, Olivia W. Brooks, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. To facilitate quantitative evaluation of deployed devices, a novel algorithm is presented that generates intuitive two-dimensional representations of wall apposition from either high-resolution contrast-enhanced cone-beam CT (Vaso...
  • Library based x-ray scatter correction for dedicated cone beam breast CT

    agosto 01, 2016
    Author(s): Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Lei Zhu
    Source: Medical physics
    PURPOSE: The image quality of dedicated cone beam breast CT (CBBCT) is limited by substantial scatter contamination, resulting in cupping artifacts and contrast-loss in reconstructed images. Such effects obscure the visibility of soft-tissue lesions and calcifications, which hinders breast cancer detection and diagnosis. In this work, we propose a library-based software approach to suppress scatter on CBBCT images with high ...
  • Detection of Klebsiella. Pneumoniae Infection with an Antisense Oligomer Against its Ribosomal RNA

    agosto 01, 2016
    Author(s): Ling Chen, Dengfeng Cheng, Guozheng Liu, Shuping Dou, Yuzhen Wang, Xinrong Liu, Yuxia Liu, Mary Rusckowski
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: Previously, we demonstrated specific accumulation into bacteria of a 12-mer phosphorodiamidate morpholino (MORF) oligomer complementary to a ribosomal RNA (rRNA) segment found in all bacteria using the universal probe called Eub338 (Eub). Here, two MORF oligomers Eco and Kpn with sequences specific to the rRNA of Escherichia coli (Eco) and Klebsiella pneumoniae (Kpn) were investigated along with Eub and control (non...
  • Grading of Regional Apposition after Flow-Diverter Treatment (GRAFT): a comparative evaluation of VasoCT and intravascular OCT

    agosto 01, 2016
    Author(s): Kajo van der Marel, Matthew J. Gounis, John P. Weaver, Antonius M. de Korte, Robert M. King, Jennifer M. Arends, Olivia W. Brooks, Ajay K. Wakhloo, Ajit S. Puri
    Source: Journal of neurointerventional surgery
    BACKGROUND: Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. To facilitate quantitative evaluation of deployed devices, a novel algorithm is presented that generates intuitive two-dimensional representations of wall apposition from either high-resolution contrast-enhanced cone-beam CT (Vaso...
  • The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation

    julio 29, 2016
    Author(s): Michael I. Carr
    Source: Morningside Graduate School of Biomedical Sciences Dissertations and Theses; Copyright is held by the author, with all rights reserved.
    The p53 tumor suppressor protein is upregulated in response to DNA damage and other stress signals. The upregulation of p53 involves freeing it from negative regulation imposed by Mdm2 and MdmX (Mdm4). Accumulating evidence indicates that phosphorylation of Mdm proteins by different stress-activated kinases such as ATM or c-Abl significantly impacts p53 functions. We have previously shown that ATM phosphorylation of Mdm2 Ser...
  • Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

    julio 25, 2016
    Author(s): Anita M. Leporati, Mikhail S. Novikov, Vladimir T. Valuev-Elliston, Sergey P. Korolev, Anastasia L. Khandazhinskaya, Sergey N. Kochetkov, Suresh Gupta, Julian Goding, Elijah M. Bolotin, Marina B. Gottikh, Alexei A. Bogdanov Jr.
    Source: Nanomedicine : nanotechnology, biology, and medicine
    Benzophenone-uracil (BPU) scaffold-derived candidate compounds are efficient non-nucleoside reverse transcriptase inhibitors (NNRTI) with extremely low solubility in water. We proposed to use hydrophobic core (methoxypolyethylene glycol-polylysine) graft copolymer (HC-PGC) technology for stabilizing nanoparticle-based formulations of BPU NNRTI in water. Co-lyophilization of NNRTI/HC-PGC mixtures resulted in dry powders that ...
  • Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery

    julio 14, 2016
    Author(s): Takamitsu Tamura, David E. Rex, Miklos G. Marosfoi, Ajit S. Puri, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    We describe an interesting case of trigeminocardiac reflex (TCR) caused by selective angiography of the middle meningeal artery (MMA). A 28-year-old woman presented with a symptomatic meningioma. Preoperative tumour embolisation was performed. In the procedure, when selective MMA angiography was done with Omnipaque 300 mg I/mL for 3 mL by manual injection, the patient complained of flashing lights in her eye followed by vomi...
  • Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm

