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Step 1 | 3 Central and Peripheral Nervous Systems

3.1       Normal processes

3.1.1    embryonic development, fetal maturation, and perinatal changes, including neural tube derivatives, cerebral ventricles, neural crest derivatives

3.1.2    organ structure and function     spinal cord     gross anatomy and blood supply     spinal reflexes     brain stem     brain     gross anatomy and blood supply     higher function: cognition, language, memory     hypothalamic function     limbic system and emotional behavior     circadian rhythms and sleep     control of eye movement     sensory systems     general sensory modalities, including proprioception and pain     special sensory modalities, including vision, hearing, balance, taste, and olfaction     motor systems     brain and spinal cord     basal ganglia and cerebellum     autonomic nervous system     peripheral nerve

3.1.3    cell/tissue structure and function     axonal transport     excitable properties of neurons, axons and dendrites, including channels     synthesis, storage, release, reuptake, and degradation of neurotransmitters and neuromodulators     pre- and postsynaptic receptor interactions, trophic and growth factors     brain metabolism     glia, myelin     brain homeostasis: blood-brain barrier; cerebrospinal fluid formation and flow; choroid plexus

3.1.4    repair, regeneration, and changes associated with stage of life

3.2       Abnormal processes

3.2.1    infectious, inflammatory, and immunologic disorders     infectious disorders (eg, meningitis, abscess, encephalitis)     demyelinating disorders, including multiple sclerosis, Guillain- Barré syndrome     myasthenia gravis     eye and ear (eg, conjunctivitis, otitis media)

3.2.2    traumatic and mechanical disorders (eg, subdural and epidural hematomas, cord compression, peripheral nerve injury)

3.2.3    neoplastic disorders     primary (eg, meningioma, astrocytoma)     metastatic

3.2.4    acquired metabolic and regulatory disorders (eg, delirium, Reye syndrome)

3.2.5    vascular disorders (eg, cerebrovascular occlusion, venous sinus thrombosis, arterial aneurysms, hemorrhage)

3.2.6    systemic disorders affecting the nervous system (eg, lupus, diabetic neuropathy)

3.2.7    idiopathic disorders affecting the nervous system

3.2.8    congenital disorders, including metabolic (eg, neural tube defects, cerebral palsy, mental retardation, Down syndrome)

3.2.9    degenerative disorders (eg, peripheral neuropathy, Alzheimer dementia, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis)

3.2.10  paroxysmal disorders (eg, epilepsy, headache, sleep disorders [narcolepsy, restless legs syndrome/periodic limb movement, circadian rhythm disorders, parasomnias], pain syndromes)

3.2.11  disorders of special senses (eg, blindness, deafness)

3.2.12 psychopathologic disorders, processes and their evaluation   early-onset disorders (eg, learning disorders)   disorders related to substance use   schizophrenia and other psychotic disorders   mood disorders   anxiety disorders   somatoform disorders   personality disorders   physical and sexual abuse of children, adults, and elders   other disorders (eg, dissociative, impulse control)

3.3       Principles of therapeutics

3.3.1    mechanisms of action, use, and adverse effects of drugs for treatment of disorders of the nervous system     anesthetics     hypnotics     psychopharmacologic agents (eg, anxiolytics, antidepressants, antipsychotic agents, mood-stabilizing agents)     anticonvulsants     analgesics     stimulants, amphetamines     antiparkinsonian drugs     skeletal muscle relaxants; botulinum toxin     neuromuscular junction blocking agents (including postsynaptic)   antiglaucoma drugs   drugs used to decrease intracranial pressure (eg, mannitol, high- dose glucocorticoids)   antimigraine agents   drugs affecting autonomic nervous system (eg, anticholinesterases)

3.3.2    other therapeutic modalities (eg, radiation, CFS shunting, surgery)

3.4       Gender, ethnic, and behavioral considerations affecting disease treatment and prevention, including psychosocial, cultural, occupational, and environmental

3.4.1    emotional and behavioral factors (eg, drug abuse, dementia, sleep deprivation, accident prevention, pets)

3.4.2    influence on person, family, and society (eg, developmental disabilities, dementia, generation reversal, nutrition, seizures, sleep disorders)

3.4.3    occupational and other environmental risk factors (eg, boxing, carbon monoxide exposure)

3.4.4    gender and ethnic factors