    julio 07, 2016
    Author(s): Eduardo Scortegagna, Adib R. Karam, Shirin Sioshansi, Adel Bozorgzadeh, Curtis T. Barry, Sarwat Hussain
    Source: Clinical Imaging
    Purpose: Evaluate the recurrence pattern of hepatocellular carcinoma (HCC) following liver transplantation. Materials and Methods: A total of 54 patients underwent liver transplantation for HCC; 9 patients developed biopsy proven recurrent HCC (16.6%). The site of HCC recurrence along with other factors were analyzed. Results: Seven patients were diagnosed with HCC prior to liver transplantation and 2 patients had incidental...
  • Trigeminocardiac reflex caused by selective angiography of the middle meningeal artery

    julio 05, 2016
    Author(s): Takamitsu Tamura, David E. Rex, Miklos G. Marosfoi, Ajit S. Puri, Matthew J. Gounis, Ajay K. Wakhloo
    Source: BMJ case reports
    We describe an interesting case of trigeminocardiac reflex (TCR) caused by selective angiography of the middle meningeal artery (MMA). A 28-year-old woman presented with a symptomatic meningioma. Preoperative tumour embolisation was performed. In the procedure, when selective MMA angiography was done with Omnipaque 300 mg I/mL for 3 mL by manual injection, the patient complained of flashing lights in her eye followed by vomi...
  • Ultrasonography of the scrotum in adults

    julio 01, 2016
    Author(s): Anna L. Kuhn, Eduardo Scortegagna, Kristina M. Nowitzki, Young H. Kim
    Source: Ultrasonography (Seoul, Korea); Copyright © 2016 Korean Society of Ultrasound in Medicine (KSUM). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Ultrasonography is the ideal noninvasive imaging modality for evaluation of scrotal abnormalities. It is capable of differentiating the most important etiologies of acute scrotal pain and swelling, including epididymitis and testicular torsion, and is the imaging modality of choice in acute scrotal trauma. In patients presenting with palpable abnormality or scrotal swelling, ultrasonography can detect, locate, and characteri...
  • Reducing Radiation Exposure Without Compromising Image Quality for Lumbar Spine CT

    julio 01, 2016
    Author(s): Byron Y. Chen, Cole DiRoberto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    In light of the heightened awareness of radiation’s cancer-causing potential and the dramatic increase in the number of CT studies, minimizing radiation exposure is a paramount objective in radiology. An issue that complicates this goal is that image quality is a function of the dose of radiation. In other words, larger doses result in higher quality images. The goal then is to strike a balance to maximize patient safety: re...
  • Redefining Budd-Chiari syndrome: A systematic review

    junio 08, 2016
    Author(s): Naomi Shin, Young H. Kim, Hao Xu, Hai-Bin Shi, Qing-Qiao Zhang, Jean Paul Colon Pons, Ducksoo Kim, Yi Xu, Fei-Yun Wu, Samuel Han, Byung-Boong Lee, Lin-Sun Li
    Source: World journal of hepatology; Copyright ©The Author(s) 2016.
    AIM: To re-examine whether hepatic vein thrombosis (HVT) (classical Budd-Chiari syndrome) and hepatic vena cava-Budd Chiari syndrome (HVC-BCS) are the same disorder. METHODS: A systematic review of observational studies conducted in adult subjects with primary BCS, hepatic vein outflow tract obstruction, membranous obstruction of the inferior vena cava (IVC), obliterative hepatocavopathy, or HVT during the period of January ...
  • Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation

    junio 02, 2016
    Author(s): Jennifer J. VanOudenhove
    Source: Morningside Graduate School of Biomedical Sciences Dissertations and Theses; Copyright is held by the author, with all rights reserved.
    Key regulatory events take place at very early stages of human embryonic stem cell (hESC) differentiation to accommodate their ability to differentiate into different lineages; this work examines two separate regulatory events. To investigate precise mechanisms that link alterations in the cell cycle and early differentiation, we examined the initial stages of mesendodermal lineage commitment and observed a cell cycle pause ...
  • ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience

    junio 01, 2016
    Author(s): Francesco Massari, Nils Henninger, Juan Diego Lozano, Anand Patel, Anna L. Kuhn, Mary Howk, Mary Perras, Christopher Brooks, Matthew J. Gounis, Peter Kan, Ajay K. Wakhloo, Ajit S. Puri
    Source: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
    BACKGROUND: A new generation of highly navigable large-bore aspiration catheters and retriever devices for intracranial mechanical thrombectomy has markedly improved recanalization rates, time and clinical outcomes. We report collected clinical data utilizing a new technique based on combined large lumen aspiration catheter and partially resheathed stent retriever (ARTS: Aspiration (catheter)-(stent) Retriever Technique for ...
  • Successful treatment of a giant pediatric fusiform basilar trunk aneurysm with surpass flow diverter

    junio 01, 2016
    Author(s): Peter Kan, Maxim Mokin, Ajit S. Puri, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    Fusiform aneurysms present a unique challenge to traditional microsurgical and endovascular treatment because of the lack of a discernible neck and the involvement of parent vessel. Flow diversion has increasingly become the treatment of choice for fusiform aneurysms in the anterior circulation, but its results in the posterior circulation are variable. We report successful treatment of a giant fusiform upper basilar trunk a...
  • Stent-assisted coil embolization of aneurysms with small parent vessels: safety and efficacy analysis

    junio 01, 2016
    Author(s): Anna L. Kuhn, Samuel Y. Hou, Ajit S. Puri, Christine F. Silva, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND: Stent-assisted coil embolization (SACE) is a viable therapeutic approach for wide-neck intracranial aneurysms. However, it can be technically challenging in small cerebral vessels ( OBJECTIVE: To present our experience with stents approved for SACE in aneurysms with small parent arteries. METHODS: All patients who underwent stent-assisted aneurysm treatment with either a Neuroform or an Enterprise stent device a...
  • T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell-Derived Experimental Glioblastomas

    junio 01, 2016
    Author(s): Letterio S. Politi, G. Brugnara, A. Castellano, M. Cadioli, L. Altabella, M. Peviani, S. Mazzoleni, A. Falini, R. Galli
    Source: AJNR. American journal of neuroradiology
    We read with great interest the article by Arevalo-Perez et al, describing the potential value of T1-weighted dynamic contrast-enhanced MR imaging (DCE-MR imaging) as a biomarker for epidermal growth factor receptor variant III (EGFRvIII) mutation in patients with glioblastoma (GBM).
  • Evaluation of Rigid-Body Motion Compensation in Cardiac Perfusion SPECT Employing Polar-Map Quantification

    junio 01, 2016
    Author(s): P. Hendrik Pretorius, Karen L. Johnson, Michael A. King
    Source: IEEE transactions on nuclear science
    We have recently been successful in the development and testing of rigid-body motion tracking, estimation and compensation for cardiac perfusion SPECT based on a visual tracking system (VTS). The goal of this study was to evaluate in patients the effectiveness of our rigid-body motion compensation strategy. Sixty-four patient volunteers were asked to remain motionless or execute some predefined body motion during an addition...
  • MRI Findings of Injury to the Longus Colli Muscle in Patients With Neck Trauma

    mayo 25, 2016
    Author(s): Deepak Takhtani, Eduardo Scortegagna, Oguz Cataltepe, Sathish Kumar Dundamadappa
    Source: AJR. American journal of roentgenology
    OBJECTIVE: The longus colli muscle (LCM) forms the bulk of the deep flexor muscles of the neck. To our knowledge, very little information on the effects of trauma on this muscle group has been published. We describe MRI findings related to injury of the LCM in patients with a history of neck trauma. MATERIAL AND METHODS: A radiology department database was searched to identify patient medical records from 2008 to 2013 that i...
  • Improving the Transcription of Patient Information From Image Requisitions to the Radiology Information System

    mayo 25, 2016
    Author(s): Cole DiRoberto, Crystal Lehto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    PURPOSE: The purpose of this study was to improve the transcription of patient information from imaging study requisitions to the radiology information database at a single institution. METHODS: Five hundred radiology reports from adult outpatient radiographic examinations were chosen randomly from the radiology information system (RIS) and categorized according to their degree of concordance with their corresponding clinica...
  • Three-dimensional reconstruction of Haversian systems in human cortical bone using synchrotron radiation-based micro-CT: morphology and quantification of branching and transverse connections across age

    mayo 01, 2016
    Author(s): Isabel S. Maggiano, Corey M. Maggiano, John G. Clement, C. David L. Thomas, Yasmin Carter, David M.L. Cooper
    Source: Journal of anatomy
    This study uses synchrotron radiation-based micro-computed tomography (CT) scans to reconstruct three-dimensional networks of Haversian systems in human cortical bone in order to observe and analyse interconnectivity of Haversian systems and the development of total Haversian networks across different ages. A better knowledge of how Haversian systems interact with each other is essential to improve understanding of remodelin...
  • Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia

    mayo 01, 2016
    Author(s): Ronn P. Walvick, John P. Roche, Austin L. Reno, Matthew J. Gounis, Mitchell S. Albert
    Source: Magnetic resonance in medicine
    PURPOSE: In this study, a new model of pulmonary embolism in rats was developed and tested, to examine if hyperpolarized (HP) (3) He MR images can measure impairment of the exchange of oxygen from the airspaces to the blood during pulmonary embolism. METHODS: HP (3) He MRI was used to image six treatment-group rats in which a branch of the pulmonary artery was embolized, and six control-group rats. HP (3) He MR images were u...
  • Improved frame-based estimation of head motion in PET brain imaging

    mayo 01, 2016
    Author(s): Joyeeta Mitra Mukherjee, Cliff Lindsay, A. Mukherjee, P. Olivier, L. Shao, Michael A. King, Robert Licho
    Source: Medical physics
    PURPOSE: Head motion during PET brain imaging can cause significant degradation of image quality. Several authors have proposed ways to compensate for PET brain motion to restore image quality and improve quantitation. Head restraints can reduce movement but are unreliable; thus the need for alternative strategies such as data-driven motion estimation or external motion tracking. Herein, the authors present a data-driven mot...
  • Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications

    mayo 01, 2016
    Author(s): Srinivasan Vedantham, Suman Shrestha, Andrew Karellas, Linxi Shi, Matthew J. Gounis, Ronaldo Bellazzini, Gloria Spandre, Alessandro Brez, Massimo Minuti
    Source: Medical physics
    PURPOSE: High-resolution, photon-counting, energy-resolved detector with fast-framing capability can facilitate simultaneous acquisition of precontrast and postcontrast images for subtraction angiography without pixel registration artifacts and can facilitate high-resolution real-time imaging during image-guided interventions. Hence, this study was conducted to determine the spatial resolution characteristics of a hexagonal ...
  • Onyx embolization in distal dissecting posterior inferior cerebellar artery aneurysms

    mayo 01, 2016
    Author(s): Ajit S. Puri, Francesca Massi, Samuel Y. Hou, Juan Diego Lozano, Mary Howk, Mary Perras, Christopher Brooks, Matthew J. Gounis, Peter Kan, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    BACKGROUND: Dissecting aneurysms located along the distal segments of the posterior inferior cerebellar artery (PICA) are extremely rare, accounting for only 0.5-0.7% of all intracranial aneurysms. Treatment of these aneurysms is challenging, both surgically and endovascularly. We present our preliminary experience and clinical data utilizing Onyx as an embolization agent in the treatment of these lesions with proximal paren...
  • The Decision Analysis Matrix: A Systematic Method to Improve Collaborative Decision Making

    abril 12, 2016
    Author(s): Cole DiRoberto, Crystal Lehto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
  • Monotherapy with stenting in subarachnoid hemorrhage (SAH) after middle cerebral artery dissection

    abril 01, 2016
    Author(s): Ajit S. Puri, Matthew J. Gounis, Francesco Massari, Mary Howk, John P. Weaver, Ajay K. Wakhloo
    Source: Journal of neurointerventional surgery
    Isolated middle cerebral artery dissection is a rare clinical entity, with descriptions limited to a few case reports and case series. Symptomatic dissection in the anterior circulation can present as an ischemic stroke in a young population; however, it is rarely associated with subarachnoid hemorrhage. We describe a young patient who presented with acute headache from a subarachnoid hemorrhage that was ultimately determine...
  • Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging

    febrero 17, 2016
    Author(s): Alexei A. Bogdanov Jr., Adam J. Dixon, Suresh Gupta, Lejie Zhang, Shaokuan Zheng, Mohammed S. Shazeeb, Surong Zhang, Alexander L. Klibanov
    Source: Bioconjugate chemistry
    Magnetic resonance (MR) and photoacoustic (PA) imaging are currently being investigated as complementing strategies for applications requiring sensitive detection of cells in vivo. While combined MR/PAI detection of cells requires biocompatible cell labeling probes, water-based synthesis of dual-modality MR/PAI probes presents significant technical challenges. Here we describe facile synthesis and characterization of hybrid ...
  • Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death

    febrero 17, 2016
    Author(s): Kasey J. Clear, Kara M. Harmatys, Douglas R. Rice, William R. Wolter, Mark A. Suckow, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
    Source: Bioconjugate chemistry
    Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich mem...
  • Substrate-Based Near-Infrared Imaging Sensors Enable Fluorescence Lifetime Contrast via Built-in Dynamic Fluorescence Quenching Elements

    febrero 09, 2016
    Author(s): Anand T. N. Kumar, William L. Rice, Jessica C. López, Suresh Gupta, Craig J. Goergen, Alexei A. Bogdanov Jr.
    Source: ACS Sensors
    Enzymatic activity sensing in fluorescence lifetime (FLT) mode with “self-quenched” macromolecular near-infrared (NIR) sensors is a highly promising strategy for in vivo imaging of proteolysis. However, the mechanisms of FLT changes in such substrate-based NIR sensors have not yet been studied. We synthesized two types of sensors by linking the near-infrared fluorophore IRDye 800CW to macromolecular graft copolymers of metho...
  • Quantitative assessment of device-clot interaction for stent retriever thrombectomy

    febrero 01, 2016
    Author(s): Kajo van der Marel, Ju-Yu Chueh, Olivia W. Brooks, Robert M. King, Miklos G. Marosfoi, Erin T. Langan, Sarena L. Carniato, Matthew J. Gounis, Raul G. Nogueira, Ajit S. Puri
    Source: Journal of neurointerventional surgery; This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:http://creativecommons.org/licen...
    PURPOSE: Rapid revascularization in emergent large vessel occlusion with endovascular embolectomy has proven clinical benefit. We sought to measure device-clot interaction as a potential mechanism for efficient embolectomy. METHODS: Two different radiopaque clot models were injected to create a middle cerebral artery occlusion in a patient-specific vascular phantom. A radiopaque stent retriever was deployed within the clot b...
  • Risk of distal embolization with stent retriever thrombectomy and ADAPT

    febrero 01, 2016
    Author(s): Ju-Yu Chueh, Ajit S. Puri, Ajay K. Wakhloo, Matthew J. Gounis
    Source: Journal of neurointerventional surgery; This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/lice...
    BACKGROUND: There is a discrepancy in clinical outcomes and the achieved recanalization rates with stent retrievers in the endovascular treatment of ischemic stroke. It is our hypothesis that procedural release of embolic particulate may be one contributor to poor outcomes and is a modifiable risk. The goal of this study is to assess various treatment strategies that reduce the risk of distal emboli. METHODS: Mechanical thro...
  • Detection of Klebsiella. Pneumoniae Infection with an Antisense Oligomer Against its Ribosomal RNA

    febrero 01, 2016
    Author(s): Ling Chen, Dengfeng Cheng, Guozheng Liu, Shuping Dou, Yuzhen Wang, Xinrong Liu, Yuxia Liu, Mary Rusckowski
    Source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
    PURPOSE: Previously, we demonstrated specific accumulation into bacteria of a 12-mer phosphorodiamidate morpholino (MORF) oligomer complementary to a ribosomal RNA (rRNA) segment found in all bacteria using the universal probe called Eub338 (Eub). Here, two MORF oligomers Eco and Kpn with sequences specific to the rRNA of Escherichia coli (Eco) and Klebsiella pneumoniae (Kpn) were investigated along with Eub and control (non...
  • Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death

    febrero 01, 2016
    Author(s): Kasey J. Clear, Kara M. Harmatys, Douglas R. Rice, William R. Wolter, Mark A. Suckow, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
    Source: Bioconjugate chemistry
    Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich mem...
  • NeuN(+) neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure

    febrero 01, 2016
    Author(s): Tobias B. Halene, Alexey Kozlenkov, Yan Jiang, Amanda C. Mitchell, Behnam Javidfar, Aslihan Dincer, Royce Park, Jennifer Wiseman, Paula L. Croxson, Eustathia Lela Giannaris, Patrick R. Hof, Panos Roussos, Stella Dracheva, Scott E. Hemby, Schahram Akbarian
    Source: Schizophrenia research
    Increased neuronal densities in subcortical white matter have been reported for some cases with schizophrenia. The underlying cellular and molecular mechanisms remain unresolved. We exposed 26 young adult macaque monkeys for 6months to either clozapine, haloperidol or placebo and measured by structural MRI frontal gray and white matter volumes before and after treatment, followed by observer-independent, flow-cytometry-based...
  • LROC Investigation of Three Strategies for Reducing the Impact of Respiratory Motion on the Detection of Solitary Pulmonary Nodules in SPECT

    febrero 01, 2016
    Author(s): Mark S. Smyczynski, Howard C. Gifford, Joyoni Dey, Andre Lehovich, Joseph E. McNamara, W. Paul Segars, Michael A. King
    Source: IEEE transactions on nuclear science
    The objective of this investigation was to determine the effectiveness of three motion reducing strategies in diminishing the degrading impact of respiratory motion on the detection of small solitary pulmonary nodules (SPN) in single photon emission computed tomographic (SPECT) imaging in comparison to a standard clinical acquisition and the ideal case of imaging in the absence of respiratory motion. To do this non-uniform r...
  • Modeling the respiratory motion of solitary pulmonary nodules and determining the impact of respiratory motion on their detection in SPECT imaging

    febrero 01, 2016
    Author(s): Mark S. Smyczynski, Howard C. Gifford, Andre Lehovich, Joseph E. McNamara, W. Paul Segars, Eric A. Hoffman, Benjamin M. W. Tsui, Michael A. King
    Source: IEEE transactions on nuclear science
    The objectives of this investigation were to model the respiratory motion of solitary pulmonary nodules (SPN) and then use this model to determine the impact of respiratory motion on the localization and detection of small SPN in SPECT imaging for four reconstruction strategies. The respiratory motion of SPN was based on that of normal anatomic structures in the lungs determined from breath-held CT images of a volunteer acqu...
  • Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator

    febrero 01, 2016
    Author(s): Michael A. King, Joyeeta Mitra Mukherjee, Arda Konik, I. George Zubal, Joyoni Dey, Robert Licho
    Source: IEEE transactions on nuclear science
    For the 2011 FDA approved Parkinson's Disease (PD) SPECT imaging agent I-123 labeled DaTscan, the volume of interest (VOI) is the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding ratio (SBR), a parameter of significance in early diagnosis, differentiation of PD from other disorders with similar clinical presentations, and monitoring progress...
  • Reducing Radiation Exposure Without Compromising Image Quality for Lumbar Spine CT

    enero 20, 2016
    Author(s): Byron Chen, Cole DiRoberto, Steven J. Baccei
    Source: Journal of the American College of Radiology : JACR
    Case study in clinical practice management on reducing radiation exposure without compromising image quality for lumbar spine CT.
  • Targeted scVEGF/(177)Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy

    enero 16, 2016
    Author(s): Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer, Joseph M. Backer
    Source: EJNMMI research; © Rusckowski et al. 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were ...
    BACKGROUND: scVEGF/(177)Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth factor receptors (VEGFR). scVEGF/(177)Lu potential as adjuvant and neoadjuvant anti-angiogenic therapy was assessed in metastatic and orthotopic mouse models of triple-negative breast cancer. METHODS: Metast...
  • Opportunities for Patient-centered Outcomes Research in Radiology

    enero 01, 2016
    Author(s): Matthew E. Zygmont, Diana L. Lam, Kristina M. Nowitzki, Kirsteen R. Burton, Leon Lenchik, Tatum A. McArthur, Aarti K. Sekhar, Jason N. Itri
    Source: Academic radiology
    Recently created in 2010, the Patient-Centered Outcomes Research Institute (PCORI) supports patient-centered comparative effectiveness research with a focus on prioritizing high-impact studies and improving trial design methodology. The Association of University Radiologists Radiology Research Alliance Task Force on patient-centered outcomes research in Radiology aims to review recently funded imaging-centric projects that a...
  • Limited-angle effect compensation for respiratory binned cardiac SPECT

    enero 01, 2016
    Author(s): Wenyuan Qi, Yongyi Yang, Miles N. Wernick, P. Hendrik Pretorius, Michael A. King
    Source: Medical physics
    PURPOSE: In cardiac single photon emission computed tomography (SPECT), respiratory-binned study is used to combat the motion blur associated with respiratory motion. However, owing to the variability in respiratory patterns during data acquisition, the acquired data counts can vary significantly both among respiratory bins and among projection angles within individual bins. If not properly accounted for, such variation coul...
  • Prototypes of self-powered radiation detectors employing intrinsic high-energy current

    enero 01, 2016
    Author(s): Piotr Zygmanski, Suman Shrestha, Davide Briovio, Andrew Karellas, Erno Sajo
    Source: Medical physics
    PURPOSE: The authors experimentally investigate the effect of direct energy conversion of x-rays via selfpowered Auger- and photocurrent, potentially suitable to practical radiation detection and dosimetry in medical applications. Experimental results are compared to computational predictions. The detector the authors consider is a thin-film multilayer device, composed of alternating disparate electrically conductive and ins...
  • Case of the Week: A 51-year-old Man with Headaches and Visual Disturbances

    diciembre 31, 2015
    Author(s): Anna L. Kuhn, Aly Abayazeed, Deepak Takhtani
    Source: American Journal of Neuroradiology
    "Case of the Week" for the American Journal of Neuroradiology, with the following description: Sagittal T1WI pre- (A) and postcontrast (B) show a large, lobulated, heterogeneously-enhancing pituitary mass that expands the sella and demonstrates a suprasellar extension. Axial (C) and sagittal (D) T2WI demonstrate diffuse thickening of the calvarium with heterogeneous marrow signal. Axial (E) and coronal (F) noncontrast CT thr...
  • Quantitative microstructural deficits in chronic phase of stroke with small volume infarcts: A Diffusion Tensor 3-D Tractographic Analysis

    diciembre 29, 2015
    Author(s): Prachi Dubey, Vasileios-Arsenios Lioutas, Rafeeque Bhadelia, Brad Manor, Peter Novak, Magdy Selim, Vera Novak
    Source: Magnetic resonance imaging
    BACKGROUND: Non-infarct zone white matter wallerian degeneration is well-documented in large volume territorial infarctions. However to what extent these abnormalities exist in small volume infarction is not known, particularly since routine T2/FLAIR MR images show minimal changes in such cases. We therefore utilized DTI based quantitative 3D tractography for quantitative assessment of white matter integrity in chronic phase...
  • Safety, efficacy, and short-term follow-up of the use of Pipeline Embolization Device in small (

    diciembre 23, 2015
    Author(s): Ajit S. Puri, Francesco Massari, Takumi Asai, Miklos G. Marosfoi, Peter Kan, Samuel Y. Hou, Mary Howk, Mary Perras, Christopher Brooks, Frederic Clarencon, Matthew J. Gounis, Ajay K. Wakhloo
    Source: Neuroradiology
    INTRODUCTION: Flow diversion is being increasingly used to treat cerebral aneurysms. We present our experience using these stents to treat aneurysms distal to the circle of Willis with parent arteries smaller than 2.5 mm. METHODS: Aneurysms treated with a Pipeline Embolization Device in vessels less than 2.5 mm between June 2012 and August 2014 were included. We evaluated risk factors, family history of aneurysms, aneurysm c...
  • Association Between Confidence Level of Acute Pulmonary Embolism Diagnosis on CTPA images and Clinical Outcomes

    diciembre 01, 2015
    Author(s): Arash Bedayat, Rani Sewatkar, Tianrun Cai, Elizabeth George, Amir Imanzadeh, Zoha Hussain, Ruth M. Dunne, Andetta R. Hunsaker, Frank J. Rybicki, Kanako K. Kumamaru
    Source: Academic radiology
    RATIONALE AND OBJECTIVES: The purpose was to evaluate clinical characteristics associated with low confidence in diagnosis of acute pulmonary embolism (PE) as expressed in computed tomography pulmonary angiography (CTPA) reports and to evaluate the effect of confidence level in PE diagnosis on patient clinical outcomes. MATERIALS AND METHODS: This study included radiology reports from 1664 consecutive CTPA considered positiv...
  • Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators

    diciembre 01, 2015
    Author(s): Peng Fan, Brian F. Hutton, Maria Holstensson, Michael Ljungberg, P. Hendrik Pretorius, Rameshwar Prasad, Tianyu Ma, Yaqiang Liu, Shi Wang, Stephanie L. Thorn, Mitchel R. Stacy, Albert J. Sinusas, Chi Liu
    Source: Medical physics
    PURPOSE: The energy spectrum for a cadmium zinc telluride (CZT) detector has a